14,865 research outputs found
An Efficient Method for the Surface Functionalization of Luminescent Quantum Dots with Lipoic Acid Based Ligands
We describe herein an operationally advantageous general methodology for efficiently activating lipoic acid based compounds, a family of popular surface ligands for semiconductor nanocrystals, through the use of a borohydride exchange resin, and the use of the activated species to replace the native surface ligands of quantum dots. The procedure enabled phase transfer of the nanocrystals between polar and aqueous media and, if unsubstituted lipoic acid was used, a facile adjustment of their solubility in a wide range of solvents with varying polarity (from hexane to water). We show that the protocol is applicable to different types of nanocrystals and a variety of lipoic acid based ligands, and that the resulting quantum dots maintain their optical properties, in particular, an intense luminescence, and long-term colloidal stability
Accurate Liability Estimation Improves Power in Ascertained Case Control Studies
Linear mixed models (LMMs) have emerged as the method of choice for
confounded genome-wide association studies. However, the performance of LMMs in
non-randomly ascertained case-control studies deteriorates with increasing
sample size. We propose a framework called LEAP (Liability Estimator As a
Phenotype, https://github.com/omerwe/LEAP) that tests for association with
estimated latent values corresponding to severity of phenotype, and demonstrate
that this can lead to a substantial power increase
Femtosecond nonlinear ultrasonics in gold probed with ultrashort surface plasmons
Fundamental interactions induced by lattice vibrations on ultrafast time
scales become increasingly important for modern nanoscience and technology.
Experimental access to the physical properties of acoustic phonons in the THz
frequency range and over the entire Brillouin zone is crucial for understanding
electric and thermal transport in solids and their compounds. Here, we report
on the generation and nonlinear propagation of giant (1 percent) acoustic
strain pulses in hybrid gold/cobalt bilayer structures probed with ultrafast
surface plasmon interferometry. This new technique allows for unambiguous
characterization of arbitrary ultrafast acoustic transients. The giant acoustic
pulses experience substantial nonlinear reshaping already after a propagation
distance of 100 nm in a crystalline gold layer. Excellent agreement with the
Korteveg-de Vries model points to future quantitative nonlinear femtosecond
THz-ultrasonics at the nano-scale in metals at room temperature
An efficient method for the surface functionalization of luminescent quantum dots with lipoic acid-based ligands
We describe an operationally advantageous general methodology to efficiently activate lipoic acid-based compounds - a
family of popular surface ligands for semiconductor nanocrystals - by
the use of a borohydride exchange resin, and the use of the activated species to replace the native surface ligands of quantum dots. The procedure enables the phase transfer of the nanocrystals between
polar and aqueous media and, if unsubstituted lipoic acid is used, a
facile adjustment of their solubility in a wide range of solvents with varying polarity (from hexane to water). We show that the protocol is applicable to different types of nanocrystals and a variety of lipoic acid-based ligands, and that the resulting quantum dots maintain their optical properties - in particular, an intense luminescence - and long
term colloidal stability
Dynamically Driven Evolution of the Interstellar Medium in M51
Massive star formation occurs in giant molecular clouds (GMCs); an understanding of the evolution of GMCs is a prerequisite to develop theories of star formation and galaxy evolution. We report the highest-fidelity observations of the grand-design spiral galaxy M51 in carbon monoxide (CO) emission, revealing the evolution of GMCs vis-a-vis the large-scale galactic structure and dynamics. The most massive GMCs (giant molecular associations (GMAs)) are first assembled and then broken up as the gas flow through the spiral arms. The GMAs and their H_2 molecules are not fully dissociated into atomic gas as predicted in stellar feedback scenarios, but are fragmented into smaller GMCs upon leaving the spiral arms. The remnants of GMAs are detected as the chains of GMCs that emerge from the spiral arms into interarm regions. The kinematic shear within the spiral arms is sufficient to unbind the GMAs against self-gravity. We conclude that the evolution of GMCs is driven by large-scale galactic dynamics—their coagulation into GMAs is due to spiral arm streaming motions upon entering the arms, followed by fragmentation due to shear as they leave the arms on the downstream side. In M51, the majority of the gas remains molecular from arm entry through the interarm region and into the next spiral arm passage
Dynamically Driven Evolution of the Interstellar Medium in M51
We report the highest-fidelity observations of the spiral galaxy M51 in CO
emission, revealing the evolution of giant molecular clouds (GMCs) vis-a-vis
the large-scale galactic structure and dynamics. The most massive GMCs
(so-called GMAs) are first assembled and then broken up as the gas flow through
the spiral arms. The GMAs and their H2 molecules are not fully dissociated into
atomic gas as predicted in stellar feedback scenarios, but are fragmented into
smaller GMCs upon leaving the spiral arms. The remnants of GMAs are detected as
the chains of GMCs that emerge from the spiral arms into interarm regions. The
kinematic shear within the spiral arms is sufficient to unbind the GMAs against
self-gravity. We conclude that the evolution of GMCs is driven by large-scale
galactic dynamics --their coagulation into GMAs is due to spiral arm streaming
motions upon entering the arms, followed by fragmentation due to shear as they
leave the arms on the downstream side. In M51, the majority of the gas remains
molecular from arm entry through the inter-arm region and into the next spiral
arm passage.Comment: 6 pages, including 3 figures. Accepted, ApJ
Changes in the use of coronary artery revascularization procedures in the Department of Veterans Affairs, the National Hospital Discharge Survey, and the Nationwide Inpatient Sample, 1991–1999
BACKGROUND: There have been dramatic increases in the number of coronary artery bypass surgeries (CABS) and percutaneous coronary interventions (PCI) performed during the last decade. Whether this finding is true for revascularization procedures performed in Department of Veterans Affairs (VA) medical centers is the subject of this paper. METHODS: This study compared the number of revascularization procedures and rates of use in the VA, the National Hospital Discharge Survey, and the Nationwide Inpatient Sample. Included were men who underwent isolated CABS and/or PCI, including stenting, between 1991 and 1999, although data for the Nationwide Inpatient Sample were available only between 1993 and 1997. Age adjusted use rates were calculated with the direct method of standardization. RESULTS: The percent of users of VA healthcare 75 years and older increased from 10% in 1991 to 20% in 1999. In the VA, the number of isolated CABS declined from 6227 in 1991 to 6147 in 1999, whereas age adjusted rates declined from 167.6 per 100,000 in 1991 to 107.9 per 100,000 in 1999. In the 2 national surveys, both the estimated numbers of procedures and use rates increased over time. In all 3 settings, there were increases in both numbers and rate of PCI from 1993, although in the VA, use rates decreased from 191.2 per 100,000 in 1996 to 139.7 per 100,000 in 1999. VA use rates for both CABS and PCI were lower than those in the 2 national surveys. CONCLUSION: Age adjusted rates of CABS and PCI were lower in the VA than in 2 national surveys. Since 1996, there has been a decrease in the rate of use of revascularization procedures in the VA
VHF radar and MF/HF dynasonde observations during Polar Mesosphere Summer Echoes conditions at EISCAT
First GIS analysis of modern stone tools used by wild chimpanzees (Pan troglodytes verus) in Bossou, Guinea, West Africa
Stone tool use by wild chimpanzees of West Africa offers a unique opportunity to explore the evolutionary roots of technology during human evolution. However, detailed analyses of chimpanzee stone artifacts are still lacking, thus precluding a comparison with the earliest archaeological record. This paper presents the first systematic study of stone tools used by wild chimpanzees to crack open nuts in Bossou (Guinea-Conakry), and applies pioneering analytical techniques to such artifacts. Automatic morphometric GIS classification enabled to create maps of use wear over the stone tools (anvils, hammers, and hammers/anvils), which were blind tested with GIS spatial analysis of damage patterns identified visually. Our analysis shows that chimpanzee stone tool use wear can be systematized and specific damage patterns discerned, allowing to discriminate between active and passive pounders in lithic assemblages. In summary, our results demonstrate the heuristic potential of combined suites of GIS techniques for the analysis of battered artifacts, and have enabled creating a referential framework of analysis in which wild chimpanzee battered tools can for the first time be directly compared to the early archaeological record.Leverhulme Trust [IN-052]; MEXT [20002001, 24000001]; JSPS-U04-PWS; FCT-Portugal [SFRH/BD/36169/2007]; Wenner-Gren Foundation for Anthropological Researc
The Hubble constant and dark energy from cosmological distance measures
We study how the determination of the Hubble constant from cosmological
distance measures is affected by models of dark energy and vice versa. For this
purpose, constraints on the Hubble constant and dark energy are investigated
using the cosmological observations of cosmic microwave background, baryon
acoustic oscillations and type Ia suprenovae. When one investigates dark
energy, the Hubble constant is often a nuisance parameter, thus it is usually
marginalized over. On the other hand, when one focuses on the Hubble constant,
simple dark energy models such as a cosmological constant and a constant
equation of state are usually assumed. Since we do not know the nature of dark
energy yet, it is interesting to investigate the Hubble constant assuming some
types of dark energy and see to what extent the constraint on the Hubble
constant is affected by the assumption concerning dark energy. We show that the
constraint on the Hubble constant is not affected much by the assumption for
dark energy. We furthermore show that this holds true even if we remove the
assumption that the universe is flat. We also discuss how the prior on the
Hubble constant affects the constraints on dark energy and/or the curvature of
the universe.Comment: 45 pages, 15 figure
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