230 research outputs found
2-(3-Oxo-2,3-dihydro-1,2-benzothiazol-2-yl)acetic acid
In the title compound, C9H7NO3S, the benzoisothiazolone ring system is essentially planar, with a maximum deviation of 0.013 (2) Å. In the crystal, molecules are linked via O—H⋯O hydrogen bonds, forming chains along [010]. In addition, weak intermolecular C—H⋯O hydrogen bonds are present
Ethyl 3-oxo-2,3-dihydro-1,2-benzothiazole-2-carboxylate
The title compound, C10H9NO3S, was synthesized by the reaction of benzo[d]isothiazol-3(2H)-one with ethyl carbonochloridate in toluol. The benzisothiazolone ring system is approximately planar, with a maximum deviation from the mean plane of 0.020 (1) Å for the N atom
Toward 6G TK Extreme Connectivity: Architecture, Key Technologies and Experiments
Sixth-generation (6G) networks are evolving towards new features and
order-of-magnitude enhancement of systematic performance metrics compared to
the current 5G. In particular, the 6G networks are expected to achieve extreme
connectivity performance with Tbps-scale data rate, Kbps/Hz-scale spectral
efficiency, and s-scale latency. To this end, an original three-layer 6G
network architecture is designed to realise uniform full-spectrum cell-free
radio access and provide task-centric agile proximate support for diverse
applications. The designed architecture is featured by super edge node (SEN)
which integrates connectivity, computing, AI, data, etc. On this basis, a
technological framework of pervasive multi-level (PML) AI is established in the
centralised unit to enable task-centric near-real-time resource allocation and
network automation. We then introduce a radio access network (RAN) architecture
of full spectrum uniform cell-free networks, which is among the most attractive
RAN candidates for 6G TK extreme connectivity. A few most promising key
technologies, i.e., cell-free massive MIMO, photonics-assisted Terahertz
wireless access and spatiotemporal two-dimensional channel coding are further
discussed. A testbed is implemented and extensive trials are conducted to
evaluate innovative technologies and methodologies. The proposed 6G network
architecture and technological framework demonstrate exciting potentials for
full-service and full-scenario applications.Comment: 15 pages, 12 figure
Time-reversal symmetry breaking driven topological phase transition in EuB
The interplay between time-reversal symmetry (TRS) and band topology plays a
crucial role in topological states of quantum matter. In
time-reversal-invariant (TRI) systems, the inversion of spin-degenerate bands
with opposite parity leads to nontrivial topological states, such as
topological insulators and Dirac semimetals. When the TRS is broken, the
exchange field induces spin splitting of the bands. The inversion of a pair of
spin-splitting subbands can generate more exotic topological states, such as
quantum anomalous Hall insulators and magnetic Weyl semimetals. So far, such
topological phase transitions driven by the TRS breaking have not been
visualized. In this work, using angle-resolved photoemission spectroscopy, we
have demonstrated that the TRS breaking induces a band inversion of a pair of
spin-splitting subbands at the TRI points of Brillouin zone in EuB, when a
long-range ferromagnetic order is developed. The dramatic changes in the
electronic structure result in a topological phase transition from a TRI
ordinary insulator state to a TRS-broken topological semimetal (TSM) state.
Remarkably, the magnetic TSM state has an ideal electronic structure, in which
the band crossings are located at the Fermi level without any interference from
other bands. Our findings not only reveal the topological phase transition
driven by the TRS breaking, but also provide an excellent platform to explore
novel physical behavior in the magnetic topological states of quantum matter.Comment: 22 pages, 7 figures, accepted by Phys. Rev.
Expression of Cystathionine β-synthase and Cystathionine γ-lyase in Human Pregnant Myometrium and Their Roles in the Control of Uterine Contractility
BACKGROUND: Human uterus undergoes distinct molecular and functional changes during pregnancy and parturition. Hydrogen sulfide (H(2)S) has recently been shown to play a key role in the control of smooth muscle tension. The role of endogenous H(2)S produced locally in the control of uterine contractility during labour is unknown. METHODOLOGY/PRINCIPAL FINDINGS: Human myometrium biopsies were obtained from pregnant women undergoing cesarean section at term. Immunohistochemistry analysis showed that cystathionine-γ-lyase (CSE) and cystathionine-β-synthetase (CBS), the principle enzymes responsible for H(2)S generation, were mainly localized to smooth muscle cells of human pregnant myometrium. The mRNA and protein expression of CBS as well as H(2)S production rate were down-regulated in labouring tissues compared to nonlabouring tissues. Cumulative administration of L-cysteine (10(-7)-10(-2) mol/L), a precursor of H(2)S, caused a dose-dependent decrease in the amplitude of spontaneous contractions in nonlabouring and labouring myometrium strips. L-cysteine at high concentration (10(-3) mol/L) increased the frequency of spontaneous contractions and induced tonic contraction. These effects of L-cysteine were blocked by the inhibitors of CBS and CSE. Pre-treatment of myometrium strips with glibenclamide, an inhibitor of ATP-sensitive potassium (K(ATP)) channels, abolished the inhibitory effect of L-cysteine on spontaneous contraction amplitude. The effects of L-cysteine on the amplitude of spontaneous contractions and baseline muscle tone were less potent in labouring tissues than that in nonlabouring strips. CONCLUSION/SIGNIFICANCE: H(2)S generated by CSE and CBS locally exerts dual effects on the contractility of pregnant myometrium. Expression of H(2)S synthetic enzymes is down-regulated during labour, suggesting that H(2)S is one of the factors involved in the transition of pregnant uterus from quiescence to contractile state after onset of parturition
Prediction of protein assemblies, the next frontier: The CASP14-CAPRI experiment
We present the results for CAPRI Round 50, the fourth joint CASP-CAPRI protein assembly prediction challenge. The Round comprised a total of twelve targets, including six dimers, three trimers, and three higher-order oligomers. Four of these were easy targets, for which good structural templates were available either for the full assembly, or for the main interfaces (of the higher-order oligomers). Eight were difficult targets for which only distantly related templates were found for the individual subunits. Twenty-five CAPRI groups including eight automatic servers submitted ~1250 models per target. Twenty groups including six servers participated in the CAPRI scoring challenge submitted ~190 models per target. The accuracy of the predicted models was evaluated using the classical CAPRI criteria. The prediction performance was measured by a weighted scoring scheme that takes into account the number of models of acceptable quality or higher submitted by each group as part of their five top-ranking models. Compared to the previous CASP-CAPRI challenge, top performing groups submitted such models for a larger fraction (70–75%) of the targets in this Round, but fewer of these models were of high accuracy. Scorer groups achieved stronger performance with more groups submitting correct models for 70–80% of the targets or achieving high accuracy predictions. Servers performed less well in general, except for the MDOCKPP and LZERD servers, who performed on par with human groups. In addition to these results, major advances in methodology are discussed, providing an informative overview of where the prediction of protein assemblies currently stands.Cancer Research UK, Grant/Award Number: FC001003; Changzhou Science and Technology Bureau, Grant/Award Number: CE20200503; Department of Energy and Climate Change, Grant/Award Numbers: DE-AR001213, DE-SC0020400, DE-SC0021303; H2020 European Institute of Innovation and Technology, Grant/Award Numbers: 675728, 777536, 823830; Institut national de recherche en informatique et en automatique (INRIA), Grant/Award Number: Cordi-S; Lietuvos Mokslo Taryba, Grant/Award Numbers: S-MIP-17-60, S-MIP-21-35; Medical Research Council, Grant/Award Number: FC001003; Japan Society for the Promotion of Science KAKENHI, Grant/Award Number: JP19J00950; Ministerio de Ciencia e Innovación, Grant/Award Number: PID2019-110167RB-I00; Narodowe Centrum Nauki, Grant/Award Numbers: UMO-2017/25/B/ST4/01026, UMO-2017/26/M/ST4/00044, UMO-2017/27/B/ST4/00926; National Institute of General Medical Sciences, Grant/Award Numbers: R21GM127952, R35GM118078, RM1135136, T32GM132024; National Institutes of Health, Grant/Award Numbers: R01GM074255, R01GM078221, R01GM093123, R01GM109980, R01GM133840, R01GN123055, R01HL142301, R35GM124952, R35GM136409; National Natural Science Foundation of China, Grant/Award Number: 81603152; National Science Foundation, Grant/Award Numbers: AF1645512, CCF1943008, CMMI1825941, DBI1759277, DBI1759934, DBI1917263, DBI20036350, IIS1763246, MCB1925643; NWO, Grant/Award Number: TOP-PUNT 718.015.001; Wellcome Trust, Grant/Award Number: FC00100
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