48 research outputs found
DIGITAL EDUCATION : TO TACKLE CLIMATE CHANGE
To achieve long-term sustainability individuals, groups, and organizations need to mitigate
climate change and adapt to the new environmental scenarios. Indeed, climate change is a process that
cannot be ignored in any way any longer. Not only it is happening everywhere, and the effects are more
noticeable every year, but it has also been happening for decades with an impact on every ecosystem
of the planet. This means that climate change is a fundamental issue that affects every person, group,
and organization.
Professionally, we need as much expertise as we can gather. More practitioners are needed
with experience in every field to help mitigate climate change as much as possible while facilitating
rapid adaptation to a progressively damaging climate change.
Climate change is caused by humans and human behavior, even if some issues seem
technological and environmental problems, the origin is still human behavior. Therefore, there is a
critical need for being able to count on behavioral experts that contribute to explaining current
behaviors. Additionally, behavior change experts who are able to motivate individuals, groups, and
organizations to engage in mitigation and adaptation behaviors are equally necessary.
To achieve this, a more comprehensive range of educational opportunities is needed. This
education must be included in vocational training and applied science universities. However, nothing
will have an impact as far-reaching as education about climate change for students during their
bachelor and master programs. The capacity of highly trained professionals with behavioral change
expertise can have a trickling-down effect that will benefit the whole world.
Because of how crucial education in climate change is, an urgent need is currently a pressing
matter to provide specialized education on how to understand and improve the sustainability behavior
of people, groups, and organizations. This need to increase both the amount and quality of
sustainability-related education is met with an insufficient amount of education resources being
offered.
Creating new courses or even programs on this topic is not a realistic possibility for many
institutions. In some cases, the development of new content might not be feasible due to local
difficulties, and in other cases, climate change might not be a preference whatsoever. Therefore, it is
crucial to offer alternatives to institutions that due to factors such as lack of local expertise, different
agendas, or the difficulties linked to generating new content cannot offer education on climate change
and behavior themselves. This education alternative should be easy to implement and adapt to the
specific programs.
The most straightforward contribution to facilitating education in climate change at bachelor
and master levels is offering online courses that can be imported. Additionally, to maximize the reach
of these courses, they should include content that can be learned in a self-guided manner. The PSYCLIC
project offers the latest content about climate change and human behavior. This material will be
available to be directly imported digitally at any university program. Additionally, it has a modular
structure that is self-guided by default.
However, the education resource that the PSYCLIC project offers will not make a meaningful
impact unless the target community (i.e., institutions that could offer education on the topic of climate
change and behavior but do not do so) is eager to use the education resources that the project will
offer.
To understand if the profile of scholars that the PSYCLIC project has as the target are ready and
kin on using what the project will offer, we reached other colleagues to explore the demands and
barriers for ready to use digital education material on climate change and behavior.ERASMUS+ / Projektname: Psychology and Climate Change - Digital Education / Projekt Akronym: PSYCLI
Bis(di-tert-butylindenyl)tetrelocenes
The synthesis and characterization of bis(di-tert-butylindenyl) germanium(II), tin(II) and lead(II) complexes are reported, which includes the first structurally authenticated example of a bis(indenyl)germanocene. The species were studied in detail in solution and in the solid, which includes single crystal X-ray diffraction and NMR spectroscopy, as well as Mössbauer spectroscopy of the tin compound
Stimulation frequency determines the distribution of language positive cortical regions during navigated transcranial magnetic brain stimulation
Pancreatic Mesenchyme Regulates Epithelial Organogenesis throughout Development
The developing pancreatic epithelium gives rise to all endocrine and exocrine cells of the mature organ. During organogenesis, the epithelial cells receive essential signals from the overlying mesenchyme. Previous studies, focusing on ex vivo tissue explants or complete knockout mice, have identified an important role for the mesenchyme in regulating the expansion of progenitor cells in the early pancreas epithelium. However, due to the lack of genetic tools directing expression specifically to the mesenchyme, the potential roles of this supporting tissue in vivo, especially in guiding later stages of pancreas organogenesis, have not been elucidated. We employed transgenic tools and fetal surgical techniques to ablate mesenchyme via Cre-mediated mesenchymal expression of Diphtheria Toxin (DT) at the onset of pancreas formation, and at later developmental stages via in utero injection of DT into transgenic mice expressing the Diphtheria Toxin receptor (DTR) in this tissue. Our results demonstrate that mesenchymal cells regulate pancreatic growth and branching at both early and late developmental stages by supporting proliferation of precursors and differentiated cells, respectively. Interestingly, while cell differentiation was not affected, the expansion of both the endocrine and exocrine compartments was equally impaired. To further elucidate signals required for mesenchymal cell function, we eliminated β-catenin signaling and determined that it is a critical pathway in regulating mesenchyme survival and growth. Our study presents the first in vivo evidence that the embryonic mesenchyme provides critical signals to the epithelium throughout pancreas organogenesis. The findings are novel and relevant as they indicate a critical role for the mesenchyme during late expansion of endocrine and exocrine compartments. In addition, our results provide a molecular mechanism for mesenchymal expansion and survival by identifying β-catenin signaling as an essential mediator of this process. These results have implications for developing strategies to expand pancreas progenitors and β-cells for clinical transplantation
Continuum Halos in Nearby Galaxies -- an EVLA Survey (CHANG-ES) -- I: Introduction to the Survey
We introduce a new survey to map the radio continuum halos of a sample of 35
edge-on spiral galaxies at 1.5 GHz and 6 GHz in all polarization products. The
survey is exploiting the new wide bandwidth capabilities of the Karl G. Jansky
Very Large Array (i.e. the Expanded Very Large Array, or EVLA) in a variety of
array configurations (B, C, and D) in order to compile the most comprehensive
data set yet obtained for the study of radio halo properties. This is the first
survey of radio halos to include all polarization products.
In this first paper, we outline the scientific motivation of the survey, the
specific science goals, and the expected improvements in noise levels and
spatial coverage from the survey. Our goals include investigating the physical
conditions and origin of halos, characterizing cosmic ray transport and wind
speed, measuring Faraday rotation and mapping the magnetic field, probing the
in-disk and extraplanar far-infrared - radio continuum relation, and
reconciling non-thermal radio emission with high-energy gamma-ray models. The
sample size allows us to search for correlations between radio halos and other
properties, including environment, star formation rate, and the presence of
AGNs. In a companion paper (Paper II) we outline the data reduction steps and
present the first results of the survey for the galaxy, NGC 4631.Comment: 17 pages, 1 figure, accepted to the Astronomical Journal, Version 2
changes: added acknowledgement to NRA
Negation and the functional sequence
There exists a general restriction on admissible functional sequences which prevents adjacent identical heads. We investigate a particular instantiation of this restriction in the domain of negation. Empirically, it manifests itself as a restriction the stacking of multiple negative morphemes. We propose a principled account of this restriction in terms of the general ban on immediately consecutive identical heads in the functional sequence on the one hand, and the presence of a Neg feature inside negative morphemes on the other hand. The account predicts that the stacking of multiple negative morphemes should be possible provided they are separated by intervening levels of structure. We show that this prediction is borne out
The impact of preoperative language mapping by repetitive navigated transcranial magnetic stimulation on the clinical course of brain tumor patients
Finishing the euchromatic sequence of the human genome
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
Background:
A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials.
Methods:
This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674.
Findings:
Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation.
Interpretation:
ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials.
Funding:
UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D’Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.
BACKGROUND: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. METHODS: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. FINDINGS: Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0-75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4-97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8-80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3-4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. INTERPRETATION: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials. FUNDING: UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D'Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca