Experimental study on LBL beams

Six specimens were made and tested to study the mechanical properties of LBL beams. The mean ultimate loading value is 68.39 MPa with a standard deviation of 6.37 MPa, giving a characteristic strength (expected to be exceeded by 95% of specimens) of 57.91 MPa, and the mean ultimate deflection is 53.3 mm with a standard deviation of 5.5 mm, giving the characteristic elastic modulus of 44.3 mm. The mean ultimate bending moment is 20.18 kN.m with a standard deviation of 1.88 kN.m, giving the characteristic elastic modulus of 17.08 kN.m. The mean elastic modulus is 9688 MPa with a standard deviation of 1765 MPa, giving the characteristic elastic modulus of 6785 MPa, and the mean modulus of rupture is 93.3 MPa with a standard deviation of 8.6 MPa, giving the characteristic elastic modulus of 79.2 MPa. The strain across the cross-section for all LBL beams is basically linear throughout the loading process, following standard beam theory

Stability of Impulsive Neural Networks with Time-Varying and Distributed Delays

This work is devoted to investigating the stability of impulsive cellular neural networks with time-varying and distributed delays. We use the new method of fixed point theory to obtain some new and concise sufficient conditions to ensure the existence and uniqueness of solution and the global exponential stability of trivial equilibrium. The presented algebraic criteria are easily checked and do not require the differentiability of delays

Combined effects of welding heat input and peak temperature on precipitation and mechanical properties of the HAZ for modified austenitic medium manganese steels

We studied the microstructure and mechanical properties of the simulated welding heat-affected zone (HAZ) for modified austenitic medium manganese steels (MAMMS) in the welding peak temperature range of 750 °C to 1050 °C. The precipitation behavior of cementite and VC particle was sensitive to the welding thermal cycle in this temperature range. When the peak temperature increased from 750 °C to 850 °C, the intergranular cementite and VC particle became coarser, leading to deterioration of toughness. However, when the peak temperature raised to 1050 °C, the intergranular cementite disappeared. The sensibility of tensile strength to heat input at high peak temperature was higher than that at low temperature, which implied that it was affected by combined effects of the two factors of heat input and peak temperature, rather than a single factor. This variation tendency was highly related with the coarsening behavior of VC particle depending on the interaction effect of these two factors. The growth rate of VC particle with peak temperature of 850 °C was ∼4 times as high as that with peak temperature of 750 °C. However, it only increased to ∼1.3 times when the peak temperature increased from 850 °C to 1050 °C

Serum Metabolomics Study of Gliclazide-Modified-Release-Treated Type 2 Diabetes Mellitus Patients Using a Gas Chromatography-Mass Spectrometry Method

Sulfonylureas are one of the commonly used drugs in type 2 diabetes mellitus (T2DM) but with considerable incidence of monotherapy failure. However, the mechanism of patients' drug response is unclear, and suitability evaluation biomarkers are in urgent need for precision medicine. In this study, a pseudotargeted gas chromatography-mass spectrometry method was employed to investigate the serum metabolic profiling of 66 significant responders and 24 nonsignificant responders at baseline and 16 weeks after gliclazide modified-release (MR) monotherapy. Clinical improvements in blood glucose level and insulin sensitivity were closely associated with the alterations of TCA cycle, ketone body metabolism, lipid oxidation, branched-chain amino acid catabolism, and gut flora metabolism. The different baseline metabolic profiling observed in the two groups implied that patients with lower dyslipidemia level may be more suitable for sulfonylurea therapy. The biomarker panel consisting of HbA1C, 5,8,11,14,17-eicosapentaenoic acid, methyl 8,11,14-eicosatrienoate, and methyl hexadecanoate shows a very good prediction ability for the suitability of glidazide treatment, and it may be meaningful in personalized medicine of T2DM patients by sulfonylurea therapy

Experimental study on LBL beams

Six specimens were made and tested to study the mechanical properties of LBL beams. The mean ultimate loading value is 68.39 MPa with a standard deviation of 6.37 MPa, giving a characteristic strength (expected to be exceeded by 95% of specimens) of 57.91 MPa, and the mean ultimate deflection is 53.3 mm with a standard deviation of 5.5 mm, giving the characteristic elastic modulus of 44.3 mm. The mean ultimate bending moment is 20.18 kN.m with a standard deviation of 1.88 kN.m, giving the characteristic elastic modulus of 17.08 kN.m. The mean elastic modulus is 9688 MPa with a standard deviation of 1765 MPa, giving the characteristic elastic modulus of 6785 MPa, and the mean modulus of rupture is 93.3 MPa with a standard deviation of 8.6 MPa, giving the characteristic elastic modulus of 79.2 MPa. The strain across the cross-section for all LBL beams is basically linear throughout the loading process, following standard beam theory

Serum Metabolomics Study of Gliclazide-Modified-Release-Treated Type 2 Diabetes Mellitus Patients Using a Gas Chromatography–Mass Spectrometry Method

Sulfonylureas are one of the commonly used drugs in type 2 diabetes mellitus (T2DM) but with considerable incidence of monotherapy failure. However, the mechanism of patients’ drug response is unclear, and suitability evaluation biomarkers are in urgent need for precision medicine. In this study, a pseudotargeted gas chromatography–mass spectrometry method was employed to investigate the serum metabolic profiling of 66 significant responders and 24 nonsignificant responders at baseline and 16 weeks after gliclazide modified-release (MR) monotherapy. Clinical improvements in blood glucose level and insulin sensitivity were closely associated with the alterations of TCA cycle, ketone body metabolism, lipid oxidation, branched-chain amino acid catabolism, and gut flora metabolism. The different baseline metabolic profiling observed in the two groups implied that patients with lower dyslipidemia level may be more suitable for sulfonylurea therapy. The biomarker panel consisting of HbA_1c, 5,8,11,14,17-eicosapentaenoic acid, methyl 8,11,14-eicosatrienoate, and methyl hexadecanoate shows a very good prediction ability for the suitability of gliclazide treatment, and it may be meaningful in personalized medicine of T2DM patients by sulfonylurea therapy