12 research outputs found
Uncoupling of oxidative phosphorylation and antioxidants affect fusion of primary human myoblasts in vitro
Reactive oxygen species are at the origin of muscular fatigue and atrophy. They are also linked to muscular dystrophies, a group of human genetic diseases. Several studies point to the benefits of application of antioxidants and uncouplers of oxidative phosphorylation to improve the functional activity of normal and pathological muscles. Other studies point to potential dangers of these compounds. Aim. To study the effect of mitochondria-targeted antioxidants and uncouplers of oxidative phosphorylation on muscle differentiation. Methods. Muscle differentiation was induced by serum starvation and monitored by troponin T staining. Results. the mitochondria-targeted uncoupler of oxidative phosphorylation C12TPP, but not the mitochondria-targeted antioxidant SkQ1, inhibit fusion of primary myoblasts upon their differentiation, but do not affect the synthesis of troponin T, a protein marker of muscle differentiation. Conclusion. The effect of C12TPP could be at least partially mediated by inhibition of reactive oxygen species (ROS) production since antioxidant N-acetylcysteine at high doses also inhibited differentiation of myoblasts.ΠΠΊΡΠΈΠ²Π½Ρ ΡΠΎΡΠΌΠΈ ΠΊΠΈΡΠ½Ρ (ΠΠ€Π) ΠΌΠΎΠΆΡΡΡ Π²ΠΈΠΊΠ»ΠΈΠΊΠ°ΡΠΈ ΠΌ'ΡΠ·ΠΎΠ²Ρ Π²ΡΠΎΠΌΡ Ρ Π°ΡΡΠΎΡΡΡ ΠΌ'ΡΠ·ΡΠ². ΠΠ€Π ΡΠ°ΠΊΠΎΠΆ ΠΏΠΎΠ²'ΡΠ·Π°Π½Ρ Π· ΠΌ'ΡΠ·ΠΎΠ²ΠΈΠΌΠΈ Π΄ΠΈΡΡΡΠΎΡΡΡ. ΠΠ΅Π·Π»ΡΡ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Ρ Π²ΠΊΠ°Π·ΡΡ Π½Π° ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΠΈΠΉ Π²ΠΏΠ»ΠΈΠ² Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΡΠ² Ρ ΡΠ°Π·ΠΎΠ±ΡΡΡΠ΅Π»Π΅ΠΉ ΠΎΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠΈΠ»ΡΠ²Π°Π½Π½Ρ Π½Π° ΡΡΠ½ΠΊΡΡΠΎΠ½Π°Π»ΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΠΌ'ΡΠ·ΡΠ² Π² Π½ΠΎΡΠΌΡ ΡΠ° ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΡΡ. ΠΠ΅ΡΠ°. ΠΠΈΠ²ΡΠΈΡΠΈ Π²ΠΏΠ»ΠΈΠ² ΠΌΡΡΠΎΡ
ΠΎΠ½Π΄ΡΡΠ°Π»ΡΠ½ΠΎΡ-ΡΠΏΡΡΠΌΠΎΠ²Π°Π½ΠΈΡ
Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΡΠ² Ρ ΡΠ°Π·ΠΎΠ±ΡΡΡΠ΅Π»Π΅ΠΉ ΠΎΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠΈΠ»ΡΠ²Π°Π½Π½Ρ Π½Π° Π΄ΠΈΡΠ΅ΡΠ΅Π½ΡΡΡΠ²Π°Π½Π½Ρ ΠΏΠ΅ΡΠ²ΠΈΠ½Π½ΠΈΡ
ΠΌΡΠΎΠ±Π»Π°ΡΡΡΠ² Π»ΡΠ΄ΠΈΠ½ΠΈ. ΠΠ΅ΡΠΎΠ΄ΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ. ΠΌΡΡΠΎΡ
ΠΎΠ½Π΄ΡΡΠ°Π»ΡΠ½ΠΎΡ-ΡΠΏΡΡΠΌΠΎΠ²Π°Π½ΠΈΠΉ ΡΠ°Π·ΠΎΠ±ΡΠΈΡΠ΅Π»Ρ ΠΎΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠΈΠ»ΡΠ²Π°Π½Π½Ρ C12TPP, Π°Π»Π΅ Π½Π΅ ΠΌΡΡΠΎΡ
ΠΎΠ½Π΄ΡΡΠ°Π»ΡΠ½ΠΎΡ-ΡΠΏΡΡΠΌΠΎΠ²Π°Π½ΠΈΠΉ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½Ρ SkQ1, ΠΏΡΠΈΠ³Π½ΡΡΡΡ Π·Π»ΠΈΡΡΡ ΠΌΡΠΎΠ±Π»Π°ΡΡΡΠ² ΠΏΡΠΈ Π΄ΠΈΡΠ΅ΡΠ΅Π½ΡΡΡΠ²Π°Π½Π½Ρ, ΠΏΡΠΈ ΡΡΠΎΠΌΡ Π½Π΅ Π²ΠΏΠ»ΠΈΠ²Π°ΡΡΠΈ Π½Π° Π΅ΠΊΡΠΏΡΠ΅ΡΡΡ ΡΡΠΎΠΏΠΎΠ½ΠΈΠ½Π° Π’, Π±ΡΠ»ΠΊΠΎΠ²ΠΎΠ³ΠΎ ΠΌΠ°ΡΠΊΠ΅ΡΠ° ΠΌ'ΡΠ·ΠΎΠ²ΠΎΡ Π΄ΠΈΡΠ΅ΡΠ΅Π½ΡΡΡΠ²Π°Π½Π½Ρ. ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. ΠΠΏΠ»ΠΈΠ² C12TPP ΠΌΠΎΠΆΠ΅ Π±ΡΡΠΈ ΡΠ°ΡΡΠΊΠΎΠ²ΠΎ Π²ΠΈΠΊΠ»ΠΈΠΊΠ°Π½ΠΎ ΠΏΡΠΈΠ³Π½ΡΡΠ΅Π½Π½ΡΠΌ ΠΠ€Π, ΡΠ°ΠΊ ΡΠΊ Π²ΠΈΡΠΎΠΊΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΡΡ ΠΊΠ»Π°ΡΠΈΡΠ½ΠΎΠ³ΠΎ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΡ N-Π°ΡΠ΅ΡΠΈΠ»ΡΠΈΡΡΠ΅ΡΠ½Ρ ΡΠ°ΠΊΠΎΠΆ ΡΠ½Π³ΡΠ±ΡΠ²Π°Π»ΠΈ Π΄ΠΈΡΠ΅ΡΠ΅Π½ΡΡΡΠ²Π°Π½Π½Ρ ΠΌΡΠΎΠ±Π»Π°ΡΡΡΠ² Π»ΡΠ΄ΠΈΠ½ΠΈ.ΠΠΊΡΠΈΠ²Π½ΡΠ΅ ΡΠΎΡΠΌΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° (ΠΠ€Π) ΠΌΠΎΠ³ΡΡ Π²ΡΠ·ΡΠ²Π°ΡΡ ΠΌΡΡΠ΅ΡΠ½ΡΡ ΡΡΡΠ°Π»ΠΎΡΡΡ ΠΈ Π°ΡΡΠΎΡΠΈΡ ΠΌΡΡΡ. ΠΠ€Π ΡΠ°ΠΊΠΆΠ΅ ΡΠ²ΡΠ·Π°Π½Ρ Ρ ΠΌΡΡΠ΅ΡΠ½ΡΠΌΠΈ Π΄ΠΈΡΡΡΠΎΡΠΈΡΠΌΠΈ. ΠΠ½ΠΎΠΆΠ΅ΡΡΠ²ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π° ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠΎΠ² ΠΈ ΡΠ°Π·ΠΎΠ±ΡΠΈΡΠ΅Π»Π΅ΠΉ ΠΎΠΊΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π° ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΌΡΡΡ Π² Π½ΠΎΡΠΌΠ΅ ΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ. Π¦Π΅Π»Ρ. ΠΠ·ΡΡΠΈΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΠΎ-Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΡ
Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠΎΠ² ΠΈ ΡΠ°Π·ΠΎΠ±ΡΠΈΡΠ΅Π»Π΅ΠΉ ΠΎΠΊΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π° Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΡ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΡ
ΠΌΠΈΠΎΠ±Π»Π°ΡΡΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. ΠΠ΅ΡΠΎΠ΄Ρ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΠΎ-Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΠΉ ΡΠ°Π·ΠΎΠ±ΡΠΈΡΠ΅Π»Ρ ΠΎΠΊΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ C12TPP, Π½ΠΎ Π½Π΅ ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΠΎ-Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΠΉ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½Ρ SkQ1, ΠΈΠ½Π³ΠΈΠ±ΠΈΡΡΠ΅Ρ ΡΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΌΠΈΠΎΠ±Π»Π°ΡΡΠΎΠ² ΠΏΡΠΈ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠ΅, ΠΏΡΠΈ ΡΡΠΎΠΌ Π½Π΅ Π²Π»ΠΈΡΡ Π½Π° ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΡΡΠΎΠΏΠΎΠ½ΠΈΠ½Π° Π’, Π±Π΅Π»ΠΊΠΎΠ²ΠΎΠ³ΠΎ ΠΌΠ°ΡΠΊΠ΅ΡΠ° ΠΌΡΡΠ΅ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ. ΠΡΠ²ΠΎΠ΄Ρ. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ C12TPP ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΡΠ°ΡΡΠΈΡΠ½ΠΎ Π²ΡΠ·Π²Π°Π½ΠΎ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΠ€Π, ΡΠ°ΠΊ ΠΊΠ°ΠΊ Π²ΡΡΠΎΠΊΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΠΊΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ° N-Π°ΡΠ΅ΡΠΈΠ»ΡΠΈΡΡΠ΅ΠΈΠ½Π° ΡΠ°ΠΊΠΆΠ΅ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π»ΠΈ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΡ ΠΌΠΈΠΎΠ±Π»Π°ΡΡΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°
Applicability of perturbative QCD to decays
We develop perturbative QCD factorization theorem for the semileptonic heavy
baryon decay , whose form factors are
expressed as the convolutions of hard quark decay amplitudes with universal
and baryon wave functions. Large logarithmic
corrections are organized to all orders by the Sudakov resummation, which
renders perturbative expansions more reliable. It is observed that perturbative
QCD is applicable to decays for velocity transfer
greater than 1.2. Under requirement of heavy quark symmetry, we predict the
branching ratio , and determine
the and baryon wave functions.Comment: 12 pages in Latex file, 3 figures in postscript files, some results
are changed, but the conclusion is the sam
Rare Decays of \Lambda_b->\Lambda + \gamma and \Lambda_b ->\Lambda + l^{+} l^{-} in the Light-cone Sum Rules
Within the Standard Model, we investigate the weak decays of and with the light-cone
sum rules approach. The higher twist distribution amplitudes of
baryon to the leading conformal spin are included in the sum rules for
transition form factors. Our results indicate that the higher twist
distribution amplitudes almost have no influences on the transition form
factors retaining the heavy quark spin symmetry, while such corrections can
result in significant impacts on the form factors breaking the heavy quark spin
symmetry. Two phenomenological models (COZ and FZOZ) for the wave function of
baryon are also employed in the sum rules for a comparison, which can
give rise to the form factors approximately 5 times larger than that in terms
of conformal expansion. Utilizing the form factors calculated in LCSR, we then
perform a careful study on the decay rate, polarization asymmetry and
forward-backward asymmetry, with respect to the decays of , .Comment: 38 pages, 15 figures, some typos are corrected and more references
are adde
Exclusive semileptonic rare decays K,K^*) \ell^+ \ell^- in supersymmetric theories
The invariant mass spectrum, forward-backward asymmetry, and lepton
polarizations of the exclusive processes are analyzed under supersymmetric context. Special attention is paid to
the effects of neutral Higgs bosons (NHBs). Our analysis shows that the
branching ratio of the process \bkm can be quite largely modified by the
effects of neutral Higgs bosons and the forward-backward asymmetry would not
vanish. For the process \bksm, the lepton transverse polarization is quite
sensitive to the effects of NHBs, while the invariant mass spectrum,
forward-backward asymmetry, and lepton longitudinal polarization are not. For
both \bkt and \bkst, the effects of NHBs are quite significant. The partial
decay widths of these processes are also analyzed, and our analysis manifest
that even taking into account the theoretical uncertainties in calculating weak
form factors, the effects of NHBs could make SUSY shown up.Comment: Several references are added, typo are correcte
Charmless Exclusive Baryonic B Decays
We present a systematical study of two-body and three-body charmless baryonic
B decays. Branching ratios for two-body modes are in general very small,
typically less than , except that \B(B^-\to p \bar\Delta^{--})\sim
1\times 10^{-6}. In general, due to
the large coupling constant for . For three-body modes we
focus on octet baryon final states. The leading three-dominated modes are with a branching ratio of
order for and
for . The penguin-dominated decays with strangeness
in the meson, e.g., and , have appreciable rates and the mass
spectrum peaks at low mass. The penguin-dominated modes containing a strange
baryon, e.g., , have
branching ratios of order . In contrast, the decay
rate of is smaller. We explain why some of
charmless three-body final states in which baryon-antibaryon pair production is
accompanied by a meson have a larger rate than their two-body counterparts:
either the pole diagrams for the former have an anti-triplet bottom baryon
intermediate state, which has a large coupling to the meson and the
nucleon, or they are dominated by the factorizable external -emission
process.Comment: 46 pages and 3 figures, to appear in Phys. Rev. D. Major changes are:
(i) Calculations of two-body baryonic B decays involving a Delta resonance
are modified, and (ii) Penguin-dominated modes B-> Sigma+N(bar)+p are
discusse
The masses and decay widths of heavy hybrid mesons
We first derive the mass sum rules for the heavy hybrid mesons to obtain the
binding energy and decay constants in the leading order of HQET. The pionic
couplings between the lightest hybrid and the lowest
three heavy meson doublets are calculated with the light cone QCD sum rules.
With flavor symmetry we calculate the widths for all the possible
two-body decay processes with a Goldstone boson in the final state. The total
width of the hybrid is estimated to be 300 MeV. We find the dominant
decay mode of the hybrid is where the
heavy meson belongs to the doublet. Its branching ratio is about
80% so this mode can be used for the experimental search of the lowest heavy
hybrid meson.Comment: 20 pages + 12 PS figures, introduction revised, Fig 7 updated, to
appear in Phys. Rev.
Heavy quarkonium: progress, puzzles, and opportunities
A golden age for heavy quarkonium physics dawned a decade ago, initiated by
the confluence of exciting advances in quantum chromodynamics (QCD) and an
explosion of related experimental activity. The early years of this period were
chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in
2004, which presented a comprehensive review of the status of the field at that
time and provided specific recommendations for further progress. However, the
broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles
could only be partially anticipated. Since the release of the YR, the BESII
program concluded only to give birth to BESIII; the -factories and CLEO-c
flourished; quarkonium production and polarization measurements at HERA and the
Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the
deconfinement regime. All these experiments leave legacies of quality,
precision, and unsolved mysteries for quarkonium physics, and therefore beg for
continuing investigations. The plethora of newly-found quarkonium-like states
unleashed a flood of theoretical investigations into new forms of matter such
as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the
spectroscopy, decays, production, and in-medium behavior of c\bar{c}, b\bar{b},
and b\bar{c} bound states have been shown to validate some theoretical
approaches to QCD and highlight lack of quantitative success for others. The
intriguing details of quarkonium suppression in heavy-ion collisions that have
emerged from RHIC have elevated the importance of separating hot- and
cold-nuclear-matter effects in quark-gluon plasma studies. This review
systematically addresses all these matters and concludes by prioritizing
directions for ongoing and future efforts.Comment: 182 pages, 112 figures. Editors: N. Brambilla, S. Eidelman, B. K.
Heltsley, R. Vogt. Section Coordinators: G. T. Bodwin, E. Eichten, A. D.
Frawley, A. B. Meyer, R. E. Mitchell, V. Papadimitriou, P. Petreczky, A. A.
Petrov, P. Robbe, A. Vair
Measurements of J/psi --> p \bar{p}
The process J/\psi --> p \bar{p} is studied using 57.7 X 10^6 J/\psi events
collected with the BESII detector at the Beijing Electron Positron Collider.
The branching ratio is determined to be Br(J/\psi --> p \bar{p})=(2.26 +- 0.01
+- 0.14) X 10^{-3}, and the angular distribution is well described by
\frac{dN}{d cos\theta_p}=1+\alpha\cos^2\theta_p with \alpha = 0.676 +- 0.036 +-
0.042, where \theta_p is the angle between the proton and beam directions. The
value of \alpha obtained is in good agreement with the predictions of
first-order QCD.Comment: 6 pages, 2 figures, RevTex4, Submitted to Phys.Lett.
Study of the decay mechanism for B+ to p pbar K+ and B+ to p pbar pi+
We study the characteristics of the low mass ppbar enhancements near
threshold in the three-body decays B+ to p pbar K+ and B+ to p pbar pi+. We
observe that the proton polar angle distributions in the ppbar helicity frame
in the two decays have the opposite polarity, and measure the forward-backward
asymmetries as a function of the ppbar mass for the p pbar K+ mode. We also
search for the intermediate two-body decays, B+ to pbar Delta++ and B+ to p
Delta0bar, and set upper limits on their branching fractions. These results are
obtained from a 414 fb^{-1} data sample that contains 449 times 10^6 BBbar
events collected near the Upsilon(4S) resonance with the Belle detector at the
KEKB asymmetric-energy e+ e- collider.Comment: 15 pages, 5 figures (14 figure files), revisions to Phys. Lett.
Uncoupling of oxidative phosphorylation and antioxidants affect fusion of primary human myoblasts in vitro
Reactive oxygen species are at the origin of muscular fatigue and atrophy. They are also linked to muscular dystrophies, a group of human genetic diseases. Several studies point to the benefits of application of antioxidants and uncouplers of oxidative phosphorylation to improve the functional activity of normal and pathological muscles. Other studies point to potential dangers of these compounds. Aim. To study the effect of mitochondria-targeted antioxidants and uncouplers of oxidative phosphorylation on muscle differentiation. Methods. Muscle differentiation was induced by serum starvation and monitored by troponin T staining. Results. the mitochondria-targeted uncoupler of oxidative phosphorylation C12TPP, but not the mitochondria-targeted antioxidant SkQ1, inhibit fusion of primary myoblasts upon their differentiation, but do not affect the synthesis of troponin T, a protein marker of muscle differentiation. Conclusion. The effect of C12TPP could be at least partially mediated by inhibition of reactive oxygen species (ROS) production since antioxidant N-acetylcysteine at high doses also inhibited differentiation of myoblasts.ΠΠΊΡΠΈΠ²Π½Ρ ΡΠΎΡΠΌΠΈ ΠΊΠΈΡΠ½Ρ (ΠΠ€Π) ΠΌΠΎΠΆΡΡΡ Π²ΠΈΠΊΠ»ΠΈΠΊΠ°ΡΠΈ ΠΌ'ΡΠ·ΠΎΠ²Ρ Π²ΡΠΎΠΌΡ Ρ Π°ΡΡΠΎΡΡΡ ΠΌ'ΡΠ·ΡΠ². ΠΠ€Π ΡΠ°ΠΊΠΎΠΆ ΠΏΠΎΠ²'ΡΠ·Π°Π½Ρ Π· ΠΌ'ΡΠ·ΠΎΠ²ΠΈΠΌΠΈ Π΄ΠΈΡΡΡΠΎΡΡΡ. ΠΠ΅Π·Π»ΡΡ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Ρ Π²ΠΊΠ°Π·ΡΡ Π½Π° ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΠΈΠΉ Π²ΠΏΠ»ΠΈΠ² Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΡΠ² Ρ ΡΠ°Π·ΠΎΠ±ΡΡΡΠ΅Π»Π΅ΠΉ ΠΎΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠΈΠ»ΡΠ²Π°Π½Π½Ρ Π½Π° ΡΡΠ½ΠΊΡΡΠΎΠ½Π°Π»ΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΠΌ'ΡΠ·ΡΠ² Π² Π½ΠΎΡΠΌΡ ΡΠ° ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΡΡ. ΠΠ΅ΡΠ°. ΠΠΈΠ²ΡΠΈΡΠΈ Π²ΠΏΠ»ΠΈΠ² ΠΌΡΡΠΎΡ
ΠΎΠ½Π΄ΡΡΠ°Π»ΡΠ½ΠΎΡ-ΡΠΏΡΡΠΌΠΎΠ²Π°Π½ΠΈΡ
Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΡΠ² Ρ ΡΠ°Π·ΠΎΠ±ΡΡΡΠ΅Π»Π΅ΠΉ ΠΎΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠΈΠ»ΡΠ²Π°Π½Π½Ρ Π½Π° Π΄ΠΈΡΠ΅ΡΠ΅Π½ΡΡΡΠ²Π°Π½Π½Ρ ΠΏΠ΅ΡΠ²ΠΈΠ½Π½ΠΈΡ
ΠΌΡΠΎΠ±Π»Π°ΡΡΡΠ² Π»ΡΠ΄ΠΈΠ½ΠΈ. ΠΠ΅ΡΠΎΠ΄ΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ. ΠΌΡΡΠΎΡ
ΠΎΠ½Π΄ΡΡΠ°Π»ΡΠ½ΠΎΡ-ΡΠΏΡΡΠΌΠΎΠ²Π°Π½ΠΈΠΉ ΡΠ°Π·ΠΎΠ±ΡΠΈΡΠ΅Π»Ρ ΠΎΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠΈΠ»ΡΠ²Π°Π½Π½Ρ C12TPP, Π°Π»Π΅ Π½Π΅ ΠΌΡΡΠΎΡ
ΠΎΠ½Π΄ΡΡΠ°Π»ΡΠ½ΠΎΡ-ΡΠΏΡΡΠΌΠΎΠ²Π°Π½ΠΈΠΉ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½Ρ SkQ1, ΠΏΡΠΈΠ³Π½ΡΡΡΡ Π·Π»ΠΈΡΡΡ ΠΌΡΠΎΠ±Π»Π°ΡΡΡΠ² ΠΏΡΠΈ Π΄ΠΈΡΠ΅ΡΠ΅Π½ΡΡΡΠ²Π°Π½Π½Ρ, ΠΏΡΠΈ ΡΡΠΎΠΌΡ Π½Π΅ Π²ΠΏΠ»ΠΈΠ²Π°ΡΡΠΈ Π½Π° Π΅ΠΊΡΠΏΡΠ΅ΡΡΡ ΡΡΠΎΠΏΠΎΠ½ΠΈΠ½Π° Π’, Π±ΡΠ»ΠΊΠΎΠ²ΠΎΠ³ΠΎ ΠΌΠ°ΡΠΊΠ΅ΡΠ° ΠΌ'ΡΠ·ΠΎΠ²ΠΎΡ Π΄ΠΈΡΠ΅ΡΠ΅Π½ΡΡΡΠ²Π°Π½Π½Ρ. ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. ΠΠΏΠ»ΠΈΠ² C12TPP ΠΌΠΎΠΆΠ΅ Π±ΡΡΠΈ ΡΠ°ΡΡΠΊΠΎΠ²ΠΎ Π²ΠΈΠΊΠ»ΠΈΠΊΠ°Π½ΠΎ ΠΏΡΠΈΠ³Π½ΡΡΠ΅Π½Π½ΡΠΌ ΠΠ€Π, ΡΠ°ΠΊ ΡΠΊ Π²ΠΈΡΠΎΠΊΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΡΡ ΠΊΠ»Π°ΡΠΈΡΠ½ΠΎΠ³ΠΎ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΡ N-Π°ΡΠ΅ΡΠΈΠ»ΡΠΈΡΡΠ΅ΡΠ½Ρ ΡΠ°ΠΊΠΎΠΆ ΡΠ½Π³ΡΠ±ΡΠ²Π°Π»ΠΈ Π΄ΠΈΡΠ΅ΡΠ΅Π½ΡΡΡΠ²Π°Π½Π½Ρ ΠΌΡΠΎΠ±Π»Π°ΡΡΡΠ² Π»ΡΠ΄ΠΈΠ½ΠΈ.ΠΠΊΡΠΈΠ²Π½ΡΠ΅ ΡΠΎΡΠΌΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° (ΠΠ€Π) ΠΌΠΎΠ³ΡΡ Π²ΡΠ·ΡΠ²Π°ΡΡ ΠΌΡΡΠ΅ΡΠ½ΡΡ ΡΡΡΠ°Π»ΠΎΡΡΡ ΠΈ Π°ΡΡΠΎΡΠΈΡ ΠΌΡΡΡ. ΠΠ€Π ΡΠ°ΠΊΠΆΠ΅ ΡΠ²ΡΠ·Π°Π½Ρ Ρ ΠΌΡΡΠ΅ΡΠ½ΡΠΌΠΈ Π΄ΠΈΡΡΡΠΎΡΠΈΡΠΌΠΈ. ΠΠ½ΠΎΠΆΠ΅ΡΡΠ²ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π° ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠΎΠ² ΠΈ ΡΠ°Π·ΠΎΠ±ΡΠΈΡΠ΅Π»Π΅ΠΉ ΠΎΠΊΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π° ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΌΡΡΡ Π² Π½ΠΎΡΠΌΠ΅ ΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ. Π¦Π΅Π»Ρ. ΠΠ·ΡΡΠΈΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΠΎ-Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΡ
Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠΎΠ² ΠΈ ΡΠ°Π·ΠΎΠ±ΡΠΈΡΠ΅Π»Π΅ΠΉ ΠΎΠΊΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π° Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΡ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΡ
ΠΌΠΈΠΎΠ±Π»Π°ΡΡΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. ΠΠ΅ΡΠΎΠ΄Ρ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΠΎ-Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΠΉ ΡΠ°Π·ΠΎΠ±ΡΠΈΡΠ΅Π»Ρ ΠΎΠΊΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ C12TPP, Π½ΠΎ Π½Π΅ ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΠΎ-Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΠΉ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½Ρ SkQ1, ΠΈΠ½Π³ΠΈΠ±ΠΈΡΡΠ΅Ρ ΡΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΌΠΈΠΎΠ±Π»Π°ΡΡΠΎΠ² ΠΏΡΠΈ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠ΅, ΠΏΡΠΈ ΡΡΠΎΠΌ Π½Π΅ Π²Π»ΠΈΡΡ Π½Π° ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΡΡΠΎΠΏΠΎΠ½ΠΈΠ½Π° Π’, Π±Π΅Π»ΠΊΠΎΠ²ΠΎΠ³ΠΎ ΠΌΠ°ΡΠΊΠ΅ΡΠ° ΠΌΡΡΠ΅ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ. ΠΡΠ²ΠΎΠ΄Ρ. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ C12TPP ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΡΠ°ΡΡΠΈΡΠ½ΠΎ Π²ΡΠ·Π²Π°Π½ΠΎ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΠ€Π, ΡΠ°ΠΊ ΠΊΠ°ΠΊ Π²ΡΡΠΎΠΊΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΠΊΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ° N-Π°ΡΠ΅ΡΠΈΠ»ΡΠΈΡΡΠ΅ΠΈΠ½Π° ΡΠ°ΠΊΠΆΠ΅ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π»ΠΈ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΡ ΠΌΠΈΠΎΠ±Π»Π°ΡΡΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°