Nano-fibrillenmiş selüloz / EPDM kompozitlerin mekanik, reolojik ve yaşlanma özellikleri

This work was aimed to develop green composite materials from nanocellulose / Ethylene Propylene Diene Monomer (EPDM) rubber. The obtained green composites were investigated in terms of chemical, thermal, mechanical, morphological, and aging properties. The results obtained in this work showed that the tensile strength and elasticity of the composites decreased with nanocellulose while permanent set values increased. Green composite materials have lower scorch values that means easier and faster vulcanization. Some cracks and staining were seen after 250h aging over 3 phr of nanocellulose whereas the surfaces were not degraded up to 100h weathering. All values are in the range of acceptable limits except for tear strength. Briefly, the study conducted reveals that nanocellulose can be used with EPDM until the concentration of 10.0 phr without any chemical degradation. Thus, sealing profiles used in automotive sector can be produced by nanocellulose/EPDM green composites instead of EPDM rubber. This can be an innovative technology in order to replace petroleum-based materials with bio-degradable materials.Bu çalışmanın amacı nanoselüloz / Etilen Propilen Dien Monomer (EPDM) kauçuktan yeşil kompozit malzemeler geliştirmektir. Elde edilen yeşil kompozitler kimyasal, termal, mekanik, morfolojik ve yaşlanma özellikleri açısından incelenmiştir. Bu çalışmada elde edilen sonuçlar, nanoselülozun eklenmesi ile kompozitlerin çekme dayanımı ve elastikiyetleri azalırken, kalıcı deformasyon değerlerinin arttığını göstermektedir. Yeşil kompozit malzemeler daha düşük scorch değerlerine sahiptir, bu da daha kolay ve daha hızlı vulkanize olacakları anlamına gelir. EPDM plakaların yüzeyleri 100 saatlik yaşlanmaya kadar bozulmazken, 250 saat yaşlandırıldıktan sonra 3 phr üzerinde nanoselüloz eklenen plakaların yüzeyinde bazı çatlaklar ve lekelenmeler gözlenmiştir. Yırtılma mukavemeti dışında tüm değerler kabul edilebilir sınırlar aralığındadır. Kısaca yapılan çalışma, nanoselülozun herhangi bir kimyasal bozulma olmaksızın 10.0 phr konsantrasyonuna kadar EPDM ile kullanılabileceğini ortaya koymaktadır. Böylelikle otomotiv sektöründe kullanılan sızdırmazlık profilleri EPDM kauçuk yerine nanoselüloz / EPDM yeşil kompozitler ile üretilebilmektedir. Bu, petrol bazlı malzemeleri biyolojik olarak parçalanabilen malzemelerle değiştirmek için yenilikçi bir teknoloji olması açısından önemlidir

Investigation of the relationship between the disease severity and quality of life of psoriasis patients and their anthropometric measurements and diets

Psoriasis is a multifaceted, chronic, inflammatory skin disease that impacts patients' quality of life. The aim of this study was to investigate the relationship between the disease severity and quality of life of psoriasis patients and their nutritional status. The study included 40 patients in the psoriasis group, compared with 40 healthy individuals in the control group. A questionnaire for determination of socio-demographic characteristics and nutritional intake, anthropometric measurements, psoriasis area and severity index (PASI), and dermatology life quality index (DLQI) were used for the assessments. Daily food consumption details were recorded for three consecutive days to determine daily energy and nutrient intakes. Compared to the control group, the frequencies of single participants, primary school graduates, and housewives were higher in the psoriasis group (p < 0.05). The psoriasis patients weighed more and had an increased waist/hip ratio in comparison with the healthy individuals. The energy intake was lower in the psoriasis group (p < 0.01). There was not a significant statistical difference in the intake of proteins, fiber, vitamin A, vitamin E, vitamin C, Zn, Fe, and Mg supplements between the groups. However, there was an inverse correlation between the daily vitamin E intake and PASI scores (p < 0.05). There was a positive moderate correlation between the DLQI and PASI scores (p < 0.01). Our study indicated that lower daily vitamin E intake levels were associated with the severity of psoriasis. In addition to this, abdominal obesity seems to be another risk factor in psoriasis patients, even if they have a normal body mass index (BMI). An integrated healthcare approach with dermatologists, family physicians, and dietitians is essential to the management of psoriasis

In a real-life setting, direct-acting antivirals to people who inject drugs with chronic hepatitis c in Turkey

Background: People who inject drugs (PWID) should be treated in order to eliminate hepatitis C virus in the world. The aim of this study was to compare direct-acting antivirals treatment of hepatitis C virus for PWID and non-PWID in a real-life setting. Methods: We performed a prospective, non-randomized, observational multicenter cohort study in 37 centers. All patients treated with direct-acting antivirals between April 1, 2017, and February 28, 2019, were included. In total, 2713 patients were included in the study among which 250 were PWID and 2463 were non-PWID. Besides patient characteristics, treatment response, follow-up, and side effects of treatment were also analyzed. Results: Genotype 1a and 3 were more prevalent in PWID-infected patients (20.4% vs 9.9% and 46.8% vs 5.3%). The number of naïve patients was higher in PWID (90.7% vs 60.0%), while the number of patients with cirrhosis was higher in non-PWID (14.1% vs 3.7%). The loss of follow-up was higher in PWID (29.6% vs 13.6%). There was no difference in the sustained virologic response at 12 weeks after treatment (98.3% vs 98.4%), but the end of treatment response was lower in PWID (96.2% vs 99.0%). In addition, the rate of treatment completion was lower in PWID (74% vs 94.4%). Conclusion: Direct-acting antivirals were safe and effective in PWID. Primary measures should be taken to prevent the loss of follow-up and poor adherence in PWID patients in order to achieve World Health Organization’s objective of eliminating viral hepatitis

Knowledge levels of personnels who work at stations of 112 emergency health services of povince of Çanakkale on disaster medicine

Amaç: Çanakkale 112 acil sağlık hizmetleri istasyonlarında çalışan personelin afet tıbbı konusundaki bilgi düzeylerini ve başta eğitim olmak üzere bazı ilişkili etmenleri ortaya koymaktır. Yöntem: Kesitsel nitelikte analitik bir araştırmadır. Araştırmanın evreni Çanakkale 112 acil sağlık hizmetleri istasyonlarında çalışan personelin tümüdür. 328 kişiden 260’ına (%79,2) ulaşılmıştır. Bağımlı değişken olan afet tıbbı bilgi düzeyi 25 soru ile 100 puan üzerinden değerlendirilmiştir. Eğitim ile ilgili değişkenler temel bağımsız değişkenlerdir. Bunlar; AYAY eğitimi alma durumu, UMKE Temel Eğitimi alma durumu, mezuniyet sonrası bir kurs programına katılma durumu, diğer eğitimlere katılma durumudur. Sosyodemografik özellikler, meslek ve afete yanıt deneyimi de diğer bağımsız değişkenlerdir. Veriler anketle, kendi kendine doldurma yöntemiyle toplanmıştır. SPSS 11.0 kullanılarak yapılan analizde Mann Whitney-U, Kruskal Wallis, Kikare testi ve lineer regresyon analizi kullanılmıştır. Anlamlılık sınırı p<0.05’dir. Bulgular: Araştırmaya katılan 260 personelin yaş ortalaması 27,6±8,5 yıldır, %56,9’u kadındır. Genel afet tıbbı bilgi düzeyi ortanca değeri 72 puandır. Personelin afet tıbbı bilgi düzeyi ile AYAY lisans eğitimi (p=0,000) ve diğer ilave eğitimler (p=0,001) arasında pozitif yönlü anlamlı bir ilişki vardır. Personelin mesleği (p=0,007) ve afet tatbikatlarına katılmış olmasının da (p=0,022) bilgi düzeyiyle ilişkisi gösterilmiş olmasına karşın; yaş, cinsiyet ve afet deneyiminin anlamlı bir ilişki göstermediği saptanmıştır. Sonuç: Personelin genel afet tıbbı bilgi düzeyleri yeterli gibi görünmekle birlikte başta eğitim olmak üzere bazı faktörlerle yakın ilişki göstermektedir. Bilgi düzeyi üzerinde en etkili eğitim yönteminin AYAY lisans eğitimi olduğu görülmüş olmakla birlikte diğer ilave eğitimlerin de etkili olduğu belirlenmiştir. Bunun yanı sıra personelin mesleğinin ve afet tatbikatına katılma deneyiminin de bilgi düzeyi üzerine etkili olduğu görülmüştür. Bu bağlamda 112 acil sağlık hizmetleri personeli afet tıbbı ile ilgili, mümkünse lisans düzeyindeki AYAY eğitimini, değilse afet tıbbı ile ilgili diğer eğitimleri almalıdır. Aldığı eğitimlere ilave olarak, düzenli aralıklarla yapılacak afet tatbikatları ile personelin bilgi düzeyi desteklenmelidir.Purpose: To reveal the knowledge levels of the personnels who work at the stations of Çanakkale 112 emergency health services on disaster medicine and some factors in connection with primarily education. Method: This sudy is a analytic research in the cross sectional nature. The scope of the research covers the all personnels who work at the stations of Çanakkale 112 emergency health services. We reached a total of 260 people out of 328 ( 79,2 %). The knowledge level of disaster medicine which is the dependant variable was evaluated by 25 questions on the scale of 100 points. The variables related to education are basic variables. Those are; the status of receiving the education of AYAY, the status of receiving the basic education of UMKE, the status of attendance in a course programme after graduation and the staus of attendance in other educations. The sociodemographic features, the vocational experience and the experience of response to disaster are the other independant variables. The data has been combined by the method of questionaire and fill-in by yourself. In the analysis conducted by using SPSS 11.0 the tests of Mann Whitney-U, Kruskal Wallis, Kikare and linear regression analysis were used. The limit of meaningfulness is p<0.05. Results:The average age of the 260 personnels who attended the research is 27,6 ±8,5 years old and 56,9 % of them are female. The median for the knowledge level of general disater medicine is 72 points. There is a meaningful relationship in the positive direction between the knowledge level of the personnels on the disaster medicine and AYAY Baccalaurate Education (p=0,000) and the other additional educations (p=0,001) even if the relationship between the personnel occupations (p=0,007) and their attendance in disaster exercises (p=0,022) and the level of knowledge was shown, it was established that age, gender and the experience of disaster did not indicate a meaningful relationship. Conclusion: The knowledge level of the personnels on the general disaster medicine is observed as sufficient, but, this state reveals a close relationship with some factors primarily education. It was seen that the most influential method of education on the knowledge level is AYAY Baccalaurate Education, but the other additional educations are also influential. Besides, it was seen that the occupations of the personnels’ and the experience of attendance in the disaster exercises are also influential on the knowledge level. In this connection, the personnels of 112 emerg ency health services should receive the AYAY education on disater medicine, if possible, at the level of baccalaurate; if not possible, the other educations related to the disaster medicine. In addition to the education which they received, the personnels’ level of knowledge should be supported by means of the disaster exercises which will be conducted at regular intervals

Synthesis and characterization of a random copolymer having variable thiophene units on the backbone

M.S. - Master of Scienc