Background: The -819C/T polymorphism in interleukin 10 (IL-10) gene has
been reported to be associated with inflammatory bowel disease (IBD)
,but the previous results are conflicting. Materials and Methods: The
present study aimed at investigating the association between this
polymorphism and risk of IBD using a meta-analysis.PubMed,Web of
Science,EMBASE,google scholar and China National Knowledge
Infrastructure (CNKI) databases were systematically searched to
identify relevant publications from their inception to April
2016.Pooled odds ratio (OR) with 95% confidence interval (CI) was
calculated using fixed- or random-effects models. Results: A total of 7
case-control studies containing 1890 patients and 2929 controls were
enrolled into this meta-analysis, and our results showed no association
between IL-10 gene -819C/T polymorphism and IBD risk(TT vs.
CC:OR=0.81,95%CI 0.64- 1.04;CT vs. CC:OR=0.92,95%CI 0.81-1.05; Dominant
model: OR=0.90,95%CI 0.80-1.02; Recessive model: OR=0.84,95%CI
0.66-1.06). In a subgroup analysis by nationality, the -819C/T
polymorphism was not associated with IBD in both Asians and Caucasians.
In the subgroup analysis stratified by IBD type, significant
association was found in Crohn\u2019s disease(CD)(CT vs.
CC:OR=0.68,95%CI 0.48-0.97). Conclusion: In summary, the present
meta-analysis suggests that the IL-10 gene -819C/T polymorphism may be
associated with CD risk