Electron Neutrino Mass from the Electron Capture of 163HO

開始ページ、終了ページ: 冊子体のページ付

The Rest Mass of the Etectron Neutrino from the Electron Capture of 163Ho

開始ページ、終了ページ: 冊子体のページ付

The mass of the electron neutrino and electron capture in <SUP>163</SUP>Ho

To determine the mass of the electron neutrino, electron capture in <SUP>163</SUP>Ho was studied. From the intensity of M X-rays and the total number of <SUP>163</SUP>Ho atoms in a source, as determined by the PIXE method, the partial M-capture half life of <SUP>163</SUP>Ho was estimated to be (4.5 ± 1.5) × 10<SUP>4</SUP> yr. A relation between the Q-value of <SUP>163</SUP>Ho and the mass of the electron neutrino was obtained

Impact of the Fibrosis-4 Index on Risk Stratification of Cardiovascular Events and Mortality in Patients with Atrial Fibrillation: Findings from a Japanese Multicenter Registry

Background: Liver diseases drive the development and progression of atrial fibrillation (AF). The Fibrosis-4 (FIB4) index is a non-invasive scoring method for detecting liver fibrosis, but the prognostic impact of using it for AF patients is still unknown. Herein, we evaluated using the FIB4 index as a risk assessment tool for cardiovascular events and mortality in patients with AF. Methods: We performed a post-hoc analysis of a prospective, observational multicenter study. A total of 3067 patients enrolled in a multicenter Japanese registry were grouped as first tertile (FIB4 index &lt; 1.75, n = 1022), second tertile (1.75 &le; FIB4 index &lt; 2.51, n = 1022), and third tertile (FIB4 index &ge; 2.51, n = 1023). Results: The third tertile had statistically significant results: older age, lower body mass index, increased heart failure prevalence, and lower clearances of hemoglobin and creatinine (all p &lt; 0.05). During the follow-up period, incidences of major bleeding, cardiovascular events, and all-cause mortality were significantly higher for the third tertile (all p &lt; 0.05). After multivariate adjustment, the third tertile associated independently with cardiovascular events (HR 1.72; 95% CI 1.31&ndash;2.25) and all-cause mortality (HR 1.43; 95% CI 1.06&ndash;1.95). Adding the FIB4 index to a baseline model with CHA2DS2-VASc score improved the prediction of cardiovascular events and all-cause mortality, as shown by the significant increase in the C-statistic (all p &lt; 0.05), net reclassification improvement (all p &lt; 0.001), and integrated discrimination improvement (all p &lt; 0.001). A FIB4 index &ge; 2.51 most strongly associated with cardiovascular events and all-cause mortality in AF patients with high CHADS2 scores (all p &lt; 0.001). Conclusions: The FIB4 index is independently associated with risks of cardiovascular events and all-cause mortality in AF patients

Low alanine aminotransferase levels are independently associated with mortality risk in patients with atrial fibrillation

Abstract Extremely low alanine aminotransferase (ALT) may reflect aging, frailty, sarcopenia, and malnutrition in several cardiovascular diseases, but the association between low ALT and patient characteristics, cardiovascular and all-cause mortality is not well investigated in the population with atrial fibrillation. We conducted a post hoc analysis of a prospective, observational multicenter study. Patients with nonvalvular AF in the SAKURA AF Registry (n = 3156) were classified into 3 tertiles according to baseline ALT: first (ALT ≤ 15 U/L, n = 1098), second (15 < ALT < 23 U/L, n = 1055), and third (ALT ≥ 23 U/L, n = 1003). The first tertile had an older age; lower body mass index (BMI); higher prevalence of heart failure; and lower hemoglobin, total cholesterol, and triglycerides (all P < 0.05). During median 39.2 months follow-up, the first tertile had significantly higher incidences of cardiovascular and all-cause mortality (log-rank P < 0.001). Lower ALT was significantly associated with the incidence of cardiovascular and all-cause mortality, even after adjusting for clinically relevant factors (P < 0.05). Low ALT may reflect aging, sarcopenia, and malnutrition and be independently associated with a high risk of all-cause mortality in patients with AF