65 research outputs found

    Filicales of the Mammoth Cave Region

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    The purpose of this investigation was to determine the distribution of each species of ferns with regard to the geologic strata, altitude and temperature and moisture relationships. A systematic classification was made of all species of ferns found in the region

    Social Media and the Activist Toolkit: User Agreements, Corporate Interests, and the Information Infrastructure of Modern Social Movements

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91171/1/j.1460-2466.2012.01636.x.pd

    Without a Song / music by Vincent Youmans; words by William Rose and Edward Eliscu

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    Cover: drawing of a lonely looking African American male staring at a distant cabin at night; Publisher: Mills Music Inc. (New York)https://egrove.olemiss.edu/sharris_d/1105/thumbnail.jp

    A trade-off between classical and quantum circuit size for an attack against CSIDH

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    International audienceWe propose a heuristic algorithm to solve the underlying hard problem of the CSIDH cryptosystem (and other isogeny-based cryp-tosystems using elliptic curves with endomorphism ring isomorphic to an imaginary quadratic order O). Let ∆ = Disc(O) (in CSIDH, ∆ = −4p for p the security parameter). Let 0 < α < 1/2, our algorithm requires: • A classical circuit of size 2Õ (log(|∆|) 1−α). • A quantum circuit of size 2Õ (log(|∆|) α). • Polynomial classical and quantum memory. Essentially, we propose to reduce the size of the quantum circuit below the state-of-the-art complexity 2Õ (log(|∆|) 1/2) at the cost of increasing the classical circuit-size required. The required classical circuit remains subexponential, which is a superpolynomial improvement over the classical state-of-the-art exponential solutions to these problems. Our method requires polynomial memory, both classical and quantum

    CARGC Briefs Volume I: ISIS Media

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    The essays that comprise CARGC Briefs Volume I: ISIS Media began their lives as presentations at a small, by-invitation workshop, “Emerging Work on Communicative Dimensions of Islamic State,” held on May 3-4, 2017 at the Center for Advanced Research in Global Communication at the Annenberg School for Communication. Consistent with CARGC’s mission to mentor early-career scholars, the workshop was a non-public event featuring graduate students, some affiliated with the Jihadi Networks of Communication and CultureS (JINCS) research group at CARGC, and others from around the United States and the world, in addition to postdocs and faculty members. Parameters were purposefully broad to encourage independent thought and intellectual exploration: contributors were asked to write short essays focusing on any single aspect of Islamic State that was part of their research. The result is a group of fascinating essays: using mostly primary sources (textual, visual, or audio-visual), examining several media platforms and modalities, considering multiple levels of theoretical deployment and construction, and shedding light on various aspects of Islamic State communication against the broad back drop of history, ideology and geopolitics, the following include some of the most innovative approaches to Islamic State to date, and promise a wave of fresh voices on one of the most important challenges to global order.https://repository.upenn.edu/cargc_briefs/1000/thumbnail.jp

    Innovative Design of an Automated, Modular Vertical Botanical Display with Integration of Architecture and Engineering

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    In the current dynamic educational landscape, the challenge of imparting engineering education is increasingly felt by both educators and students worldwide. Universities are striving to furnish students with the essential skills and knowledge that will seamlessly transition them into professional engineering roles, further studies, or other professional domains. This educational approach equips students with practical applications of engineering and science to enhance the physical world. It prepares graduates to join and contribute to the engineering and scientific communities, aiming to better the human condition. The Thurman Botanical Tapestry at Oral Roberts University embodies a revolutionary blend of aesthetics, research, and education in botany. Spanning an impressive 280 square feet within the Biology Department's atrium, this living wall integrates a diverse range of plants such as Monstera, Alocasia, and Philodendron, transcending mere visual appeal to serve as a vibrant research laboratory. Equipped with advanced sensors and methodologies, it offers students an invaluable hands-on experience in plant care and environmental research. This project is a testament to the seamless integration of artistic creativity with scientific innovation, fostering environmental stewardship and nurturing future scientists. Its design, process, and educational implications highlight the collaborative intersection of biology and engineering, making the Thurman Botanical Tapestry not just a remarkable centerpiece but a dynamic platform for ecological and educational exploration

    Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

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    <p>Abstract</p> <p>Background</p> <p>The form(s) of amyloid-β peptide (Aβ) associated with the pathology characteristic of Alzheimer's disease (AD) remains unclear. In particular, the neurotoxicity of intraneuronal Aβ accumulation is an issue of considerable controversy; even the existence of Aβ deposits within neurons has recently been challenged by Winton and co-workers. These authors purport that it is actually intraneuronal APP that is being detected by antibodies thought to be specific for Aβ. To further address this issue, an anti-Aβ antibody was developed (MOAB-2) that specifically detects Aβ, but not APP. This antibody allows for the further evaluation of the early accumulation of intraneuronal Aβ in transgenic mice with increased levels of human Aβ in 5xFAD and 3xTg mice.</p> <p>Results</p> <p>MOAB-2 (mouse IgG<sub>2b</sub>) is a pan-specific, high-titer antibody to Aβ residues 1-4 as demonstrated by biochemical and immunohistochemical analyses (IHC), particularly compared to 6E10 (a commonly used commercial antibody to Aβ residues 3-8). MOAB-2 did not detect APP or APP-CTFs in cell culture media/lysates (HEK-APP<sub>Swe </sub>or HEK-APP<sub>Swe</sub>/BACE1) or in brain homogenates from transgenic mice expressing 5 familial AD (FAD) mutation (5xFAD mice). Using IHC on 5xFAD brain tissue, MOAB-2 immunoreactivity co-localized with C-terminal antibodies specific for Aβ40 and Aβ42. MOAB-2 did not co-localize with either N- or C-terminal antibodies to APP. In addition, no MOAB-2-immunreactivity was observed in the brains of 5xFAD/BACE<sup>-/- </sup>mice, although significant amounts of APP were detected by N- and C-terminal antibodies to APP, as well as by 6E10. In both 5xFAD and 3xTg mouse brain tissue, MOAB-2 co-localized with cathepsin-D, a marker for acidic organelles, further evidence for intraneuronal Aβ, distinct from Aβ associated with the cell membrane. MOAB-2 demonstrated strong intraneuronal and extra-cellular immunoreactivity in 5xFAD and 3xTg mouse brain tissues.</p> <p>Conclusions</p> <p>Both intraneuronal Aβ accumulation and extracellular Aβ deposition was demonstrated in 5xFAD mice and 3xTg mice with MOAB-2, an antibody that will help differentiate intracellular Aβ from APP. However, further investigation is required to determine whether a molecular mechanism links the presence of intraneuronal Aβ with neurotoxicity. As well, understanding the relevance of these observations to human AD patients is critical.</p
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