Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Global coupling and decoupling of the APS storage ring

This Paper describes a study of controlling the coupling between the horizontal and the vertical betatron oscillations in the APS storage ring. First, we investigate the strengthening of coupling using two families of skew quadrupoles. Using smooth approximation, we obtained the formulae to estimate the coupling ratio defined as the ratio of the vertical and horizontal emittances or, for a single particle, the ratio of the maximum values of the Courant Snyder invariants. Since we knew that the coupling is mostly enhanced by the 21st harmonic content of skew quadrupole distribution, we carried out the harmonic analysis in order to find the optimum arrangement of the skew quadrupoles. The numerical results from tracking a single particle are presented for the various configurations of skew quadrupoles. Second, we describe the global decoupling procedure to minimize the unwanted coupling effects. These are mainly due to the random roll errors of normal quadrupoles. It is shown that even with the rather large rms roll error of 2 mrad we can reduce the Coupling from 70 percent to 10 percent with a skew quadrupole strength which is one order of magnitude lower than the typical normal quadrupole strength

Hybrid of global path planning and local navigation implemented on a mobile robot in indoor environment

IEEE International Symposium on Intelligent Control - Proceedings821-82685PU

Use of slow-release fertilizer and biopolymers for stimulating hydrocarbon biodegradation in oil-contaminated beach sediments

Marine Pollution Bulletin518-121101-1110MPNB

Effect of fertilizer and biopolymers on hydrocarbon biodegradation in sediments

Remediation of Contaminated Sediments - 2003: Proceedings of the Second International Conference on Remediation of Contaminated Sediments293-29

What Motivates and Deters Nut Consumption among the General Public in New Zealand

Background: Despite the well-documented health benefits of nuts, consumption at the population level remains low. Understanding motivators of and deterrents to consuming nuts among the general public may inform the development of initiatives to improve levels of consumption [...

Figure 3 from: Tan Y-H, Li D-R, Zhou S-S, Chen Y-J, Bramley GLC, Li B (2018) Premna grandipaniculata (Lamiaceae, Premnoideae), a remarkable new species from north Myanmar. In: Jin X-H, Shui Y-M, Tan Y-H, Kang M (Eds) Plant diversity in Southeast Asia. PhytoKeys 94: 117-123. https://doi.org/10.3897/phytokeys.94.22033

A remarkable new Premna species from Myanmar, P. grandipaniculata Y.H.Tan &amp;amp; Bo Li (Lamiaceae), is here described and illustrated. It differs from all known congeneric taxa by having huge complicated panicles which have tertiary branches formed by spike-like thyrses. In Premna, such a spike-like thyrse is found in P. bracteata and P. interrupta, but those species can be easily distinguished from P. grandipaniculata by their habit, indumentum, leaf size and inflorescence structure

A 0.53pJK27000μm2resistor-based temperature sensor with an inaccuracy of ±0.35°C (3σ) in 65nm CMOS

In microprocessors and DRAMs, on-chip temperature sensors are essential components, ensuring reliability by monitoring thermal gradients and hot spots. Such sensors must be as small as possible, since multiple sensors are required for dense thermal monitoring. However, conventional BJT-based temperature sensors are not compatible with the sub-1V supply of advanced processes. Subthreshold MOSFETs can operate from lower supplies, but at high temperatures their performance is limited by leakage [1,2]. Thermal diffusivity (TD) sensors achieve sub-1V operation and small area with moderate accuracy, but require milliwatts of power [3]. Recently, resistor-based sensors based on RC WienBridge (WB) filters have realized high resolution and energy efficiency [4,5]. Fundamentally, they are robust to process and supply-voltage scaling. However, their readout circuitry has been based on continuous-time (CT) ΔΣ ADCs or frequency-locked loops (FLLs), which require precision analog circuits and occupy considerable area (&gt;0.7mm 2 ).Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Microelectronic

Via resistance reduction using "cool" PVD-Ta processing

10.1149/1.1621417Journal of the Electrochemical Society15012G766-G770JESO