A Frequency Multiplier Based on Time Recursive Processing

This paper describes a digital frequency multiplier for a pulse rate. The multiplier is based on the recursive processing of the input and output periods and their time differences. Special emphasis is devoted to the techniques which provide the development of multipliers based on this principle. The circuit is defined by two system parameters. One is the ratio of two clock frequencies and the other is a division factor of a binary counter. The realization of the circuit is described. The region of the system parameters for the stable circuit is presented. The different aspects of applications and limitations in realization of the circuit are considered. All mathematical analyses are made using a Z transform approach. It is shown that the circuit can be also used in tracking and prediction applications. Computer simulations are performed to prove the correctness of the math and the whole approach

Coulomb breakup of neutron-rich 29,30^{29,30}Na isotopes near the island of inversion

First results are reported on the ground state configurations of the neutron-rich $^{29,30}$Na isotopes, obtained via Coulomb dissociation (CD) measurements as a method of the direct probe. The invariant mass spectra of those nuclei have been obtained through measurement of the four-momentum of all decay products after Coulomb excitation on a $^{208}Pb$ target at energies of 400-430 MeV/nucleon using FRS-ALADIN-LAND setup at GSI, Darmstadt. Integrated Coulomb-dissociation cross-sections (CD) of 89 $(7)$ mb and 167 $(13)$ mb up to excitation energy of 10 MeV for one neutron removal from $^{29}$Na and $^{30}$Na respectively, have been extracted. The major part of one neutron removal, CD cross-sections of those nuclei populate core, in its' ground state. A comparison with the direct breakup model, suggests the predominant occupation of the valence neutron in the ground state of $^{29}$Na${(3/2^+)}$ and $^{30}$Na${(2^+)}$ is the $d$ orbital with small contribution in the $s$-orbital which are coupled with ground state of the core. The ground state configurations of these nuclei are as $^{28}$Na_{gs (1^+)\otimes\nu_{s,d} and $^{29}$Na$_{gs}(3/2^+)\otimes\nu_{ s,d}$, respectively. The ground state spin and parity of these nuclei, obtained from this experiment are in agreement with earlier reported values. The spectroscopic factors for the valence neutron occupying the $s$ and $d$ orbitals for these nuclei in the ground state have been extracted and reported for the first time. A comparison of the experimental findings with the shell model calculation using MCSM suggests a lower limit of around 4.3 MeV of the sd-pf shell gap in $^{30}$Na.Comment: Modified version of the manuscript is accepted for publication in Journal of Physics G, Jan., 201

The ASY-EOS experiment at GSI: investigating the symmetry energy at supra-saturation densities

The elliptic-flow ratio of neutrons with respect to protons in reactions of neutron rich heavy-ions systems at intermediate energies has been proposed as an observable sensitive to the strength of the symmetry term in the nuclear Equation Of State (EOS) at supra-saturation densities. The recent results obtained from the existing FOPI/LAND data for $^{197}$Au+$^{197}$Au collisions at 400 MeV/nucleon in comparison with the UrQMD model allowed a first estimate of the symmetry term of the EOS but suffer from a considerable statistical uncertainty. In order to obtain an improved data set for Au+Au collisions and to extend the study to other systems, a new experiment was carried out at the GSI laboratory by the ASY-EOS collaboration in May 2011.Comment: Talk given by P. Russotto at the 11th International Conference on Nucleus-Nucleus Collisions (NN2012), San Antonio, Texas, USA, May 27-June 1, 2012. To appear in the NN2012 Proceedings in Journal of Physics: Conference Series (JPCS

Shrinking-Hole Colloidal Lithography: Self-Aligned Nanofabrication of Complex Plasmonic Nanoantennas

Plasmonic nanoantennas create locally strongly enhanced electric fields in so-called hot spots. To place a relevant nanoobject with high accuracy in such a hot spot is crucial to fully capitalize on the potential of nanoantennas to control, detect, and enhance processes at the nanoscale. With state-of-the-art nanofabrication, in particular when several materials are to be used, small gaps between antenna elements are sought, and large surface areas are to be patterned, this is a grand challenge. Here we introduce self-aligned, bottom-up and self-assembly based Shrinking-Hole Colloidal Lithography, which provides (i) unique control of the size and position of subsequently deposited particles forming the nanoantenna itself, and (ii) allows delivery of nanoobjects consisting of a material of choice to the antenna hot spot, all in a single lithography step and, if desired, uniformly covering several square centimeters of surface. We illustrate the functionality of SHCL nanoantenna arrangements by (i) an optical hydrogen sensor exploiting the polarization dependent sensitivity of an Au-Pd nanoantenna ensemble; and (ii) single particle hydrogen sensing with an Au dimer nanoantenna with a small Pd nanoparticle in the hot spot

A module-based analytical strategy to identify novel disease-associated genes shows an inhibitory role for interleukin 7 Receptor in allergic inflammation

<p>Abstract</p> <p>Background</p> <p>The identification of novel genes by high-throughput studies of complex diseases is complicated by the large number of potential genes. However, since disease-associated genes tend to interact, one solution is to arrange them in modules based on co-expression data and known gene interactions. The hypothesis of this study was that such a module could be a) found and validated in allergic disease and b) used to find and validate one ore more novel disease-associated genes.</p> <p>Results</p> <p>To test these hypotheses integrated analysis of a large number of gene expression microarray experiments from different forms of allergy was performed. This led to the identification of an experimentally validated reference gene that was used to construct a module of co-expressed and interacting genes. This module was validated in an independent material, by replicating the expression changes in allergen-challenged CD4⁺cells. Moreover, the changes were reversed following treatment with corticosteroids. The module contained several novel disease-associated genes, of which the one with the highest number of interactions with known disease genes, <it>IL7R</it>, was selected for further validation. The expression levels of <it>IL7R </it>in allergen challenged CD4⁺cells decreased following challenge but increased after treatment. This suggested an inhibitory role, which was confirmed by functional studies.</p> <p>Conclusion</p> <p>We propose that a module-based analytical strategy is generally applicable to find novel genes in complex diseases.</p

Direct experimental evidence for a multiparticle-hole ground state configuration of deformed Mg-33

The first direct experimental evidence of a multiparticle-hole ground state configuration of the neutron-rich Mg-33 isotope has been obtained via intermediate energy (400 A MeV) Coulomb dissociation measurement. The major part similar to(70 +/- 13)% of the cross section is observed to populate the excited states of Mg-32 after the Coulomb breakup of Mg-33. The shapes of the differential Coulomb dissociation cross sections in coincidence with different core excited states favor that the valence neutron occupies both the s(1/2) and p(3/2) orbitals. These experimental findings suggest a significant reduction and merging of sd-pf shell gaps at N similar to 20 and 28. The ground state configuration of Mg-33 is predominantly a combination of Mg-32(3.0,3.5MeV; 2(-), 1(-)) circle times nu(s1/2), Mg-32(2.5MeV; 2(+)) circle times nu(p3/2), and Mg-32(0; 0(+)) circle times nu(p3/2). The experimentally obtained quantitative spectroscopic information for the valence neutron occupation of the s and p orbitals, coupled with different core states, is in agreement with Monte Carlo shell model (MCSM) calculation using 3 MeV as the shell gap at N = 20