Micromachined membrane particle filters

We report here several particle membrane filters (8 x 8 mm^2) with circular, hexagonal and rectangular through holes. By varying hole dimensions from 6 to 12 pm, opening factors from 4 to 45 % are achieved. In order to improve the filter robustness, a composite silicon nitride/Parylene membrane technology is developed. More importantly, fluid dynamic performance of the filters is also studied by both experiments and numerical simulations. It is found that the gaseous flow through the filters depends strongly on opening factors, and the measured pressure drops are much lower than that from numerical simulation using the Navier-Stokes equation. Interestingly, surface velocity slip can only account for a minor part of the discrepancy. This suggests that a very interesting topic for micro fluid mechanics research is identified

Improved tabu search and simulated annealing methods for nonlinear data assimilation

Nonlinear data assimilation can be a very challenging task. Four local search methods are proposed for nonlinear data assimilation in this paper. The methods work as follows: At each iteration, the observation operator is linearized around the current solution, and a gradient approximation of the three dimensional variational (3D-Var) cost function is obtained. Then, samples along potential steepest descent directions of the 3D-Var cost function are generated, and the acceptance/rejection criteria for such samples are similar to those proposed by the Tabu Search and the Simulated Annealing framework. In addition, such samples can be drawn within certain sub-spaces so as to reduce the computational effort of computing search directions. Once a posterior mode is estimated, matrix-free ensemble Kalman filter approaches can be implemented to estimate posterior members. Furthermore, the convergence of the proposed methods is theoretically proven based on the necessary assumptions and conditions. Numerical experiments have been performed by using the Lorenz-96 model. The numerical results show that the cost function values on average can be reduced by several orders of magnitudes by using the proposed methods. Even more, the proposed methods can converge faster to posterior modes when sub-space approximations are employed to reduce the computational efforts among iterations

MRI-guided gene therapy

Cataloged from PDF version of article.MRI has the ability to generate high-contrast and high-resolution images, to obtain multiple diagnostic evaluations of organ function and morphology, and to provide multiple image planes with no risk of ionizing radiation. Recent efforts have focused on using MR technology to monitor gene delivery, to enhance gene transfection/transduction, and to track gene expression. This review summarizes the current status of MRIguided gene therapy. (C) 2006 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societie

Analyse de fiabilité en modélisation hydrologique: Concepts et applications au modèle pluies-débits GR3

Pour étudier les incertitudes d'un modèle hydrologique, on peut employer l'analyse de fiabilité, méthode couramment utilisée dans le domaine de la résistance des structures et du génie hydraulique. Cet outil peut être transposé dans le domaine hydrologique pour juger de la qualité d'un modèle. Un modèle hydrologique sera fiable si, sur une série de données test, l'ajustement obtenu avec un jeu de paramètres recommandé pour un fonctionnement passe-partout est, selon toute probabilité, d'une qualité proche de l'ajustement idéal correspondant au calage du jeu de paramètres sur l'échantillon test. Ce papier montre comment adapter chacun des concepts de l'analyse de fiabilité en hydrologie et détaille la technique des deux premiers moments afin de calculer explicitement la fiabilité d'un modèle-pluie débit en réalisant un développement limité au voisinage du point de fonctionnement du modèle.Cette approche par analyse de fiabilité est appliquée au modèle GR3 à titre d'illustration pour juger de la pertinence de ce modèle pluie-débit conceptuel à trois paramètres en situation de prédiction des crues à court pas de temps sur un bassin versant situé dans la région de la Côte d'Azur en France . Les résultats numériques obtenus montrent le caractère opérationnel de cette approche très simple. D'autre part, ces calculs de fiabilité mettent en évidence la réponse du modèle à chacun des paramètres. Enfin en mesurant la performance de représentativité d'un modèle selon plusieurs dimensions telles l'erreur quadratique d'ajustement, l'erreur sur le volume de crue prévue ou l'importance de l'écart de pointe de crue, l'analyse de fiabilité peut être naturellement étendue vers une approche multicritère en considérant des probabilités conjointes de satisfaction du modèle sur chacun de ces critères.Reliability analysis is a method for evaluating the risk of failure of a system and this concept is widely used in structure design. The theory can be conveniently transposed to the field of water sciences so as to evaluate the quality of hydrologic models. Hydrological reliability of a model is defined as the probability that there will not be significant different performances between this model, with parameters assessed on the basis of a large sample including various hydrological conditions, and the same model running with ad hoc parameters estimated from the test sample. Consequently a tolerance threshold has to be introduced in reliability analysis for hydrological models. A number of conceptual differences between validation and reliability analysis are reviewed and categorized.This paper shows how to adapt the concepts of reliability to hydrology and gives details of the first two moment technique that can be implemented to compute the reliability of a rainfall runoff model. This technique is based on a Taylor series developed in the neighborhood of the model working point. This simplification allows for an explicit expression of the expectation and the variance of the hydrological model performance as functions of the marginal sensitivity of the criterion and the parameter uncertainties. A Student ratio can be easily computed to evaluate the quality of a hydrological model from a reliability-based point of view.The GR3 model is used to illustrate this technique. A reliability analysis of this three parameter conceptual rainfall-runoff model gives new insight into the performance of the model for short-term flood prediction in the Réal Collobrier river basin located in the French Côte d'Azur. Numerical results show that the reliability analysis approach is very simple and of practical interest. For 16 of the 18 samples used for validation, the GR3 rainfall runoff model proved to be reliable on the basis of the three criteria used in this paper to evaluate the quality of a hydrological model (general quadratic deviation loss of runoffs, flood volume error and flood peak error). Using reliability analysis, contributions of each parameter to the variance of the performance function can be conveniently identified. For the GR3 model and the Réal Collobrier case study, the impacts of each parameter on the model efficiency are as follows:- The contribution of a parameter varies from one criterion to another. This indicates that a parameter originally designed to play a specific role in the modeling of the rainfall runoff transformation process does contribute to the criterion that best describes this function, which confirms the conceptual "good sense" of GR3. - For each criterion, the cross contributions are very low: the GR3 model satisfies the principle of parsimony and each parameter adds something different to the general behavior of GR3. In this case study, the GR3 model exhibits a good balance between complexity and quality for hydrological models.Finally, reliability analysis can provide a multicriteria point of view of the model qualities by changing the various indices of performance. Extension of reliability analysis towards engineering risk would include the estimation of joint probability distributions for these multiple criteria of interest

Late Holocene forcing of the Asian winter and summer monsoon as evidenced by proxy records from the northern Qinghai-Tibetan Plateau

Little is known about decadal- to centennial-scale climate variability and its associated forcing mechanisms on the Qinghai-Tibetan Plateau. A decadal-resolution record of total organic carbon (TOC) and grainsize retrieved from a composite piston core from Kusai Lake, NW China, provides solid evidence for decadal- to centennial-scale Asian monsoon variability for the Northern Qinghai-Tibetan Plateau during the last 3770 yr. Intensified winter and summer monsoons are well correlated with respective reductions and increases in solar irradiance. A number of intensified Asian winter monsoon phases are potentially correlated with North Atlantic climatic variations including Bond events 0 to 2 and more recent subtle climate changes from the Medieval Warm Period to the Little Ice Age. Our findings indicate that Asian monsoon changes during the late Holocene are forced by changes in both solar output and oceanic-atmospheric circulation patterns. Our results demonstrate that these forcing mechanisms operate not only in low latitudes but also in mid-latitude regions (the Northern Qinghai-Tibetan Plateau)

Structure-Induced Reversible Anionic Redox Activity in Na Layered Oxide Cathode

Anionic redox reaction (ARR) in lithium- and sodium-ion batteries is under hot discussion, mainly regarding how oxygen anion participates and to what extent oxygen can be reversibly oxidized and reduced. Here, a P3-type Na0.6[Li0.2Mn0.8]O2 with reversible capacity from pure ARR was studied. The interlayer O-O distance (peroxo-like O-O dimer, 2.506(3) Å), associated with oxidization of oxygen anions, was directly detected by using a neutron total scattering technique. Different from Li2RuO3 or Li2IrO3 with strong metal-oxygen (M-O) bonding, for P3-type Na0.6[Li0.2Mn0.8]O2 with relatively weak Mn-O covalent bonding, crystal structure factors might play an even more important role in stabilizing the oxidized species, as both Li and Mn ions are immobile in the structure and thus may inhibit the irreversible transformation of the oxidized species to O2 gas. Utilization of anionic redox reaction (ARR) on oxygen has been considered as an effective way to promote the charge-discharge capacity of the layered oxide cathodes for lithium- or sodium-ion batteries. The detailed mechanism of ARR, in particular how crystal structure affects and coordinates with the ARR, is not yet well understood. In the present work, a combination of X-ray and neutron total scattering measurements has been performed to study the structure of the prototype P3-type layered Na0.6[Li0.2Mn0.8]O2 with pure ARR. Unique structural characteristics, rather than prevailing knowledge of covalency of metal-oxygen, enable the stabilization of the crystal structure of Na0.6[Li0.2Mn0.8]O2 along with the ARR. This work suggests that reversible ARR can be manipulated by proper structure designs, thus to achieve high lithium or sodium storage in layered oxide cathodes. For P3-type Na0.6[Li0.2Mn0.8]O2 with relatively weak Mn-O covalent bonding, crystal structure factors play an important role in stabilizing the oxidized species, inhibiting the irreversible transformation of the oxidized species to O2 gas. The finding is important for better design of layered oxide positive materials with higher reversible capacity via the introduction of a reversible anionic redox reaction

Ant colony optimization with immigrants schemes in dynamic environments

This is the post-print version of this article. The official published version can be accessed from the link below - Copyright @ 2010 Springer-VerlagIn recent years, there has been a growing interest in addressing dynamic optimization problems (DOPs) using evolutionary algorithms (EAs). Several approaches have been developed for EAs to increase the diversity of the population and enhance the performance of the algorithm for DOPs. Among these approaches, immigrants schemes have been found beneficial for EAs for DOPs. In this paper, random, elitismbased, and hybrid immigrants schemes are applied to ant colony optimization (ACO) for the dynamic travelling salesman problem (DTSP). The experimental results show that random immigrants are beneficial for ACO in fast changing environments, whereas elitism-based immigrants are beneficial for ACO in slowly changing environments. The ACO algorithm with hybrid immigrants scheme combines the merits of the random and elitism-based immigrants schemes. Moreover, the results show that the proposed algorithms outperform compared approaches in almost all dynamic test cases and that immigrant schemes efficiently improve the performance of ACO algorithms in DTSP.This work was supported by the Engineering and Physical Sciences Research Council (EPSRC) of UK under Grant EP/E060722/1

Effects of nano-void density, size, and spatial population on thermal conductivity: a case study of GaN crystal

The thermal conductivity of a crystal is sensitive to the presence of surfaces and nanoscale defects. While this opens tremendous opportunities to tailor thermal conductivity, a true "phonon engineering" of nanocrystals for a specific electronic or thermoelectric application can only be achieved when the dependence of thermal conductivity on the defect density, size, and spatial population is understood and quantified. Unfortunately, experimental studies of effects of nanoscale defects are quite challenging. While molecular dynamics simulations are effective in calculating thermal conductivity, the defect density range that can be explored with feasible computing resources is unrealistically high. As a result, previous work has not generated a fully detailed understanding of the dependence of thermal conductivity on nanoscale defects. Using GaN as an example, we have combined physically-motivated analytical model and highly-converged large scale molecular dynamics simulations to study effects of defects on thermal conductivity. An analytical expression for thermal conductivity as a function of void density, size, and population has been derived and corroborated with the model, simulations, and experiments