876 research outputs found

    dc-europe bulletin no. 1974.9

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    Published by Groupe democrate-chrétien du Parlement europée

    LEAD: Liberal Feature-based Distillation for Dense Retrieval

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    Knowledge distillation is often used to transfer knowledge from a strong teacher model to a relatively weak student model. Traditional knowledge distillation methods include response-based methods and feature-based methods. Response-based methods are used the most widely but suffer from lower upper limit of model performance, while feature-based methods have constraints on the vocabularies and tokenizers. In this paper, we propose a tokenizer-free method liberal feature-based distillation (LEAD). LEAD aligns the distribution between teacher model and student model, which is effective, extendable, portable and has no requirements on vocabularies, tokenizer, or model architecture. Extensive experiments show the effectiveness of LEAD on several widely-used benchmarks, including MS MARCO Passage, TREC Passage 19, TREC Passage 20, MS MARCO Document, TREC Document 19 and TREC Document 20.Comment: Work in progres

    Functional molecules in mesothelial to mesenchymal transition revealed by transcriptome analyses

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    Peritoneal fibrosis is a common complication of abdominal and pelvic surgery, and can also be triggered by peritoneal dialysis, resulting in treatment failure. In these settings, fibrosis is driven by activated myofibroblasts that are considered to be partly derived by mesothelial‐to‐mesenchymal transition (MMT). We hypothesized that, if the molecular signature of MMT could be better defined, these insights could be exploited to block this pathological cellular transition. Rat peritoneal mesothelial cells were purified by the use of an antibody against HBME1, a protein present on mesothelial cell microvilli, and streptavidin nanobead technology. After exposure of sorted cells to a well‐known mediator of MMT, transforming growth factor (TGF)‐β1, RNA sequencing was undertaken to define the transcriptomes of mesothelial cells before and during early‐phase MMT. MMT was associated with dysregulation of transcripts encoding molecules involved in insulin‐like growth factor (IGF) and bone morphogenetic protein (BMP) signalling. The application of either recombinant BMP4 or IGF‐binding protein 4 (IGFBP4) ameliorated TGF‐β1‐induced MMT in culture, as judged from the retention of epithelial morphological and molecular phenotypes, and reduced migration. Furthermore, peritoneal tissue from peritoneal dialysis patients showed less prominent immunostaining than control tissue for IGFBP4 and BMP4 on the peritoneal surface. In a mouse model of TGF‐β1‐induced peritoneal thickening, BMP4 immunostaining on the peritoneal surface was attenuated as compared with healthy controls. Finally, genetic lineage tracing of mesothelial cells was used in mice with peritoneal injury. In this model, administration of BMP4 ameliorated the injury‐induced shape change and migration of mesothelial cells. Our findings demonstrate a distinctive MMT signature, and highlight the therapeutic potential for BMP4, and possibly IGFBP4, to reduce MMT

    Measurement of azimuthal asymmetries in inclusive charged dipion production in e+ee^+e^- annihilations at s\sqrt{s} = 3.65 GeV

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    We present a measurement of the azimuthal asymmetries of two charged pions in the inclusive process e+eππXe^+e^-\rightarrow \pi\pi X based on a data set of 62 pb1\rm{pb}^{-1} at the center-of-mass energy s=3.65\sqrt{s}=3.65 GeV collected with the BESIII detector. These asymmetries can be attributed to the Collins fragmentation function. We observe a nonzero asymmetry, which increases with increasing pion momentum. As our energy scale is close to that of the existing semi-inclusive deep inelastic scattering experimental data, the measured asymmetries are important inputs for the global analysis of extracting the quark transversity distribution inside the nucleon and are valuable to explore the energy evolution of the spin-dependent fragmentation function.Comment: 7 pages, 5 figure

    Measurement of the e+eπ+π\mathrm e^+\mathrm e^-\rightarrow\mathrm\pi^+\mathrm\pi^- Cross Section between 600 and 900 MeV Using Initial State Radiation

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    We extract the e+eπ+πe^+e^-\rightarrow \pi^+\pi^- cross section in the energy range between 600 and 900 MeV, exploiting the method of initial state radiation. A data set with an integrated luminosity of 2.93 fb1^{-1} taken at a center-of-mass energy of 3.773 GeV with the BESIII detector at the BEPCII collider is used. The cross section is measured with a systematic uncertainty of 0.9%. We extract the pion form factor Fπ2|F_\pi|^2 as well as the contribution of the measured cross section to the leading order hadronic vacuum polarization contribution to (g2)μ(g-2)_\mu. We find this value to be aμππ,LO(600900  MeV)=(368.2±2.5stat±3.3sys)1010a_\mu^{\pi\pi,\rm LO}(600-900\;\rm MeV) = (368.2 \pm 2.5_{\rm stat} \pm 3.3_{\rm sys})\cdot 10^{-10}.Comment: 14 pages, 7 figures, accepted by PL

    Study of D+Kπ+e+νeD^{+} \to K^{-} \pi^+ e^+ \nu_e

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    We present an analysis of the decay D+Kπ+e+νeD^{+} \to K^{-} \pi^+ e^+ \nu_e based on data collected by the BESIII experiment at the ψ(3770)\psi(3770) resonance. Using a nearly background-free sample of 18262 events, we measure the branching fraction B(D+Kπ+e+νe)=(3.71±0.03±0.08)%\mathcal{B}(D^{+} \to K^{-} \pi^+ e^+ \nu_e) = (3.71 \pm 0.03 \pm 0.08)\%. For 0.8<mKπ<1.00.8<m_{K\pi}<1.0 GeV/c2c^{2} the partial branching fraction is B(D+Kπ+e+νe)[0.8,1]=(3.33±0.03±0.07)%\mathcal{B}(D^{+} \to K^{-} \pi^+ e^+ \nu_e)_{[0.8,1]} = (3.33 \pm 0.03 \pm 0.07)\%. A partial wave analysis shows that the dominant Kˉ(892)0\bar K^{*}(892)^{0} component is accompanied by an \emph{S}-wave contribution accounting for (6.05±0.22±0.18)%(6.05\pm0.22\pm0.18)\% of the total rate and that other components are negligible. The parameters of the Kˉ(892)0\bar K^{*}(892)^{0} resonance and of the form factors based on the spectroscopic pole dominance predictions are also measured. We also present a measurement of the Kˉ(892)0\bar K^{*}(892)^{0} helicity basis form factors in a model-independent way.Comment: 17 pages, 6 figure

    Study of J/ψJ/\psi and ψ(3686)Σ(1385)0Σˉ(1385)0\psi(3686)\rightarrow\Sigma(1385)^{0}\bar\Sigma(1385)^{0} and Ξ0Ξˉ0\Xi^0\bar\Xi^{0}

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    We study the decays of J/ψJ/\psi and ψ(3686)\psi(3686) to the final states Σ(1385)0Σˉ(1385)0\Sigma(1385)^{0}\bar\Sigma(1385)^{0} and Ξ0Ξˉ0\Xi^0\bar\Xi^{0} based on a single baryon tag method using data samples of (1310.6±7.0)×106(1310.6 \pm 7.0) \times 10^{6} J/ψJ/\psi and (447.9±2.9)×106(447.9 \pm 2.9) \times 10^{6} ψ(3686)\psi(3686) events collected with the BESIII detector at the BEPCII collider. The decays to Σ(1385)0Σˉ(1385)0\Sigma(1385)^{0}\bar\Sigma(1385)^{0} are observed for the first time. The measured branching fractions of J/ψJ/\psi and ψ(3686)Ξ0Ξˉ0\psi(3686)\rightarrow\Xi^0\bar\Xi^{0} are in good agreement with, and much more precise, than the previously published results. The angular parameters for these decays are also measured for the first time. The measured angular decay parameter for J/ψΣ(1385)0Σˉ(1385)0J/\psi\rightarrow\Sigma(1385)^{0}\bar\Sigma(1385)^{0}, α=0.64±0.03±0.10\alpha =-0.64 \pm 0.03 \pm 0.10, is found to be negative, different to the other decay processes in this measurement. In addition, the "12\% rule" and isospin symmetry in the J/ψJ/\psi and ψ(3686)ΞΞˉ\psi(3686)\rightarrow\Xi\bar\Xi and Σ(1385)Σˉ(1385)\Sigma(1385)\bar{\Sigma}(1385) systems are tested.Comment: 11 pages, 7 figures. This version is consistent with paper published in Phys.Lett. B770 (2017) 217-22
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