PREVALENCE OF MUSCULOSKELETAL DISORDER AND ITS DETERMINANT FACTORS AMONG DENTISTS: PREVALENSI MUSCULOSKELETAL DISORDER DAN FAKTOR-FAKTOR YANG MEMPENGARUHI PADA DOKTER GIGI

Musculoskeletal pain has been found to be a health problem for dental practitioners. If the disorders ignored, cumulative damage may result in lowered productivity and even early retirement, injury or disability. Reported prevalence musculoskeletal disorders (MSD) to the dental practitioners in Indonesia were not yet known for certain. The aims of this study were to determine the prevalence of MSD among dental practitioners in Malang, Indonesia and to identify the factors that affect the occurrence of MSD. The study design was a cross-sectional analysis. The participants were 95 general dentists in Malang-Indonesia who asked self-administrated filled out the questionnaire. The questionnaire contained inquiry about: age, gender, body mass index, the time-lapse as a dentist, working hours, number of patients, working with an assistant, exercises on the sidelines of working time, sports activity, working position and asking whether they were suffering from musculoskeletal disorders in the last 12 months. The data analyzed by descriptive and logistic regression. The results showed 58.9% dentists complaint musculoskeletal pain in the last 12 months. The common complaints felt by the participants were back pain 34.6%, shoulder 18,9% and neck 16.9%. The determinants factors statistically significant correlations on MSD were working hours per week, working position, and exercises on sidelines working time

ANALISIS KARAKTERISTIK DAN PERILAKU PEMBELIAN MASYARAKAT SEBAGAI DASAR PENYUSUNAN UPAYA PEMASARAN PELAYANAN UNIT RAWAT JALAN PUSKESMAS TAMAN

Penelitian ini merupakan cross sectional study dengan metod.e survei. Pengarnbilan sampel diJaksanakan pada bulan Mei 2004. Dati 120 responden yang diarnbil dengan teknik multistage random sampling, basiJ dari penelitian ini menunjukkan tipe perilaku pembeJian terbanyak adaIah tipe rutin. Dengan uji chisquare didapatkan p > 0,05 (p = 0,057). lni berarti tidak ada perbedaan bermakna antara perilaku pembelian pengglDl8 dan non penggWla Puskesmas Taman. Semua faktor karakteristik masyaraJeat berpengaruh terbadap perilaku pembeIiannya kecuali jenis kelamin. Ini disebabkan karena dengan uji regresi logistik multinomial hanya faktor jenis keJamin yang memptmyai p > 0,05 (p = 0,157). Sarana pelayanan kesehatan yang dipilih terbanyak adalah Puskesmas Taman yaitu sebesar 56,7 %. Adapun alasan utama masyarakat ketika memilih sarana pelayanan rawat jalan, sebagian besar pengguna Puskesmas Taman menjawab karena jaraknya dekat dengan kediaman mereka, sedangkan non pengguna terbanyak memilib karena keterampilan petugasny

Knowledge, Dental Anxiety, and Patient Expectations During the COVID-19 Pandemic

Objective: To assess the knowledge, dental anxiety, and expectations regarding dental services during the COVID-19 pandemic. Material and Methods: The respondents were Indonesian citizens above 18 years old. An online Google survey was administered using a structured questionnaire with a snowball sampling technique. Survey items comprised knowledge related to COVID-19, dental anxiety assessed using the modified DAS (Dental Anxiety Scale) and expectations regarding dental services using four dimensions of dental service quality. All questionnaires were tested for reliability and indicated acceptable and good agreement. The data were analyzed descriptively. Results: A total of 553 responses were analysed. Most respondents were female (72.9%), 76.7% knew of recommendations to postpone dentist visits and 86.8% knew methods of preventing COVID-19 transmission. More than 70% of respondents knew the precaution procedures in the dental office during COVID-19, and only 27.9% had moderate-severe anxiety. Most respondents’ expectations regarding dental services during the pandemic era were related to the quality domain of reliability and responsiveness. Conclusion: Respondents knew about COVID-19 transmission and prevention, emergency conditions warranting a visit to the dentist and the procedures used at the dental office. Most respondents stated that they were not anxious about visiting a dentist during the pandemic. The respondents expect the dentist to provide sufficient information to improve oral health and treatment plan

Knowledge, Dental Anxiety, and Patient Expectations During the COVID-19 Pandemic

Objective: To assess the knowledge, dental anxiety, and expectations regarding dental services during the COVID-19 pandemic. Material and Methods: The respondents were Indonesian citizens above 18 years old. An online Google survey was administered using a structured questionnaire with a snowball sampling technique. Survey items comprised knowledge related to COVID-19, dental anxiety assessed using the modified DAS (Dental Anxiety Scale) and expectations regarding dental services using four dimensions of dental service quality. All questionnaires were tested for reliability and indicated acceptable and good agreement. The data were analyzed descriptively. Results: A total of 553 responses were analysed. Most respondents were female (72.9%), 76.7% knew of recommendations to postpone dentist visits and 86.8% knew methods of preventing COVID-19 transmission. More than 70% of respondents knew the precaution procedures in the dental office during COVID-19, and only 27.9% had moderate-severe anxiety. Most respondents’ expectations regarding dental services during the pandemic era were related to the quality domain of reliability and responsiveness. Conclusion: Respondents knew about COVID-19 transmission and prevention, emergency conditions warranting a visit to the dentist and the procedures used at the dental office. Most respondents stated that they were not anxious about visiting a dentist during the pandemic. The respondents expect the dentist to provide sufficient information to improve oral health and treatment plan

Binahong leaf extract (anredera cordifolia) mucoadhesive patch as an alternative therapy for recurrent aphthous stomatitis

Background: Recurrent Aphthous Stomatitis (RAS) is one of the most common oral diseases of all ages. There has been no study that defines the leading cause of RAS. The utilization of binahong leaves (Anredera cordifolia) can be beneficial for the treatment of RAS as it acts as an anti-inflammatory and accelerates the proliferation of fibroblasts. The combination between binahong leaves and the mucoadhesive patch will increase the effectiveness of RAS treatment.Method: Literature study through PubMed and Google Scholar databases was conducted using PRISMA flow chart looking for the efficacy of binahong leaves (Anredera cordifolia) for mucosa wound healing and mucoadhesive patches for the treatment of RAS.Result: The search results found 31 articles that met the criteria for analysis. Flavonoids and saponins in binahong leaves extract act as an anti-inflammatory and increase the proliferation of wound healing. Mucoadhesive patch formulation can increase the effectiveness of RAS treatment on the mucosa.Conclusion: Binahong leaves extract in the form of mucoadhesive patches can be used as an alternative treatment for Recurrent Aphthous Stomatitis

Binahong leaf extract (anredera cordifolia) mucoadhesive patch as an alternative therapy for recurrent aphthous stomatitis

Background: Recurrent Aphthous Stomatitis (RAS) is one of the most common oral diseases of all ages. There has been no study that defines the leading cause of RAS. The utilization of binahong leaves (Anredera cordifolia) can be beneficial for the treatment of RAS as it acts as an anti-inflammatory and accelerates the proliferation of fibroblasts. The combination between binahong leaves and the mucoadhesive patch will increase the effectiveness of RAS treatment.Method: Literature study through PubMed and Google Scholar databases was conducted using PRISMA flow chart looking for the efficacy of binahong leaves (Anredera cordifolia) for mucosa wound healing and mucoadhesive patches for the treatment of RAS.Result: The search results found 31 articles that met the criteria for analysis. Flavonoids and saponins in binahong leaves extract act as an anti-inflammatory and increase the proliferation of wound healing. Mucoadhesive patch formulation can increase the effectiveness of RAS treatment on the mucosa.Conclusion: Binahong leaves extract in the form of mucoadhesive patches can be used as an alternative treatment for Recurrent Aphthous Stomatitis

Synergistic effect of the combination of Chrysanthemum cinerariifolium (Trev.) and doxorubicin in inhibiting PI3K and Cyclin D in oral squamous cell carcinoma: in vitro study

Background: The most common type of lips and oral cavity cancer is oral squamous cell carcinoma (OSCC). Doxorubicin (DX) is commonly used as a chemotherapy drug, but its use is limited due to risk factors and drug resistance. Chrysanthemum cinerariifolium (Trev.) (CC) has potential as an anticancer agent. Combining the plant extract and chemotherapy drug might prevent OSCC proliferation by inhibiting PI3K and cyclin D protein. Therefore, the present study aimed to determine the synergistic effect of the combination of C. cinerariifolium (Trev.) and doxorubicin in inhibiting PI3K and Cyclin D protein. Methods: Human oral squamous carcinoma cell lines SCC-9 were used in this study. A cytotoxicity assay was performed to obtain the IC50 value of CC ethanol extract and DX on the SCC-9 cell line. Synergism evaluation of the combination CC and DX was analyzed using CompuSyn software. ELISA and the immunofluorescent assay were performed to determine the level of PI3K and cyclin D in the SCC-9 cell line after being treated with IC50 value of CC, IC50 value of DX and three combinations of CC and DX [7/8 IC50 CC + 1/8 IC50 DX (dose 1), 6/8 IC50 CC + 2/8 IC50 DX (dose 2), and 4/8 IC50 CC + 4/8 IC50 DX (dose 3). Results: CC stem ethanol extract and DX inhibited the proliferation of SCC-9 cell lines with the IC50 value of 133.4 µg/mL and 288.3 nM, respectively. The combination of CC and DX at dose 2 (6/8 IC50 CC + 2/8 IC50 DX) exhibited a high decrease in PI3K and cyclin D expression. Conclusions: The combination of C. cinerariifolium and doxorubicin synergistically declined OSCC proliferation by inhibiting PI3K and cyclin D expression

Analysis of the metabolite compound of the ethanol extract of Chrysanthemum cinerariifolium stem and activity for inhibition of Oral Squamous Cell Carcinoma (OSCC) in silico study

Background: Oral cancer is a deadly disease that is expected to increase yearly. Current cancer treatment methods have side effects. C. cinerariifolium plants have potential as anticancer agents. Objective: To evaluate the anti-OSCC properties of the ethanol extract of C. cinerariifolium stems via an in-silico study. Materials and Methods: Analysis of active compounds in ethanol extracts of C. cinerariifolium stems using TLC and UPLC-QToF-MS/MS metabolic profiling. The data were analysed statistically using principal component analysis (PCA). In silico of C. cinerariifolium compounds on protein (PI3K and Cyclin D) from OSCC. Results: TLC procedures utilizing UV light with λ 366 nm after spraying with H2SO4 revealed multiple-colored spots, indicating that H2SO4 is a specific spray detector for terpenoid and carotene. Metabolic profiling in ethanol extract of C. cinerariifolium stem included Pronethalol (3.96%), 1-(4-Methoxyphenyl)-N-(1 naphthylmethyl) methanamine (7.34%), Orphenadrine (24.27%), Pentazocine (5.09%), 4-(Dodecyloxy) aniline (6.30%), Linoleamide (4.95%), and Pheophorbide A (8.05%). Orphenadrine had the highest percentage. Based on the Lipinski rule of five, pronethalol has the potential to be used as a drug-like therapy for OSCC. The anticancer activity profile is predicted by PASS online with a likely range of 0.065 to 0.385. An in-silico study showed that the strongest binding affinity is pronethalol to Cyclin D1 and pheophorbide A to the PI3K protein. Conclusion: The active metabolite of the ethanolic extract of C. cinerariifolium stem exhibits potency against oral squamous cell carcinoma via the downregulation of the cell cycle (cyclin D1) and P13K, especially pronethalo

Potensi Ekstrak Daun Binahong (Anredera cordifolia) pada Penyembuhan Recurrent Aphthous Stomatitis (RAS): Literatur Review

Recurrent Aphthous Stomatitis (RAS) atau sariawan merupakan penyakit yang timbul pada mukosa mulut dan paling umum terjadi pada semua usia. RAS ditandai dengan timbulnya gejala prodromal, seperti gatal, nyeri, dan rasa terbakar. Pada umumnya, pemakaian kortikosteroid dan obat kumur menjadi pilihan utama untuk mengatasi RAS. Bahan herbal seperti daun binahong dapat menjadi alternatif pengobatan RAS. Penelitian ini bertujuan untuk mengetahui keefektifan ekstrak daun binahong (Anredera cordifolia) pada proses penyembuhan Recurrent Aphthous Stomatitis (RAS). Metode yang digunakan pada penelitian ini adalah studi literatur review dari database PubMed dan Google Scholar yang dipublikasikan mulai tahun 2011 hingga 2021. Rancangan penelitian ini menggunakan rancangan PRISMA (Prefferred Reporting Items for Systematic Reviews and Meta-Analysis) dan setelah diseleksi didapatkan 16 literatur yang relevan untuk kemudian dianalisis sehingga diperoleh datanya. Dari hasil penelitian didapatkan bahwa ekstrak daun binahong (A. cordifilia) efektif dalam menyembuhkan RAS. Senyawa flavonoid dan saponin yang terkandung dalam ekstrak daun binahong memiliki fungsi antiinflamasi dan dapat meningkatkan proliferasi sel sehingga mempercepat penutupan luka RA