Using Machine Learning to Uncover Latent Research Topics in Fishery Models

© 2018 The Author(s). Published with license by Taylor & Francis © 2018, Shaheen Syed and Charlotte Teresa Weber. Modeling has become the most commonly used method in fisheries science, with numerous types of models and approaches available today. The large variety of models and the overwhelming amount of scientific literature published yearly can make it difficult to effectively access and use the output of fisheries modeling publications. In particular, the underlying topic of an article cannot always be detected using keyword searches. As a consequence, identifying the developments and trends within fisheries modeling research can be challenging and time-consuming. This paper utilizes a machine learning algorithm to uncover hidden topics and subtopics from peer-reviewed fisheries modeling publications and identifies temporal trends using 22,236 full-text articles extracted from 13 top-tier fisheries journals from 1990 to 2016. Two modeling topics were discovered: estimation models (a topic that contains the idea of catch, effort, and abundance estimation) and stock assessment models (a topic on the assessment of the current state of a fishery and future projections of fish stock responses and management effects). The underlying modeling subtopics show a change in the research focus of modeling publications over the last 26 years

Survey of Activated FLT3 Signaling in Leukemia

Activating mutations of FMS-like tyrosine kinase-3 (FLT3) are found in approximately 30% of patients with acute myeloid leukemia (AML). FLT3 is therefore an attractive drug target. However, the molecular mechanisms by which FLT3 mutations lead to cell transformation in AML remain unclear. To develop a better understanding of FLT3 signaling as well as its downstream effectors, we performed detailed phosphoproteomic analysis of FLT3 signaling in human leukemia cells. We identified over 1000 tyrosine phosphorylation sites from about 750 proteins in both AML (wild type and mutant FLT3) and B cell acute lymphoblastic leukemia (normal and amplification of FLT3) cell lines. Furthermore, using stable isotope labeling by amino acids in cell culture (SILAC), we were able to quantified over 400 phosphorylation sites (pTyr, pSer, and pThr) that were responsive to FLT3 inhibition in FLT3 driven human leukemia cell lines. We also extended this phosphoproteomic analysis on bone marrow from primary AML patient samples, and identify over 200 tyrosine and 800 serine/threonine phosphorylation sites in vivo. This study showed that oncogenic FLT3 regulates proteins involving diverse cellular processes and affects multiple signaling pathways in human leukemia that we previously appreciated, such as Fc epsilon RI-mediated signaling, BCR, and CD40 signaling pathways. It provides a valuable resource for investigation of oncogenic FLT3 signaling in human leukemia

Mobility, Expansion and Management of a Multi-Species Scuba Diving Fishery in East Africa

Background: Scuba diving fishing, predominantly targeting sea cucumbers, has been documented to occur in an uncontrolled manner in the Western Indian Ocean and in other tropical regions. Although this type of fishing generally indicates a destructive activity, little attention has been directed towards this category of fishery, a major knowledge gap and barrier to management. Methodology and Principal Findings: With the aim to capture geographic scales, fishing processes and social aspects the scuba diving fishery that operate out of Zanzibar was studied using interviews, discussions, participant observations and catch monitoring. The diving fishery was resilient to resource declines and had expanded to new species, new depths and new fishing grounds, sometimes operating approximately 250 km away from Zanzibar at depths down to 50 meters, as a result of depleted easy-access stock. The diving operations were embedded in a regional and global trade network, and its actors operated in a roving manner on multiple spatial levels, taking advantage of unfair patron-client relationships and of the insufficient management in Zanzibar. Conclusions and Significance: This study illustrates that roving dynamics in fisheries, which have been predominantly addressed on a global scale, also take place at a considerably smaller spatial scale. Importantly, while proposed management of the sea cucumber fishery is often generic to a simplified fishery situation, this study illustrates

Mesure absolue des radioéléments émetteurs β par la méthode de l'angle solide défini

La méthode de l'angle solide défini a été modifiée de façon à éliminer la plupart des corrections qu'elle impose généralement. En outre, on a développé une méthode de détermination de la fraction transmise du rayonnement. Cette méthode a été utilisée, tant pour la mesure d'émetteurs β purs (32P, 35S), que pour les émetteurs β-γ (60Co, 131I et 24Na). Les déterminations faites à l'aide de cette méthode et celles obtenues par d'autres (4π, coïncidences β-γ) sont toujours en bon accord et dans les limites de précision escomptées