Calidad y evaluación en las instituciones técnicas y tecnológicas en Colombia

Este artículo presenta una síntesis del estado del arte sobre una investigación acerca de los sistemas de evaluación en las instituciones técnicas y tecnológicas en Colombia, a partir de aspectos como la normatividad vigente en materia de educación superior nacional, los documentos institucionales y datos estadísticos del Sistema Nacional de Información de Educación Superior (en adelante, SNIES), el Consejo Nacional de Acreditación y el Ministerio de Educación Nacional. El estudio se desarrolla bajo un enfoque descriptivo y propositivo. Como resultado se presenta la identificación de los criterios que sustentan la selección, permanencia, promoción y grado de los estudiantes de las instituciones técnicas y tecnológicas de la ciudad de Bogotá

Comparing assembly strategies for third-generation sequencing technologies across different genomes

The recent advent of long-read sequencing technologies, such as Pacific Biosciences (PacBio) and Oxford Nanopore technology (ONT), has led to substantial accuracy and computational cost improvements. However, de novo whole-genome assembly still presents significant challenges related to the computational cost and the quality of the results. Accordingly, sequencing accuracy and throughput continue to improve, and many tools are constantly emerging. Therefore, selecting the correct sequencing platform, the proper sequencing depth and the assembly tools are necessary to perform high-quality assembly. This paper evaluates the primary assembly reconstruction from recent hybrid and non-hybrid pipelines on different genomes. We find that using PacBio high-fidelity long-read (HiFi) plays an essential role in haplotype construction with respect to ONT reads. However, we observe a substantial improvement in the correctness of the assembly from high-fidelity ONT datasets and combining it with HiFi or short-reads.This work has been partially supported by the Spanish MINECO PID2019-105396RB-I00, Junta de Andalucia JA2018 P18-FR-3433, and UMA18-FEDERJA-197 projects. Funding for open access charge: Universidad de Málaga/CBUA.Peer ReviewedPostprint (published version

Comparing assembly strategies for third-generation sequencing technologies across different genomes

The recent advent of long-read sequencing technologies, such as Pacific Biosciences (PacBio) and Oxford Nanopore technology (ONT), has led to substantial accuracy and computational cost improvements. However, de novo whole-genome assembly still presents significant challenges related to the computational cost and the quality of the results. Accordingly, sequencing accuracy and throughput continue to improve, and many tools are constantly emerging. Therefore, selecting the correct sequencing platform, the proper sequencing depth and the assembly tools are necessary to perform high-quality assembly. This paper evaluates the primary assembly reconstruction from recent hybrid and non-hybrid pipelines on different genomes. We find that using PacBio high-fidelity long-read (HiFi) plays an essential role in haplotype construction with respect to ONT reads. However, we observe a substantial improvement in the correctness of the assembly from high-fidelity ONT datasets and combining it with HiFi or short-reads.Funding for open access charge: Universidad de Málaga / CBU

San Isidro (Madrid): 1862-2002. Nuevos hallazgos Paleolíticos en la terraza de +30 m del río Manzanares

The archaeo-palaeontological survey carried out on a site located at Cerro de San Isidro (Madrid), because of a project of construction in that place, has led to the documentation of a small part of the ancient terrace which has almost totally disappeared as a result of quarrying. The study of the stratigraphic sequence, the recovery of several pieces of lithic industry, as well as pollen analyses, have allowed us to contribute new data to the already known “Terrace of San Isidro” that was known from the middle of the nineteenth century.El seguimiento arqueo-paleontológico realizado en un solar sito en el Cerro de San Isidro, con motivo de un proyecto constructivo en dicho lugar, ha llevado a la documentación de un pequeño resto de la antigua terraza a +30 m, probablemente muy mal conservada por su explotación como arenero en el pasado y por las actuaciones urbanísticas en la zona. El estudio de la secuencia estratigráfica, la recuperación de varias piezas de industria lítica, así como la realización de análisis polínicos, ha permitido aportar nuevos datos a los ya conocidos de la denominada “Terraza de San Isidro” que se remontan a mediados del siglo XIX

Negligible exposure to nifurtimox through breast milk during maternal treatment for Chagas Disease

Background treatment with nifurtimox (NF) for Chagas disease is discouraged during breast-feeding because no information on NF transfer into breast milk is available. NF is safe and effective for paediatric and adult Chagas disease. We evaluated the degree of NF transfer into breast milk in lactating women with Chagas disease. Patients and methods Prospective study of a cohort of lactating women with Chagas disease. Patients were treated with NF for 1 month. NF was measured in plasma and milk by high performance liquid chromatography (HPLC). Breastfed infants were evaluated at admission, 7th and 30th day of treatment (and monthly thereafter, for 6 months). Results Lactating women with chronic Chagas disease (N = 10) were enrolled (median age 28 years, range 17-36). Median NF dose was 9.75 mg/kg/day three times a day (TID). Six mothers had mild adverse drug reactions (ADRs), but no ADRs were observed in any of the breastfed infants. No interruption of breastfeeding was observed. Median NF concentrations were 2.15 mg/L (Inter quartil range (IQR) 1.32-4.55) in milk and 0.30 mg/L (IQR 0.20-0.95) in plasma. Median NF milk/plasma ratio was 16 (range 8.75-30.25). Median relative infant NF dose (assuming a daily breastmilk intake of 150 mL/ kg/day) was 6.7% of the maternal dose/kg/day (IQR 2.35-7.19%). Conclusions The low concentrations of NF in breast milk and the normal clinical evaluation of the breastfed babies imply that maternal NF treatment for Chagas disease during breastfeeding is unlikely to lead to clinically relevant exposures in the breastfed infants.Fil: Moroni, Samanta. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Parasitología y Chagas; ArgentinaFil: Marson, Maria Elena. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Moscatelli, Guillermo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Parasitología y Chagas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mastrantonio Garrido, Guido Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Área de Toxicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Bisio, Margarita María Catalina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Parasitología y Chagas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zapata González, Nicolas. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Parasitología y Chagas; ArgentinaFil: Ballering, Griselda Edith. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Parasitología y Chagas; ArgentinaFil: Altcheh, Jaime Marcelo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Parasitología y Chagas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garcia Bournissen, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Parasitología y Chagas; Argentin

Gestión Logística en la Industria de las Flores en Colombia

Este documento es un proyecto en el que se aplica y analiza todo el conocimiento del curso de Gestión de la Cadena de Suministro y la profundización logística, en el que se analiza y estudia la situación actual del sistema logístico implementado por la industria de las flores en Colombia. Donde se analizan puntos como producción, ventas y distribución con los que trabaja la industria de la flor de Colom-bian, para proponer estrategias correctivas para mejorar y lograr una mejor rentabilidad, según sea el caso. También analizará las competencias y los sistemas logísticos en términos de la forma de transporte, información, tecnología, tiempo y distribución entre la industria de flores de diferentes países para hacer una comparación, y luego propondrá y diseñará un plan de mejora en logística. Actualmente gestionado por las industrias de flores colombianas.This document is a project in which all the knowledge of the Supply Chain Management and logistics deepening course is applied and analyzed, in which the current situa-tion of the logistics system implemented by the flower industry in Colombia is analyzed and stud-ied. Where are analyzed points such as production, sales and distribution with which the Colom-bian flower industry is working, to propose corrective strategies to improve and achieve better profitability, as the case may be. It will also analyze the competencies and logistics systems in terms of the form of transport, information, technology, timing and distribution among the flower industry of dif-ferent countries in order to make a comparison, and then propose and design an improvement plan in logistics currently managed by Colombian flower industrie

Proctitis in patients with monkeypox infection: a single‑center analysis of 42 consecutive cases from a multidisciplinary observational study on monkeypox proctitis

Background: The current monkeypox (MP) virus outbreak was declared an international emergency in July 2022. The aim of this report is to describe our initial experience with patients with MP, focusing on proctitis. Methods: We conducted an observational study between 20 May and 31 July 2022, on patients with MP at a reference tertiary center in Madrid, Spain. A descriptive analysis on MP was performed, focusing on its characteristics, symptoms, diagnosis, and outcomes. Results: A total of 143 positive MP cases were diagnosed in our center; 42 of them [all male, median age 39 years (range: 22–57 years)] had proctitis (29.37%), and 3 patients (2.09%/MP total cases and 7.14%/MP proctitis) required surgical drainage of a perianal abscess. Conclusions: General and digestive surgeons must be aware of the presence of proctological impairment and complications due to MP viru

Mediterranean Diet and its Effects on Silent Brain Infarcts in a Cohort of Patients With Atrial Fibrillation

[Background and Aims] The benefits of Mediterranean Diet (MeDiet) in prevention of cardiovascular diseases (CVD) in general and ischemic stroke (IS) have been extensively studied and reported. We hypothesize that the consumption of nutrients typical of MeDiet would also reduce the rate of silent brain infarcts (SBI) among AF patients.[Methods and Results] Patients with a history of AF who scored 0 to 1 in the CHADS2 score, ⩾50 years and with absence of neurological symptoms were selected from Seville urban area using the Andalusian electronic healthcare database. A 3T brain MRI was performed to all participants. Demographic and clinical data and food-frequency questionnaire (FFQ) were collected. Of the 443 scanned patients, 66 presented SBI. Of them 52 accepted to be scheduled for a clinical visit and were included in the diet sub study and 41 controls were matched per age and sex. There were no statistically significant differences in baseline characteristics. After logistic regression analysis, we found that a higher consumption of fiber from fruit was independently associated with a lower risk of SBI, while a higher consumption of high glycemic load (GL) foods was associated with a higher risk of SBI in a population with AF[Conclusion] Our findings support that MeDiet could be suggested as a prevention strategy for SBI in patients with AF.The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The Spanish Ministry of Economy, Industry and Competitiveness (grant RTC-2016 5300-1), the Junta de Andalucía (grant PIN-0144-2016) and Neuroprotección Avanzada Reposicionando Drogas y Nutraceúticos para el Ictus en Andalucía: Proyecto NARDNIA (PE-0527-2019), the European Project ITRIBIS (registration number REGPOT-2013-1), and Cooperative Cerebrovascular Disease Research Network (INVICTUS+, RD16/0019/0015) supported the study. The Fundación Cajasol also contributed to the study.Peer reviewe