HSC4D: Human-centered 4D Scene Capture in Large-scale Indoor-outdoor Space Using Wearable IMUs and LiDAR

We propose Human-centered 4D Scene Capture (HSC4D) to accurately and efficiently create a dynamic digital world, containing large-scale indoor-outdoor scenes, diverse human motions, and rich interactions between humans and environments. Using only body-mounted IMUs and LiDAR, HSC4D is space-free without any external devices' constraints and map-free without pre-built maps. Considering that IMUs can capture human poses but always drift for long-period use, while LiDAR is stable for global localization but rough for local positions and orientations, HSC4D makes both sensors complement each other by a joint optimization and achieves promising results for long-term capture. Relationships between humans and environments are also explored to make their interaction more realistic. To facilitate many down-stream tasks, like AR, VR, robots, autonomous driving, etc., we propose a dataset containing three large scenes (1k-5k $m^2$) with accurate dynamic human motions and locations. Diverse scenarios (climbing gym, multi-story building, slope, etc.) and challenging human activities (exercising, walking up/down stairs, climbing, etc.) demonstrate the effectiveness and the generalization ability of HSC4D. The dataset and code are available at http://www.lidarhumanmotion.net/hsc4d/.Comment: 10 pages, 8 figures, CVPR202

Cardiolipin externalization mediates prion protein (PrP) peptide 106–126-associated mitophagy and mitochondrial dysfunction

Proper mitochondrial performance is imperative for the maintenance of normal neuronal function to prevent the development of neurodegenerative diseases. Persistent accumulation of damaged mitochondria plays a role in prion disease pathogenesis, which involves a chain of events that culminate in the generation of reactive oxygen species and neuronal death. Our previous studies have demonstrated that PINK1/Parkin-mediated mitophagy induced by PrP106−126 is defective and leads to an accumulation of damaged mitochondria after PrP106−126 treatment. Externalized cardiolipin (CL), a mitochondria-specific phospholipid, has been reported to play a role in mitophagy by directly interacting with LC3II at the outer mitochondrial membrane. The involvement of CL externalization in PrP106−126-induced mitophagy and its significance in other physiological processes of N2a cells treated with PrP106−126 remain unknown. We demonstrate that the PrP106−126 peptide caused a temporal course of mitophagy in N2a cells, which gradually increased and subsequently decreased. A similar trend in CL externalization to the mitochondrial surface was seen, resulting in a gradual decrease in CL content at the cellular level. Inhibition of CL externalization by knockdown of CL synthase, responsible for de novo synthesis of CL, or phospholipid scramblase-3 and NDPK-D, responsible for CL translocation to the mitochondrial surface, significantly decreased PrP106−126-induced mitophagy in N2a cells. Meanwhile, the inhibition of CL redistribution significantly decreased PINK1 and DRP1 recruitment in PrP106−126 treatment but had no significant decrease in Parkin recruitment. Furthermore, the inhibition of CL externalization resulted in impaired oxidative phosphorylation and severe oxidative stress, which led to mitochondrial dysfunction. Our results indicate that CL externalization induced by PrP106−126 on N2a cells plays a positive role in the initiation of mitophagy, leading to the stabilization of mitochondrial function

Flexible dimensional hierarchy of higher-order topology in the stacked Kagome-chain acoustic crystal

Abstract Manipulating wave propagation and energy collection plays a core role in modern physics, for which topological insulators hosting robust boundary states offer an ideal platform. However, there exist challenges in integrating multiple topological states like two-dimensional (2D) surface state, one-dimensional (1D) hinge state, and zero-dimensional (0D) corner state into a single three-dimensional (3D) architecture. Here we introduce a dimensional hierarchy acoustic structure with a piled 3D Kagome-chain crystal. By tuning the inter- and intra-layer hopping, we lift the 3D bulk states into 2D surface states. A further distortion on the in-plane unit cell makes the system support the 1D hinge and 0D corner states simultaneously. This hierarchy keeps the parent architecture unchanged. Analytically, we prove the robustness of our framework in different geometrical configurations. Our research offers insight for the practical use of the sonic or optical device with diversified topological modes like wave concentrations and transmissions

Heat-induced molten pool boundary softening behavior and its effect on tensile properties of laser additive manufactured aluminum alloy

Changes in the microstructure and the mechanical properties of AlSi10 Mg alloy fabricated by selective laser melting combined with the subsequent heat treatment have been studied. The influence of the heat treatment on the molten pool boundary softening, microstructure evolution and the resultant mechanical properties has been elucidated. The as-fabricated specimens exhibited the various Si phase patterns within the different regions of the molten pool corresponding to the columnar perpendicular to the molten pool boundary and cellular columnar in the upper center region due to the various thermal behaviors. The solubility of Si atoms was decreased and rejected into fine Si particles with the formation of the molten pool boundary softening and the homogeneous distribution in the heat induced part, playing a key role in the mechanical properties of AlSi10 Mg alloy. The ultimate tensile strength decreased from 476.8 MPa for the as-fabricated part to 320.5 MPa while, the fracture ductility significantly increased from 7.33% to 13.3% as the test specimens were heat treated at 573 K for 2 h. It indicated that the microstructure evolution and tensile properties of the as-fabricated AlSi10 Mg alloy could be tailored through molten pool softening and size and morphology of the Si phase at the suitable heat treatments

Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population

Objective: To evaluate the diagnostic value of fluorescence in situ hybridization (FISH) in bladder cancer. Methods: We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008. Receiver operating characteristic (ROC) curve analysis was performed and the area under curve (AUC) values were calculated for both the FISH and urine cytology tests. Results: A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population. A total of 4807 patients with hematuria were prospectively, randomly enrolled for the simultaneous analysis of urine cytology, FISH testing, and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen. Overall, the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%, while that of cytology was 33.4% (p < 0.001). The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7% and 89.6%, respectively (p = 0.004). The sensitivity values of FISH for low and high grade bladder cancer were 82.6% and 90.1%, respectively (p = 0.002). Conclusion: FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages. Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. Keywords: Bladder transitional-cell carcinoma, Fluorescence in situ hybridization, Detection, Grade, Stag

CEPC Technical Design Report -- Accelerator

International audienceThe Circular Electron Positron Collider (CEPC) is a large scientific project initiated and hosted by China, fostered through extensive collaboration with international partners. The complex comprises four accelerators: a 30 GeV Linac, a 1.1 GeV Damping Ring, a Booster capable of achieving energies up to 180 GeV, and a Collider operating at varying energy modes (Z, W, H, and ttbar). The Linac and Damping Ring are situated on the surface, while the Booster and Collider are housed in a 100 km circumference underground tunnel, strategically accommodating future expansion with provisions for a Super Proton Proton Collider (SPPC). The CEPC primarily serves as a Higgs factory. In its baseline design with synchrotron radiation (SR) power of 30 MW per beam, it can achieve a luminosity of 5e34 /cm^2/s^1, resulting in an integrated luminosity of 13 /ab for two interaction points over a decade, producing 2.6 million Higgs bosons. Increasing the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons, facilitating precise measurements of Higgs coupling at sub-percent levels, exceeding the precision expected from the HL-LHC by an order of magnitude. This Technical Design Report (TDR) follows the Preliminary Conceptual Design Report (Pre-CDR, 2015) and the Conceptual Design Report (CDR, 2018), comprehensively detailing the machine's layout and performance, physical design and analysis, technical systems design, R&D and prototyping efforts, and associated civil engineering aspects. Additionally, it includes a cost estimate and a preliminary construction timeline, establishing a framework for forthcoming engineering design phase and site selection procedures. Construction is anticipated to begin around 2027-2028, pending government approval, with an estimated duration of 8 years. The commencement of experiments could potentially initiate in the mid-2030s