A novel SWB antenna with triple band-notches based on elliptical slot and rectangular split ring resonators

In this paper, a wideband antenna was designed for super-wideband (SWB) applications. The proposed antenna was fed with a rectangular tapered microstrip feed line, which operated over a SWB frequency range (1.42 GHz to 50 GHz). The antenna was implemented at a compact size with electrical dimensions of 0.16 ¿ × 0.27 ¿ × 0.0047 ¿ mm3, where ¿ was with respect to the lowest resonance frequency. The proposed antenna prototype was fabricated on a F4B substrate, which had a permittivity of 2.65 and 1 mm thickness. The SWB antenna exhibited an impedance bandwidth of 189% and a bandwidth ratio of 35.2:1. Additionally, the proposed antenna design exhibited three band notch characteristics that were necessary to eradicate interference from WLAN, WiMAX, and X bands in the SWB range. One notch was achieved by etching an elliptical split ring resonator (ESRR) in the radiator and the other two notches were achieved by placing rectangular split ring resonators close to the signal line. The first notch was tuned by incorporating a varactor diode into the ESRR. The prototype was experimentally validated with, with notch and without notch characteristics for SWB applications. The experimental results showed good agreement with simulated results.Postprint (published version

Stereoselective Synthesis of Chiral Isatin Containing Bisphosphonates as Potential Anti-Resorption Bone Drugs

Bisphosphonates are currently the major class of drugs used for the treatment of osteoporosis, a disease that leads to bone fragility and increase in fracture risk that affects hundreds of million elderly individual worldwide. All commercially available bisphosphonates are achiral albeit their activity is demonstrated to be related to inactivation of specific enzymes. Cinchona alkaloid urea derivatives are efficient organocatalysts for the asymmetric aldol reaction of ketones to an isatin containing bisphosphonate precursor to provide a class of new chiral enantioenriched potentially anti-resorption bone drugs. High chemical yields were generally achieved in a wide array of substrates tested an

Preclinical Pharmacology of AZD5363, an Inhibitor of AKT: Pharmacodynamics, Antitumor Activity, and Correlation of Monotherapy Activity with Genetic Background

AKT is a key node in the most frequently deregulated signaling network in human cancer. AZD5363, a novel pyrrolopyrimidine-derived compound, inhibited all AKT isoforms with a potency of 10 nmol/L or less and inhibited phosphorylation of AKT substrates in cells with a potency of approximately 0.3 to 0.8 mmol/L. AZD5363 monotherapy inhibited the proliferation of 41 of 182 solid and hematologic tumor cell lines with a potency of 3 mmol/L or less. Cell lines derived from breast cancers showed the highest frequency of sensitivity. There was a significant relationship between the presence of PIK3CA and/or PTEN mutations and sensitivity to AZD5363 and between RAS mutations and resistance. Oral dosing of AZD5363 to nude mice caused dose- and time-dependent reduction of PRAS40, GSK3β, and S6 phosphorylation in BT474c xenografts (PRAS40 phosphorylation EC 50 ∼ 0.1 μmol/L total plasma exposure), reversible increases in blood glucose concentrations, and dose-dependent decreases in 2[18F]fluoro-2-deoxy-D-glucose ( 18F-FDG) uptake in U87-MG xenografts. Chronic oral dosing of AZD5363 caused dose-dependent growth inhibition of xenografts derived from various tumor types, including HER2 + breast cancer models that are resistant to trastuzumab. AZD5363 also significantly enhanced the antitumor activity of docetaxel, lapatinib, and trastuzumab in breast cancer xenografts. It is concluded that AZD5363 is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent, and has potential for personalized medicine based on the genetic status of PIK3CA, PTEN, and RAS. AZD5363 is currently in phase I clinical trials. ©2012 AACR

Real-time Inserting Virtual Characters into Dynamic Video Scene

National audienceThe integration of moving virtual objects into real live-action scenes is an emerging topic. One difficult problem is to detect the presence of real moving obstacles, such as real people walking around, and to control the motion of virtual objects accordingly. This problem is however important to achieve geometrically coherent mixed reality content and to avoid irrealistic collisions between real and virtual objects. We propose a video-based solution. First, by analyzing the input video in real time, the motion states of the real targets are recovered into real 3D world. Secondly, under the constraint of the real dynamic targets, the virtual objects are controlled to move around and avoid the real targets in real time. Finally, to compute the visibility of each target, we extract each targets silhouette accurately which guarantees the computation of occlusion and location for the targets. Several examples demonstrate the efficacy of the proposed algorithm

Research on the Influence of Wheel Polygonization on Axle Stress

To study the influence of wheel polygonization on the dynamic stress of the wheel axle, a vehicle-track rigid-flexible coupling dynamic model was established. In the model, the wheelset, axle box, and track system were modelled as flexible bodies to consider the influence of elastic vibration. At the same time, the dynamic stress on key positions of the axle under the wheel polygonization excitation was measured on the high-frequency vibration test rig. The accuracy of the model was verified by comparison with the test results. The wheel axle stress under the excitation of the wheel polygonization with different orders, wave depths, and running speed was calculated. The results show that the wheel polygonization can increase the amplitude of the axle dynamic stress, and the larger the wave depth of the wheel polygonization, the larger the stress amplitude. When the wheel polygonization frequency is close to the frequency of the wheelset elastic vibration mode, the wheelset first-order bending and second-order bending modes have a great influence on the axle stress. The resonance vibration of the wheelset elastic modal can cause the dynamic stress on key positions of the axle increase sharply