1,876 research outputs found
Recommended from our members
Rain, waves, and short-term evolution of composite seacliffs in southern California
AGS and other tissue culture cells can unknowingly be persistently infected with PIV5; A virus that blocks interferon signalling by degrading STAT1
AbstractWhilst screening various cell lines for their ability to respond to interferon (IFN), we noted that in comparison to other tissue culture cells AGS tumour cells, which are widely used in biomedical research, had very low levels of STAT1. Subsequent analysis showed that the reason for this is that AGS cells are persistently infected with parainfluenza virus type 5 (PIV5; formally known as SV5), a virus that blocks the interferon (IFN) response by targeting STAT1 for proteasome-mediated degradation. Virus protein expression in AGS is altered in comparison to the normal pattern of virus protein synthesis observed in acutely infected cells, suggesting that the AGS virus is defective. We discuss the relevance of these results in terms of the need to screen cell lines for persistent virus infections that can alter cellular functions
A revised age, structural model and origin for the North Pennine Orefield in the Alston Block, northern England: intrusion (Whin Sill)-related base metal (Cu–Pb–Zn–F) mineralization
Mineralization and associated fluid migration events in the c. 1500 km2 North Pennine Orefield (NPO) are known to be associated with tectonic activity, but the age of these tectonic events and origins of the base metal sulfide mineralization remain unresolved. New fieldwork in the Alston Block shows that mineralization post-dates a weakly developed phase of north–south shortening consistent with far-field Variscan basin inversion during the late Carboniferous. New observations of field relationships, coupled with microstructural observations and stress inversion analyses, together with Re–Os sulfide geochronology show that the vein-hosted mineralization (apart from barium minerals) was synchronous with a phase of north–south extension and east–west shortening coeval with emplacement of the Whin Sill (c. 297–294 Ma). Thus the development of the NPO was related to an early Permian regional phase of transtensional deformation, mantle-sourced hydrothermal mineralization and magmatism in northern Britain. Previously proposed Mississippi Valley Type models, or alternatives relating mineralization to the influx of Mesozoic brines, can no longer be applied to the development of the NPO in the Alston Block. Our findings also mean that existing models for equivalent base metal sulfide fields worldwide (e.g. Zn–Pb districts of Silesia, Poland and Tennessee, USA) may need to be reassessed
Antithetic Conjuncts in Written English
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68390/2/10.1177_003368827901000204.pd
Superconductors with Magnetic Impurities: Instantons and Sub-gap States
When subject to a weak magnetic impurity potential, the order parameter and
quasi-particle energy gap of a bulk singlet superconductor are suppressed.
According to the conventional mean-field theory of Abrikosov and Gor'kov, the
integrity of the energy gap is maintained up to a critical concentration of
magnetic impurities. In this paper, a field theoretic approach is developed to
critically analyze the validity of the mean field theory. Using the
supersymmetry technique we find a spatially homogeneous saddle-point that
reproduces the Abrikosov-Gor'kov theory, and identify instanton contributions
to the density of states that render the quasi-particle energy gap soft at any
non-zero magnetic impurity concentration. The sub-gap states are associated
with supersymmetry broken field configurations of the action. An analysis of
fluctuations around these configurations shows how the underlying supersymmetry
of the action is restored by zero modes. An estimate of the density of states
is given for all dimensionalities. To illustrate the universality of the
present scheme we apply the same method to study `gap fluctuations' in a normal
quantum dot coupled to a superconducting terminal. Using the same instanton
approach, we recover the universal result recently proposed by Vavilov et al.
Finally, we emphasize the universality of the present scheme for the
description of gap fluctuations in d-dimensional superconducting/normal
structures.Comment: 18 pages, 9 eps figure
Electronics Letters
The optimal refined instrumental variable method for the estimation of the Box-Jenkins (BJ) model is modified so that it functions as an optimal filter and state-estimation algorithm. In contrast to the previously developed minimal and non-minimal state-space (NMSS) forms for an Auto-Regressive Moving Average with eXogenous variables (ARMAX) model, the new algorithm requires the introduction of a novel extended NMSS form. This facilitates representation of the more general noise component of the BJ model. The approach can be used for adaptive filtering and state variable feedback control
Study of the three-dimensional shape and dynamics of coronal loops observed by Hinode/EIS
We study plasma flows along selected coronal loops in NOAA Active Region
10926, observed on 3 December 2006 with Hinode's EUV Imaging Spectrograph
(EIS). From the shape of the loops traced on intensity images and the Doppler
shifts measured along their length we compute their three-dimensional (3D)
shape and plasma flow velocity using a simple geometrical model. This
calculation was performed for loops visible in the Fe VIII 185 Ang., Fe X 184
Ang., Fe XII 195 Ang., Fe XIII 202 Ang., and Fe XV 284 Ang. spectral lines. In
most cases the flow is unidirectional from one footpoint to the other but there
are also cases of draining motions from the top of the loops to their
footpoints. Our results indicate that the same loop may show different flow
patterns when observed in different spectral lines, suggesting a dynamically
complex rather than a monolithic structure. We have also carried out magnetic
extrapolations in the linear force-free field approximation using SOHO/MDI
magnetograms, aiming toward a first-order identification of extrapolated
magnetic field lines corresponding to the reconstructed loops. In all cases,
the best-fit extrapolated lines exhibit left-handed twist (alpha < 0), in
agreement with the dominant twist of the region.Comment: 17 pages, 6 figure
Atenolol versus losartan in children and young adults with Marfan's syndrome
BACKGROUND : Aortic-root dissection is the leading cause of death in Marfan's syndrome. Studies suggest that with regard to slowing aortic-root enlargement, losartan may be more effective than beta-blockers, the current standard therapy in most centers.
METHODS : We conducted a randomized trial comparing losartan with atenolol in children and young adults with Marfan's syndrome. The primary outcome was the rate of aortic-root enlargement, expressed as the change in the maximum aortic-root-diameter z score indexed to body-surface area (hereafter, aortic-root z score) over a 3-year period. Secondary outcomes included the rate of change in the absolute diameter of the aortic root; the rate of change in aortic regurgitation; the time to aortic dissection, aortic-root surgery, or death; somatic growth; and the incidence of adverse events.
RESULTS : From January 2007 through February 2011, a total of 21 clinical centers enrolled 608 participants, 6 months to 25 years of age (mean [+/- SD] age, 11.5 +/- 6.5 years in the atenolol group and 11.0 +/- 6.2 years in the losartan group), who had an aorticroot z score greater than 3.0. The baseline-adjusted rate of change (+/- SE) in the aortic-root z score did not differ significantly between the atenolol group and the losartan group (-0.139 +/- 0.013 and -0.107 +/- 0.013 standard-deviation units per year, respectively; P = 0.08). Both slopes were significantly less than zero, indicating a decrease in the degree of aortic-root dilatation relative to body-surface area with either treatment. The 3-year rates of aortic-root surgery, aortic dissection, death, and a composite of these events did not differ significantly between the two treatment groups.
CONCLUSIONS : Among children and young adults with Marfan's syndrome who were randomly assigned to losartan or atenolol, we found no significant difference in the rate of aorticroot dilatation between the two treatment groups over a 3-year period
Pair creation of anti-de Sitter black holes on a cosmic string background
We analyze the quantum process in which a cosmic string breaks in an anti-de
Sitter (AdS) background, and a pair of charged or neutral black holes is
produced at the ends of the strings. The energy to materialize and accelerate
the pair comes from the strings tension. In an AdS background this is the only
study done in the process of production of a pair of correlated black holes
with spherical topology. The acceleration of the produced black holes is
necessarily greater than (|L|/3)^(1/2), where L<0 is the cosmological constant.
Only in this case the virtual pair of black holes can overcome the attractive
background AdS potential well and become real. The instantons that describe
this process are constructed through the analytical continuation of the AdS
C-metric. Then, we explicitly compute the pair creation rate of the process,
and we verify that (as occurs with pair creation in other backgrounds) the pair
production of nonextreme black holes is enhanced relative to the pair creation
of extreme black holes by a factor of exp(Area/4), where Area is the black hole
horizon area. We also conclude that the general behavior of the pair creation
rate with the mass and acceleration of the black holes is similar in the AdS,
flat and de Sitter cases, and our AdS results reduce to the ones of the flat
case when L=0.Comment: 13 pages, 3 figures, ReVTeX
Developing mHealth Apps with researchers: multi-stakeholder design considerations
The authors have been involved with developing a number of mHealth smartphone Apps for use in health or wellness research in collaboration with researchers, clinicians and patient groups for clinical areas including Sickle Cell Disease, Attention Deficit Hyperactivity Disorder, asthma and infertility treatment. In these types of applications, end-users self-report their symptoms and quality of life or conduct psychometric tests. Physiological data may also be captured using sensors that are internal or external to the device.
Following a discussion of the multiple stakeholders that are typically involved in small scale research projects involving end-user data collection, four Apps are used as case studies to explore the issue of non-functional requirements
- …