647 research outputs found
Prenatal exposures and exposomics of asthma
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- Adamko DJ Sykes BD, Rowe BH
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- Bilbo SD
- Bilbo SD Schwarz JM
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- Chaouiya C
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- Weschler CJ
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- Wieslander G Norback D, Edling C
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- Wild CP
- Wilkinson DJ
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- Yang IV Schwartz DA
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- Zittermann A Dembinski J, Stehle P
- Zock JP Plana E, Jarvis D, et al.
- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2015
- Field of study
This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental medi
Pin1 and neurodegeneration: a new player for prion disorders?
- Author
- Anderson JP Walker DE, Goldstein JM, et al.
- Bae B-I Xu H, Igarashi S, et al.
- Bayer E Goettsch S, Mueller JW, et al.
- Bertoni A Giuliano P, Galgani M, et al.
- Binder LI Guillozet-Bongaarts AL, Garcia-Sierra
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- Cancino GI Miller FD, Kaplan DR
- Chen C-H Li W, Sultana R, et al.
- Cisbani G Cicchetti F
- Dauer W Przedborski S
- Frankenfield KN Powers ET, Kelly JW
- Gendron TF Petrucelli L
- Ghosh A Saminathan H, Kanthasamy A, et al.
- Giannopoulos PN Robertson C, Jodoin J, et al.
- Grison A Mantovani F, Comel A, et al.
- Hardy J Selkoe DJ
- Huang Y Mucke L
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- Iqbal K Grundke-Iqbal I
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- Kim S Nollen EA, Kitagawa K, et al.
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- LaFerla FM
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- Liou Y-C Sun A, Ryo A, et al.
- Liou Y-C Zhou XZ, Lu KP
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- Lu KP Zhou XZ
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- Nixon RA Shea TB
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- Prusiner SB
- Prusiner SB
- Prusiner SB
- Prusiner SB
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- Rouget R Sharma G, LeBlanc AC
- Rudrabhatla P Jaffe H, Pant HC
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- Taylor JP Hardy J, Fischbeck KH
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- Vöhringer-Martinez E Verstraelen T, Ayers PW
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- Wang J-Z Zhang Y
- Yotsumoto K Saito T, Asada A, et al.
- Yuan A Sasaki T, Rao MV, et al.
- Zhou Z Xiao G
- Zita MM Marchionni I, Bottos E, et al.
- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2015
- Field of study
Pin1 is a peptidyl-prolyl isomerase that catalyzes the cis/trans conversion of phosphorylated proteins at serine or threonine residues which precede a proline. The peptidyl-prolyl isomerization induces a conformational change of the proteins involved in cell signaling process. Pin1 dysregulation has been associated with some neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease. Proline-directed phosphorylation is a common regulator of these pathologies and a recent work showed that it is also involved in prion disorders. In fact, prion protein phosphorylation at the Ser-43-Pro motif induces prion protein conversion into a disease-associated form. Furthermore, phosphorylation at Ser-43-Pro has been observed to increase in the cerebral spinal fluid of sporadic Creutzfeldt-Jakob Disease patients. These findings provide new insights into the pathogenesis of prion disorders, suggesting Pin1 as a potential new player in the disease. In this paper, we review the mechanisms underlying Pin1 involvement in the aforementioned neurodegenerative pathologies focusing on the potential role of Pin1 in prion disorders
DNA damage by lipid peroxidation products: implications in cancer, inflammation and autoimmunity
- Author
- Akagawa M Ito S, Toyoda K, et al.
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2017
- Field of study
Oxidative stress and lipid peroxidation (LPO) induced by inflammation, excess metal storage and excess caloric intake cause generalized DNA damage, producing genotoxic and mutagenic effects. The consequent deregulation of cell homeostasis is implicated in the pathogenesis of a number of malignancies and degenerative diseases. Reactive aldehydes produced by LPO, such as malondialdehyde, acrolein, crotonaldehyde and 4-hydroxy-2-nonenal, react with DNA bases, generating promutagenic exocyclic DNA adducts, which likely contribute to the mutagenic and carcinogenic effects associated with oxidative stress-induced LPO. However, reactive aldehydes, when added to tumor cells, can exert an anticancerous effect. They act, analogously to other chemotherapeutic drugs, by forming DNA adducts and, in this way, they drive the tumor cells toward apoptosis. The aldehyde-DNA adducts, which can be observed during inflammation, play an important role by inducing epigenetic changes which, in turn, can modulate the inflammatory process. The pathogenic role of the adducts formed by the products of LPO with biological macromolecules in the breaking of immunological tolerance to self antigens and in the development of autoimmunity has been supported by a wealth of evidence. The instrumental role of the adducts of reactive LPO products with self protein antigens in the sensitization of autoreactive cells to the respective unmodified proteins and in the intermolecular spreading of the autoimmune responses to aldehyde-modified and native DNA is well documented. In contrast, further investigation is required in order to establish whether the formation of adducts of LPO products with DNA might incite substantial immune responsivity and might be instrumental for the spreading of the immunological responses from aldehyde-modified DNA to native DNA and similarly modified, unmodified and/or structurally analogous self protein antigens, thus leading to autoimmunity
The disruption of proteostasis in neurodegenerative diseases
- Author
- Abravaya K Phillips B, Morimoto RI
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- Zolkiewski M
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2015
- Field of study
Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.info:eu-repo/semantics/publishedVersio
Identification and Classification of Conserved RNA Secondary Structures in the Human Genome
- Author
- Adam Siepel
- Angrand PO Apiou F, Stewart AF, Dutrillaux B, Losson R, et al.
- Aparicio S Chapman J, Stupka E, Putnam N, Chia JM, et al.
- Bentwich I Avniel A, Karov Y, Aharonov R, Gilad S, et al.
- Berezikov E Guryev V, van de Belt J, Wienholds E, Plasterk RH, et al.
- Berry MJ Banu L, Chen YY, Mandel SJ, Kieffer JD, et al.
- Blanchette M Kent WJ, Riemer C, Elnitski L, Smit AF, et al.
- Bompfünewerer AF Flamm C, Fried C, Fritzsch G, Hofacker IL, et al.
- Brudno M Do CB, Cooper GM, Kim MF, Davydov E, et al.
- Chimpanzee Sequencing and Analysis Consortium
- David Haussler
- Eric S Lander
- Gibbs RA Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, et al.
- Gill Bejerano
- Gregory RI Yan KP, Amuthan G, Chendrimada T, Doratotaj B, et al.
- Griffiths-Jones S Moxon S, Marshall M, Khanna A, Eddy SR, et al.
- Higuchi M Maas S, Single FN, Hartner J, Rozov A, et al.
- Hillier LW Miller W, Birney E, Warren W, Hardison RC, et al.
- Howard MT Aggarwal G, Anderson CB, Khatri S, Flanigan KM, et al.
- International Human Genome Sequencing Consortium
- Jakob Skou Pedersen
- Jim Kent
- Kate Rosenbloom
- Kent WJ Sugnet CW, Furey TS, Roskin KM, Pringle TH, et al.
- Kerstin Lindblad-Toh
- Kryukov GV Castellano S, Novoselov SV, Lobanov AV, Zehtab O, et al.
- Lagos-Quintana M Rauhut R, Yalcin A, Meyer J, Lendeckel W, et al.
- Lim LP Lau NC, Weinstein EG, Abdelhakim A, Yekta S, et al.
- Matsufuji S Matsufuji T, Miyazaki Y, Murakami Y, Atkins JF, et al.
- Pahl PM Hodges YK, Meltesen L, Perryman MB, Horwitz KB, et al.
- Richard Durbin
- Schwartz S Kent WJ, Smit A, Zhang Z, Baertsch R, et al.
- Siepel A Bejerano G, Pedersen JS, Hinrichs AS, Hou M, et al.
- Waterston RH Lindblad-Toh K, Birney E, Rogers J, Abril JF, et al.
- Webb Miller
- Xie X Lu J, Kulbokas EJ, Golub TR, Mootha V, et al.
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2005
- Field of study
The discoveries of microRNAs and riboswitches, among others, have shown functional RNAs to be biologically more important and genomically more prevalent than previously anticipated. We have developed a general comparative genomics method based on phylogenetic stochastic context-free grammars for identifying functional RNAs encoded in the human genome and used it to survey an eight-way genome-wide alignment of the human, chimpanzee, mouse, rat, dog, chicken, zebra-fish, and puffer-fish genomes for deeply conserved functional RNAs. At a loose threshold for acceptance, this search resulted in a set of 48,479 candidate RNA structures. This screen finds a large number of known functional RNAs, including 195 miRNAs, 62 histone 3′UTR stem loops, and various types of known genetic recoding elements. Among the highest-scoring new predictions are 169 new miRNA candidates, as well as new candidate selenocysteine insertion sites, RNA editing hairpins, RNAs involved in transcript auto regulation, and many folds that form singletons or small functional RNA families of completely unknown function. While the rate of false positives in the overall set is difficult to estimate and is likely to be substantial, the results nevertheless provide evidence for many new human functional RNAs and present specific predictions to facilitate their further characterization
Reconstruction of the Dark Energy equation of state
- Author
- A. De Felice
- A. de la Macorra
- A. Lewis
- A. Shafieloo
- A.G. Riess .
- A.G. Riess et. al.
- A.N Lasenby
- B.A. Bassett
- C. Deffayet
- D. Rubin .
- E. Komatsu .
- H. Jeffreys
- H. Zhang
- I. Sendra
- J. Alberto Vázquez
- J. Dunkley .
- J. Lu
- J.A. Vazquez
- J.L. Cervantes-Cota
- L.P. Chimento
- M Bridges
- M. Seikel
- M.P Hobson
- N. Pan
- R. Amanullah .
- R. Lazkoz
- R. Maartens
- R.A. Daly
- S. Burles
- S. Hannestad
- Supernova Cosmology Project collaboration
- U. Alam
- V. Marra
- V. Pettorino
- V. Sahni
- W. Valkenburg
- Y. Gong
- Publication venue
- 'IOP Publishing'
- Publication date
- 18/08/2012
- Field of study
One of the main challenges of modern cosmology is to investigate the nature
of dark energy in our Universe. The properties of such a component are normally
summarised as a perfect fluid with a (potentially) time-dependent
equation-of-state parameter w(z). We investigate the evolution of this
parameter with redshift by performing a Bayesian analysis of current
cosmological observations. We model the temporal evolution as piecewise linear
in redshift between `nodes', whose w-values and redshifts are allowed to
vary. The optimal number of nodes is chosen by the Bayesian evidence. In this
way, we can both determine the complexity supported by current data and locate
any features present in w(z). We compare this node-based reconstruction with
some previously well-studied parameterisations: the Chevallier-Polarski-Linder
(CPL), the Jassal-Bagla-Padmanabhan (JBP) and the Felice-Nesseris-Tsujikawa
(FNT). By comparing the Bayesian evidence for all of these models we find an
indication towards possible time-dependence in the dark energy
equation-of-state. It is also worth noting that the CPL and JBP models are
strongly disfavoured, whilst the FNT is just significantly disfavoured, when
compared to a simple cosmological constant w=−1. We find that our node-based
reconstruction model is slightly disfavoured with respect to the ΛCDM
model.Comment: 17 pages, 5 figures, minor correction
Potential therapeutic applications of microbial surface-activecompounds
- Author
- Bĕ
- Baltz RH Miao V, Wrigley SK
- Banat IM Franzetti A, Gandolfi I, et al.
- Banat IM Makkar RS, Cameotra SS
- Banat IM Rienzo MAD, Quinn GA
- Benincasa M Abalos A, Oliveira I, et al.
- Cao XH Wang AH, Wang CL, et al.
- Carrillo C Teruel JA, Aranda FA, et al.
- Chen J Song X, Zhang H, et al.
- Chen ML Penfold J, Thomas R.K, et al.
- Chen ML Penfold J, Thomas RK, et al.
- Cochis A Fracchia L, Martinotti MG, et al.
- D'Britto V Kapse H, Babrekar H, et al.
- de Sainte Claire P
- Deleu M Paquot M, Nylander T
- Denning DW
- Ding R Wu XC, Qian CD, et al.
- Donlan RM Costerton JW
- Emiroglu M
- Faivre V Rosilio V
- Gomaa EZ
- Hajfarajollah H Mokhtarani B, Noghabi KA
- Hegstad K Langsrud S, Lunestad BT, et al.
- Horn JN Sengillo JD, Lin D, et al.
- Huang X Lu Z, Zhao H, et al.
- Kadouri DE Shanks RM
- Kitamoto D Isoda H, Nakahara T
- Kitamoto D Yanagishita H, Shinbo T, et al.
- Kumar CG Mamidyala SK, Das B, et al.
- Kurtz S Ong K, Lau E, et al.
- Landman D Georgescu C, Martin DA, et al.
- Liang TW Wu CC, Cheng WT, et al.
- Magalhã
- Maget-Dana R Harnois I, Ptak M
- Makamba H Kim JH, Lim K, et al.
- Mandal SM Barbosa AE, Franco OL
- Mangoni ML Shai Y
- Ngai AL Bourque MR, Lupinacci RJ, et al.
- Nguyen TTL Edelen A, Neighbors B, et al.
- Nickzad A Deziel E
- Ortiz A Teruel JA, Espuny MJ, et al.
- Palanisamy P Raichur AM
- Park SY Kim Y
- Park SY Kim YH, Kim EK, et al.
- Pinto S Alves P, Matos CM, et al.
- Plaza GA Chojniak J, Banat IM
- Pradhan AK Pradhan N, Mall G, et al.
- Pradhan AK Pradhan N, Sukla LB, et al.
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- Reddy AS Chen CY, Chen CC, et al.
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- Robbel L Marahiel MA
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- Rufino RD Luna JM, Sarubbo LA, et al.
- Saini HS Barragán-Huerta BE, Lebrón-Paler A, et
- Samadi N Abadian N, Ahmadkhaniha R, et al.
- Scott WR Baek SB, Jung D, et al.
- Shah V Doncel GF, Seyoum T, et al.
- Singh BR Dwivedi S, Al-Khedhairy AA, et al.
- Singh N Pemmaraju SC, Pruthi PA, et al.
- Song B Rong Y-J, Zhao M-X, et al.
- Soon RL Velkov T, Chiu F, et al.
- Sotirova A Spasova D, Vasileva-Tonkova E, et al.
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- Wasserman HH Keggi JJ, Mckeon JE
- Zaragoza A Aranda FJ, Espuny MJ, et al.
- Zeraik AE Nitschke M
- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2015
- Field of study
Numerous investigations of microbial surface-active compounds or biosurfactants over the past two decades have led to the discovery of many interesting physicochemical and biological properties including antimicrobial, anti-biofilm and therapeutic among many other pharmaceutical and medical applications. Microbial control and inhibition strategies involving the use of antibiotics are becoming continually challenged due to the emergence of resistant strains mostly embedded within biofilm formations that are difficult to eradicate. Different aspects of antimicrobial and anti-biofilm control are becoming issues of increasing importance in clinical, hygiene, therapeutic and other applications. Biosurfactants research has resulted in increasing interest into their ability to inhibit microbial activity and disperse microbial biofilms in addition to being mostly nontoxic and stable at extremes conditions. Some biosurfactants are now in use in clinical, food and environmental fields, whilst others remain under investigation and development. The dispersal properties of biosurfactants have been shown to rival that of conventional inhibitory agents against bacterial, fungal and yeast biofilms as well as viral membrane structures. This presents them as potential candidates for future uses in new generations of antimicrobial agents or as adjuvants to other antibiotics and use as preservatives for microbial suppression and eradication strategies
Effects of rapid urbanisation on the urban thermal environment between 1990 and 2011 in Dhaka Megacity, Bangladesh
- Author
- Adams J
- Ahmed B Kamruzzaman M, Zhu X, et al.
- Artis DA Carnahan WH
- Azad A Kitada T
- Black D Henderson V
- Brown M Lewis HG, Gunn SR
- Carlson TN Arthur ST
- Carlson TN Gillies RR, Perry EM
- Carlson TN Ripley DA
- Carnahan WH Larson RC
- Chander G Markham B
- Chander G Markham BL, Helder DL
- Chen XL Zhao HM, Li P, et al.
- Dewan AM Yamaguchi Y
- Foley JA Defries R, Asner GP, et al.
- Giri C Pengra B, Zhu Z, et al.
- Green AA Berman M, Switzer P, et al.
- Grimm NB Faeth SH, Golubiewski NE, et al.
- Hasan S Mulamoottil G
- Hashizume M Dewan AM, Sunahara T, et al.
- Huete A Didan K, Miura T, et al.
- Jiménez-Muñoz JC Sobrino JA
- Kovats S Akhtar H
- Li J Song C, Cao L, et al.
- Li J Wang J, Ma J, et al.
- Li Y Zhang H, Kainz W
- Liu H Weng Q
- Lo CP Quattrochi DA
- Ma Y Kuang Y, Huang N
- Mackey CW Lee X, Smith RB
- Mas J
- Owen TW Carlson TN, Gillies RR
- Patz JA Olson SH
- Qin Z Karnieli A, Berliner P
- Rana MMP
- Roth M Oke TR, Emery WJ
- Saaroni H Ben-Dor E, Bitan A, et al.
- Sobrino JA Caselles V, Becker F
- Sobrino JA Jiménez-Muñoz JC, Paolini L
- Sobrino JA Jiménez-Muñoz JC, Sòria G, et al.
- Song C Woodcock CE, Seto KC
- Streutker DR
- Sun F Sun W, Chen J, et al.
- Tan KC San-Lim H, Matjafri MZ, et al.
- Voogt JA Oke TR
- Voogt JA Oke TR
- Weng Q
- Weng Q
- Weng Q Hu X, Lu D
- Weng Q Lu D
- Weng Q Lu D, Schubring J
- Wong NH Yu C
- Wu C
- Xiao H Weng Q
- Xiao R Ouyang Z, Zheng H, et al.
- Xu H Dongfeng L, Tang F
- Yang X Liu Z
- Yow DM
- Yuan F Bauer ME
- Zha Y Gao J, Ni S
- Zhang X Zhong T, Wang K, et al.
- Zhou X Wang YC
- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2017
- Field of study
This study investigates the influence of land-use/land-cover (LULC) change on land surface temperature (LST) in Dhaka Megacity, Bangladesh during a period of rapid urbanisation. LST was derived from Landsat 5 TM scenes captured in 1990, 2000 and 2011 and compared to contemporaneous LULC maps. We compared index-based and linear spectral mixture analysis (LSMA) techniques for modelling LST. LSMA derived biophysical parameters corresponded more strongly to LST than those produced using index-based parameters. Results indicated that vegetation and water surfaces had relatively stable LST but it increased by around 2 °C when these surfaces were converted to built-up areas with extensive impervious surfaces. Knowledge of the expected change in LST when one land-cover is converted to another can inform land planners of the potential impact of future changes and urges the development of better management strategies
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogana T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Aktas A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Aranda CP
- Arce ATH
- Archambault JP
- Arfaoui S
- Arguin J-F
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnault C
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Asfandiyarov R
- Ask S
- Asman B
- Asner D
- Asquith L
- Assamagan K
- Astbury A
- Astvatsatourov A
- Atoian G
- Aubert B
- Auge E
- Augsten K
- Aurousseau M
- Austin N
- Avolio G
- Avramidou R
- Axen D
- Ay C
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Bachy G
- Backes M
- Backhaus M
- Badescu E
- Bagnaia P
- Bahinipati S
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker MD
- Baker OK
- Baker S
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barajas CAC
- Barak L
- Baranov SP
- Barashkou A
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Barrera CO
- Barrillon P
- Bartoldus R
- Barton AE
- Bartsch D
- Bartsch V
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Battistoni G
- Bauer F
- Bawa HS
- Beare B
- Beau T
- Beauchemin PH
- Beccherle R
- Bechtle P
- Beck GA
- Beck HP
- Beckingham M
- Becks KH
- Beddall A
- Beddall AJ
- Bedikian S
- Bednyakov VA
- Bee CP
- Begel M
- Behera PK
- Beimforde M
- Belanger-Champagne C
- Belenguer MJ
- Bell PJ
- Bell WH
- Bella G
- Bella LA
- Bellagamba L
- Bellina F
- Bellomo M
- Belloni A
- Beloborodova O
- Belotskiy K
- Beltramello O
- Ben Ami S
- Benary O
- Benchekroun D
- Benchouk C
- Bendel M
- Benekos N
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Benslama K
- Bentvelsen S
- Beretta M
- Berge D
- Berger N
- Berghaus F
- Berglund E
- Beringer J
- Bernardet K
- Bernat P
- Bernhard R
- Bernius C
- Berry T
- Bertin A
- Bertinelli F
- Bertolucci F
- Besana MI
- Besson N
- Bethke S
- Bhimji W
- Bianchi RM
- Bianco M
- Biebel O
- Bieniek SP
- Bierwagen K
- Biesiada J
- Biglietti M
- Bilokon H
- Bindi M
- Binet S
- Bingul A
- Bini C
- Biscarat C
- Bitenc U
- Black KM
- Blair RE
- Blanchard J-B
- Blanchot G
- Blazek T
- Blocker C
- Blocki J
- Blondel A
- Blum W
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
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- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or τ lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, φ, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan β in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
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