3,318 research outputs found
Inhibition of T-cell function by FK 506 and cyclosporine is not accompanied by alterations in intracellular calcium
Arrows in Biology: Lack of Clarity and Consistency Points to Confusion for Learners
In this article, we begin to unpack the phenomenon of representational competence by ex¬ploring how arrow symbols are used in introductory biology textbook figures. Out of 1214 figures in an introductory biology textbook, 632 (52%) of them contained arrows that were used to represent many different concepts or processes. Analysis of these figures revealed little correlation between arrow style and meaning. A more focused study of 86 figures containing 230 arrows from a second textbook showed the same pattern of inconsistency. Interviews with undergraduates confirmed that arrows in selected textbook figures were confusing and did not readily convey the information intended by the authors. We also present findings from an online survey in which subjects were asked to infer meaning of different styles of arrows in the absence of context. Few arrow styles had intrinsic meaning to participants, and illustrators did not always use those arrows for the meanings expected by students. Thus, certain styles of arrows triggered confusion and/or incorrect conceptual ideas. We argue that 1) illustrators need to be more clear and consistent when using arrow symbols, 2) instructors need to be cognizant of the level of clarity of representations used during instruction, and 3) instructors should help students learn how to interpret representations containing arrows
Force Oscillations Distort Avalanche Shapes
Contradictory scaling behavior in experiments testing the principle of universality may be due to external oscillations. Thus, the effect of damped oscillatory external forces on slip avalanches in slowly deformed solids is simulated using a mean-field model. Akin to a resonance effect, oscillatory driving forces change the dynamics of avalanches with durations close to the oscillation period. This problem can be avoided by tuning mechanical resonance frequencies away from the range of the inverse avalanche durations. The results provide critical guidance for experimental tests for universality and a quantitative understanding of avalanche dynamics under a wide range of driving conditions
The stability of poloidal magnetic fields in rotating stars
The stability of large-scale magnetic fields in rotating stars is explored,
using 3D numerical hydrodynamics to follow the evolution of an initial poloidal
field. It is found that the field is subject to an instability, located
initially on the magnetic equator, whereby the gas is displaced in a direction
parallel to the magnetic axis. If the magnetic axis is parallel to the rotation
axis, the rotation does not affect the initial linear growth of the
instability, but does restrict the growth of the instability outside of the
equatorial zone. The magnetic energy decays on a timescale which is a function
of the Alfv\'en crossing time and the rotation speed, but short compared to any
evolutionary timescale. No evidence is found for a possible stable end state to
evolve from an initial axisymmetric poloidal field. The field of an oblique
rotator is similarly unstable, in both cases regardless of the rotation speed.Comment: A&A accepted. Animations available at
http://www.cita.utoronto.ca/~jon/research/rp_anims.htm
A temperate former West Antarctic ice sheet suggested by an extensive zone of bed channels
Several recent studies predict that the West Antarctic Ice Sheet will become increasingly unstable under warmer conditions. Insights on such change can be assisted through investigations of the subglacial landscape, which contains imprints of former ice-sheet behavior. Here, we present radio-echo sounding data and satellite imagery revealing a series of ancient large sub-parallel subglacial bed channels preserved in the region between the Möller and Foundation Ice Streams, West Antarctica. We suggest that these newly recognized channels were formed by significant meltwater routed along the icesheet bed. The volume of water required is likely substantial and can most easily be explained by water generated at the ice surface. The Greenland Ice Sheet today exemplifies how significant seasonal surface melt can be transferred to the bed via englacial routing. For West Antarctica, the Pliocene (2.6–5.3 Ma) represents the most recent sustained period when temperatures could have been high enough to generate surface melt comparable to that of present-day Greenland. We propose, therefore, that a temperate ice sheet covered this location during Pliocene warm periods
Applied-force oscillations in avalanche dynamics
Until now most studies of discrete plasticity have focused on systems that are assumed to be driven by a monotonically increasing force; in many real systems, however, the driving force includes damped oscillations or oscillations induced by the propagation of discrete events or “slip avalanches.” In both cases, these oscillations may obscure the true dynamics. Here we effectively consider both cases by investigating the effects of damped oscillations in the external driving force on avalanche dynamics. We compare model simulations of slip avalanches under mean-field dynamics with observations in slip-avalanche experiments on slowly compressed micrometer-sized Au specimens using open-loop force control. The studies show very good agreement between simulations and experiments. We find that an oscillatory external driving force changes the average avalanche shapes only for avalanches with durations close to the period of oscillation of the external force. This effect on the avalanche shapes can be addressed in experiments by choosing suitable specimen dimensions so that the mechanical resonance does not interact with the avalanche dynamics. These results are important for the interpretation of avalanche experiments with built-in oscillators, and for the prediction and analysis of avalanche dynamics in systems with resonant vibrations
Strategies for living well with hormone-responsive advanced prostate cancer—a qualitative exploration
Purpose:
Due to recent treatment advances, men are increasingly living longer with advanced prostate cancer (PCa). This study sought to understand men’s experiences of living with and adjusting to advanced hormone-responsive PCa and how this influenced their quality of life (QoL), in order to highlight how support could be optimized. /
Methods:
Participants were recruited through a UK wide survey—the ‘Life After Prostate Cancer Diagnosis’ study. In-depth telephone interviews were conducted with 24 men (aged 46–77 years) with advanced (stage IV) hormone-responsive PCa diagnosed 18–42 months previously. Thematic analysis was undertaken using a framework approach. /
Results:
Most participants perceived their QoL to be relatively good, which was influenced by the following factors (enablers to ‘living well’ with PCa): a sense of connectedness to others, engagement in meaningful activities, resources (social, cognitive, financial), ability to manage uncertainty, utilization of adjustment strategies and support, communication and information from health professionals. Barriers to ‘living well’ with PCa were often the converse of these factors. These also included more troublesome PCa-related symptoms and stronger perceptions of loss and restriction. /
Conclusions:
In our study, men living with advanced hormone-responsive PCa often reported a good QoL. Exploring the influences on QoL in men with advanced PCa indicates how future interventions might improve the QoL of men who are struggling. Further research is required to develop and test interventions that enhance QoL for these men
HATS-13b and HATS-14b: two transiting hot Jupiters from the HATSouth survey
We report the discovery of HATS-13b and HATS-14b, two hot-Jupiter transiting
planets discovered by the HATSouth survey. The host stars are quite similar to
each other (HATS-13: V = 13.9 mag, M* = 0.96 Msun, R* = 0.89 Rsun, Teff = 5500
K, [Fe/H] = 0.05; HATS-14: V = 13.8 mag, M* = 0.97 Msun, R* = 0.93 Rsun, Teff =
5350 K, [Fe/H] = 0.33) and both the planets orbit around them with a period of
roughly 3 days and a separation of roughly 0.04 au. However, even though they
are irradiated in a similar way, the physical characteristics of the two
planets are very different. HATS-13b, with a mass of Mp = 0.543 MJ and a radius
of Rp = 1.212 RJ, appears as an inflated planet, while HATS-14b, having a mass
of Mp = 1.071 MJ and a radius of Rp = 1.039 RJ, is only slightly larger in
radius than Jupiter.Comment: 13 pages, 7 figures, Submitted to Astronomy & Astrophysics. arXiv
admin note: text overlap with arXiv:1503.0006
Did female prisoners with mental disorders receive psychiatric treatment before imprisonment?
© 2015 Mundt et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain
Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article,
unless otherwise stated.BackgroundThroughout the world, high prevalence rates of mental disorders have been found in prison populations, especially in females. It has been suggested that these populations do not access psychiatric treatment. The aim of this study was to establish rates of psychiatric in- and outpatient treatments prior to imprisonment in female prisoners and to explore reasons for discontinuation of such treatments.Methods150 consecutively admitted female prisoners were interviewed in Berlin, Germany. Socio-demographic characteristics, mental disorders, and previous psychiatric in- and outpatient treatments were assessed by trained researchers. Open questions were used to explore reasons for ending previous psychiatric treatment.ResultsA vast majority of 99 prisoners (66%; 95% CI: 58¿73) of the total sample reported that they had previously been in psychiatric treatment, 80 (53%; 95 CI: 45¿61) in inpatient treatment, 62 (41%; 95 CI: 34¿49) in outpatient treatment and 42 (29%; 21¿39) in both in- and outpatient treatments. All prisoners with psychosis and 72% of the ones with any lifetime mental health disorder had been in previous treatment. The number of inpatient treatments and imprisonments were positively correlated (rho¿=¿0.27; p¿<¿0.01). Inpatient treatment was described as successfully completed by 56% (N¿=¿41) of those having given reasons for ending such treatment, whilst various reasons were reported for prematurely ending outpatient treatments.ConclusionThe data do not support the notion of a general `mental health treatment gap¿ in female prisoners. Although inpatient care is often successfully completed, repeated inpatient treatments are not linked with fewer imprisonments. Improved transition from inpatient to outpatient treatment and services that engage female prisoners to sustained outpatient treatments are needed
Nonlocal looking equations can make nonlinear quantum dynamics local
A general method for extending a non-dissipative nonlinear Schr\"odinger and
Liouville-von Neumann 1-particle dynamics to an arbitrary number of particles
is described. It is shown at a general level that the dynamics so obtained is
completely separable, which is the strongest condition one can impose on
dynamics of composite systems. It requires that for all initial states
(entangled or not) a subsystem not only cannot be influenced by any action
undertaken by an observer in a separated system (strong separability), but
additionally that the self-consistency condition is fulfilled. It is shown that a correct
extension to particles involves integro-differential equations which, in
spite of their nonlocal appearance, make the theory fully local. As a
consequence a much larger class of nonlinearities satisfying the complete
separability condition is allowed than has been assumed so far. In particular
all nonlinearities of the form are acceptable. This shows that
the locality condition does not single out logarithmic or 1-homeogeneous
nonlinearities.Comment: revtex, final version, accepted in Phys.Rev.A (June 1998
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