351 research outputs found
Non-linear response of a Kondo system: Perturbation approach to the time dependent Anderson impurity model
Nonlinear tunneling current through a quantum dot
(an Anderson impurity system) subject to both constant and alternating
electric fields is studied in the Kondo regime. A systematic diagram technique
is developed for perturbation study of the current in physical systems out of
equilibrium governed by time - dependent Hamiltonians of the Anderson and the
Kondo models. The ensuing calculations prove to be too complicated for the
Anderson model, and hence, a mapping on an effective Kondo problem is called
for. This is achieved by constructing a time - dependent version of the
Schrieffer - Wolff transformation. Perturbation expansion of the current is
then carried out up to third order in the Kondo coupling J yielding a set of
remarkably simple analytical expressions for the current. The zero - bias
anomaly of the direct current differential conductance is shown to be
suppressed by the alternating field while side peaks develop at finite source -
drain voltage. Both the direct component and the first harmonics of the time -
dependent response are equally enhanced due to the Kondo effect, while
amplitudes of higher harmonics are shown to be relatively small. A zero
alternating bias anomaly is found in the alternating current differential
conductance, that is, it peaks around zero alternating bias. This peak is
suppressed by the constant bias. No side peaks show up in the differential
alternating - conductance but their counterpart is found in the derivative of
the alternating current with respect to the direct bias. The results pertaining
to nonlinear response are shown to be valid also below the Kondo temperature.Comment: 55 latex pages 11 ps figure
Pumping spin with electrical fields
Spin currents can be obtained through adiabatic pumping by means of
electrical gating only. This is possible by making use of the tunability of the
Rashba spin-orbit coupling in semiconductor heterostructures. We demonstrate
the principles of this effect by considering a single-channel wire with a
constriction. We also consider realistic structures, consisting of several open
channels where subband spin-mixing and disorder are present, and we confirm our
predictions. Two different ways to detect the spin-pumping effect, either using
ferromagnetic leads or applying a magnetic field, are discussed.Comment: 5 pages, 2 figures; minor changes, typos correcte
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Modernization and Its Discontents
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67022/2/10.1177_000276427702100208.pd
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusions involving tumor suppressors have the opposite effect. For fusions involving kinases, we found 1,275 with an intact kinase domain, the proportion of which varied significantly across cancer types. Our study suggests that fusions drive the development of 16.5% of cancer cases and function as the sole driver in more than 1% of them. Finally, we identified druggable fusions involving genes such as TMPRSS2, RET, FGFR3, ALK, and ESR1 in 6.0% of cases, and we predicted immunogenic peptides, suggesting that fusions may provide leads for targeted drug and immune therapy
Velocity-space sensitivity of the time-of-flight neutron spectrometer at JET
The velocity-space sensitivities of fast-ion diagnostics are often described by so-called weight functions. Recently, we formulated weight functions showing the velocity-space sensitivity of the often dominant beam-target part of neutron energy spectra. These weight functions for neutron emission spectrometry (NES) are independent of the particular NES diagnostic. Here we apply these NES weight functions to the time-of-flight spectrometer TOFOR at JET. By taking the instrumental response function of TOFOR into account, we calculate time-of-flight NES weight functions that enable us to directly determine the velocity-space sensitivity of a given part of a measured time-of-flight spectrum from TOFOR
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