System Dynamics Based Simulation Study On Storage and Distribution Integration of Electronic Commerce Enterprise

With the strong advocacy of national policies and the rapid development of electronic commerce, offline logistics operation has become the key to efficient and fast e-commerce. This paper will use the system dynamic method to build an integrated warehousing and distribution system of e-commerce, applying the computer simulation to analyze the change of each parameter after the target inventory and delay time have changed. Suggestions will be put forward at last: building of an info-sharing mechanism, reducing the delay time via active coordination, predicting the target inventory of distribution center on time. Through these to reduce the average cost and the possibility of short supply at distribution center, and thus guarantee the delivery quality and speed, optimize buyers’ shopping experience, form a virtuous circle and enhance the overall competence of the supply chain

A compendium of genetic regulatory effects across pig tissues

The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms to variation in phenotypes, helping fundamental biological discovery and exploitation in animal breeding and human biomedicine. Here we show results from the pilot phase of PigGTEx by processing 5,457 RNA-sequencing and 1,602 whole-genome sequencing samples passing quality control from pigs. We build a pig genotype imputation panel and associate millions of genetic variants with five types of transcriptomic phenotypes in 34 tissues. We evaluate tissue specificity of regulatory effects and elucidate molecular mechanisms of their action using multi-omics data. Leveraging this resource, we decipher regulatory mechanisms underlying 207 pig complex phenotypes and demonstrate the similarity of pigs to humans in gene expression and the genetic regulation behind complex phenotypes, supporting the importance of pigs as a human biomedical model.</p

INTERNET BASED FLEET MANAGEMENT USING GPS AND GSM/GPRS

International Telemetering Conference Proceedings / October 20-23, 2003 / Riviera Hotel and Convention Center, Las Vegas, NevadaThis paper presents the design and implementation of a large fleet management system, which is a true convergence solution of GPS, web-based GIS, GSM, GPRS and Internet technologies. The Short Message Service of the GSM is used to substitute the GPRS where GPRS is not available. A protocol stack including TCP/IP and PPP is implemented in vehicle unit to transmit data via Internet. A communication gateway is designed to distribute the location and control messages. The system tests confirm that the proposed scheme can perform a reliable management service for large fleets at low operating and maintaining costs.International Foundation for TelemeteringProceedings from the International Telemetering Conference are made available by the International Foundation for Telemetering and the University of Arizona Libraries. Visit http://www.telemetry.org/index.php/contact-us if you have questions about items in this collection

Modeling and Solution of Vehicle Routing Problem with Grey Time Windows and Multiobjective Constraints

Purpose. In order to study the impact of grey delivery time uncertainty on customer satisfaction and delivery costs, a vehicle routing problem with grey delivery time windows and multiobjective constraints is defined. Method. The paper first defines the uncertainty of the delivery vehicle’s arrival time to the customer as grey uncertainty and then whitens the grey time windows; at the same time, the customer’s hard time windows is expanded into a soft time windows to measure customer satisfaction when the vehicle arrives. Experiment. In order to verify the validity of the established model, numerical experiments are carried out in two groups based on the Solomon example, and the solution is solved based on the improved quantum evolution algorithm. Analysis. Distribution cost fluctuations and customer satisfaction fluctuations with grey time windows are relatively small; under different satisfaction threshold conditions, the distribution cost is increased gently with the satisfaction threshold. Conclusion. The grey delivery time windows have certain advantages in solving the random travel time vehicle routing problem

Macular Retinal Vessel Oxygen Saturation Elevation in Chinese Central Serous Chorioretinopathy

Purpose. To evaluate the retinal vessel oxygen saturation in central serous chorioretinopathy (CSC) cases among the Chinese. Methods. Relative oxygen saturation of retinal blood vessels was measured in 33 Chinese patients with single-eye CSC using the Oxymap T1 retinal oximeter. The contralateral eyes were the control. The mean saturation of the retinal arteriole (AS) and venule (VS), arteriovenous difference (AVS), and arteriole and venule diameters (AD, VD) was analyzed in the optic disc area and macular region. Results. In the optic disc area, the inferotemporal quadrant (TI) AS (93.2 ± 10.2%) and inferonasal quadrant (NI) VS (61.3 ± 7.3%) were higher in the affected eyes than in the contralateral eyes (88.7 ± 7.7% and 56.9 ± 6.5%) and AVS in NI (36.7 ± 10.4%) decreased compared to the contralateral eyes (41.5 ± 11.2%). The VD in TI was expanded (19.9 ± 2.5 pixels versus 18.1 ± 3.4 pixels). Around the macular region, AS was 93.6 ± 7.6%, higher than in the contralateral eyes (89.5 ± 6.3%). No other significant changes were found. Conclusions. AS increased in the TI, and VS decreased in the NI in the eyes with CSC. In addition, AS also increased around the macular region, suggesting that these are contributors to CSC pathophysiology

A compendium of genetic regulatory effects across pig tissues

Altres ajuts: Medical Research Council (MRC) MR/R025851/1 i MR/P015514/1. Biotechnology and Biological Sciences Research Council BBS/E/D/10002070 i BBS/E/D/30002275. United States Department of Agriculture 2019-67015-29321 i 2021-67015-33409. National Natural Science Foundation of China (National Science Foundation of China) 32022078.The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms to variation in phenotypes, helping fundamental biological discovery and exploitation in animal breeding and human biomedicine. Here we show results from the pilot phase of PigGTEx by processing 5,457 RNA-sequencing and 1,602 whole-genome sequencing samples passing quality control from pigs. We build a pig genotype imputation panel and associate millions of genetic variants with five types of transcriptomic phenotypes in 34 tissues. We evaluate tissue specificity of regulatory effects and elucidate molecular mechanisms of their action using multi-omics data. Leveraging this resource, we decipher regulatory mechanisms underlying 207 pig complex phenotypes and demonstrate the similarity of pigs to humans in gene expression and the genetic regulation behind complex phenotypes, supporting the importance of pigs as a human biomedical model. The pilot phase of PigGTEx, re-analyzing 5,457 published RNA-seq samples, presents a pan-tissue catalog of molecular quantitative trait loci. Cross-species comparisons identify traits with shared genetic regulation in humans