Effects of Sesamin on the Glycemic Index, Lipid Profile, and Serum Malondialdehyde Level of Patients with Type II Diabetes

BACKGROUND AND OBJECTIVE: Diabetes mellitus is the most prevalent endocrine disorder associated with increased risk of cardiovascular diseases. Considering the possible effects of sesamin, the most important sesame lignan, on the prevention of metabolic disorders leading to diabetes, this study aimed to evaluate the effects of sesamin supplementation on glycemic indices, serum levels of lipid profile and Malondialdehyde (MDA) in patients with type II diabetes. METHODS: This double-blind clinical trial was conducted on 44 patients with type II diabetes referring to the endocrine clinic of Golestan Hospital in Ahvaz, Iran (IRCT: 2014061818134N1). Patients were randomly divided into two groups of intervention and control. Patients of the intervention group received a daily dose of sesamin (200 mg capsules), and control subjects were administered with an equivalent dose of placebo. Anthropometric indices, fasting blood sugar (FBS), glycated hemoglobin (HbA1c), insulin level, insulin resistance (HOMA-IR) index, triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and malondialdehyde (MDA) levels were evaluated before and eight weeks after the intervention. FINDINGS: Comparison of different indices before and after the intervention indicated that sesamin significantly decreased the serum levels of FBS (138.59±36.89 versus 172.50±53.9 mg/dl) (p=0.016), HbA1c (7.51±1.14% versus 8.28±1.55%) (p=0.002), TC (141.50±29.03 versus 164.54±45.96 mg/dl) (p=0.015), and LDL-C (73.86±18.34 versus 89.22±32.96 mg/dl) (p=0.008) in the intervention group compared to the control group. Moreover, after eight weeks of sesamin treatment in the intervention group, a significant reduction was observed in TG (139.04±78.46 versus 168.31±68.45 mg/dl) (p=0.021), MDA (1.93±0.30 versus 2.21±0.55 µmol/L) (p=0.023), waist circumference (101.65±9.78 versus 103.77±10.84 cm) (p=0.006), and body adiposity index (34.90±5.68 versus 36.02±5.56) (p=0.000). No significant differences were observed in the other studied variables. CONCLUSION: According to the results of this study, daily administration of sesamin (200 mg) significantly improved the glycemic index, lipid profile, and serum MDA levels in type II diabetic patients. Therefore, sesamin could be effective in the prevention and control of type II diabetes complications

Factor V leiden mutation in Behcet’s disease and the relationship with clinical manifestations

"n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Behcet's disease (BD) is a multisystemic inflammatory disease with unknown origin characterized by recurrent oral aphtous ulcers, genital, ocular and skin lesions. A single point mutation 1691G to A in the factor V gene increases the risk of venous thrombosis. This study designed to determine factor V Leiden mutation in Behcet's disease, and to find out it's relationship with the clinical manifestations in Khuzestan province, Iran. "n"nMethods: One hundred patients with Behcet's Disease (44 males and 56 females) based on international diagnostic criteria and 70 healthy subjects were included in the study. Patients and controls were tested for the presence of factor V Leiden mutation using polymerase chain reaction method."n"nResults: The prevalence of factor V Leiden mutation was significantly higher in BD (10 out of 100, 10%) compared with healthy control subjects (1 out of 70, 1.4%), (p=0.025). Vascular lesions in this study were deep vein thrombosis (DVT) (7%), subcutaneous thrombophlebitis (5%), stroke (1%) and retinal vasculitis (39%). It was found that there was no association between venous thrombosis and the factor V Leiden mutation in Khuzestanian patients. Also, no association between other vascular lesions and the factor V Leiden mutation was recognized. On the other hand there was a significant association between DVT and anterior uveitis (p=0.033). "n"nConclusion: In this study we did not find any association between clinical manifestations in BD patients and factor V Leiden mutation in Khuzestan province, Iran but in BD patients with DVT, factor V Leiden mutation might be a risk factor for the development of anterior uveitis

Correlation between non-alcoholic fatty liver disease and carotid Intima-Media thickness in patient with type II diabetes

Non-Alcoholic Fatty Liver Disease (NAFLD) is a very prevalent condition determined by the infiltration of fat of liver cells. This study was conducted to evaluate the correlation between NAFLD and Carotid Intima-Media Thickness (CIMT) in patient with type II diabetes. This case-control study included three groups, including those with type II diabetes without NAFLD (n = 85), those with type II diabetes and NAFLD (n = 85) and non-diabetic individuals with only NAFLD (n = 85). The CIMT and the grading of the NAFLD were determined using an ultrasound B-mode. There was no significant difference between the case and control groups in term of overall mean of age (57±10 years vs. 56.9±8 years, respectively). Considering the two factors (diabetes and NAFLD) effect, with adjustment for age and gender as a confounding effect of diabetes (p = 0.01) and NAFLD (p = 0.022) on CIMT was significant. The mean right CIMT, left CIMT and overall CIMT in three different study groups of diabetic patients, according to various NAFLD grading showed no significant difference. Our findings showed a considerable association between NAFLD and increased CIMT, in which this association is not affected by the severity of fatty liver. So, immediate ultrasound screening and treatment for the patients with NAFLD are recommended to prevent CVD complications such as atherosclerosis considering early stages of fatty liver disease. © 2015 Asian Network for Scientific Information