96 research outputs found
Spin gating electrical current
We use an aluminium single electron transistor with a magnetic gate to
directly quantify the chemical potential anisotropy of GaMnAs materials.
Uniaxial and cubic contributions to the chemical potential anisotropy are
determined from field rotation experiments. In performing magnetic field sweeps
we observe additional isotropic magnetic field dependence of the chemical
potential which shows a non-monotonic behavior. The observed effects are
explained by calculations based on the kinetic
exchange model of ferromagnetism in GaMnAs. Our device inverts the conventional
approach for constructing spin transistors: instead of spin-transport
controlled by ordinary gates we spin-gate ordinary charge transport.Comment: 5 pages, 4 figure
Reconfigurable Boolean Logic using Magnetic Single-Electron Transistors
We propose a novel hybrid single-electron device for reprogrammable low-power
logic operations, the magnetic single-electron transistor (MSET). The device
consists of an aluminium single-electron transistors with a GaMnAs magnetic
back-gate. Changing between different logic gate functions is realized by
reorienting the magnetic moments of the magnetic layer which induce a voltage
shift on the Coulomb blockade oscillations of the MSET. We show that we can
arbitrarily reprogram the function of the device from an n-type SET for
in-plane magnetization of the GaMnAs layer to p-type SET for out-of-plane
magnetization orientation. Moreover, we demonstrate a set of reprogrammable
Boolean gates and its logical complement at the single device level. Finally,
we propose two sets of reconfigurable binary gates using combinations of two
MSETs in a pull-down network
Spin Hall effect transistor
Spin transistors and spin Hall effects have been two separate leading
directions of research in semiconductor spintronics which seeks new paradigms
for information processing technologies. We have brought the two directions
together to realize an all-semiconductor spin Hall effect transistor. Our
scheme circumvents semiconductor-ferromagnet interface problems of the original
Datta-Das spin transistor concept and demonstrates the utility of the spin Hall
effects in microelectronics. The devices use diffusive transport and operate
without electrical current, i.e., without Joule heating in the active part of
the transistor. We demonstrate a spin AND logic function in a semiconductor
channel with two gates. Our experimental study is complemented by numerical
Monte Carlo simulations of spin-diffusion through the transistor channel.Comment: 11 pages, 3 figure
Spatial Current Patterns, Dephasing and Current Imaging in Graphene Nanoribbons
Using the non-equilibrium Keldysh Green's function formalism, we investigate
the local, non-equilibrium charge transport in graphene nanoribbons (GNRs). In
particular, we demonstrate that the spatial current patterns associated with
discrete transmission resonances sensitively depend on the GNRs' geometry,
size, and aspect ratio, the location and number of leads, and the presence of
dephasing. We identify a relation between the spatial form of the current
patterns, and the number of degenerate energy states participating in the
charge transport. Furthermore, we demonstrate a principle of superposition for
the conductance and spatial current patterns in multiple-lead configurations.
We demonstrate that scanning tunneling microscopy (STM) can be employed to
image spatial current paths in GNR with atomic resolution, providing important
insight into the form of local charge transport. Finally, we investigate the
effects of dephasing on the spatial current patterns, and show that with
decreasing dephasing time, the current patterns evolve smoothly from those of a
ballistic quantum network to those of classical resistor network.Comment: 25 pages, 12 figure
Comparative effectiveness of Cladribine tablets vs other drugs in relapsing-remitting multiple sclerosis: an approach merging randomized controlled trial with real life data
Comparative effectiveness of dimethyl fumarate, teriflunomide, interferon-beta and glatiramer acetate on newly diagnosed patients: a propensity score-matched analysis from a multicenter Italian group
Data monitoring roadmap. The experience of the Italian Multiple Sclerosis and Related Disorders Register
Introduction Over the years, disease registers have been increasingly considered a source of reliable and valuable population studies. However, the validity and reliability of data from registers may be limited by missing data, selection bias or data quality not adequately evaluated or checked.This study reports the analysis of the consistency and completeness of the data in the Italian Multiple Sclerosis and Related Disorders Register.MethodsThe Register collects, through a standardized Web-based Application, unique patients.Data are exported bimonthly and evaluated to assess the updating and completeness, and to check the quality and consistency. Eight clinical indicators are evaluated.ResultsThe Register counts 77,628 patients registered by 126 centres. The number of centres has increased over time, as their capacity to collect patients.The percentages of updated patients (with at least one visit in the last 24 months) have increased from 33% (enrolment period 2000-2015) to 60% (enrolment period 2016-2022). In the cohort of patients registered after 2016, there were >= 75% updated patients in 30% of the small centres (33), in 9% of the medium centres (11), and in all the large centres (2).Clinical indicators show significant improvement for the active patients, expanded disability status scale every 6 months or once every 12 months, visits every 6 months, first visit within 1 year and MRI every 12 months.ConclusionsData from disease registers provide guidance for evidence-based health policies and research, so methods and strategies ensuring their quality and reliability are crucial and have several potential applications
Low tumour cell proliferation at the invasive margin is associated with a poor prognosis in Dukes' stage B colorectal cancers
The conflicting results about the prognostic impact of tumour cell proliferation in colorectal cancer might be explained by the heterogeneity observed within these tumours. We have investigated whether a systematic spatial heterogeneity exists between different compartments, and whether the presence of such a systematic heterogeneity has any impact on survival. Fifty-six Dukes' stage B colorectal cancers were carefully morphometrically quantified with respect to the immunohistochemical expression of the proliferative marker Ki-67 at both the luminal border and the invasive margin. The proliferative activity was significantly higher at the luminal border compared with the invasive margin (P < 0.001), although the two compartments were also significantly correlated with each other. Tumours with low proliferation at the invasive margin had a significantly poorer prognosis both in univariate (P = 0.014) and in multivariate survival analyses (P = 0.042). We conclude that Dukes' B colorectal cancers exhibit a systematic spatial heterogeneity with respect to proliferation, and tumours with low proliferation at the invasive margin had a poor prognosis. The present data independently confirm recent results from the authors, and provide new insights into the understanding of tumour cell proliferation in colorectal cancer. © 1999 Cancer Research Campaig
Rhabdomyoblastic Differentiation in Head and Neck Malignancies Other Than Rhabdomyosarcoma
Rhabdomyosarcoma is a relatively common soft tissue sarcoma that frequently affects children and adolescents and may involve the head and neck. Rhabdomyosarcoma is defined by skeletal muscle differentiation which can be suggested by routine histology and confirmed by immunohistochemistry for the skeletal muscle-specific markers myogenin or myoD1. At the same time, it must be remembered that when it comes to head and neck malignancies, skeletal muscle differentiation is not limited to rhabdomyosarcoma. A lack of awareness of this phenomenon could lead to misdiagnosis and, subsequently, inappropriate therapeutic interventions. This review focuses on malignant neoplasms of the head and neck other than rhabdomyosarcoma that may exhibit rhabdomyoblastic differentiation, with an emphasis on strategies to resolve the diagnostic dilemmas these tumors may present. Axiomatically, no primary central nervous system tumors will be discussed.info:eu-repo/semantics/publishedVersio
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