24 research outputs found
Safety and efficacy of an intra-oral electrostimulator for the relief of dry mouth in patients with chronic graft versus host disease: case Series
Objectives: Patients with chronic graft-versus-host disease (cGVHD) often suffer from dry mouth and oral mu
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cosal lesions. The primary objective of this study was to investigate the safety of an intra-oral electrostimulator
(GenNarino) in symptomatic cGVHD patients. The secondary objective was to study the impact on the salivary
gland involvement of cGVHD patients.
Study Design: This paper presents a case series. The study included patients treated for 4 weeks, randomly as
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signed to the active device and then crossed-over to a sham-device or vice versa. The patients and clinicians were
blind to the treatment delivered. Data regarding oral mucosal and salivary gland involvement were collected.
Results: Six patients were included in this series. Most of the intraoral areas with manifestations of cGVHD were
not in contact with the GenNarino device. Two patients developed mild mucosal lesions in areas in contact with
the GenNarino during the study. However, only one of them had a change in the National Institutes of Health
(NIH) score for oral cGVHD. The unstimulated and stimulated salivary flow rate increased in 4 out of the 5 pa
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tients included in this analysis. Symptoms of dry mouth and general oral comfort improved.
Conclusion: This study suggests that GenNarino is safe in cGVHD patients with respect to oral tissues. Furthermore
the use of GenNarino resulted in subjective and objective improvements in dry mouth symptoms. A large scale study
is needed to confirm the impact and safety of GenNarino on systemic cGVHD
Clinical use of photobiomodulation for the prevention and treatment of oral mucositis: the real-life experience of MASCC/ISOO members
AimTo assess clinical use and patient outcome of photobiomodulation (PBM) for oral mucositis (OM) prevention and treatment among specialized practitioners.MethodsA poll was emailed to the members of the Mucositis Study Group of MASCC/ISOO. The PBM parameters used by the respondents were analyzed using exploratory statistical methods to identify combinations of PBM parameters (patterns) that characterize the variance in the protocols (principal component analysis).ResultsResponses were received from 101 MSG members, with 78 providing analyzable data. Most of the responders were dental practitioners or oral medicine specialists. PBM was used by 59% of the responders for OM or targeted therapy stomatitis. Technical parameters varied widely. Most responders used wavelengths & SIM;650 nm intra-orally. The spot-size and distance from the tissue were the main factors driving the variation. All PBM users noted that PBM relieved pain, either immediately or a delayed effect. High likelihood of pain relief (measured as responder's report of pain relief in 67-100% of patients) was reported by 22% and 19% of PBM users for immediate pain relief and delayed pain relief, respectively. The most common reported barriers to using PBM were financial considerations, time constraints, lack of training or experience and concern about the potential for malignant transformation or increased risk of cancer recurrence.ConclusionsThe use of PBM for OM prevention or treatment is in early phases of adoption in practices, facing some obstacles to implement it. A wide variation in technical parameters was found. Nonetheless, responses indicate that PBM provided pain relief
Case report on trial: Do you, Doctor, swear to tell the truth, the whole truth and nothing but the truth?
We are in the era of "evidence based medicine" in which our knowledge is stratified from top to bottom in a hierarchy of evidence. Many in the medical and dental communities highly value randomized clinical trials as the gold standard of care and undervalue clinical reports. The aim of this editorial is to emphasize the benefits of case reports in dental and oral medicine, and encourage those of us who write and read them
Pharmacotherapy of oral mucosal manifestations of chronic graft-versus-host disease: When? What? and How?
Photobiomodulation for the palliation of oral mucositis in cancer patients: the future is here
Development of the MASCC/ISOO Clinical Practice Guidelines for Mucositis: considerations underlying the process
On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO)The Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) recently conducted a systematic review to update the MASCC/ISOO clinical practice guidelines for oral and gastrointestinal mucositis. Here, we discuss the details of some considerations underlying the process used.Sharon Elad & Joanne Bowen & Yehuda Zadik & Rajesh V. Lall
Clarithromycin as the empiric antibiotic therapy for medication-related osteonecrosis of the jaw in multiple myeloma patients
MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients
10.1007/s00520-020-05803-4SUPPORTIVE CARE IN CANCER2973539-356