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Low tumour cell proliferation at the invasive margin is associated with a poor prognosis in Dukes' stage B colorectal cancers
Authors
A Paradiso
AH Mulder
+40 more
B Tavelin
CE Dukes
DA Rew
ER Weibel
FJ Mullan
G Evan
G Lindmark
GE Nichols
HJG Gundersen
HJG Gundersen
HJG Gundersen
IF Al-Sheneber
J N Rutegård
JP Neoptolemos
JR Jass
K Porter-Jordan
K Taniyama
K Taniyama
KD Bauer
L Roncucci
LH Hartwell
M Koha
M Ramires
N Pietra
NA Shepherd
P Quirke
P Sellberg
PA Hall
PB Vermeulen
R Palmqvist
R Palmqvist
R Stenling
RJ Zarbo
RN Butler
SP Harlow
T Lehy
TE Witzig
TM Grogan
Y Kubota
Å Öberg
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Publisher
Nature Publishing Group
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PubMed
Abstract
The conflicting results about the prognostic impact of tumour cell proliferation in colorectal cancer might be explained by the heterogeneity observed within these tumours. We have investigated whether a systematic spatial heterogeneity exists between different compartments, and whether the presence of such a systematic heterogeneity has any impact on survival. Fifty-six Dukes' stage B colorectal cancers were carefully morphometrically quantified with respect to the immunohistochemical expression of the proliferative marker Ki-67 at both the luminal border and the invasive margin. The proliferative activity was significantly higher at the luminal border compared with the invasive margin (P < 0.001), although the two compartments were also significantly correlated with each other. Tumours with low proliferation at the invasive margin had a significantly poorer prognosis both in univariate (P = 0.014) and in multivariate survival analyses (P = 0.042). We conclude that Dukes' B colorectal cancers exhibit a systematic spatial heterogeneity with respect to proliferation, and tumours with low proliferation at the invasive margin had a poor prognosis. The present data independently confirm recent results from the authors, and provide new insights into the understanding of tumour cell proliferation in colorectal cancer. © 1999 Cancer Research Campaig
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Last time updated on 03/12/2019