462 research outputs found
Dispersion Curve Engineering of TiO2/Silver Hybrid Substrates for Enhanced Surface Plasmon Resonance Detection
As surface plasmon resonance (SPR)-based biosensors are well translated into biological, chemical, environmental, and clinical fields, it is critical to further realize stable and sustainable systems, avoiding oxidation susceptibility of metal films—in particular, silver substrates. We report an enhanced SPR detection performance by incorporating a TiO2 layer on top of a thin silver film. A uniform TiO2 film fabricated by electron beam evaporation at room temperature is an effective alternative in bypassing oxidation of a silver film. Based on our finding that the sensor sensitivity is strongly correlated with the slope of dispersion curves, SPR sensing results obtained by parylene film deposition shows that TiO2/silver hybrid substrates provide notable sensitivity improvement compared to a conventional bare silver film, which confirms the possibility of engineering the dispersion characteristic according to the incidence wavelength. The reported SPR structures with TiO2 films enhance the sensitivity significantly in water and air environments and its overall qualitative trend in sensitivity improvement is consistent with numerical simulations. Thus, we expect that our approach can extend the applicability of TiO2-mediated SPR biosensors to highly sensitive detection for biomolecular binding events of low concentrations, while serving a practical and reliable biosensing platform
GALEX Ultraviolet Photometry of Globular Clusters in M31
We present ultraviolet photometry for globular clusters (GCs) in M31 from 15
square deg of imaging using the Galaxy Evolution Explorer (GALEX). We detect
200 and 94 GCs with certainty in the near-ultraviolet (NUV; 1750 - 2750
Angstroms) and far-ultraviolet (FUV; 1350 - 1750 Angstroms) bandpasses,
respectively. Our rate of detection is about 50% in the NUV and 23% in the FUV,
to an approximate limiting V magnitude of 19. Out of six clusters with
[Fe/H]>-1 seen in the NUV, none is detected in the FUV bandpass. Furthermore,
we find no candidate metal-rich clusters with significant FUV flux, because of
the contribution of blue horizontal-branch (HB) stars, such as NGC 6388 and NGC
6441, which are metal-rich Galactic GCs with hot HB stars. We show that our
GALEX photometry follows the general color trends established in previous UV
studies of GCs in M31 and the Galaxy. Comparing our data with Galactic GCs in
the UV and with population synthesis models, we suggest that the age range of
M31 and Galactic halo GCs are similar.Comment: This paper will be published as part of the Galaxy Evolution Explorer
(GALEX) Astrophysical Journal Letters Special Issue. Links to the full set of
papers will be available at http://www.galex.caltech.edu/PUBLICATIONS/ after
November 22, 200
Prophylactic and Therapeutic Efficacy of Avian Antibodies against Influenza Virus H5N1 and H1N1 in Mice
Background: Pandemic influenza poses a serious threat to global health and the world economy. While vaccines are currently under development, passive immunization could offer an alternative strategy to prevent and treat influenza virus infection. Attempts to develop monoclonal antibodies (mAbs) have been made. However, passive immunization based on mAbs may require a cocktail of mAbs with broader specificity in order to provide full protection since mAbs are generally specific for single epitopes. Chicken immunoglobulins (IgY) found in egg yolk have been used mainly for treatment of infectious diseases of the gastrointestinal tract. Because the recent epidemic of highly pathogenic avian influenza virus (HPAIV) strain H5N1 has resulted in serious economic losses to the poultry industry, many countries including Vietnam have introduced mass vaccination of poultry with H5N1 virus vaccines. We reasoned that IgY from consumable eggs available in supermarkets in Vietnam could provide protection against infections with HPAIV H5N1.
Methods and Findings: We found that H5N1-specific IgY that are prepared from eggs available in supermarkets in Vietnam by a rapid and simple water dilution method cross-protect against infections with HPAIV H5N1 and related H5N2 strains in mice. When administered intranasally before or after lethal infection, the IgY prevent the infection or significantly reduce viral replication resulting in complete recovery from the disease, respectively. We further generated H1N1 virus-specific IgY by immunization of hens with inactivated H1N1 A/PR/8/34 as a model virus for the current pandemic H1N1/09 and found that such H1N1-specific IgY protect mice from lethal influenza virus infection.
Conclusions: The findings suggest that readily available H5N1-specific IgY offer an enormous source of valuable biological material to combat a potential H5N1 pandemic. In addition, our study provides a proof-of-concept for the approach using virus-specific IgY as affordable, safe, and effective alternative for the control of influenza outbreaks, including the current H1N1 pandemic
The Star Formation Rate Function of the Local Universe
We have derived the bivariate luminosity function for the far ultraviolet
(1530Angstroms) and far infrared (60 microns). We used matched GALEX and IRAS
data, and redshifts from NED and PSC-z. We have derived a total star formation
luminosity function phi(L_{tot}), with L_{tot} = L_{FUV}+L_{FIR}. Using these,
we determined the cosmic ``star formation rate'' function and density for the
local universe. The total SFR function is fit very well by a log-normal
distribution over five decades of luminosity. We find that the bivariate
luminosity function phi(L_{FUV},L_{FIR}) shows a bimodal behavior, with L_{FIR}
tracking L_{FUV} for L_{TOT}< 10^10 L_sun, and L_{FUV} saturating at 10^10
L_sun, while L_{TOT} L_{FIR} for higher luminosities. We also calculate the SFR
density and compare it to other measurements.Comment: This paper will be published as part of the Galaxy Evolution Explorer
(GALEX) Astrophysical Journal Letters Special Issue. Links to the full set of
papers will be available at http:/www.galex.caltech.edu/PUBLICATIONS/ after
November 22, 200
UV emission and Star Formation in Stephan's Quintet
we present the first GALEX UV images of the well known interacting group of
galaxies, Stephan's Quintet (SQ). We detect widespread UV emission throughout
the group. However, there is no consistent coincidence between UV structure and
emission in the optical, H\alpha, or HI. Excluding the foreground galaxy
NGC7320 (Sd), most of the UV emission is found in regions associated with the
two spiral members of the group, NGC7319 and NGC7318b, and the intragroup
medium starburst SQ-A. The extinction corrected UV data are analyzed to
investigate the overall star formation activity in SQ. It is found that the
total star formation rate (SFR) of SQ is 6.69+-0.65 M_\sun/yr. Among this,
1.34+-0.16 M_sun/yr is due to SQ-A. This is in excellent agreement with that
derived from extinction corrected H\alpha luminosity of SQ-A. The SFR in
regions related to NGC 7319 is 1.98+-0.58 M_\sun/yr, most of which(68%) is
contributed by the disk. The contribution from the 'young tail' is only 15%. In
the UV, the 'young tail' is more extended (~100 kpc) and shows a loop-like
structure, including the optical tail, the extragalactic HII regions recently
discovered in H\alpha, and other UV emission regions discovered for the first
time. The UV and optical colors of the 'old tail' are consistent with a single
stellar population of age t ~10^{8.5+-0.4} yrs. The UV emission associated with
NGC 7318b is found in a very large (~80 kpc) disk, with a net SFR of 3.37+-0.25
M_sun/yr. Several large UV emission regions are 30 -- 40 kpc away from the
nucleus of NGC7318b. Although both NGC7319 and NGC7318b show peculiar UV
morphology, their SFR is consistent with that of normal Sbc galaxies,
indicating that the strength of star formation activity is not enhenced by
interactions.Comment: This paper will be published as part of the Galaxy Evolution
Explorer(GALEX) Astrophysical Journal Letters Special Issue. Links to the
full set of papers will be available at
http:/www.galex.caltech.edu/PUBLICATIONS/ after November 22, 200
Recent star formation in nearby galaxies from GALEX imaging:M101 and M51
The GALEX (Galaxy Evolution Explorer) Nearby Galaxies Survey is providing
deep far-UV and near-UV imaging for a representative sample of galaxies in the
local universe. We present early results for M51 and M101, from GALEX UV
imaging and SDSS optical data in five bands. The multi-band photometry of
compact stellar complexes in M101 is compared to population synthesis models,
to derive ages, reddening, reddening-corrected luminosities and current/initial
masses. The GALEX UV photometry provides a complete census of young compact
complexes on a approximately 160pc scale. A galactocentric gradient of the
far-UV - near-UV color indicates younger stellar populations towards the outer
parts of the galaxy disks, the effect being more pronounced in M101 than in
M51.Comment: This paper will be published as part of the Galaxy Evolution Explorer
(GALEX) Astrophysical Journal Letters Special Issue. Full paper available
from http://dolomiti.pha.jhu.edu . Links to full set of papers will be
available at http://www.galex.caltech.edu/PUBLICATIONS/ after November 22,
200
The On-Orbit Performance of the Galaxy Evolution Explorer
We report the first year on-orbit performance results for the Galaxy
Evolution Explorer (GALEX), a NASA Small Explorer that is performing a survey
of the sky in two ultraviolet bands. The instrument comprises a 50 cm diameter
modified Ritchey-Chretien telescope with a 1.25 degree field of view,
selectable imaging and objective grism spectroscopic modes, and an innovative
optical system with a thin-film multilayer dichroic beam splitter that enables
simultaneous imaging by a pair of photon counting, microchannel plate, delay
line readout detectors. Initial measurements demonstrate that GALEX is
performing well, meeting its requirements for resolution, efficiency,
astrometry, bandpass definition and survey sensitivity.Comment: This paper will be published as part of the Galaxy Evolution Explorer
(GALEX) Astrophysical Journal Letters Special Issu
Structural Properties of Central Galaxies in Groups and Clusters
Using a representative sample of 911 central galaxies (CENs) from the SDSS
DR4 group catalogue, we study how the structure of the most massive members in
groups and clusters depend on (1) galaxy stellar mass (Mstar), (2) dark matter
halo mass of the host group (Mhalo), and (3) their halo-centric position. We
establish and thoroughly test a GALFIT-based pipeline to fit 2D Sersic models
to SDSS data. We find that the fitting results are most sensitive to the
background sky level determination and strongly recommend using the SDSS global
value. We find that uncertainties in the background translate into a strong
covariance between the total magnitude, half-light size (r50), and Sersic index
(n), especially for bright/massive galaxies. We find that n depends strongly on
Mstar for CENs, but only weakly or not at all on Mhalo. Less (more) massive
CENs tend to be disk (spheroid)-like over the full Mhalo range. Likewise, there
is a clear r50-Mstar relation for CENs, with separate slopes for disks and
spheroids. When comparing CENs with satellite galaxies (SATs), we find that low
mass (<10e10.75 Msun/h^2) SATs have larger median n than CENs of similar Mstar.
Low mass, late-type SATs have moderately smaller r50 than late-type CENs of the
same Mstar. However, we find no size differences between spheroid-like CENs and
SATs, and no structural differences between CENs and SATs matched in both mass
and colour. The similarity of massive SATs and CENs shows that this distinction
has no significant impact on the structure of spheroids. We conclude that Mstar
is the most fundamental property determining the basic structure of a galaxy.
The lack of a clear n-Mhalo relation rules out a distinct group mass for
producing spheroids, and the responsible morphological transformation processes
must occur at the centres of groups spanning a wide range of masses. (abridged)Comment: 22 pages, 14 figures, submitted to MNRA
Pharmacokinetic study of meropenem in healthy beagle dogs receiving intermittent hemodialysis
Meropenem, a second carbapenem antimicrobial agent with a broad spectrum of activity, is used to treat sepsis and resistant-bacterial infections in veterinary medicine. The objective of this study was to identify the pharmacokinetics of meropenem in dogs receiving intermittent hemodialysis (IHD) and to determine the proper dosing in renal failure patients receiving IHD. Five healthy beagle dogs were given a single i.v. dose of 24 mg/kg of meropenem and received IHD. The blood flow rate, dialysate flow, and ultrafiltration rate were maintained at 40 mL/min, 300 mL/min, and 40 mL/h, respectively. Blood samples were collected for 24 h from the jugular vein and from the extracorporeal arterial and venous line. Urine samples and dialysate were also collected. The concentrations of meropenem were assayed using HPLC/MS/MS determination. The peak plasma concentration was 116 +/- 37 mu g/mL at 15 min. The systemic clearance was 347 +/- 117 mL/h/kg, and the steady-state volume of distribution was 223 +/- 67 mL/kg. Dialysis clearance was 71.1 +/- 34.3 mL/h/kg, and the extraction ratio by hemodialysis was 0.455 +/- 0.150. The half-life (T-1/2) in dogs with IHD decreased compared with those without IHD, and the reduction in T1/2 was greater in renal failure patients than in normal patients. Sixty-nine percent and 21% of the administered drug were recovered by urine and dialysate in the unchanged form, respectively. In conclusion, additional dosing of 24 mg/kg of meropenem after dialysis could be necessary according to the residual renal function of the patient based on the simulated data.OAIID:RECH_ACHV_DSTSH_NO:T201621129RECH_ACHV_FG:RR00200001ADJUST_YN:EMP_ID:A003050CITE_RATE:1.279FILENAME:Byun_et_al-2016-Journal_of_Veterinary_Pharmacology_and_Therapeutics.pdfDEPT_NM:수의학과EMAIL:[email protected]_YN:YFILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/eb2b2d93-6cb2-4420-a374-90eb43215957/linkCONFIRM:
SRAO CO Observation of 11 Supernova Remnants in l = 70 to 190 deg
We present the results of 12CO J = 1-0 line observations of eleven Galactic
supernova remnants (SNRs) obtained using the Seoul Radio Astronomy Observatory
(SRAO) 6-m radio telescope. The observation was made as a part of the SRAO CO
survey of SNRs between l = 70 and 190 deg, which is intended to identify SNRs
interacting with molecular clouds. The mapping areas for the individual SNRs
are determined to cover their full extent in the radio continuum. We used
halfbeam grid spacing (60") for 9 SNRs and full-beam grid spacing (120") for
the rest. We detected CO emission towards most of the remnants. In six SNRs,
molecular clouds showed a good spatial relation with their radio morphology,
although no direct evidence for the interaction was detected. Two SNRs are
particularly interesting: G85.4+0.7, where there is a filamentary molecular
cloud along the radio shell, and 3C434.1, where a large molecular cloud appears
to block the western half of the remnant. We briefly summarize the results
obtained for individual SNRs.Comment: Accepted for publication in Astrophysics & Space Science. 12 pages,
12 figures, and 3 table
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