18,922 research outputs found
Charge transfer complexes and radical cation salts of chiral methylated organosulfur donors
The single crystal X-ray structure of the all-axial conformer of the (R,R,R,R) enantiomer of the chiral donor tetramethyl-BEDT-TTF (TM-BEDT-TTF) was described and compared to the all-equatorial conformer. (S,S,S,S)-Tetramethyl-BEDT-TTF formed crystalline 1 : 1 complexes with TCNQ and TCNQ-F4, as well as a THF solvate of the TCNQ complex. Donors bis((2S,4S)-pentane-2,4-dithio)tetrathiafulvalene and (ethylenedithio)((2S,4S)-pentane-2,4-dithio)tetrathiafulvalene, which contain seven-membered rings bearing chirally oriented methyl groups, only formed complexes with TCNQ-F4. The TCNQ-F4 complexes contain planar organosulfur systems, in contrast to the TCNQ complexes in which there is minimal charge transfer. A variety of crystal packing modes were observed. Electrocrystallization experiments with both enantiomers and the racemic form of tetramethyl-BEDT-TTF afforded mixed valence radical cation salts with the AsF6 and SbF6 anions formulated as (TM-BEDT-TTF)2XF6 (X = As, Sb). Electrical conductivity was only found in one charge transfer complex, while the radical cation salts are all semiconducting
Synthesis of new chiral organosulfur donors with hydrogen bonding functionality and their first charge transfer salts
The syntheses of a range of enantiopure organosulfur donors with hydrogen bonding groups are described including TTF related materials with two, four, six and eight hydroxyl groups and multiple stereogenic centres and a pair of chiral N-substituted BEDT-TTF acetamides. Three charge transfer salts of enantiopure poly-hydroxy-substituted donors are reported, including a 4:1 salt with the meso stereoisomer of the dinuclear [Fe2(oxalate)5 ]4- anion in which both cation and anion have chiral components linked together by hydrogen bonding, and a semiconducting salt with triiodide
Progression of Coronary Artery Calcium and Incident Heart Failure: The Multi-Ethnic Study of Atherosclerosis.
BackgroundAlthough the association between coronary artery calcium (CAC) and future heart failure (HF) has been shown previously, the value of CAC progression in the prediction of HF has not been investigated. In this study, we investigated the association of CAC progression with subclinical left ventricular (LV) dysfunction and incident HF in the Multi-Ethnic Study of Atherosclerosis.Methods and resultsThe Multi-Ethnic Study of Atherosclerosis is a population-based study consisting of 6814 men and women aged 45 to 84, free of overt cardiovascular disease at enrollment, who were recruited from 4 ethnicities. We included 5644 Multi-Ethnic Study of Atherosclerosis participants who had baseline and follow-up cardiac computed tomography and were free of HF and coronary heart disease before the second cardiac computed tomography. Mean (±SD) age was 61.7±10.2 years and 47.2% were male. The Cox proportional hazard models and multivariable linear regression models were deployed to determine the association of CAC progression with incident HF and subclinical LV dysfunction, respectively. Over a median follow-up of 9.6 (interquartile range: 8.8-10.6) years, 182 participants developed incident HF. CAC progression of 10 units per year was associated with 3% of increased risk of HF independent of overt coronary heart disease (P=0.008). In 2818 participants with available cardiac magnetic resonance images, CAC progression was associated with increased LV end diastolic volume (ÎČ=0.16; P=0.03) and LV end systolic volume (ÎČ=0.12; P=0.006) after excluding participants with any coronary heart disease.ConclusionsCAC progression was associated with incident HF and modestly increased LV end diastolic volume and LV end systolic volume at follow-up exam independent of overt coronary heart disease
Acoustic Disturbances in Galaxy Clusters
Galaxy cluster cores are pervaded by hot gas which radiates at far too high a
rate to maintain any semblance of a steady state; this is referred to as the
cooling flow problem. Of the many heating mechanisms that have been proposed to
balance radiative cooling, one of the most attractive is dissipation of
acoustic waves generated by Active Galactic Nuclei (AGN). Fabian (2005) showed
that if the waves are nearly adiabatic, wave damping due to heat conduction and
viscosity must be well below standard Coulomb rates in order to allow the waves
to propagate throughout the core. Because of the importance of this result, we
have revisited wave dissipation under galaxy cluster conditions in a way that
accounts for the self limiting nature of dissipation by electron thermal
conduction, allows the electron and ion temperature perturbations in the waves
to evolve separately, and estimates kinetic effects by comparing to a
semi-collisionless theory. While these effects considerably enlarge the toolkit
for analyzing observations of wavelike structures and developing a quantitative
theory for wave heating, the drastic reduction of transport coefficients
proposed in Fabian (2005) remains the most viable path to acoustic wave heating
of galaxy cluster cores
Ensemble of Hankel Matrices for Face Emotion Recognition
In this paper, a face emotion is considered as the result of the composition
of multiple concurrent signals, each corresponding to the movements of a
specific facial muscle. These concurrent signals are represented by means of a
set of multi-scale appearance features that might be correlated with one or
more concurrent signals. The extraction of these appearance features from a
sequence of face images yields to a set of time series. This paper proposes to
use the dynamics regulating each appearance feature time series to recognize
among different face emotions. To this purpose, an ensemble of Hankel matrices
corresponding to the extracted time series is used for emotion classification
within a framework that combines nearest neighbor and a majority vote schema.
Experimental results on a public available dataset shows that the adopted
representation is promising and yields state-of-the-art accuracy in emotion
classification.Comment: Paper to appear in Proc. of ICIAP 2015. arXiv admin note: text
overlap with arXiv:1506.0500
Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection
Many new gene copies emerged by gene duplication in hominoids, but little is known with respect to their functional evolution. Glutamate dehydrogenase (GLUD) is an enzyme central to the glutamate and energy metabolism of the cell. In addition to the single, GLUD-encoding gene present in all mammals (GLUD1), humans and apes acquired a second GLUD gene (GLUD2) through retroduplication of GLUD1, which codes for an enzyme with unique, potentially brain-adapted properties. Here we show that whereas the GLUD1 parental protein localizes to mitochondria and the cytoplasm, GLUD2 is specifically targeted to mitochondria. Using evolutionary analysis and resurrected ancestral protein variants, we demonstrate that the enhanced mitochondrial targeting specificity of GLUD2 is due to a single positively selected glutamic acid-to-lysine substitution, which was fixed in the N-terminal mitochondrial targeting sequence (MTS) of GLUD2 soon after the duplication event in the hominoid ancestor ~18â25 million years ago. This MTS substitution arose in parallel with two crucial adaptive amino acid changes in the enzyme and likely contributed to the functional adaptation of GLUD2 to the glutamate metabolism of the hominoid brain and other tissues. We suggest that rapid, selectively driven subcellular adaptation, as exemplified by GLUD2, represents a common route underlying the emergence of new gene functions
Resting-state EEG power and coherence vary between migraine phases
© 2016, The Author(s). Background: Migraine is characterized by a series of phases (inter-ictal, pre-ictal, ictal, and post-ictal). It is of great interest whether resting-state electroencephalography (EEG) is differentiable between these phases. Methods: We compared resting-state EEG energy intensity and effective connectivity in different migraine phases using EEG power and coherence analyses in patients with migraine without aura as compared with healthy controls (HCs). EEG power and isolated effective coherence of delta (1â3.5 Hz), theta (4â7.5 Hz), alpha (8â12.5 Hz), and beta (13â30 Hz) bands were calculated in the frontal, central, temporal, parietal, and occipital regions. Results: Fifty patients with episodic migraine (1â5 headache days/month) and 20 HCs completed the study. Patients were classified into inter-ictal, pre-ictal, ictal, and post-ictal phases (n = 22, 12, 8, 8, respectively), using 36-h criteria. Compared to HCs, inter-ictal and ictal patients, but not pre- or post-ictal patients, had lower EEG power and coherence, except for a higher effective connectivity in fronto-occipital network in inter-ictal patients (p <.05). Compared to data obtained from the inter-ictal group, EEG power and coherence were increased in the pre-ictal group, with the exception of a lower effective connectivity in fronto-occipital network (p <.05). Inter-ictal and ictal patients had decreased EEG power and coherence relative to HCs, which were ânormalizedâ in the pre-ictal or post-ictal groups. Conclusion: Resting-state EEG power density and effective connectivity differ between migraine phases and provide an insight into the complex neurophysiology of migraine
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