A national school-based screening program for mental health problems among children aged 6 to 12 years in Iran:scale development and psychometric evaluation

Schools are an ideal setting in which to measure and promote mental health difficulties. The aim of present study was to develop the Nemad Electronic Mental-Health Assessment Devices for Children (NEMAD-C) aged 6 to 12 years in Iran. A sample of parents and teachers (N = 10,163) were recruited to complete the parent and teacher reports. Totally, explorative and confirmatory factor analyses showed that the eight-factor model provides a better fit for both parental report and teacher report versions. Results revealed a screening tool consisting of eight dimensions: child abuse risk, self-harm, anxiety, depression, disruptive behavior disorders, attention deficit/hyperactivity disorders, academic achievement deficit, and self-regulation. Findings showed that the internal consistency coefficients of the subscales were high, and convergent validity was evidenced by significant correlations with theoretically related constructs. Therefore, the NEMAD-C has adequate reliability and validity and could be used for multi-dimensional assessment of mental health problems in Iran

Mental Health Problems Scale for Adolescents- Parent Report: Development and Preliminary Technical Properties

This research aimed to develop a scale for adolescent psychological health problems (APHP). The population consisted of parents of high school pupils in six provinces in 2016: Alborz, Kermanshah, East Azarbaijan, Sistan and Baluchistan, Fars, and Razavi Khorasan. For each province, two cities (the provincial center and a low-income city) were selected on purpose. The selection of six institutions in each city was based on a random sampling method, and the selection of parents was based on available sampling. There were 308 parents in the sample, including 195 mothers and 111 fathers. After the data were collected, they were input into the 18th version of the statistical software for social sciences (SPSS). 133 items were examined for their adequacy using seven indicators (mean, standard deviation, standard skew, standard kurtosis, deletion alpha coefficient, multiple correlation, and correlation coefficient with total score) during item analysis. The item analysis revealed that the majority of objects possessed appropriate properties. Exploratory factor analysis of the coefficient revealed six factors that explain 42% of the variance. Internal homogeneity coefficients for the subscales ranged from 0.78 (attention deficit hyperactivity disorder) to 0.95 (deficit in assignments and self-control) and 0.95 for the full scale. The results indicated that the preliminary version of the instrument has adequate psychometric properties

Prevalence, awareness, treatment, and control of hypertension based on ACC/AHA versus JNC7 guidelines in the PERSIAN cohort study

In this cross-sectional population-based study, we used the baseline data of the Prospective Epidemiologic Research Studies in IrAN cohort study collected in Iran from 2014 to 2020. The main outcomes were the prevalence of hypertension and proportion of awareness, treatment, and control based on the 2017 ACC/AHA guideline compared to the seventh report of the Joint National Committee (JNC7). Of the total of 163,770 participants, aged 35–70 years, 55.2% were female. The sex-age standardized prevalence of hypertension was 22.3% (95% CI 20.6, 24.1) based on the JNC7 guideline and 36.5% (31.1, 41.8) based on the ACC/AHA guideline. A total of 24,312 participants [14.1% (10.1, 18.1)] were newly diagnosed based on the ACC/AHA guideline. Compared to adults diagnosed with hypertension based on the JNC7 guideline, the newly diagnosed participants were mainly young literate males who had low levels of risk factors and were free from conventional comorbidities of hypertension. About 30.7% (25.9, 35.4) of them (4.3% of the entire population) were eligible for pharmacologic intervention based on the ACC/AHA guideline. Implementation of the new guideline may impose additional burden on health systems. However, early detection and management of elevated blood pressure may reduce the ultimate burden of hypertension in Iran

Optical and electrical characteristics of pyrite films prepared by a new spray method using PVDF as a polymeric binder

Pyrite thin films were deposited on glass substrates by a new and simple spray method using polyvinylidene fluoride as polymeric binder. Prepared pyrite films were characterized by field emission scanning electron microscopy, ultraviolet-visible spectroscopy and Hall auto-measuring instrument. Hall measurements showed p-type conduction of all the prepared thin films. The film prepared by using binder concentration of 2 wt.% showed the best results. Its band gap was estimated 1.55 eV. Also, electrical characteristics of the deposited film were obtained by I-V characteristic curve

Comparative study on the impact of ‘Infographic versus video feedback’ on enhancing students’ clinical skills in basic life support

Abstract Background Effective cardiopulmonary resuscitation (CPR) training for nursing students is crucial for improving patient outcomes in cardiac arrest scenarios. This study assesses the impact of infographic versus video feedback on enhancing nursing students’ clinical skills in Basic Life Support (BLS). Methods In a randomized controlled setting, 76 nursing students at Torbat Heydariyeh University of Medical Sciences were divided into two groups: one received infographic-based education and the other video feedback training. Pre- and post-intervention assessments measured knowledge and skill retention using validated questionnaires. Results Post-training, the infographic group showed significantly higher knowledge scores, while the video feedback group exhibited greater improvement in CPR skill performance. No significant differences were noted in pre-training assessment scores between the groups. Conclusion Infographic-based education enhances BLS knowledge retention, and video feedback improves practical CPR skills. This suggests potential benefits of a combined infographic and video feedback approach for optimizing CPR training outcomes, addressing a critical need in medical education

6-Gingerol modulates miRNAs and PODXL gene expression via methyltransferase enzymes in NB4 cells: an in silico and in vitro study

Abstract This investigation delves into the influence of predicted microRNAs on DNA methyltransferases (DNMTs) and the PODXL gene within the NB4 cell line, aiming to elucidate their roles in the pathogenesis of acute myeloid leukemia (AML). A comprehensive methodological framework was adopted to explore the therapeutic implications of 6-gingerol on DNMTs. This encompassed a suite of bioinformatics tools for protein structure prediction, docking, molecular dynamics, and ADMET profiling, alongside empirical assessments of miRNA and PODXL expression levels. Such a multifaceted strategy facilitated an in-depth understanding of 6-gingerol’s potential efficacy in DNMT modulation. The findings indicate a nuanced interplay where 6-gingerol administration modulated miRNA expression levels, decreasing in DNMT1 and DNMT3A expression in NB4 cells. This alteration indirectly influenced PODXL expression, contributing to the manifestation of oncogenic phenotypes. The overexpression of DNMT1 and DNMT3A in NB4 cells may contribute to AML, which appears modulable via microRNAs such as miR-193a and miR-200c. Post-treatment with 6-gingerol, DNMT1 and DNMT3A expression alterations were observed, culminating in the upregulation of miR-193a and miR-200c. This cascade effect led to the dysregulation of tumor suppressor genes in cancer cells, including downregulation of PODXL, and the emergence of cancerous traits. These insights underscore the therapeutic promise of 6-gingerol in targeting DNMTs and microRNAs within the AML context