401 research outputs found
Reaction sintered Fe–Sialon ceramic composite: Processing, characterization and high temperature erosion wear behavior
AbstractFe–Sialon ceramic matrix composite has been newly developed from ferro-silicon alloy and commercial-grade industrial alumina powders by reaction sintering under a nitrogen atmosphere. The phase composition, mechanical properties and impact erosion wear behavior were investigated. The solid particle erosion tests have been conducted at elevated temperatures ranging from 25°C to 1200°C. Sharp SiC particles between 325 and 830μm in diameter were employed as impact abrasives. The results showed that Fe–Sialon ceramic consisted of β-Sialon and Fe3Si phases. The Z value of the as-formed β-Sialon varied from 0 to 3.2 with increasing the alumina content in the starting powders. The bending strength and Rockwell hardness gradually increased with raising the alumina addition. The erosion rate of Fe–Sialon ceramic is highly dependent on the testing temperature. The minor erosion took place at room temperature or 1200°C, while the major erosion occurred at 600–1000°C. Fe–Sialon composites showed better erosion wear resistance than the control material of alumina ceramic at 1200°C, although having much lower density and slightly lower bending strength
The clinical efficacy of ozone combined with steroid in the treatment of discogenic low back pain: a randomized, double-blinded clinical study
ObjectiveThis randomized double-blinded clinical study is to investigate the clinical efficacy of per-paravertebral disk ozone injection combined with steroids in the treatment of patients with chronic discogenic low back pain (CDLBP).MethodsGroup A (N = 60) received a per-paravertebral injection of a steroid mixture of 10 mL with pure oxygen 20 mL, while group B (N = 60) received a per-paravertebral injection of a steroid mixture of 10 mL combined with ozone 20 mL (30 μg/mL). Injections were administered once a week for 3 weeks, with a follow-up of 6 months. Clinical outcomes were assessed at week 1, month 3, and month 6 with the help of Visual Analog Scale (VAS) scores and Macnab efficacy evaluation.ResultsThe VAS score of both group A (1.65 vs. 6.87, p = 0.000) and group B (1.25 vs. 6.85, p = 0.000) at week 1 was significantly reduced compared to baseline. The effect was sustained at the 3- and 6-month follow-up periods (p < 0.05). Group B had significantly lower VAS scores at month 3 (1.53 vs. 3.82, p = 0.000) and month 6 (2.80 vs. 5.05, p = 0.000) compared to group A, respectively. Based on Macnab criteria, 95 and 96.7% of patients in groups A and B had good rates “excellent plus good” at week 1, respectively. Good rates were significantly higher in group B at month 3 (91.7 vs. 78.3%, p = 0.041) and month 6 (85.0 vs. 68.3%, p = 0.031) compared to group A, respectively. No serious adverse events were noted in both groups.ConclusionPer-paravertebral injection of steroid and ozone combination resulted in better relief of CDLBP compared to pure oxygen plus steroid.Clinical Trial RegistrationChiCTR2100044434 https://www.chictr.org.cn/showproj.html?proj=121571
Experiments on bright field and dark field high energy electron imaging with thick target material
Using a high energy electron beam for the imaging of high density matter with
both high spatial-temporal and areal density resolution under extreme states of
temperature and pressure is one of the critical challenges in high energy
density physics . When a charged particle beam passes through an opaque target,
the beam will be scattered with a distribution that depends on the thickness of
the material. By collecting the scattered beam either near or off axis,
so-called bright field or dark field images can be obtained. Here we report on
an electron radiography experiment using 45 MeV electrons from an S-band
photo-injector, where scattered electrons, after interacting with a sample, are
collected and imaged by a quadrupole imaging system. We achieved a few
micrometers (about 4 micrometers) spatial resolution and about 10 micrometers
thickness resolution for a silicon target of 300-600 micron thickness. With
addition of dark field images that are captured by selecting electrons with
large scattering angle, we show that more useful information in determining
external details such as outlines, boundaries and defects can be obtained.Comment: 7pages, 7 figure
The role of biochar properties in influencing the sorption and desorption of Pb(II), Cd(II) and As(III) in aqueous solution
The chemical and physical properties of 20 biochars produced at 350, 450, 550 and 650 °C were investigated to determine the key roles they play in the sorption and desorption of three potentially toxic elements (Pb, Cd, As). Biochar surfaces were studied using scanning electron microscopy, Fourier transform infra-red spectroscopy, X-ray diffraction and X-ray photoelectron spectroscopy. Organic functional groups (e.g. single bondCOOH, Cdouble bond; length as m-dashO, Csingle bondX), inorganic minerals (CaCO3, SiO2, Ca2Si5O10·3H2O) and cations (K+, Ca2+, Mg2+, Na+) controlled PTE sorption significantly while physical properties (morphology, surface area) showed little influence on the sorption of potentially toxic elements. Four major mechanisms accounted for the exceptionally high Pb(II) sorption by all 20 biochars (97.5–99.8%) while Cd(II) and As(III) sorption (<90% and 42% respectively) were controlled by two mechanisms (precipitation and electrostatic attraction) only. Thermodynamic studies suggested that Pb and Cd sorption on a majority of biochars was spontaneous and endothermic while As sorption was also endothermic but not spontaneous. Sorbed PTEs were observed to be very stable over a wide range of pH values (3.5–9.5) with desorption ranging from 0.2 - 16.5%. Detailed understanding of how biochar surface properties interact with PTEs increases the possibility of developing cost effective and engineered biochars with exceptional sorption characteristics
MiR-9-1 Suppresses Cell Proliferation and Promotes Apoptosis by Targeting UHRF1 in Lung Cancer
Lung cancer is listed as the most common reason for cancer-related death all over the world despite diagnostic improvements and the development of chemotherapy and targeted therapies. MicroRNAs control both physiological and pathological processes including development and cancer. A microRNA-9 to 1 (miR-9 to 1) overexpression model in lung cancer cell lines was established and miR-9 to 1 was found to significantly suppress the proliferation rate in lung cancer cell lines, colony formation in vitro, and tumorigenicity in nude mice of A549 cells. Ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) was then identified to direct target of miR-9 to 1. The inhibition of UHRF1 by miR-9 to 1 causes G1 arrest and p15, p16, and p21 were re-expressed in miR-9 to 1 group in mRNA level and protein level. Silence of UHRF1 expression in A549 cells resulted in the similar re-expression of p15, p16, p21 which is similar with miR-9 to 1 infection. Therefore, we concluded that UHRF1 is a new target for miR-9 to 1 to suppress cell proliferation by re-expression of tumor suppressors p15, p16, and p21 mediated by UHRF1
Central Role of Adenosine 5′-Phosphosulfate Reductase in the Control of Plant Hydrogen Sulfide Metabolism
Hydrogen sulfide (H2S) has been postulated to be the third gasotransmitter in both animals and plants after nitric oxide (NO) and carbon monoxide (CO). In this review, the physiological roles of H2S in plant growth, development and responses to biotic, and abiotic stresses are summarized. The enzymes which generate H2S are subjected to tight regulation to produce H2S when needed, contributing to delicate responses of H2S to environmental stimuli. H2S occupies a central position in plant sulfur metabolism as it is the link of inorganic sulfur to the first organic sulfur-containing compound cysteine which is the starting point for the synthesis of methionine, coenzyme A, vitamins, etc. In sulfur assimilation, adenosine 5′-phosphosulfate reductase (APR) is the rate-limiting enzyme with the greatest control over the pathway and probably the generation of H2S which is an essential component in this process. APR is an evolutionarily conserved protein among plants, and two conserved domains PAPS_reductase and Thioredoxin are found in APR. Sulfate reduction including the APR-catalyzing step is carried out in chloroplasts. APR, the key enzyme in sulfur assimilation, is mainly regulated at transcription level by transcription factors in response to sulfur availability and environmental stimuli. The cis-acting elements in the promoter region of all the three APR genes in Solanum lycopersicum suggest that multiple factors such as sulfur starvation, cytokinins, CO2, and pathogens may regulate the expression of SlAPRs. In conclusion, as a critical enzyme in regulating sulfur assimilation, APR is probably critical for H2S generation during plants’ response to diverse environmental factors
Evaluating biochar and its modifications for the removal of ammonium, nitrate, and phosphate in water
Removal of nitrogen (N) and phosphorus (P) from water through the use of various sorbents is often considered an economically viable way for supplementing conventional methods. Biochar has been widely studied for its potential adsorption capabilities for soluble N and P, but the performance of different types of biochars can vary widely. In this review, we summarized the adsorption capacities of biochars in removing N (NH4-N and NO3-N) and P (PO4-P) based on the reported data, and discussed the possible mechanisms and influencing factors. In general, the NH4-N adsorption capacity of unmodified biochars is relatively low, at levels of less than 20 mg/g. This adsorption is mainly via ion exchange and/or interactions with oxygen-containing functional groups on biochar surfaces. The affinity is even lower for NO3-N, because of electrostatic repulsion by negatively charged biochar surfaces. Precipitation of PO4-P by metals/metal oxides in biochar is the primary mechanism for PO4-P removal. Biochars modified by metals have a significantly higher capacity to remove NH4-N, NO3-N, and PO4-P than unmodified biochar, due to the change in surface charge and the increase in metal oxides on the biochar surface. Ambient conditions in the aqueous phase, including temperature, pH, and co-existing ions, can significantly alter the adsorption of N and P by biochars, indicating the importance of optimal processing parameters for N and P removal. However, the release of endogenous N and P from biochar to water can impede its performance, and the presence of competing ions in water poses practical challenges for the use of biochar for nutrient removal. This review demonstrates that progress is needed to improve the performance of biochars and overcome challenges before the widespread field application of biochar for N and P removal is realized
Cost-effectiveness analysis of neonatal hearing screening program in china: should universal screening be prioritized?
Photodegradation of organic pollutants RhB dye using UV simulated sunlight on ceria based TiO2 nanomaterials for antibacterial applications
To photo-catalytically degrade RhB dye using solar irradiation, CeO2 doped TiO2 nanocomposites were synthesized hydrothermally at 700 °C for 9 hrs. All emission spectra showed a prominent band centered at 442 nm that was attributed to oxygen related defects in the CeO2-TiO2 nanocrystals. Two sharp absorption bands at 1418 cm−1 and 3323 cm−1 were attributed to the deformation and stretching vibration, and bending vibration of the OH group of water physisorbed to TiO2, respectively. The photocatalytic activities of Ce-TiO2 nanocrystals were investigated through the degradation of RhB under UV and UV+ visible light over a period of 8 hrs. After 8 hrs, the most intense absorption peak at 579 nm disappeared under the highest photocatalytic activity and 99.89% of RhB degraded under solar irradiation. Visible light-activated TiO2 could be prepared from metal-ion incorporation, reduction of TiO2, non-metal doping or sensitizing of TiO2 using dyes. Studying the antibacterial activity of Ce-TiO2 nanocrystals against E. coli revealed significant activity when 10 μg was used, suggesting that it can be used as an antibacterial agent. Its effectiveness is likely related to its strong oxidation activity and superhydrophilicity. This study also discusses the mechanism of heterogeneous photocatalysis in the presence of TiO2
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