Decision-Making and Sustainable Drainage: Design and Scale

Sustainable Drainage (SuDS) improves water quality, reduces runoff water quantity, increases amenity and biodiversity benefits, and can also mitigate and adapt to climate change. However, an optimal solution has to be designed to be fit for purpose. Most research concentrates on individual devices, but the focus of this paper is on a full management train, showing the scale-related decision-making process in its design with reference to the city of Coventry, a local government authority in central England. It illustrates this with a large scale site-specific model which identifies the SuDS devices suitable for the area and also at the smaller scale, in order to achieve greenfield runoff rates. A method to create a series of maps using geographical information is shown, to indicate feasible locations for SuDS devices across the local government authority area. Applying the larger scale maps, a management train was designed for a smaller-scale regeneration site using MicroDrainage® software to control runoff at greenfield rates. The generated maps were constructed to provide initial guidance to local government on suitable SuDS at individual sites in a planning area. At all scales, the decision about which device to select was complex and influenced by a range of factors, with slightly different problems encountered. There was overall agreement between large and small scale models

Rainfall–runoff simulations to assess the potential of SuDS for mitigating flooding in highly urbanized catchments

Sustainable Urban Drainage Systems (SuDS) constitute an alternative to conventional drainage when managing stormwater in cities, reducing the impact of urbanization by decreasing the amount of runoff generated by a rainfall event. This paper shows the potential benefits of installing different types of SuDS in preventing flooding in comparison with the common urban drainage strategies consisting of sewer networks of manholes and pipes. The impact of these systems on urban water was studied using Geographic Information Systems (GIS), which are useful tools when both delineating catchments and parameterizing the elements that define a stormwater drainage system. Taking these GIS-based data as inputs, a series of rainfall–runoff simulations were run in a real catchment located in the city of Donostia (Northern Spain) using stormwater computer models, in order to compare the flow rates and depths produced by a design storm before and after installing SuDS. The proposed methodology overcomes the lack of precision found in former GIS-based stormwater approaches when dealing with the modeling of highly urbanized catchments, while the results demonstrated the usefulness of these systems in reducing the volume of water generated after a rainfall event and their ability to prevent localized flooding and surcharges along the sewer network

Self-Esteem in Adults with Tourette Syndrome and Chronic Tic Disorders: The Roles of Tic Severity, Treatment, and Comorbidity

Background Tourette syndrome (TS) and chronic tic disorders (CTD) are stigmatizing disorders that may significantly impact self-esteem. Alternatively, comorbid psychiatric illnesses may affect self-esteem more than tics themselves. Extant research on self-esteem in TS/CTD is limited, has inconsistently examined the effect of comorbidities on self-esteem, and yields mixed findings. Method This study aimed to clarify the roles of tics versus comorbid diagnoses on self-esteem in a large, carefully diagnosed sample of adults with TS/CTD (N = 122) receiving 10 weeks of Comprehensive Behavioral Intervention for Tics (CBIT) or Psychoeducation and Supportive Therapy (PST). Results Baseline self-esteem did not differ between adults with TS/CTD only and normative means, whereas self-esteem was significantly lower among adults with TS/CTD with a comorbid psychiatric illness. In a multiple regression testing the baseline association between tic severity, presence of comorbid psychiatric illness, and depression severity with self-esteem, comorbidity and depression severity were significantly associated with self-esteem, whereas tic severity was not. Finally, using a generalized linear model, we tested the effects of treatment assignment, comorbidity, and their interaction on changes in self-esteem across treatment, controlling for baseline depression severity. Results showed that for those with a comorbid illness, self-esteem improved significantly more with CBIT than with PST. Conclusions Comorbid illnesses appear to affect self-esteem more so than tics among adults with TS/CTD. Therapeutic attention should be paid to treating comorbid diagnoses alongside tics when treating TS/CTD

SuDS & sponge cities:A comparative analysis of the implementation of pluvial flood management in the UK and China

In recent decades, rapid urbanization has resulted in a growing urban population, transformed into regions of exceptional socio-economic value. By removing vegetation and soil, grading the land surface and saturating soil air content, urban developments are more likely to be flooded, which will be further exacerbated by an anticipated increase in the number of intense rainfall events, due to climate change. To date, data collected show that urban pluvial flood events are on the rise for both the UK and China. This paper presents a critical review of existing sustainable approaches to urban flood management, by comparing UK practice with that in China and critically assessing whether lessons can be learnt from the Sponge City initiative. The authors have identified a strategic research plan to ensure that the sponge city initiative can successfully respond to extreme climatic events and tackle pluvial flooding. Hence, this review suggests that future research should focus on (1) the development of a more localized rainfall model for the Chinese climate; (2) the role of retrofit SuDS (Sustainable Drainage Systems) in challenging water environments; (3) the development of a robust SuDS selection tool, ensuring that the most effective devices are installed, based on local factors; and (4) dissemination of current information, and increased understanding of maintenance and whole life-costing, alongside monitoring the success of sponge cities to increase the confidence of decision makers (5) the community engagement and education about sponge cities

Coupling GIS with Stormwater Modelling for the Location Prioritization and Hydrological Simulation of Permeable Pavements in Urban Catchments

Permeable Pavement Systems (PPS) are an alternative to conventional paving systems that allow water to filter through their layers instead of running off them. They are structural source control Sustainable Drainage System (SuDS), which can contribute to reducing increased flood risk due to the combination of two of the greatest challenges with which cities will have to deal in the future: urbanization and Climate Change. Hence, this research consisted of the design of a site selection methodology for the location prioritization of PPS in urban catchments, in order to simulate their potential to attenuate flooding caused by severe rainfall events. This was achieved through the coupling of Geographic Information Systems (GIS) and stormwater models, whose combination provided a framework for both locating and characterizing PPS. The usefulness of the methodology was tested through a real case study consisting of an urban catchment located in Espoo (southern Finland), which demonstrated that PPS can make a significant difference in the amount of runoff generated in an urban catchment due to intense storms

BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation

Assembly of the CARD11/CARMA1-BCL10-MALT1 (CBM) signaling complex upon T or B cell antigen receptor (TCR or BCR) engagement drives lymphocyte activation. Recruitment of pre-assembled BCL10-MALT1 complexes to CARD11 fosters activation of the MALT1 protease and canonical NF-κB signaling. Structural data and in vitro assays have suggested that CARD11 acts as a seed that nucleates the assembly of BCL10 filaments, but the relevance of these findings for CBM complex assembly in cells remains unresolved. To uncouple cellular CARD11 recruitment of BCL10 and BCL10 filament assembly, we generated a BCL10-CARD11 fusion protein that links the C-terminus of BCL10 to the N-terminus of CARD11. When stably expressed in CARD11 KO Jurkat T cells, the BCL10-CARD11 fusion induced constitutive MALT1 activation. Furthermore, in CARD11 KO BJAB B cells, BCL10-CARD11 promoted constitutive NF-κB activation to a similar extent as CARD11 containing oncogenic driver mutations. Using structure-guided destructive mutations in the CARD11-BCL10 (CARD11 R35A) or BCL10-BCL10 (BCL10 R42E) interfaces, we demonstrate that chronic activation by the BCL10-CARD11 fusion protein was independent of the CARD11 CARD. However, activation strictly relied upon the ability of the BCL10 CARD to form oligomers. Thus, by combining distinct CARD mutations in the context of constitutively active BCL10-CARD11 fusion proteins, we provide evidence that BCL10-MALT1 recruitment to CARD11 and BCL10 oligomerization are interconnected processes, which bridge the CARD11 seed to downstream pathways in lymphocytes