117 research outputs found
Stable One-Dimensional Integral Representations of One-Loop N-Point Functions in the General Massive Case: I - Three Point Functions
In this article we provide representations for the one-loop three point
functions in 4 and 6 dimensions in the general case with complex masses. The
latter are part of the GOLEM library used for the computation of one-loop
multileg amplitudes. These representations are one-dimensional integrals
designed to be free of instabilites induced by inverse powers of Gram
determinants, therefore suitable for stable numerical implementations.Comment: 40 pages, 1 figur
A new feature extraction method based on clustering for face recognition
Part 13: Feature Extraction - MinimizationInternational audienceWhen solving a pattern classification problem, it is common to apply a feature extraction method as a pre-processing step, not only to reduce the computation complexity but also to obtain better classification performance by reducing the amount of irrelevant and redundant information in the data. In this study, we investigate a novel schema for linear feature extraction in classification problems. The method we have proposed is based on clustering technique to realize feature extraction. It focuses in identifying and transforming redundant information in the data. A new similarity measure-based trend analysis is devised to identify those features. The simulation results on face recognition show that the proposed method gives better or competitive results when compared to conventional unsupervised methods like PCA and ICA
A high throughput genotyping approach reveals distinctive autosomal genetic signatures for European and Near Eastern wild boar
The lack of a Near Eastern genetic signature in modern European porcine breeds indicates that, although domestic pigs from the Fertile Crescent entered Europe during the Neolithic, they were completely replaced by their European counterparts in a short window of time. Whilst the absence of such genetic signature has been convincingly demonstrated at the mitochondrial level, variation at the autosomal genomes of European and Near Eastern Sus scrofa has not been compared yet. Herewith, we have explored the genetic relationships among 43 wild boar from Europe (N = 21), Near East (N = 19) and Korea (N = 3), and 40 Iberian (N = 16), Canarian (N = 4) and Mangalitza (N = 20) pigs by using a high throughput SNP genotyping platform. After data filtering, 37,167 autosomal SNPs were used to perform population genetics analyses. A multidimensional scaling plot based on genome-wide identity-by-state pairwise distances inferred with PLINK showed that Near Eastern and European wild boar populations are genetically differentiated. Maximum likelihood trees built with TreeMix supported this conclusion i.e. an early population split between Near Eastern and European Sus scrofa was observed. Moreover, analysis of the data with Structure evidenced that the sampled Iberian, Canarian and Mangalitza pigs did not carry any autosomal signature compatible with a Near Eastern ancestry, a finding that agrees well with previous mitochondrial studies
Beta catenin and cytokine pathway dysregulation in patients with manifestations of the "PTEN hamartoma tumor syndrome"
Background.
The "PTEN hamartoma tumor syndrome" (PHTS) includes a group of syndromes caused by germline mutations within the tumor suppressor gene "phosphatase and tensin homolog deleted on chromosome ten" (PTEN), characterized by multiple polyps in the gastrointestinal tract and by a highly increased risk of developing malignant tumours in many tissues.
The current work clarifies the molecular basis of PHTS in three unrelated Italian patients, and sheds light on molecular pathway disregulation constitutively associated to PTEN alteration.
Methods.
We performed a combination of RT-PCR, PCR, sequencing of the amplified fragments, Real Time PCR and western blot techniques.
Results.
Our data provide the first evidence of β-catenin accumulation in blood cells of patients with hereditary cancer syndrome caused by germ-line PTEN alteration. In addition, for the first time we show, in all PHTS patients analysed, alterations in the expression of TNFα, its receptors and IL-10. Importantly, the isoform of TNFRI that lacks the DEATH domain (TNFRSF1β) was found to be overexpressed.
Conclusion.
In light of our findings, we suggest that the PTEN pathway disregulation could determine, in non-neoplastic cells of PHTS patients, cell survival and pro-inflammatory stimulation, mediated by the expression of molecules such as β-catenin, TNFα and TNFα receptors, which could predispose these patients to the development of multiple cancers
Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications
Superparamagnetic iron oxide nanoparticles
can providemultiple benefits for biomedical applications
in aqueous environments such asmagnetic separation or
magnetic resonance imaging. To increase the colloidal
stability and allow subsequent reactions, the introduction
of hydrophilic functional groups onto the particles’
surface is essential. During this process, the original
coating is exchanged by preferably covalently bonded
ligands such as trialkoxysilanes. The duration of the
silane exchange reaction, which commonly takes more
than 24 h, is an important drawback for this approach. In
this paper, we present a novel method, which introduces
ultrasonication as an energy source to dramatically
accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove
the generic character, different functional groups were
introduced on the surface including polyethylene glycol
chains, carboxylic acid, amine, and thiol groups. Their
colloidal stability in various aqueous buffer solutions as
well as human plasma and serum was investigated to
allow implementation in biomedical and sensing
applications.status: publishe
Remodeling of the bone material containing microcracks: A theoretical analysis
The question is, what happens when the bone loses its ability for load-driven
adaptation, when damage is no longer repaired as it seems to be the case for bone loss
associated with age, medication or disease? In this study, we tempt to show how damage
can influence the remodeling process. A thermodynamic theoretical framework is therefore
provided as a basis for a consistent formulation of bone remodeling involving a
chemical reaction and mass transfer between two constituents in presence of microcracks
Contribution to the study of the bone remodeling theory using n unit-elements model
Our work presents the study of bone remodeling scheme
in the general case of n unit-elements model. The analytical result for
the stationary states presented here as original was obtained and a
condition which is necessary for the stability of the remodeling theory was
derived. Forward finite-difference time-stepping is used to verify the
prediction of the analytical study. This numerical study appears to confirm
the analytical results
Dynamic Performance of an HVDC Link
This paper presents the results of a simulation study on a 12 pulse HVDC (High Voltage Direct Current) using a system in Matlab/Simulink. The object of the study is to investigate the steady state and dynamic performance of the system. First we examine response of current regulator after change in current reference in order to see the behavior of the controllers in controlling the desired current. Next, we present the digital simulation of a test system and show the response to a DC fault in the line and the AC fault at inverter side. The results are evaluated to enhance the recovery of the system from the disturbances for a full range of typical disturbances. The presented approach benefits from Simulink’s advantages in modeling and simulating dynamical systems
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