Relationship between IL-10 gene -819C/T polymorphism and the risk of inflammatory bowel disease: A meta-analysis

Background: The -819C/T polymorphism in interleukin 10 (IL-10) gene has been reported to be associated with inflammatory bowel disease (IBD) ,but the previous results are conflicting.Materials and methods: The present study aimed at investigating the association between this polymorphism and risk of IBD using a meta-analysis.PubMed,Web of Science,EMBASE,google scholar and China National Knowledge Infrastructure (CNKI) databases were systematically searched to identify relevant publications from their inception to April 2016.Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects models.Results: A total of 7 case-control studies containing 1890 patients and 2929 controls were enrolled into this meta-analysis, and our results showed no association between IL-10 gene -819C/T polymorphism and IBD risk(TT vs. CC:OR=0.81,95%CI 0.64- 1.04;CT vs. CC:OR=0.92,95%CI 0.81-1.05; Dominant model: OR=0.90,95%CI 0.80-1.02; Recessive model: OR=0.84,95%CI 0.66-1.06). In a subgroup analysis by nationality, the -819C/T polymorphism was not associated with IBD in both Asians and Caucasians. In the subgroup analysis stratified by IBD type, significant association was found in Crohn’s disease(CD)(CT vs. CC:OR=0.68,95%CI 0.48-0.97).Conclusion: In summary, the present meta-analysis suggests that the IL-10 gene -819C/T polymorphism may be associated with CD risk.Keywords: Interleukin 10, -819C/T polymorphism, inflammatory bowel diseaseDue to errors in the previous PDF especially in the 'Cite as' authors names, the PDF fulltext has been reloaded. This information is now correct

Experimental Investigation on the Early Stage Spray Characteristics with Biodiesel and Diesel

[EN] The early stage spray characteristics have a great impact on the secondary atomization progress, and thus affect the engine combustion and emission performances. The experimental investigation of the early stage spray behaviors with biodiesel and diesel was carried out by employing a laser-based Mie-scattering method. The results show that the spray tip penetration for biodiesel is higher than that for diesel at the early stage spray under the same injection pressure. Moreover, the early stage spray tip penetration can be longer under high injection pressures for two fuels. Besides, the early stage spray cone angle for biodiesel is narrower than that for diesel, and the spray cone angle is especially higher than biodiesel by 25.8% after start of injection time of 0.01ms. Furthermore, under the same injection condition, the difference of early stage spray area between diesel and biodiesel is not obvious, while the spray volume for biodiesel is larger than that for diesel, and also the spray volume can be enlarged by increasing injection pressure for both fuels.This work was supported by the contribution of China postdoctoral fund projects [grant number2013M530236]; The projects of ‘Six talent peak’ [grant number 2014-ZBZZ-014]; Research start-up found projects of Jiangsu university [grant number 13JDG104]; Natural Science Foundation of Jiangsu Province of China [grant number BK20150520]；The Priority Academic Program Development of Jiangsu Higher Education Institutions [PAPD]Yu, S.; Yin, B.; Wen, S.; Li, X.; Jia, H.; Yu, J. (2017). Experimental Investigation on the Early Stage Spray Characteristics with Biodiesel and Diesel. En Ilass Europe. 28th european conference on Liquid Atomization and Spray Systems. Editorial Universitat Politècnica de València. 473-479. https://doi.org/10.4995/ILASS2017.2017.4651OCS47347

Relationship between IL-10 gene -819C/T polymorphism and the risk of inflammatory bowel disease: a meta-analysis.

Background: The -819C/T polymorphism in interleukin 10 (IL-10) gene has been reported to be associated with inflammatory bowel disease (IBD) ,but the previous results are conflicting. Materials and Methods: The present study aimed at investigating the association between this polymorphism and risk of IBD using a meta-analysis.PubMed,Web of Science,EMBASE,google scholar and China National Knowledge Infrastructure (CNKI) databases were systematically searched to identify relevant publications from their inception to April 2016.Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects models. Results: A total of 7 case-control studies containing 1890 patients and 2929 controls were enrolled into this meta-analysis, and our results showed no association between IL-10 gene -819C/T polymorphism and IBD risk(TT vs. CC:OR=0.81,95%CI 0.64- 1.04;CT vs. CC:OR=0.92,95%CI 0.81-1.05; Dominant model: OR=0.90,95%CI 0.80-1.02; Recessive model: OR=0.84,95%CI 0.66-1.06). In a subgroup analysis by nationality, the -819C/T polymorphism was not associated with IBD in both Asians and Caucasians. In the subgroup analysis stratified by IBD type, significant association was found in Crohn\u2019s disease(CD)(CT vs. CC:OR=0.68,95%CI 0.48-0.97). Conclusion: In summary, the present meta-analysis suggests that the IL-10 gene -819C/T polymorphism may be associated with CD risk

Higher Prevalence of Sexual Transmitted Diseases and Correlates of Genital Warts among Heterosexual Males Attending Sexually Transmitted Infection Clinics (MSCs) in Jiangmen, China: Implication for the Up-Taking of STD Related Service

<div><p>Background</p><p>Increasing burden of STDs is one of China’s major public health concerns. However, only a limited number of studies have ever investigated the prevalence of these STDs, particular for genital warts and its correlates among heterosexual males attending STD clinics in China. In order to fill this gap, we conducted a cross-sectional study among MSCs in Jiangmen, China, between the years of 2009 and 2010.</p><p>Method</p><p>The eligible participants were recruited from several STD-clinics in public hospitals. We collected demographic information and behaviors of the participants. After HIV and syphilis testing, we further checked whether the participants had genital warts and genital herpes. In addition, urine samples were collected from part of the participants for CT and NG testing.</p><p>Results</p><p>Of the 533 eligible participants, over three-fifths were aged 35 or below, nearly three quarters had no college degree, over three-fifths were residence of Jiangmen. The prevalence of HIV, syphilis, genital warts, genital herpes, CT and NG were 0.19%, 7.50%, 7.32%, 5.25%, 9.73% and 6.19%, respectively. Living with family members (versus living alone), no STD-related service in past year, experiencing STDs related symptoms in past year, and sex with FSWs in last three months were positively associated with genital warts, with adjusted ORs of 5.54 (95% CI 1.94–15.81), 2.26 (95% CI 1.08–4.74), 1.99 (95% CI 1.00–3.99) and 2.01 (95% CI 1.00–4.04), respectively.</p><p>Conclusion</p><p>Our study indicates that the prevalence of STDs among MSCs in Jiangmen was high, which may further spread HIV among MSCs. Targeted interventions that focused on STDs related services uptake should be implemented urgently.</p></div

Socio-demographic and STDs risky behaviors of among heterosexual males attending sexually transmitted infection clinics in Jiangmen, China, 2009 (N = 533).

<p>Socio-demographic and STDs risky behaviors of among heterosexual males attending sexually transmitted infection clinics in Jiangmen, China, 2009 (N = 533).</p

Prevalence of STDs among heterosexual males attending sexually transmitted infection clinics in Jiangmen, China, 2009 (N = 533).

<p>Prevalence of STDs among heterosexual males attending sexually transmitted infection clinics in Jiangmen, China, 2009 (N = 533).</p

Prevalence of STDs among heterosexual males attending sexually transmitted infection clinics in Jiangmen, China, 2009 (N = 533).

<p>Note: *226 participants were tested for CT and NG</p><p>Prevalence of STDs among heterosexual males attending sexually transmitted infection clinics in Jiangmen, China, 2009 (N = 533).</p