1,348 research outputs found
A spectroscopic and thermal investigation into the relationship between composition, secondary structure and physical characteristics of electrospun zein nanofibers
Electrospun zein nanofibers have attracted interest as drug delivery systems due to their propensity for controlled drug release, flexible structure and low toxicity. However, comparatively little is known regarding the relationship between production method and fiber characteristics, both in terms of fiber architecture and protein structure. Here we use a range of imaging and spectroscopic techniques to elucidate the effects of solvent composition on zein secondary structure, fiber diameter and fiber integrity, plus we utilize the new technique of transition temperature microscopy to examine the thermal properties of the fibers. Zein nanofibers were prepared using ethanol, acetic acid and water mixes as solvents, alone and with plasticizers (polyethylene glycol, glycerol) and casein. Electrospinning was performed under controlled conditions and the products characterized using scanning electron microscopy (SEM), attenuated total reflection Fourier Transform infrared spectrometry (ATR - FTIR) and transition temperature microscopy (TTM). The choice of solvent, concentration and voltage, alongside the presence of additives (plasticizers and casein) were noted to influence both the diameter of the fibers and the tendency for bead formation. A relationship was noted between protein secondary structure and fiber architecture, with an enhanced β-sheet content, enhanced by the inclusion of casein, being associated with higher beading. In addition, thermal imaging of electrospun zein fiber mats was successfully achieved using TTM via two dimensional mapping of the softening temperatures across the spun samples, in particular demonstrating the plasticizing effects of the polyethylene glycol and glycerol
Prevention of childhood poisoning in the home: overview of systematic reviews and a systematic review of primary studies
Unintentional poisoning is a significant child public health problem. This systematic overview of reviews, supplemented with a systematic review of recently published primary studies synthesizes evidence on non-legislative interventions to reduce childhood poisonings in the home with particular reference to interventions that could be implemented by Children's Centres in England or community health or social care services in other high income countries. Thirteen systematic reviews, two meta-analyses and 47 primary studies were identified. The interventions most commonly comprised education, provision of cupboard/drawer locks, and poison control centre (PCC) number stickers. Meta-analyses and primary studies provided evidence that interventions improved poison prevention practices. Twenty eight per cent of studies reporting safe medicine storage (OR from meta-analysis 1.57, 95% CI 1.22–2.02), 23% reporting safe storage of other products (OR from meta-analysis 1.63, 95% CI 1.22–2.17) and 46% reporting availability of PCC numbers (OR from meta-analysis 3.67, 95% CI 1.84–7.33) demonstrated significant effects favouring the intervention group. There was a lack of evidence that interventions reduced poisoning rates. Parents should be provided with poison prevention education, cupboard/drawer locks and emergency contact numbers to use in the event of a poisoning. Further research is required to determine whether improving poison prevention practices reduces poisoning rates
Physical Properties of Wave Motion in Inclined Magnetic Fields Within Sunspot Penumbrae
At the surface of the Sun, acoustic waves appear to be affected by the
presence of strong magnetic fields in active regions. We explore the
possibility that the inclined magnetic field in sunspot penumbrae may convert
primarily vertically propagating acoustic waves into elliptical motion. We use
helioseismic holography to measure the modulus and phase of the correlation
between incoming acoustic waves and the local surface motion within two
sunspots. These correlations are modeled assuming the surface motion is
elliptical, and we explore the properties of the elliptical motion on the
magnetic field inclination. We also demonstrate that the phase shift of the
outward propagating waves is opposite to the phase shift of the inward
propagating waves in stronger, more vertical fields, but similar to the inward
phase shifts in weaker, more inclined fields.Comment: 22 pages, 13 figure
Determining Absorption, Emissivity Reduction, and Local Suppression Coefficients inside Sunspots
The power of solar acoustic waves is reduced inside sunspots mainly due to
absorption, emissivity reduction, and local suppression. The coefficients of
these power-reduction mechanisms can be determined by comparing time-distance
cross-covariances obtained from sunspots and from the quiet Sun. By analyzing
47 active regions observed by SOHO/MDI without using signal filters, we have
determined the coefficients of surface absorption, deep absorption, emissivity
reduction, and local suppression. The dissipation in the quiet Sun is derived
as well. All of the cross-covariances are width corrected to offset the effect
of dispersion. We find that absorption is the dominant mechanism of the power
deficit in sunspots for short travel distances, but gradually drops to zero at
travel distances longer than about 6 degrees. The absorption in sunspot
interiors is also significant. The emissivity-reduction coefficient ranges from
about 0.44 to 1.00 within the umbra and 0.29 to 0.72 in the sunspot, and
accounts for only about 21.5% of the umbra's and 16.5% of the sunspot's total
power reduction. Local suppression is nearly constant as a function of travel
distance with values of 0.80 and 0.665 for umbrae and whole sunspots
respectively, and is the major cause of the power deficit at large travel
distances.Comment: 14 pages, 21 Figure
Suppression of Superconducting Critical Current Density by Small Flux Jumps in Thin Films
By doing magnetization measurements during magnetic field sweeps on thin
films of the new superconductor , it is found that in a low temperature
and low field region small flux jumps are taking place. This effect strongly
suppresses the central magnetization peak leading to reduced nominal
superconducting critical current density at low temperatures. A borderline for
this effect to occur is determined on the field-temperature (H-T) phase
diagram. It is suggested that the small size of the flux jumps in films is due
to the higher density of small defects and the relatively easy thermal
diffusion in thin films in comparison with bulk samples.Comment: 7 figures Phys. Rev. B accepted scheduled issue: 01 Feb 200
Melting behavior of ultrathin titanium nanowires
The thermal stability and melting behavior of ultrathin titanium nanowires
with multi-shell cylindrical structures are studied using molecular dynamic
simulation. The melting temperatures of titanium nanowires show remarkable
dependence on wire sizes and structures. For the nanowire thinner than 1.2 nm,
there is no clear characteristic of first-order phase transition during the
melting, implying a coexistence of solid and liquid phases due to finite size
effect. An interesting structural transformation from helical multi-shell
cylindrical to bulk-like rectangular is observed in the melting process of a
thicker hexagonal nanowire with 1.7 nm diameter.Comment: 4 pages, 4 figure
Local threshold field for dendritic instability in superconducting MgB2 films
Using magneto-optical imaging the phenomenon of dendritic flux penetration in
superconducting films was studied. Flux dendrites were abruptly formed in a 300
nm thick film of MgB2 by applying a perpendicular magnetic field. Detailed
measurements of flux density distributions show that there exists a local
threshold field controlling the nucleation and termination of the dendritic
growth. At 4 K the local threshold field is close to 12 mT in this sample,
where the critical current density is 10^7 A/cm^2. The dendritic instability in
thin films is believed to be of thermo-magnetic origin, but the existence of a
local threshold field, and its small value are features that distinctly
contrast the thermo-magnetic instability (flux jumps) in bulk superconductors.Comment: 6 pages, 6 figures, submitted to Phys. Rev.
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Unbiased, optimal, and in-betweens: the trade-off in discrete finite impulse response filtering
In this survey, the authors examine the trade-off between the unbiased, optimal, and in-between solutions in finite impulse response (FIR) filtering. Specifically, they refer to linear discrete real-time invariant state-space models with zero mean noise sources having arbitrary covariances (not obligatorily delta shaped) and distributions (not obligatorily Gaussian). They systematically analyse the following batch filtering algorithms: unbiased FIR (UFIR) subject to the unbiasedness condition, optimal FIR (OFIR) which minimises the mean square error (MSE), OFIR with embedded unbiasedness (EU) which minimises the MSE subject to the unbiasedness constraint, and optimal UFIR (OUFIR) which minimises the MSE in the UFIR estimate. Based on extensive investigations of the polynomial and harmonic models, the authors show that the OFIR-EU and OUFIR filters have higher immunity against errors in the noise statistics and better robustness against temporary model uncertainties than the OFIR and Kalman filters
Self-Assembled Local Artificial Substrates of GaAs on Si Substrate
We propose a self-assembling procedure for the fabrication of GaAs islands by Droplet Epitaxy on silicon substrate. Controlling substrate temperature and amount of supplied gallium is possible to tune the base size of the islands from 70 up to 250 nm and the density from 107 to 109 cm−2. The islands show a standard deviation of base size distribution below 10% and their shape evolves changing the aspect ratio from 0.3 to 0.5 as size increases. Due to their characteristics, these islands are suitable to be used as local artificial substrates for the integration of III–V quantum nanostructures directly on silicon substrate
Helioseismology of Sunspots: A Case Study of NOAA Region 9787
Various methods of helioseismology are used to study the subsurface
properties of the sunspot in NOAA Active Region 9787. This sunspot was chosen
because it is axisymmetric, shows little evolution during 20-28 January 2002,
and was observed continuously by the MDI/SOHO instrument. (...) Wave travel
times and mode frequencies are affected by the sunspot. In most cases, wave
packets that propagate through the sunspot have reduced travel times. At short
travel distances, however, the sign of the travel-time shifts appears to depend
sensitively on how the data are processed and, in particular, on filtering in
frequency-wavenumber space. We carry out two linear inversions for wave speed:
one using travel-times and phase-speed filters and the other one using mode
frequencies from ring analysis. These two inversions give subsurface wave-speed
profiles with opposite signs and different amplitudes. (...) From this study of
AR9787, we conclude that we are currently unable to provide a unified
description of the subsurface structure and dynamics of the sunspot.Comment: 28 pages, 18 figure
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