İzmir Aliağa endüstri bölgesinde hava kirliliğine neden olan organik ve inorganik kirleticilerin düzeylerinin, kaynaklarının ve sağlık etkilerinin belirlenmesi

TÜBİTAK ÇAYDAG01.07.200

Spatial and temporal heterogeneity in human mobility patterns in Holocene Southwest Asia and the East Mediterranean

We present a spatiotemporal picture of human genetic diversity in Anatolia, Iran, Levant, South Caucasus, and the Aegean, a broad region that experienced the earliest Neolithic transition and the emergence of complex hierarchical societies. Combining 35 new ancient shotgun genomes with 382 ancient and 23 present-day published genomes, we found that genetic diversity within each region steadily increased through the Holocene. We further observed that the inferred sources of gene flow shifted in time. In the first half of the Holocene, Southwest Asian and the East Mediterranean populations homogenized among themselves. Starting with the Bronze Age, however, regional populations diverged from each other, most likely driven by gene flow from external sources, which we term “the expanding mobility model.” Interestingly, this increase in inter-regional divergence can be captured by outgroup-f$_3$-based genetic distances, but not by the commonly used F$_{ST}$ statistic, due to the sensitivity of F$_{ST}$, but not outgroup-f$_3$, to within-population diversity. Finally, we report a temporal trend of increasing male bias in admixture events through the Holocene

Bursa atmosferinde organik kirleticilerin mekansal dağılımı : mevsimselliği ve sağlık etkisi.

The assessment of volatile organic compounds (VOCs) has become an area of particular interest in the field of atmospheric pollution due to their adverse health and environmental effects. This study is aimed to identify, quantify and characterize VOC in different urban areas and industrial areas in Bursa. The spatial distribution, seasonal variation as well as health risks assessment of VOC were discussed. Air samples were collected by means of sorbent passive sampling at over 50 sampling points in Bursa and analyzed by GC-thermal desorption. A total of seven weekly measurement periods were completed across the city center from 2005 to 2007. The source of VOC was apportioned with the commonly used receptor model, namely Factor Analysis. Motor vehicles and industrial solvent usage are the most abundant VOC sources to contribute to urban atmosphere in Bursa, 63% and 20%, respectively. The health risks of VOC were also evaluated. The questionnaire was filled out by selected people living in Bursa to obtain time-activity pattern for health risk assessment. Lifetime cancer risks were estimated with the measured VOC data. All the statistical parameters used to represent cancer risks for the selected compounds exceeded the stated level. Benzene had the highest adverse health effect among these compounds according to USEPA (2009) calculation with the mean cancer risk 3x10-4. In addition to intensive field sampling campaigns conducted in Bursa, the VOC measurement were completed for a period of six months to evaluate uptake rate of VOC in Ankara. Uptake rate equations depending on relative humidity and wind speed were developed for 25 VOCs.Ph.D. - Doctoral Progra

Cumhuriyet Döneminden Günümüze , Geleneksel Halk Sanatlarımızdan Etkilenen Resim Sanatçılarımız ( Bedri Rahmi Eyüboğlu )

Tez (Yüksek lisans) -- Giresun Üniversitesi. Kaynakça var.xıı , 84 s. ; 28 cm.Demirbaş: 0063244

Atmosferdeki Parçacık Sayısal Konsantrasyonu Ile Kütlesel Konsantrasyonu Arasındaki Iliskinin Kurulması Ve Parçacık Sayısal Boyut Dagılımlarının Atmosferik Olaylardan Ne Kadar Etkilendiginin Incelenmesi

Proje parçacık boyut dagılımı ve bu dagılımın çesitli çevresel faktörlerle iliskisini incelemeye yönelik bir çalısmadır. Diger bir deyisle atmosfrdeki parçacık boyut dagılımının ne tür parametrelerle ne sekilde degistigini ortaya çıkarmak hedeflemistir. Çalısma birisi Ankara?da ODTÜ?de digeri ise Marmaristeki meteoroloji radarında kurulan iki istasyonda yürütülmüstür. Bu istasyonlarda bulunan lazer spektrometreler yardımıyla daikalik sayısal boyut dagılımları ile PM10, PM2.5 ve PM1 kütlesel konsantrasyonları ölçülmüstür. Istasyonlardaki deneysel çalısmalar baslamadan önce çalısmada kullanılacak bütün cihazlar ankara?da bir araya getirilmis ve bir interkalibrasyon çalısması gerçeklestirilmistir. Intercalibrasyon çalısmasının sonunda farklı cihazlardan elde edilen sonuçların birbirleriyle çok uyumllu oldugu görülmüstür. Ayrıca, Ankara istasyonunda lazer spektrometre ile ölçülen PM10 ve PM2.5 konsantrasyonlarının Ankara?daki yedi hava kirliligi izleme istasyonunda ölçülen PM10 ve PM2.5 konsantrasyonları ile uyum içerisinde oldugu, ancak yüksek konsantrasyonlarda bizim istastasyonumuzun daha yüksek degerler ölçtügü görülmüstür. Yapılan ölçüm ve degerlendirmeler tozun boyut dagılımının çok stabil bir parametre olmadıgını ve meteorolji, tasınım gibi etmenlerle degisiklik gösterdigini ortya koymustur

Serum Apelin Levels and Ascending Aortic Aneurysm in Adults

Apelin is a peptide isolated from bovine stomach and has vasodilator and inotropic activities. The aim of this study was to confirm the relationship between serum apelin levels and ascending aortic dilatation in adult patients. This study included 39 patients with ascending aortic aneurysm who applied to the cardiovascular surgery outpatient clinic between 1 June 2019 and 31 August 2019 and 50 healthy volunteers. Serum apelin and serum apelin receptor levels were measured with ELISA method. Serum apelin levels were lower in patients with aortic aneurysm compared to the control group, while serum apelin receptor levels were higher. These findings may show that serum apelin and apelin receptor levels may be a potential biomarker for aortic aneurysm

Reversible Sensorineural Hearing Loss in Celiac Disease: Is it A Coincidental Finding?

Celiac Disease (CD) is an autoimmune disease of the small intestine characterized by the immune response against ingested gluten. This response causes characteristic damage to the villi, which in turn results in malabsorption. Clinical signs and symptoms of CD may start early in childhood or in adulthood. Some people are completely asymptomatic. The term celiac crisis is used for patients with acute-onset severe abdominal pain which is potentially fatal. Although various extraintestinal signs and symptoms have been defined in CD, there are contradictory reports regarding hearing loss. We hereby report a patient with celiac disease who was investigated for malabsorption and was diagnosed with mild to medium temporary sudden sensorineural hearing loss (SNHL). (The Medical Bulletin of Haseki 2013;51:190-2

Comprehensive multi-technique approach reveals the high diversity of microcystins in field collections and an associated isolate of Microcystis aeruginosa from a Turkish lake

Microcystins (MCs) are hepatotoxic and potentially carcinogenic cyanotoxins. They exhibit high structural variability, with nearly 250 variants described to date. This variability can result in incomplete detection of MC variants during lake surveys due to the frequent use of targeted analytical methods and a lack of standards available for identification and quantitation. In this study, Lake Uluabat in Turkey was sampled during the summer of 2015. Phylogenetic analysis of the environmental mcyA sequences suggested Microcystis spp. were the major MC contributors. A combination of liquid chromatography-tandem mass spectrometry (LC-MS/MS), liquid chromatography with UV detection and mass spectrometry (LC-UV-MS), and a novel liquid chromatography-high resolution mass spectrometry (LC-HRMS) method, together with thiol and periodate reactivity, revealed more than 36 MC variants in the lake samples and a strain of M. aeruginosa (AQUAMEB-24) isolated from Lake Uluabat. Only MCs containing arginine at position-4 were detected in the culture, while MC-LA, -LY, -LW and -LF were also detected in the lake samples, suggesting the presence of other MC producers in the lake. The previously unreported MCs MC-(H2)YR (dihydrotyrosine at position-2) (17), [epoxyAdda(5)]MC-LR, [DMAdda(5)]MC-RR (1) and [Mser(7)]MC-RR (8) were detected in the culture and/or field samples. This study is a good example of how commonly used targeted LC-MS methods can underestimate the diversity of MCs in freshwater lakes and cyanobacteria cultures and how untargeted LC-MS methods can be used to comprehensively assess MC diversity present in a new system

Spatial and temporal variations in atmospheric VOCs, NO2, SO2, and O3 concentrations at a heavily industrialized region in Western Turkey, and assessment of the carcinogenic risk levels of benzene

Ambient concentrations of volatile organic compounds (VOCs), nitrogen dioxide (NO2), sulphur dioxide (SO2) and ground-level ozone (O3) were measured at 55 locations around a densely populated industrial zone, hosting a petrochemical complex (Petkim), a petroleum refinery (Tupras), ship-dismantling facilities, several iron and steel plants, and a gas-fired power plant. Five passive sampling campaigns were performed covering summer and winter seasons of 2005 and 2007. Elevated concentrations of VOCs, NO2 and SO2 around the refinery, petrochemical complex and roads indicated that industrial activities and vehicular emissions are the main sources of these pollutants in the region. Ozone concentrations were low at the industrial zone and settlement areas, but high in rural stations downwind from these sources due to NO distillation. The United States Environmental Protection Agency's positive matrix factorization receptor model (EPA PMF) was employed to apportion ambient concentrations of VOCs into six factors, which were associated with emissions sources. Traffic was found to be highest contributor to measured ∑VOCs concentrations, followed by the Petkim and Tupras.Median cancer risk due to benzene inhalation calculated using a Monte Carlo simulation was approximately 4 per-one-million population, which exceeded the U.S. EPA benchmark of 1 per one million. Petkim, Tupras and traffic emissions were the major sources of cancer risk due to benzene inhalation in the Aliaga airshed. Relative contributions of these two source groups changes significantly from one location to another, demonstrating the limitation of determining source contributions and calculating health risk using data from one or two permanent stations in an industrial area.TUBITAK (104Y276