Ideological State Apparatuses, Consumerism, and U.S. Capitalism: Lessons for the Left

Althusser's pioneering concept of "ideological state apparatuses" is extended to the unique role of consumerism as a particular ideology enabling and supporting U.S. capitalism. It is argued that rising levels of worker consumption have functioned effectively to compensate workers for (and thereby allow) rising rates of exploitation and their negative social effects. For such compensation to succeed requires that workers embrace an ideology stressing the importance of consumption, namely consumerism. It is argued that the weakness of the US left (in labor unions, parties, and movements) stems in part from having endorsed this consumerism rather than undermining it within the framework of an anti-capitalist politics.Exploitation, Consumerism, Ideology, Althusser

Inflación, Economía de Mercado y Guerra de Clases

Richard D. Wolff carries out a caustic and solid critique against the conventional perspective that presents inflation as a natural phenomenon of the adjustment of the universal law of supply and demand. Nothing could be further from the truth, behind the recent rise in prices there is a class war and a dislocated market economy led by a minority elite that intends to further squeeze a citizenry sunk by debt and the meteoric rise of the interest rates. Wolff also offers a number of anti-inflationary policy alternatives recorded in US history that were able to reduce inflation and inequality.Richard D. Wolff realiza una caustica y sólida crítica contra la perspectiva convencional que presenta la inflación como un fenómeno natural del ajuste de la ley universal de la oferta y de la demanda. Nada más lejos de la realidad, detrás de la reciente subida de precios hay una guerra de clases y una economía dislocada de mercado a cuyos mandos de control se encuentra una minoría elitaria que pretende exprimir aún más a una ciudadanía hundida por la deuda y el ascenso meteórico de los tipos de interés. Wolff ofrece, además, una serie de alternativas políticas antiinflacionarias que en el pasado estadounidense contuvieron la inflación y el aumento de la desigualdad

Applied Force and sEMG Muscle Activity Required To Operate Pistol Grip Control in an Electric Utility Aerial Bucket

Electric utility line workers report high levels of fatigue in forearm muscles when operating a conventional pistol grip control in aerial buckets. This study measured the applied force and surface electromyographic (sEMG) signals from four upper extremity muscles required to operate the pistol grip control in two tasks. The first task was movement of the pistol grip in six directions (up/down, forward/rearward, clockwise/counter-clockwise), and the second task was movement of the bucket from its resting position on the truck bed to an overhead conductor on top of a 40 ft tall pole. The force applied to the pistol grip was measured in 14 aerial bucket trucks, and sEMG activity was measured on eight apprentice line workers. The applied force required to move the pistol grip control in the six directions ranged from 12 to 15 lb. The sEMG activity in the extensor digitorum communis (EDC) forearm muscle was approximately twice as great or more than the other three muscles (flexor digitorum superficialis, triceps, and biceps). Line workers exerted 14 to 30% MVCEMG to move the pistol grip in the six directions. Average %MVCEMG of the EDC to move the bucket from the truck platform to an overhead line ranged from 26 to 30% across the four phases of the task. The sEMG findings from this study provide physiologic evidence to support the anecdotal reports of muscle fatigue from line workers after using the pistol grip control for repeated, long durations

Fixed Point Action and Topology in the CP^3 Model

We define a fixed point action in two-dimensional lattice ${\rm CP}^{N-1}$ models. The fixed point action is a classical perfect lattice action, which is expected to show strongly reduced cutoff effects in numerical simulations. Furthermore, the action has scale-invariant instanton solutions, which enables us to define a correct topological charge without topological defects. Using a parametrization of the fixed point action for the ${\rm CP}^{3}$ model in a Monte Carlo simulation, we study the topological susceptibility.Comment: 27 pages, 5 figures, typeset using REVTEX, Sec. 6 rewritten (additional numerical results), to be published in Phys.Rev.

Toxicogenomic Profiling of 28 Nanomaterials in Mouse Airways

Toxicogenomics opens novel opportunities for hazard assessment by utilizing computational methods to map molecular events and biological processes. In this study, the transcriptomic and immunopathological changes associated with airway exposure to a total of 28 engineered nanomaterials (ENM) are investigated. The ENM are selected to have different core (Ag, Au, TiO2, CuO, nanodiamond, and multiwalled carbon nanotubes) and surface chemistries (COOH, NH2, or polyethylene glycosylation (PEG)). Additionally, ENM with variations in either size (Au) or shape (TiO2) are included. Mice are exposed to 10 mu g of ENM by oropharyngeal aspiration for 4 consecutive days, followed by extensive histological/cytological analyses and transcriptomic characterization of lung tissue. The results demonstrate that transcriptomic alterations are correlated with the inflammatory cell infiltrate in the lungs. Surface modification has varying effects on the airways with amination rendering the strongest inflammatory response, while PEGylation suppresses toxicity. However, toxicological responses are also dependent on ENM core chemistry. In addition to ENM-specific transcriptional changes, a subset of 50 shared differentially expressed genes is also highlighted that cluster these ENM according to their toxicity. This study provides the largest in vivo data set currently available and as such provides valuable information to be utilized in developing predictive models for ENM toxicity.Peer reviewe

Genotoxic agents promote the nuclear accumulation of annexin A2: role of annexin A2 in mitigating DNA damage

Annexin A2 is an abundant cellular protein that is mainly localized in the cytoplasm and plasma membrane, however a small population has been found in the nucleus, suggesting a nuclear function for the protein. Annexin A2 possesses a nuclear export sequence (NES) and inhibition of the NES is sufficient to cause nuclear accumulation. Here we show that annexin A2 accumulates in the nucleus in response to genotoxic agents including gamma-radiation, UV radiation, etoposide and chromium VI and that this event is mediated by the nuclear export sequence of annexin A2. Nuclear accumulation of annexin A2 is blocked by the antioxidant agent N-acetyl cysteine (NAC) and stimulated by hydrogen peroxide (H2O2), suggesting that this is a reactive oxygen species dependent event. In response to genotoxic agents, cells depleted of annexin A2 show enhanced phospho-histone H2AX and p53 levels, increased numbers of p53-binding protein 1 nuclear foci and increased levels of nuclear 8-oxo-2'-deoxyguanine, suggesting that annexin A2 plays a role in protecting DNA from damage. This is the first report showing the nuclear translocation of annexin A2 in response to genotoxic agents and its role in mitigating DNA damage.Natural Sciences and Engineering Research Council of Canada (NSERC); European Union [PCOFUND-GA-2009-246542]; Foundation for Science and Technology of Portugal; Beatrice Hunter Cancer Research Institute; Terry Fox Foundationinfo:eu-repo/semantics/publishedVersio

Synthesis and characterization of metal (M=Al or Ga) 2-phosphino (phenolate/benzenethiolate) complexes and their electrochemical behavior in the presence of CO2

A series of Group 13 complexes MLX2 (M = Al or Ga, L = SC6H4-2-PtBu2 or OC6H4-2-PtBu2, X = Me or C6F5) have been synthesized and characterized by multinuclear NMR spectroscopy and single crystal X-ray diffraction. Reactions of Me3Al or Me3Ga with an equivalent of either 2-tBu2P(C6H4)OH (1) or 2-tBu2P(C6H4)SH (5) resulted in the formation of four new (2,3,6, and 7), 4-coordinate dimethyl chelate (S,P or O,P) complexes via methane elimination. The dimethyl gallium complexes (3 and 7) underwent a further reaction with excess B(C6F5)3, and through ligand exchange (methyl/pentafluorophenyl), resulted in the disubstituted bis(pentafluorophenyl) analogs (4 and 8). Cyclic voltammetry (CV) experiments for all compounds in the presence of and the absence of (1–8) CO2 were performed. For compounds showing cathodic reduction waves under CO2 (2,3,4, and 6), bulk electrolysis experiments were performed. Electrochemical studies indicate that, for several compounds, a transient CO2 adduct is formed which undergoes a one-electron, irreversible (or partially irreversible) reduction to form an unstable radical anion

Methylation of HOXA9 and ISL1 predicts patient outcome in high-grade non-invasive bladder cancer

Introduction Inappropriate DNA methylation is frequently associated with human tumour development, and in specific cases, is associated with clinical outcomes. Previous reports of DNA methylation in low/intermediate grade non-muscle invasive bladder cancer (NMIBC) have suggested that specific patterns of DNA methylation may have a role as diagnostic or prognostic biomarkers. In view of the aggressive and clinically unpredictable nature of high-grade (HG) NMIBC, and the current shortage of the preferred treatment option (Bacillus:Calmette-Guerin), novel methylation analyses may similarly reveal biomarkers of disease outcome that could risk-stratify patients and guide clinical management at initial diagnosis. Methods Promoter-associated CpG island methylation was determined in primary tumour tissue of 36 initial presentation high-grade NMIBCs, 12 low/intermediate-grade NMIBCs and 3 normal bladder controls. The genes HOXA9, ISL1, NKX6-2, SPAG6, ZIC1 and ZNF154 were selected for investigation on the basis of previous reports and/or prognostic utility in low/intermediate-grade NMIBC. Methylation was determined by Pyrosequencing of sodium-bisulphite converted DNA, and then correlated with gene expression using RT-qPCR. Methylation was additionally correlated with tumour behaviour, including tumour recurrence and progression to muscle invasive bladder cancer or metastases. Results The ISL1 genes’ promoter-associated island was more frequently methylated in recurrent and progressive high-grade tumours than their non-recurrent counterparts (60.0% vs. 18.2%, p = 0.008). ISL1 and HOXA9 showed significantly higher mean methylation in recurrent and progressive tumours compared to non-recurrent tumours (43.3% vs. 20.9%, p = 0.016 and 34.5% vs 17.6%, p = 0.017, respectively). Concurrent ISL1/HOXA9 methylation in HG-NMIBC reliably predicted tumour recurrence and progression within one year (Positive Predictive Value 91.7%), and was associated with disease-specific mortality (DSM). Conclusions In this study we report methylation differences and similarities between clinical sub-types of high-grade NMIBC. We report the potential ability of methylation biomarkers, at initial diagnosis, to predict tumour recurrence and progression within one year of diagnosis. We found that specific biomarkers reliably predict disease outcome and therefore may help guide patient treatment despite the unpredictable clinical course and heterogeneity of high-grade NMIBC. Further investigation is required, including validation in a larger patient cohort, to confirm the clinical utility of methylation biomarkers in high-grade NMIBC