Conference: Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI)
Location: Lisbon, PORTUGAL
Date: JUN 01-05, 2019Background : Food allergies impose a significant burden on the life of the child and the family. In this study, to determine the demographic characteristics of food allergies, we investigated the characteristics of patients with food allergies in different regions of Pediatric Allergy- Immunology departments in Turkey. Method : Turkey ' s National Study of Allergy and Clinical Immunology Society has conducted a Study Group on Food Allergies. 25 centers participated in this multicenter, cross- sectional and descriptive study.European Academy of Allergy and Clinical Immunolog

Akdemir, Meltem

Akçal, Ömer

Anıl, Hülya

Arik Yılmaz, Ebru

Arikoğlu, Tuğba

Asilsoy, Suna

Bingöl, Ayşen

Bingöl, Gülbin

Birol Bostancı, İlknur

Bozdoğan, Günseli

Büyüktiryaki, Betül

Can, Ceren

Can, Demet

Civelek, Ersoy

Demir, Esen

Doğruel, Dilek

Eren Akarcan, Sanem

Erengin, Hakan

Ertuğrul, Ayşin

Harmancı, Koray

Kan, Ahmet

Karakoç Aydıner, Elif

Kılıç, Mehmet

Kuyucu, Semanur

Köse, Şirin

Külhaş Çelik, İlknur

Nacaroğlu, Tekin

Orhan, Fazıl

Sapan, Nihat

Saçkesen, Cansin

Sipahi, Seyhan

Tamay, Zeynep

Tuncel, Tuba

Türktaş, İpek

Ufuk Altıntaş, Derya

Uygun, Kocacık

Yazıcıoğlu, Mehtap

Zeyrek, Dost

Çekiç, Şükrü

Çokuğraş, Haluk

Özdemir, Pınar Gökmirza

Özen, Ahmet Oğuzhan

Şekerel, Bülent Enis

Şenol, Handan Duman

Allergy

English

İstanbul Medipol University Institutional Repository

     |  503ABSTRACTS SUNDAY, 2 JUNE 2019  TPS 17  EPIDEMIOLOGY OF FOOD ALLERGY I  TP0911  |  Substantial variation in food allergy prevalence and causative foods in adults across Europe  Lyons  SA 1  ;  Burney  PGJ 2  ;  Ballmer-Weber  BK 3,4,5  ;  Fernandez-Rivas  M 6  ;  Barreales  L 7  ;  Clausen  M 8  ;  Dubakiene  R 9  ;  Fernandez-Perez  C 7  ;  Fritsche  P 3  ;  Jedrzejczak-Czechowicz  M 10  ;  Kowalski  ML 10  ;  Kralimarkova  T 11  ;  Kummeling  I 1  ;  Lebens  AFM 1  ;  Mustakov  T 11  ;  Van Os-Medendorp  H 1  ;  Papadopoulos  NG 12,13  ;  Popov  TA 14  ;  Sakellariou  A 12  ;  Welsing  PMJ 15,16  ;  Potts  J 2  ;  Mills  ENC 17  ;  Van Ree  R 18  ;  Knulst  AC 1  ;  Le  TTM 1   1 Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, The Netherlands ;   2 Population Health & Occupational Disease, National Heart and Lung Institute, Imperial College London, London, United Kingdom ;   3 Allergy Unit, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland ;   4 Faculty of Medicine, University of Zurich, Zurich, Switzerland ;   5 Clinic for Dermatology and Allergology, Kantonsspital St. Gallen, St. Gallen, Switzerland ;   6 Allergy Department, Hospital Clinico San Carlos, IdISSC, ARADyAL, RD16/0006/0009, Madrid, Spain ;   7 Servicio de Medicina Preventiva, Epidemiology Unit, Hospital Clinico San Carlos, IdISSC, Madrid, Spain ;   8 Children ' s Hospital, Landspitali University Hospital, Reykjavik, Iceland ;   9 Medical Faculty, Vilnius University, Vilnius, Lithuania ;   10 Department of Allergy and Immunology, Medical University of Lodz, Lodz, Poland ;   11 Clinical Centre of Allergology of the Alexandrovska Hospital, Medical University of Sofia, Sofia, Bulgaria ;   12 Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece ;   13 Division of infection, Immunity and Respiratory Medicine, Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, United Kingdom ;   14 University Hospital Sv. Ivan Rilski, Sofia, Bulgaria ;   15 Division of Internal Medicine and Dermatology, University Medical Center Utrecht, Utrecht, The Netherlands ;   16 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands ;   17 Division of Infection, Immunity and Respiratory Medicine, Manchester Institute of Biotechnology & Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, United Kingdom ;   18 Department of Experimental Immunology and Department of Otorhinolaryngology, Amsterdam University Medical Center, Amsterdam, The Netherlands  Background :  Prevalence of self- reported food allergy ranges from 1% to 19% for foods frequently consumed and commonly impli-cated across Europe. Data on prevalence of clinically manifest food allergy are lacking, especially in adults, and incomparable study protocols hamper accurate evaluation of intracontinental differences. The aim of this study was to determine the preva-lence of food allergy, defined as symptoms plus sIgE- sensitisation, to 24 relevant foods in adults across Europe, using a standardised protocol.  Method :  In the EuroPrevall project, a pan European study inves-tigating the prevalence of food allergy, a screening questionnaire was sent to a random sample of the general adult population in eight European centres. All responders reporting symptoms to one of 24 pre- selected commonly implicated foods and a control group consisting of a random sample of responders who did not report symptoms to any of the selected foods, were invited for broader evaluation, comprising an extensive questionnaire on reactions to the 24 selected foods, and measurement of sIgE against these foods. Multiple imputation was performed to estimate missing symptom and serology information for non- responders.  Results :  Overall prevalence of food allergy was highest in Zurich at 5.6%, followed by 3.3% in Madrid, 2.8% in Lodz, 2.1% in Utrecht, 1.4% in Reykjavik and 0.3% in Athens. In Zurich, Lodz and Utrecht, the highest prevalence was found for hazelnut (respectively 2.6%, 1.3% and 0.9%), peach (respectively 2.0%, 0.5% and 0.6%) and apple (respectively 1.9%, 0.8% and 0.9%). Peach was also one of the top three causative foods in Madrid (1.6%), along with melon (1.0%) and shrimp (0.8%); and in Athens (0.1%), along with walnut (0.3%) and sunflower seed (0.1%). In Reykjavik, the highest prevalence esti-mates were found for banana (0.5%), carrot (0.4%) and shrimp (0.4%).  Conclusion :  Food allergy shows substantial geographical variation in prevalence and causative foods in adults across Europe. Although food allergy defined as symptoms plus sIgE- sensitisation was less common than self- reported FA, prevalence still reached 6% in parts of Europe. Plant foods dominated as most common causative foods, with the exception of shrimp in Spain and Iceland, suggest-ing that prevalence is likely related to pollen exposure and possibly consumption.   TP0912  |  Characteristics of food allergy in children: National multicenter study  Bingol  A 1  ;  Kocacik Uygun  DF 1  ;  Akdemir  M 2  ;  Erengin  H 2  ;  Bozdogan  G 3  ;  Bingol  G 3  ;  Orhan  F 4  ;  Buyuktiryaki  B 5  ;  Sekerel  B 5  ;  Kilic  M 6  ;  Sackesen  C 7  ;  Eren Akarcan  S 8  ;  Demir  E 8  ;  Kose S.  S 9  ;  Asilsoy  S 9  ;  Kan  A 10  ;  Turktas  I 10  ;  Arikoglu  T 11  ;  Kuyucu  S 11  ;  Sipahi  S 12  ;  Tamay  Z 12  ;  Nacaroglu  T 13  ;  Gokmirza Ozdemir  P 14  ;  Yazicioglu  M 14  ;  Cekic  S 15  ;  Sapan  N 15  ;  Zeyrek  D 16  ;  Dogruel  D 17  ;  Karakoc Aydiner  E 18  ;  Ozen  AO 18  ;  Can  C 19  ;  Ertugrul  A 20  ;  Bostanci  I 20  ;  Akcal  O 21  ;  Can  D 21  ;  Arik Yilmaz  E 22  ;  Anil  H 23  ;  Harmanci  K 23  ;  Kulhascelik  I 24  ;  Civelek  E 24  ;  Cokugras  H 25  ;  Duman Senol  H 26  ;  Tuncel  T 26  ;  Ufuk Altintas  D 17   1 Akdeniz University School of Medicine Pediatric Allergy- Immunology Department, Antalya, Turkey ;   2 Akdeniz University School of Medicine Public Health Department, Antalya, Turkey ;   3 Acibadem University School of Medicine Pediatric Allergy- Immunology Department, Istanbul, Turkey ;   4 Karadeniz Technically University School of Medicine Pediatric Allergy- Immunology Department, Trabzon, Turkey ;   5 Hacettepe University School of Medicine Pediatric Allergy- Immunology Department, Ankara, Turkey ;   6 Firat University School of Medicine Pediatric Allergy- Immunology Department, Elazig, Turkey ;   7 Koc University School of Medicine Pediatric Allergy- Immunology Department, Istanbul, Turkey ;   8 Ege University School of Medicine Pediatric Allergy- Immunology Department, Izmir, Turkey ;   9 DokuzEylul University School of Medicine Pediatric Allergy- Immunology 504  |     ABSTRACTSDepartment, Izmir, Turkey ;   10 Gazi University School of Medicine Pediatric Allergy- Immunology Department, Ankara, Turkey ;   11 Mersin University School of Medicine Pediatric Allergy- Immunology Department, Mersin, Turkey ;   12 Istanbul University School of Medicine Pediatric Allergy- Immunology Department, Istanbul, Turkey ;   13 Medipol University School of Medicine Pediatric Allergy- Immunology Department, Istanbul, Turkey ;   14 Trakya University School of Medicine Pediatric Allergy- Immunology Department, Edirne, Turkey ;   15 Uludag University School of Medicine Pediatric Allergy- Immunology Department, Bursa, Turkey ;   16 Istanbul Yeniyuzyil University School of Medicine Pediatric Allergy- Immunology Department, Istanbul, Turkey ;   17 Cukurova University School of Medicine Pediatric Allergy- Immunology Department, Adana, Turkey ;   18 Marmara University School of Medicine Pediatric Allergy- Immunology Department, Istanbul, Turkey ;   19 Sadi Konuk Research and Training Hospital Pediatric Allergy- Immunology Department, Istanbul, Turkey ;   20 Sami Ulus Research and Training Hospital Pediatric Allergy- Immunology Department, Ankara, Turkey ;   21 Balikesir University School of Medicine Pediatric Allergy- Immunology Department, Balikesir, Turkey ;   22 Pamukkale University School of Medicine Pediatric Allergy- Immunology Department, Denizli, Turkey ;   23 Osmangazi University School of Medicine Pediatric Allergy- Immunology Department, Eskisehir, Turkey ;   24 Diskapi Hematology- Oncology Research and Training Hospital Pediatric Allergy- Immunology Department, Ankara, Turkey ;   25 Cerrahpasa University School of Medicine Pediatric Allergy- Immunology Department, Istanbul, Turkey ;   26 Izmir Katip Celebi University School of Medicine Pediatric Allergy- Immunology Department, Izmir, Turkey  Background :  Food allergies impose a significant burden on the life of the child and the family. In this study, to determine the demographic characteristics of food allergies, we investigated the characteris-tics of patients with food allergies in different regions of Pediatric Allergy- Immunology departments in Turkey.  Method :  Turkey ' s National Study of Allergy and Clinical Immunology Society has conducted a Study Group on Food Allergies. 25 cent-ers participated in this multicenter, cross- sectional and descriptive study.  Results :  A total of 1248 children were included in the study (62.0% boy, 38.0% girl) consisting IgE- mediated, non- IgE mediated and mixed- type cases of food allergy in a percentage of 71.8%, 16.1% and 12.1%, respectively.  In the IgE- mediated group, the age of onset and diagnosis were 8.26 ± 16.98 months and 13.73 ± 24.58 months, respectively, and 64.7% of the cases were male. The most common types of food allergy were egg white, cow ' s milk, egg yolk and hazelnut. The most common initial symptoms were urticaria- angioedema, eczema and anaphylaxis. There was no relationship with the family history of atopy.  In the non- IgE mediated group, the age of onset and diagnosis were 4.51 ± 11.21 months and 7.16 ± 12.82 months, respectively, and 54.2% of the cases were male. Milk, eggs, beef and wheat were generally responsible for this type of atopy mostly admitting with proctocolitis.  In boys and in children whose parents have low level of education, the commonest type of food allergy was IgE- mediated ( P < 0.01 for each). Non- IgE- mediated food allergy found to be significantly more frequent in girls and in the families with good income ( P < 0.01 for each).  Conclusion :  In this study, clinical characteristics and risk factors and phenotypes of food allergies in Turkey were investigated.   TP0913  |  Clinical features of 4458 food allergic children from 5 year ' s registry  Ogura  K ;  Takahashi  K ;  Nishino  M ;  Asaumi  T ;  Nagakura  K ;  Yanagida  N ;  Sato  S ;  Ebisawa  M  National Hospital Organization, Sagamihara National Hospital, Sagamihara, Japan  Background :  The purpose of this study is to clarify clinical features of food allergy (FA) among Japanese children by using database reg-istry at our department.  Method :  We have previously established the database registry system on immediate type of food allergy (FA) patients from 2008. The system can integrates the sequential information on medical history, Ag- IgE, SPT and oral food challenge (OFC). We have analyzed the 5 year ' s database from 2010 to 2014. The database included total of 4458 patients. The median age of FA diagnosis was 7 months old and that of 1st immediate allergic reaction 10 months old. The numbers of patients with the history of immediate type of allergic reactions and anaphylaxis (An) by their past history or OFC were 3.906 (88%) and 1.756 (39%), respectively.  Results :  There were 10 703 registered food allergens. The num-ber of allergens with immediate type reactions was 6356 (59%). OFC was performed 7205 times and 2535 of them were positive. Concerning itemized food allergens, Hen ' s egg (HE), cow ' s milk (CM), peanut (PN) and wheat (W) were major allergens and that ratios of HE/CM/PN/W per registered whole allergens were 27%, 17%, 10% and 10%, respectively. The ratio of An per immediate histories, CM, PN, W and buckwheat (BW) were significantly higher and the ra-tios of CM/PN/W/BW were 51%, 49%, 46% and 44%, respectively ( P < 0.05). The ratio of past history of using adrenaline injection per immediate histories about CM, PN, W and BW were 16%, 15%, 12% and 12%, respectively ( P < 0.05). There were 2978 food allergens which had acquired tolerance during the 5 years. Ways to acquire tolerance were by dietary instruction without OFC (33%), dietary instruction based on OFC results (60%), and judgement of sustained unresponsiveness after oral immunotherapy (7%), respectively.  Conclusion :  By using the large database, we could obtain the real clinical features of immediate type FA (mostly challenge proven), in-cidence of An and rates of tolerance acquisition during the 5 years. Furthermore, prevalent severe allergic reactions can be recognized in CM, PN, W and BW in Japan.   TP0914  |  Profilin sensitization – a review of 5 years follow up in an allergy department  Sangalho  I ;  Gonçalves  T ;  Lobato  M ;  Palma-Carlos  S ;  Alves  C ;  Rosa  S ;  Pinto  PL  Allergy and Clinical Immunology Department, Hospital de Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central, E.P.E, Lisboa, Portugal  Background :  Profilin is a minor allergen ubiquitously spread in pol-len and plant food species. It can show cross reactivity between 

Characteristics of food allergy in children: National multicenter study

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Characteristics of food allergy in children: National multicenter study

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