An Investigation of the Contributions of Gender, Shopping Orientation, Online Experience, and Website\u27s Interactive Features to Consumers\u27 Intentions to Engage in Apparel E-commerce Shopping

E-commerce has experienced exponential growth within the last few years. The rapid growth of e-commerce has created a need to improve consumer acceptance and the consumer\u27s intention to engage in e-commerce. Female consumers have yet to embrace e-commerce as readily as male consumers. Differences between male and female consumer shopping behavior were examined. This study developed and empirically tested a model to predict the consumer\u27s intention to engage in apparel e-commerce shopping based on the constructs of gender, shopping orientation, online experience, and Website\u27s interactive features. Male and female U.S. consumers age 18 and older were surveyed to determine their intention to engage in apparel e-commerce shopping. A total of 240 responses were received. After the pre-analysis data screening, a total of 216 responses were available for further analyses. Factor analysis was conducted by using principal component analysis (PCA) with VARIMAX rotation. The PCA resulted in four new factors including consumer shopping preference (CSP), personalization Website features (PWF), shopping environment (SE), and social interaction (SI). The statistical method Ordinal Logistic Regression (OLR) was used to predict whether gender (G1), CSP, PWF, SE, and SI have a significant influence on the consumer\u27s intention to engage in apparel e-commerce shopping. Results of the OLR indicated that CSP was the only significant predictor of INT. A second OLR model was developed to determine the interaction effect of G1, CSP, PWF, SE, and SI used to predict the probability of INT. Results indicated the interactions of G1 and CSP, CSP and PWF, G1 and PWF, as well as SE and SI were significant predictors of INT. Two important contributions of this study include 1) an investigation of the key constructs that contribute to the consumer\u27s intention to engage in apparel e-commerce shopping, and 2) an investigation of the interaction effect between the key constructs used to predict the consumer\u27s intention to engage in apparel e-commerce shopping. The investigation results provide online retailers with the knowledge of how to increase e-commerce acceptance through understanding differences in male and female consumer shopping behaviors

Ancient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals

Mammals diversified by colonizing drastically different environments, with each transition yielding numerous molecular changes, including losses of protein function. Though not initially deleterious, these losses could subsequently carry deleterious pleiotropic consequences. We have used phylogenetic methods to identify convergent functional losses across independent marine mammal lineages. In one extreme case, Paraoxonase 1 (PON1) accrued lesions in all marine lineages, while remaining intact in all terrestrial mammals. These lesions coincide with PON1 enzymatic activity loss in marine species’ blood plasma. This convergent loss is likely explained by parallel shifts in marine ancestors’ lipid metabolism and/or bloodstream oxidative environment affecting PON1’s role in fatty acid oxidation. PON1 loss also eliminates marine mammals’ main defense against neurotoxicity from specific man-made organophosphorus compounds, implying potential risks in modern environment

Ancient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals

Mammals diversified by colonizing drastically different environments, with each transition yielding numerous molecular changes, including losses of protein function. Though not initially deleterious, these losses could subsequently carry deleterious pleiotropic consequences. We have used phylogenetic methods to identify convergent functional losses across independent marine mammal lineages. In one extreme case, Paraoxonase 1 (PON1) accrued lesions in all marine lineages, while remaining intact in all terrestrial mammals. These lesions coincide with PON1 enzymatic activity loss in marine species’ blood plasma. This convergent loss is likely explained by parallel shifts in marine ancestors’ lipid metabolism and/or bloodstream oxidative environment affecting PON1’s role in fatty acid oxidation. PON1 loss also eliminates marine mammals’ main defense against neurotoxicity from specific man-made organophosphorus compounds, implying potential risks in modern environment

Oscillatory activity in the infant brain and the representation of small numbers

Gamma-band oscillatory activity (GBA) is an established neural signature of sustained occluded object representation in infants and adults. However, it is not yet known whether the magnitude of GBA in the infant brain reflects the quantity of occluded items held in memory. To examine this, we compared GBA of 6–8 month-old infants during occlusion periods after the representation of two objects vs. that of one object. We found that maintaining a representation of two objects during occlusion resulted in significantly greater GBA relative to maintaining a single object. Further, this enhancement was located in the right occipital region, which is consistent with previous object representation research in adults and infants. We conclude that enhanced GBA reflects neural processes underlying infants’ representation of small numbers

Muc5ac: a critical component mediating the rejection of enteric nematodes

The mucin Muc5ac is essential for the expulsion of Trichuris muris and other gut-dwelling nematodes

DNAJC21 Mutations Link a Cancer-Prone Bone Marrow Failure Syndrome to Corruption in 60S Ribosome Subunit Maturation

This work was funded by The Medical Research Council UK (MR/K000292/1), Children with Cancer UK (2013/144), Barts and The London Charity (845/1796), and Leukaemia Lymphoma Research/Bloodwise (14032)

The evolution of Home Economics as a subject in Irish primary and post-primary education from the 1800s to the twenty-first century

This paper is a historical review, documenting the evolution of Home Economics as a subject in Irish primary and post-primary education from the 1800s to the twenty-first century. In the 1800s and early twentieth-century domestic subjects, including cookery, was widely taught to females in both primary and post-primary schools. The philosophical underpinning of the subject was to enhance the quality of life for families. The subject remained a popular choice for young women up until the establishment of the Irish Free State which, thereafter, witnessed many changes in the teaching of cookery and domestic science in primary and post-primary schools. The core ideology of the subject has remained relevant and it aims to provide students with knowledge, practical skills, understanding and attitudes for everyday life as individuals and as family members. This reflects the richness of the subject from the past and the relevance of the subject in addressing issues of a twenty-first century society

Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine

Despite rapid technical progress and demonstrable effectiveness for some types of diagnosis and therapy, much remains to be learned about clinical genome and exome sequencing (CGES) and its role within the practice of medicine. The Clinical Sequencing Exploratory Research (CSER) consortium includes 18 extramural research projects, one National Human Genome Research Institute (NHGRI) intramural project, and a coordinating center funded by the NHGRI and National Cancer Institute. The consortium is exploring analytic and clinical validity and utility, as well as the ethical, legal, and social implications of sequencing via multidisciplinary approaches; it has thus far recruited 5,577 participants across a spectrum of symptomatic and healthy children and adults by utilizing both germline and cancer sequencing. The CSER consortium is analyzing data and creating publically available procedures and tools related to participant preferences and consent, variant classification, disclosure and management of primary and secondary findings, health outcomes, and integration with electronic health records. Future research directions will refine measures of clinical utility of CGES in both germline and somatic testing, evaluate the use of CGES for screening in healthy individuals, explore the penetrance of pathogenic variants through extensive phenotyping, reduce discordances in public databases of genes and variants, examine social and ethnic disparities in the provision of genomics services, explore regulatory issues, and estimate the value and downstream costs of sequencing. The CSER consortium has established a shared community of research sites by using diverse approaches to pursue the evidence-based development of best practices in genomic medicine