Intrepid: A Mission to Pluto

A proposal for an exploratory spacecraft mission to Pluto/Charon system was written in response to the request for proposal for an unmannned probe to pluto (RFP). The design requirements of the RFP are presented and under the guidance of these requirements, the spacecraft Intrepid was designed. The RPF requirement that was of primary importance is the minimization of cost. Also, the reduction of flight time was of extreme importance because the atmosphere of Pluto is expected to collapse close to the Year 2020. If intrepid should arrive after the collapse, the mission would be a failure; for Pluto would be only a solid rock of ice. The topics presented include: (1) scientific instrumentation; (2) mission management, planning, and costing; (3) power and propulsion subsystem; (4) structural subsystem; (5) command, control, and communications; and (6) attitude and articulation control

Effects of Changing Work Environments on Employer Support for Physical Activity During COVID-19

COVID-19 dramatically accelerated evolving changes in the way we define the “work environment” in the United States. In response to COVID-19, many employers have offered increased flexibility for where employees work, including remote (an employee’s workstation is at home) and hybrid work (an employee works both at the employer worksite and remotely, on predetermined schedules). Accordingly, worksite physical activity (PA) and sedentary behaviors (SB) such as extended sitting time (ST) may have changed.1,2 However, little is known about whether these work arrangements are associated with changes in employer support for PA. Interviews were conducted to assess this gap in understanding. Because little is known about employer support for equity with respect to PA and SB, this study sought to identify potential strategies to assure equity in PA opportunities across work environments

Genomic analysis of atypical fibroxanthoma

Atypical fibroxanthoma (AFX), is a rare type of skin cancer affecting older individuals with sun damaged skin. Since there is limited genomic information about AFX, our study seeks to improve the understanding of AFX through whole-exome and RNA sequencing of 8 matched tumor-normal samples. AFX is a highly mutated malignancy with recurrent mutations in a number of genes, including COL11A1, ERBB4, CSMD3, and FAT1. The majority of mutations identified were UV signature (C>T in dipyrimidines). We observed deletion of chromosomal segments on chr9p and chr13q, including tumor suppressor genes such as KANK1 and CDKN2A, but no gene fusions were found. Gene expression profiling revealed several biological pathways that are upregulated in AFX, including tumor associated macrophage response, GPCR signaling, and epithelial to mesenchymal transition (EMT). To further investigate the presence of EMT in AFX, we conducted a gene expression meta-analysis that incorporated RNA-seq data from dermal fibroblasts and keratinocytes. Ours is the first study to employ high throughput sequencing for molecular profiling of AFX. These data provide valuable insights to inform models of carcinogenesis and additional research towards tumor-directed therapy

Travailler l’alliance éducative avec les mineurs migrants

International audienceOver recent years, more and more unaccompanied minors have been arriving on French territory in search of a better future. As a result of their complicated journey before, during and after the migration, these youngsters have specific psychological needs which are not always recognised by the professionals working with them. Research has highlighted the elements weakening the educational alliance between youngsters and the adults surrounding them