Information systems deployment in Libyan oil companies: two case studies

This article assesses information systems deployment in two oil companies in Libya and thereby helps address the general shortage of information on the implementation of information systems in Libyan companies. It explores the information systems strategies of these two companies and explores and analyses how these have been implemented in recent years. One company has pursued an in-house/best of breed approach, whilst the other is in the process of migrating to an integrated ERP software solution. The study uses a number of analytical models developed in a western context in recent years to assess the status and nature of IS deployment, and concludes that a combination of these models is of value in an IS industry context in developing world countries

X-ray and optical observations of the unique binary system HD49798/RXJ0648.0-4418

We report the results of XMM-Newton observations of HD49798/RXJ0648.0-4418, the only known X-ray binary consisting of a hot sub-dwarf and a white dwarf. The white dwarf rotates very rapidly (P=13.2 s) and has a dynamically measured mass of 1.28+/-0.05 M_sun. Its X-ray emission consists of a strongly pulsed, soft component, well fit by a blackbody with kT~40 eV, accounting for most of the luminosity, and a fainter hard power-law component (photon index ~1.6). A luminosity of ~10^{32} erg/s is produced by accretion onto the white dwarf of the helium-rich matter from the wind of the companion, which is one of the few hot sub-dwarfs showing evidence of mass-loss. A search for optical pulsations at the South African Astronomical Observatory 1.9-m telescope gave negative results. X-rays were detected also during the white dwarf eclipse. This emission, with luminosity 2x10^{30} erg/s, can be attributed to HD 49798 and represents the first detection of a hot sub-dwarf star in the X-ray band. HD49798/RXJ0648.0-4418 is a post-common envelope binary which most likely originated from a pair of stars with masses ~8-10 M_sun. After the current He-burning phase, HD 49798 will expand and reach the Roche-lobe, causing a higher accretion rate onto the white dwarf which can reach the Chandrasekhar limit. Considering the fast spin of the white dwarf, this could lead to the formation of a millisecond pulsar. Alternatively, this system could be a Type Ia supernova progenitor with the appealing characteristic of a short time delay, being the descendent of relatively massive stars.Comment: Accepted for publication on The Astrophysical Journa

Gamma-ray bursts, supernova kicks, and gravitational radiation

We suggest that the collapsing core of a massive rotating star may fragment to produce two or more compact objects. Their coalescence under gravitational radiation gives the resulting black hole or neutron star a significant kick velocity, which may explain those observed in pulsars. A gamma-ray burst can result only when this kick is small. Thus only a small fraction of core-collapse supernovae produce gamma-ray bursts. The burst may be delayed significantly (hours - days) after the supernova, as suggested by recent observations. If this picture is correct, core-collapse supernovae should be significant sources of gravitational radiation with a chirp signal similar to a coalescing binary.Comment: 10 pages, 2 figures; submitted to ApJ Letter

High-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow-derived macrophages

Macrophages are important immune cells operating at the forefront of innate immunity by taking up foreign particles and microbes through phagocytosis. The RAW 264.7 cell line is commonly used for experiments in the macrophage and phagocytosis field. However, little is known how its functions compare to primary macrophages. Here, we have performed an in‐depth proteomics characterization of phagosomes from RAW 264.7 and bone marrow derived macrophages by quantifying more than 2500 phagosomal proteins. Our data indicate that there are significant differences for a large number of proteins including important receptors such as mannose receptor 1 and Siglec‐1. Moreover, bone marrow derived macrophages phagosomes mature considerably faster by fusion with endosomes and the lysosome which we validated using fluorogenic phagocytic assays. We provide a valuable resource for researcher in the field and recommend careful use of the RAW 264.7 cell line when studying phagosome functions. All MS data have been deposited in the ProteomeXchange with identifier PXD001293 (http://proteomecentral.proteomexchange.org/dataset/PXD001293)

Periprosthetic fractures: the next fragility fracture epidemic? A national observational study

Objectives: Periprosthetic fractures have considerable clinical implications for patients and financial implications for healthcare systems. This study aims to determine the burden of periprosthetic fractures of the lower and upper limbs in England and identify any factors associated with differences in treatment and outcome. Design: A national, observational study. Setting: England. Participants: All individuals admitted to hospital with periprosthetic fractures between 1 April 2015 and 31 December 2018. Primary and secondary outcome measures: Mortality, length of stay, change in rate of admissions. Methods: We analysed Hospital Episode Statistics data using the International Classification of Diseases 10th Revision code M96.6 (Fracture of bone following insertion of orthopaedic implant, joint prosthesis, or bone plate) to identify periprosthetic fractures recorded between April 2013 and December 2018. We determined the demographics, procedures performed, mortality rates and discharge destinations. Patient characteristics associated with having a procedure during the index admission were estimated using logistic regression. The annual rate of increase in admissions was estimated using Poisson regression. Results: Between 1 April 2015 and 31 December 2018, there were 13 565 patients who had 18 888 admissions (89.5% emergency) with M96.6 in the primary diagnosis field. There was a 13% year-on-year increase in admissions for periprosthetic fracture in England during that period. Older people, people living in deprived areas and those with heart failure or neurological disorders were less likely to receive an operation. 14.4% of patients did not return home after hospital discharge. The overall inpatient mortality was 4.3% and total 30-day mortality was 3.3%. Conclusions: The clinical and operational burden of periprosthetic fractures is considerable and increasing rapidly. We suggest that the management of people with periprosthetic fractures should be undertaken and funded in a similar manner to that successfully employed for people sustaining hip fractures, using national standards and data collection to monitor and improve performance

Periprosthetic fractures: the next fragility fracture epidemic? A national observational study

Objectives: Periprosthetic fractures have considerable clinical implications for patients and financial implications for healthcare systems. This study aims to determine the burden of periprosthetic fractures of the lower and upper limbs in England and identify any factors associated with differences in treatment and outcome. Design: A national, observational study. Setting: England. Participants: All individuals admitted to hospital with periprosthetic fractures between 1 April 2015 and 31 December 2018. Primary and secondary outcome measures: Mortality, length of stay, change in rate of admissions. Methods: We analysed Hospital Episode Statistics data using the International Classification of Diseases 10th Revision code M96.6 (Fracture of bone following insertion of orthopaedic implant, joint prosthesis, or bone plate) to identify periprosthetic fractures recorded between April 2013 and December 2018. We determined the demographics, procedures performed, mortality rates and discharge destinations. Patient characteristics associated with having a procedure during the index admission were estimated using logistic regression. The annual rate of increase in admissions was estimated using Poisson regression. Results: Between 1 April 2015 and 31 December 2018, there were 13 565 patients who had 18 888 admissions (89.5% emergency) with M96.6 in the primary diagnosis field. There was a 13% year-on-year increase in admissions for periprosthetic fracture in England during that period. Older people, people living in deprived areas and those with heart failure or neurological disorders were less likely to receive an operation. 14.4% of patients did not return home after hospital discharge. The overall inpatient mortality was 4.3% and total 30-day mortality was 3.3%. Conclusions: The clinical and operational burden of periprosthetic fractures is considerable and increasing rapidly. We suggest that the management of people with periprosthetic fractures should be undertaken and funded in a similar manner to that successfully employed for people sustaining hip fractures, using national standards and data collection to monitor and improve performance