Can thiamine pyrophosphate prevent desflurane induced hepatotoxicity in rats?

Cetin, Nihal/0000-0003-3233-8009; Arslan, Aynur/0000-0001-5968-5823; yilmaz, adnan/0000-0003-4842-1173WOS: 000374189100004PubMed: 27050787PURPOSE: To investigate the effects of thiamine pyrophosphate (TPP) against desflurane induced hepatotoxicity. METHODS: Thirty experimental animals were divided into groups as healthy (HG), desflurane control (DCG), TPP and desflurane group (TDG). 20 mg/kg TPP was injected to intraperitoneally TDG. After one hour of TPP administration, desflurane was applied for two hours. After 24 hours, liver tissues of the animals killed with decapitation were removed. the oxidant/antioxidant levels and ALT, AST and LDH activities were measured. the histopathological examinations were performed in the liver tissues for all rats. RESULTS: Notwithstanding the levels of oxidants and liver enzymes were significantly increased (p<0.0001), antioxidant levels were significantly decreased in DCG (p<0.0001). on contrary to the antioxidant parameters were increased (p<0.05) the oxidant parameters and liver enzymes were decreased in TDG (p<0.0001). Whereas multiple prominent, congestion, hemorrhage and dilatation were observed in sinusoids and lymphocyte-rich inflammation results in the centrilobular and portal areas of liver tissue in DCG, these findings were observed less frequently in TDG. CONCLUSION: Thiamine pyrophosphate prevented liver oxidative damage induced with desflurane and may be useful in prophylaxis of desflurane induced hepatotoxicity.Erzincan University Scientific Research Projects DepartmentErzincan Binali Yildirim University [SAG-B-080715-0173]Erzincan University Scientific Research Projects Department (Project no SAG-B-080715-0173

Phytochemical profile and some biological activities of three Centaurea species from Turkey

Purpose: To characterise the phytochemical profile of whole plants of Centaurea balsamita, C. depressa and C. lycopifolia with LC-ESI-MS/MS, and as well as their antioxidant, anticholinesterase and antimicrobial activities.Methods: Organic and aqueous extracts of the three Centaurea species were evaluated for DPPH free radical, ABTS cation radical scavenging and cupric reducing antioxidant capacity (CUPRAC). Acetyland butyryl-cholinesterase enzyme inhibition abilities of the extracts using petroleum ether, acetone, methanol and water were studied to determine anticholinesterase activity, while antimicrobial activity was determined by disc diffusion method using appropriate antimicrobial standards and organisms. The phytochemical components of the methanol extracts were assessed by LC-MS/MS.Results: The methanol extract of C. balsamita exhibited much higher DPPH free and ABTS cation radicals scavenging activities (with IC50 of 62.65 ± 0.97 and 24.21 ± 0.70 mg/ml, respectively) than the other extracts. The petroleum ether extracts of the plant species exhibited moderate inhibitory activity against butyrylcholinesterase enzymes while the acetone extract of C. balsamita showed good antifungal activity against Candida albicans. Quinic acid (17513 ± 813 μg/g, 63874 ± 3066 μg/g and 108234 ± 5195 μg/g) was the major compound found in the methanol extracts of C. balsamita, C. depressa and C. Lycopifolia, respectively.Conclusion: These results indicate quinic acid is the major compound in the three plant species and that Centaurea balsamita has significant antioxidant, anticholinesterase and antimicrobial properties. Further studies to identify the compounds in the extracts responsible for the activities are required.Keywords: Centaurea, LC-ESI-MS/MS, Anticholinesterase, Antioxidant, Antimicrobia

Characteristics of food allergy in children: National multicenter study

Conference: Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) Location: Lisbon, PORTUGAL Date: JUN 01-05, 2019Background : Food allergies impose a significant burden on the life of the child and the family. In this study, to determine the demographic characteristics of food allergies, we investigated the characteristics of patients with food allergies in different regions of Pediatric Allergy- Immunology departments in Turkey. Method : Turkey ' s National Study of Allergy and Clinical Immunology Society has conducted a Study Group on Food Allergies. 25 centers participated in this multicenter, cross- sectional and descriptive study.European Academy of Allergy and Clinical Immunolog

The relationship between the technological pedagogical field knowledge of vocational professionality of class.

TEZ12946Tez (Yüksek Lisans) -- Çukurova Üniversitesi, Adana, 2020.Kaynakça (s. 65-74) var.XV, 82 s. :_tablo ;_29 cm.Bu araştırmanın genel amacı; sınıf öğretmenlerinin teknolojik pedagojik alan bilgisi ile mesleki profesyonelliği arasındaki ilişkisini ortaya koymaktır. Araştırmanın evreni 2018-2019 eğitim-öğretim yılı süresinde Adana ili merkez ve Karataş ilçesi ilkokullarında görev yapan sınıf öğretmenleri, örneklemi ise Adana ili dört merkez ilçe ve Karataş ilçesindeki resmi ilkokullarda görev yapan 257 sınıf öğretmeni oluşturmaktadır. Bu çalışma tarama modelinin kullanıldığı betimsel bir çalışmadır. Araştırmanın veri toplama araçları olarak Schmidt, Baran, Thompson, Mishra, Koehler ve Shin, (2009) tarafından geliştirilen ve Türkçe uyarlaması, geçerliği ve güvenirliği Öztürk ve Horzum (2011) tarafından yapılan “Teknolojik Pedagojik İçerik Bilgisi Ölçeği” ile Yılmaz ve Altınkurt (2014) tarafından geliştirilen “Öğretmenlerin Mesleki Profesyonellik Ölçeği” kullanılmıştır. Elde edilen veriler SPSS 22 programına girilerek analiz edilmiştir. Araştırmanın bağımlı değişkeni olan “Öğretmenlerin Mesleki Profesyonelliği” ile bağımsız değişkeni olan “Teknolojik Pedagojik Alan Bilgisi” ve demografik değişkenler arasındaki ilişkiler t testi, tek yönlü varyans analizi ve korelasyon yöntemi ile incelenmiştir. Çalışma sonucunda sınıf öğretmenlerinin teknolojik pedagojik alan bilgisi ile mesleki profesyonellikleri arasında orta düzeyde pozitif yönde ilişki olduğu sonucuna ulaşılmıştır. Ayrıca sınıf öğretmenlerinin teknolojik pedagojik içerik bilgisi alt boyutlarında pedagojik bilgi alt boyunun en yüksek ortalamaya sahip olduğu, teknoloji bilgisi alt boyutunun ise en düşük ortalamaya sahip olduğu sonucu ortaya çıkmıştır. Öğretmenlerin mesleki profesyonelliği alt boyutlarında ise en yüksek ortalamanın duygusal emek alt boyutu, en düşük ortalamanın ise kişisel gelişim alt boyutunun olduğu sonucuna varılmıştır. Teknolojik pedagojik içerik bilgisi alt boyutları ile demografik değişkenler arasındaki ilişkilerin incelenmesi sonucunda sınıf öğretmenlerinin eğitim düzeylerine, hizmet süresine ve teknolojiye erişe bilirlik düzeylerine göre anlamlı bir fark olmadığı ancak cinsiyete göre dört alt boyutta erkek öğretmenler lehine, yaş aralığına göre bir alt boyutta 41 ve üzeri yaş aralığında olanlar lehine, teknolojiye kullanma seviyelerine göre beş alt boyutta yeterli cevabını verenler lehine ve hizmet içi eğitime katılıp katılmama durumlarına göre tüm alt boyutlarda evet cevabını verenler lehine anlamlı bir farklılaşma olduğu sonucuna ulaşılmıştır.The general purpose of this research is to reveal the relationship between Class Teachers' Technological Pedagogical Content Knowledge and Vocational Professionalism. The universe of the research consists of class teachers working in Adana city center and primary schools in Karataş district during the academic year 2018-2019, and the sample consists of 257 class teachers working in official primary schools in four central districts of Adana Province and Karataş district. This study is a descriptive study using the screening model. As data collection tools of the research “Technological Pedagogical Content Knowledge” developed by Schmidt, Baran, Thompson, Mishra, Koehler ve Shin (2009) and its adaptation into Turkish and also its validity and reliability done by Öztürk and Horzum (2011) and Scale “Professional professionalism scale of teachers” developed by Yılmaz and Altınkurt (2014) were used. The data obtained were analyzed by entering the SPSS 22 program. The relationship between the dependent variable of the research, "Professional Professionalism of Teachers" and the independent variable "Technological Pedagogical Content Knowledge" and demographic variables were examined by the test, one-way analysis of variance and correlation method. As a result of the study, it has been concluded that there is a moderate positive relationship between Technological Pedagogical Content Knowledge and Vocational Professionalism. In addition, it has been concluded that the Pedagogical Knowledge sub-dimension has the highest average in the Technological Pedagogical Content information sub-dimensions and the Technology Info sub-dimension has the lowest average. It has been concluded that the highest mean average emotional labor sub-dimension and the lowest mean personal development sub-dimension were the teachers' Professional Professional sub-dimensions. As a result of the examination of the relationships between the Technological Pedagogical Content Knowledge sub-dimensions and demographic variables, there is no significant difference in the level of education, service duration and technology accessibility levels of the class teachers, but in the age range of 41 and over in the sub-dimension, in favor of male teachers in four sub-dimensions, by age range. It has been concluded that there is a significant difference in favor of those who gave adequate answers in five sub-dimensions according to their level of use in technology and in favor of those who answered yes in all sub-dimensions according to their participation in in-service training or not

Postharvest Treatments of Different Doses of Calcium Lactate in Combination with Chitosan Improves Biochemical Characters of Cucumis sativus L. during Storage

This study aimed to determine the effects of the postharvest coating created with different doses of calcium compounds and chitosan on the quality of the cucumbers during storage. For this purpose, cucumber fruits were dipped into solutions containing the doses of 2, 4, and 6% calcium chloride (CaCl2), calcium propionate (C6H10CaO4), and calcium lactate (C6H10CaO6) + 1.0% chitosan separately before storage. After the treatments, the cucumber fruits were dried and placed in boxes with plastic lids and stored at 7±1oC and 90-95% relative humidity for 20 days. Calcium change in fruits, flesh firmness (N), weight loss (%), fruit skin color (L*, a*, b*, hue angle, yellowness index), chlorophyll SPAD amount, total soluble solids (TSS), titratable acid (%), taste quality, electrolyte leakage (%), decay rate  (%) observations and analyzes were evaluated at five-day intervals during storage. According to the results, it was found that especially the dose of 2% calcium lactate was more effective in preserving fruit firmness and green color, increasing the amount of TSS, and also delaying the decay, amongst calcium chloride, calcium propionate, and calcium lactate treatments. The KT and CaP4 treatments were successful in reducing weight loss, whereas CaL4 and CaL6 were found to be effective in maintaining chlorophyll content. Also, it observed that CaK4 and CaK6 treatments were increased electrolyte leakage due to causing damage to the cell wall, thus the shortened storage time of cucumber fruits in this study

Chemoradiotherapy-Associated Myelosuppression: A Retrospective Analysis of Risk Factors for Patients with Non-Small Cell Lung Cancer

Objective: Concomitant chemoradiotherapy (CRT) is the standard treatment for patients with stage III non-small cell lung cancer (NSCLC). Myelosuppression can be a significant problem in concomitant CRT. The aim of this study was to assess the parameters obtained before concomitant CRT to define the risk factors for myelosuppression in patients with locally advanced NSCLC. Methods: We retrospectively analyzed 81 patients with NSCLC who received concomitant platinum-based chemoradiotherapy between January 2008 and December 2012. Seventy-eight patients (96.2%) received etoposide (50 mg/m2, intravenously on days 1–5, 29–33) plus cisplatin (50 mg/m2, on days 1, 8, 29, and 36), and 3 patients (3.8%) received docetaxel (20 mg/m2/w, on weeks 1–8) plus cisplatin (20 mg/m2/w, on weeks 1–8) concurrently with thoracic radiotherapy to a total dose of 40–66.6 Gy. The risk factors were examined for their association with myelosupression (grade 3 or 4 leukopenia, neutropenia, thrombocytopenia, or anemia) by logistic regression analysis. Results: Grade 3 or higher neutropenia, leukopenia, thrombocytopenia, or anemia occurred in 51.8%, 53%, 8.6%, and 7.4% of the patients, respectively. Multivariate analysis revealed that the risk factors for neutropenia were performance status (p=0.032), white blood cell count (p=0.023), and pretreatment creatinine level (p=0.018). On multivariate analysis, white blood cell count (OR, 3.311; p=0.027; 95% CI, 1.148–9.545) was found as significant risk factor for CRT-induced leukopenia Conclusion: Patients with a poor pretreatment performance status, low white blood cell count, and high creatinine level are at a risk of myelosupression. These characteristics of the patients should be considered while making treatment decisions