Kinematics of W UMa-type binaries and evidences on the two types of formation

The kinematics of 129 W UMa binaries is studied and its implications on the contact binary evolution is discussed. The sample is found to be heterogeneous in the velocity space that kinematically younger and older contact binaries exist in the sample. Kinematically young (0.5 Gyr) sub-sample (MG) is formed by selecting the systems which are satisfying the kinematical criteria of moving groups. After removing the possible MG members and the systems which are known to be members of open clusters, the rest of the sample is called Field Contact Binaries (FCB). The FCB has further divided into four groups according to The orbital period ranges. Then a correlation has been found in the sense that shorter period less massive systems have larger velocity dispersions than the longer period more massive systems. Dispersions in the velocity space indicates 5.47 Gyr kinematical age for the FCB group. Comparing with the field chromospherically active binaries (CAB), presumably detached binary progenitors of the contact systems, the FCB appears to be 1.61 Gyr older. Assuming an equilibrium in the formation and destruction of CAB and W UMa systems in the Galaxy, this age difference is treated as empirically deduced lifetime of the contact stage. Since the kinematical ages of the four sub groups of FCB are much longer than the 1.61 Gyr lifetime of the contact stage, the pre-contact stages of FCB must dominantly be producing the large dispersions. The kinematically young (0.5 Gyr) MG group covers the same total mass, period and spectral ranges as the FCB. But, the very young age of this group does not leave enough room for pre-contact stages, thus it is most likely that those systems were formed in the beginning of the main-sequence or during the pre-main-sequence contraction phase.Comment: 19 pages, including 11 figures and 5 tables, accepted for publication in MNRA

Kinematics of the chromospherically active binaries and evidence of an orbital period decrease in binary evolution

Kinematics of 237 Chromospherically Active Binaries (CAB) were studied. The sample is heterogeneous with different orbits and physically different components from F to M spectral type main sequence stars to G and K giants and super giants. The computed $U$, $V$, $W$ space velocities indicate the sample is also heterogeneous in the velocity space. That is, both kinematically younger and older systems exist among the non-evolved main sequence and the evolved binaries containing giants and sub giants. The kinematically young (0.95 Gyr) sub-sample (N=95), which is formed according to the kinematical criteria of moving groups, was compared to the rest (N=142) of the sample (3.86 Gyr) in order to investigate observational clues of the binary evolution. Comparing the orbital period histograms between the younger and older sub-samples, evidences were found supporting Demircan's (1999) finding that the CAB binaries lose mass (and angular momentum) and evolve towards shorter orbital periods. The evidence of mass loss is noticeable on the histograms of the total mass ($M_{h}+M_{c}$), which is compared between the younger (available only N=53 systems) and older sub-samples (available only N=66 systems). The orbital period decrease during binary evolution is found to be clearly indicated by the kinematical ages of 6.69, 5.19, and 3.02 Gyr which were found in the sub samples according to the period ranges of $logP\leq0.8$, $0.8<logP\leq1.7$, and $1.7<logP\leq3$ among the binaries in the older sub sample.Comment: 26 pages, including 11 figures and 5 tables, 2004, MNRAS, 349, 106

MnOx-Promoted PdAg Alloy Nanoparticles for the Additive-Free Dehydrogenation of Formic Acid at Room Temperature

Formic acid (HCOOH) has a great potential as a safe and a convenient hydrogen carrier for fuel cell applications. However, efficient and CO-free hydrogen production through the decomposition of formic acid at low temperatures (&lt;363 K) in the absence of additives constitutes a major challenge. Herein, we present a new heterogeneous catalyst system composed of bimetallic PdAg alloy and MnOx nanoparticles supported on amine-grafted silica facilitating the liberation of hydrogen at room temperature through the dehydrogenation of formic acid in the absence of any additives with remarkable activity (330 mol H2·mol catalyst-1·h-1) and selectivity (&gt;99%) at complete conversion (&gt;99%). Moreover this new catalytic system enables facile catalyst recovery and very high stability against agglomeration, leaching, and CO poisoning. Through a comprehensive set of structural and functional characterization experiments, mechanistic origins of the unusually high catalytic activity, selectivity, and stability of this unique catalytic system are elucidated. Current heterogeneous catalytic architecture presents itself as an excellent contender for clean hydrogen production via room-temperature additive-free dehydrogenation of formic acid for on-board hydrogen fuel cell applications. © 2015 American Chemical Society

Persistent Activist Communication in Occupy Gezi

We revisit the notion of activist persistence against the backdrop of protest communication on Twitter. We take an event-based approach and examine Occupy Gezi, a series of protests that occurred in Turkey in the early summer of 2013. By cross-referencing survey data with longitudinal Twitter data and in-depth interviews, we investigate the relationship between biographical availability, relational and organisational ties, social and personal costs to persistent activism online and on-location. Contrary to expectations, we find no clear-cut relationship between those factors and sustained commitment to participation in the occupation. We show that persistent activist communication did not feed into enduring organisational structures despite the continuous online activity observed during and beyond the peak of the Gezi occupation. The article concludes with reflections on the organisational ramifications of persistent communication and its significance in a political context posing high risks to participation in dissident politics

High-Coverage Whole-Exome Sequencing Identifies Candidate Genes for Suicide in Victims with Major Depressive Disorder

We carried out whole-exome ultra-high throughput sequencing in brain samples of suicide victims who had suffered from major depressive disorder and control subjects who had died from other causes. This study aimed to reveal the selective accumulation of rare variants in the coding and the UTR sequences within the genes of suicide victims. We also analysed the potential effect of STR and CNV variations, as well as the infection of the brain with neurovirulent viruses in this behavioural disorder. As a result, we have identified several candidate genes, among others three calcium channel genes that may potentially contribute to completed suicide. We also explored the potential implication of the TGF-β signalling pathway in the pathogenesis of suicidal behaviour. To our best knowledge, this is the first study that uses whole-exome sequencing for the investigation of suicide

Metaphors in Nanomedicine: The Case of Targeted Drug Delivery

International audienceThe promises of nanotechnology have been framed by a variety of metaphors, that not only channel the attention of the public, orient the questions asked by researchers, and convey epistemic choices closely linked to ethical preferences. In particular, the image of the 'therapeutic missile' commonly used to present targeted drug delivery devices emphasizes precision, control, surveillance and efficiency. Such values are highly praised in the current context of crisis of pharmaceutical innovation where military metaphors foster a general mobilization of resources from multiple fields of cutting-edge research. The missile metaphor, reminiscent of Paul Ehrlich's 'magic bullet', has framed the problem in simple terms: how to deliver the right dose in the right place at the right moment? Chemists, physicists and engineers who design multi-functional devices operating in vitro can think in such terms, as long as the devices are not actually operating through the messy environment of the body. A close look at what has been done and what remains to be done suggests that the metaphor of the "therapeutic missile" is neither sufficient, nor even necessary. Recent developments in nanomedicine suggest that therapeutic efficacy cannot be obtained without negotiating with the biological milieu and taking advantage of what it affords. An 'oïkological' approach seems more appropriate, more heuristic and more promising than the popular missile. It is based on the view of organism as an oikos that has to be carefully managed. The dispositions of nanocapsules have to be coupled with the affordances of the environment. As it requires dealing with nanoparticles as relational entities (defined by their potential for interactions) rather than as stable substances (defined by intrinsic properties) this metaphor eventually might well change research priorities in nanotechnology in general

Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons.

An increasing number of studies show that the activation of the innate immune system and inflammatory mechanisms play an important role in the pathogenesis of numerous diseases. The innate immune system is present in almost all multicellular organisms and its activation occurs in response to pathogens or tissue injury via pattern-recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs). Intracellular pathways, linking immune and inflammatory response to ion channel expression and function, have been recently identified. Among ion channels, the transient receptor potential (TRP) channels are a major family of non-selective cation-permeable channels that function as polymodal cellular sensors involved in many physiological and pathological processes.In this review, we summarize current knowledge of interactions between immune cells and PRRs and ion channels of TRP families with PAMPs and DAMPs to provide new insights into the pathogenesis of inflammatory diseases. TRP channels have been found to interfere with innate immunity via both nuclear factor-kB and procaspase-1 activation to generate the mature caspase-1 that cleaves pro-interleukin-1ß cytokine into the mature interleukin-1ß.Sensory neurons are also adapted to recognize dangers by virtue of their sensitivity to intense mechanical, thermal and irritant chemical stimuli. As immune cells, they possess many of the same molecular recognition pathways for danger. Thus, they express PRRs including Toll-like receptors 3, 4, 7, and 9, and stimulation by Toll-like receptor ligands leads to induction of inward currents and sensitization in TRPs. In addition, the expression of inflammasomes in neurons and the involvement of TRPs in central nervous system diseases strongly support a role of TRPs in inflammasome-mediated neurodegenerative pathologies. This field is still at its beginning and further studies may be required.Overall, these studies highlight the therapeutic potential of targeting the inflammasomes in proinflammatory, autoinflammatory and metabolic disorders associated with undesirable activation of the inflammasome by using specific TRP antagonists, anti-human TRP monoclonal antibody or different molecules able to abrogate the TRP channel-mediated inflammatory signals