Aqua Fitness as one of the methods of prevention of hip osteoarthritis

Aqua fitness training is one of the most effective methods for improving physical health and reducing pain in orthopedic patients. This training due to the extensive number of modules can be used at any age regardless of gender. Aquafitness due to the environment in which it takes place gives great effects in the treatment of osteoarthritis, especially in combination with other physiotherapeutic treatments and kinesitherapy

The key role of physical exercise in the prevention and treatment of osteoporosis

Osteoporosis is a commonly occurring condition that affects, mainly elderly people. Bone loss may be caused many factors, such as menopausal period, slender body structure, inappropriate diet, or genetic determinants. The systematic and properly performed physical activity is of a significant importance in the prevention and control of the disease symptoms. Beneficial results are obtained by implementation of exercises of the following types: strength, endurance, stretching and mixed efforts. Performing physical activity accurately results in lowering of the risk of early osteoporosis and reduces the intensity of bone degeneration processes by inhibiting and stimulating appropriate mechanisms within the bone tissue

The influence of physiotherapy on the treatment of inflammatory bowel diseases – a short overview

Background of Inflammatory diseases of the intestines affect more and more people, this is caused not only by genetic determinants but also by environmental conditions and lifestyle. Lack of physical activity may affect the symptoms of the disease and increase their intensity, therefore during the remission of the disease it is recommended to use training and physiotherapeutic techniques to reduce the symptoms, such as pain, fatigue or reduced quality of life. The below systematic review shows the impact of individual physical trainings and physiotherapeutic techniques on symptoms resulting from inflammatory bowel diseases

ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation

Lipid peroxidation (LPO) products are relatively stable and abundant metabolites, which accumulate in tissues of mammals with aging, being able to modify all cellular nucleophiles, creating protein and DNA adducts including crosslinks. Here, we used cells and mice deficient in the ERCC1-XPF endonuclease required for nucleotide excision repair and the repair of DNA interstrand crosslinks to ask if specifically LPO-induced DNA damage contributes to loss of cell and tissue homeostasis. Ercc1-/- mouse embryonic fibroblasts were more sensitive than wild-type (WT) cells to the LPO products: 4-hydroxy-2-nonenal (HNE), crotonaldehyde and malondialdehyde. ERCC1-XPF hypomorphic mice were hypersensitive to CCl4 and a diet rich in polyunsaturated fatty acids, two potent inducers of endogenous LPO. To gain insight into the mechanism of how LPO influences DNA repair-deficient cells, we measured the impact of the major endogenous LPO product, HNE, on WT and Ercc1-/- cells. HNE inhibited proliferation, stimulated ROS and LPO formation, induced DNA base damage, strand breaks, error-prone translesion DNA synthesis and cellular senescence much more potently in Ercc1-/- cells than in DNA repair-competent control cells. HNE also deregulated base excision repair and energy production pathways. Our observations that ERCC1-deficient cells and mice are hypersensitive to LPO implicates LPO-induced DNA damage in contributing to cellular demise and tissue degeneration, notably even when the source of LPO is dietary polyunsaturated fats

The use of selected plant materials obtained from South Asia in cosmetology

Bogactwo flory w zróżnicowanym klimacie Azji Południowej, stanowi potencjalne źródło surowców roślinnych, mających zastosowanie w kosmetologii i dermatologii. Rośliny południowoazjatyckie są obiektem nieustannych badań pod względem fitochemicznym i farmakologicznym. Otrzymywane z nich substancje wykorzystywane są przez przemysł kosmetyczny w produkcji nowatorskich kosmetyków. W pierwszej części pracy przedstawiono ogólną charakterystykę kontynentu azjatyckiego i regionów Azji Południowej, z uwzględnieniem ich położenia geograficznego i klimatu. W części zasadniczej opisano strefy roślinne występujące na tym obszarze oraz scharakteryzowano najważniejsze gatunki roślin i pozyskiwane z nich surowce, mające zastosowanie w kosmetologii. Przedstawiono ich opis botaniczny, składniki chemiczne i działanie wraz z zastosowaniem w ludowej i współczesnej medycynie i kosmetologii. W następnej części omówiono produkty kosmetyczne, dostępne obecnie na rynku, które zawierają w swym składzie opisane wcześniej surowce roślinne. Kosmetyki podzielono na kategorie i omówiono ich działanie na skórę i włosy. W ostatniej części przedstawiono zabiegi kosmetyczne, w których wykorzystuje się południowoazjatyckie surowce roślinne.The variety of flora in the diverse climate of South Asia is a potential source of plant materials that can be used in cosmetology and dermatology. South Asian plants are the subject of constant research in phytochemical and pharmacological terms. The substances obtained from them are used by the cosmetics industry in the production of innovative cosmetics. The first part of the work presents the general characteristics of the Asian continent and regions of South Asia, including their geographical location and climate. The main part describes the plant zones occuring in this area and characterized the most important plant species and raw materials obtained from them, which are used in cosmetology. Their botanical description and chemical components were presented and action together with application in folk and modern medicine and cosmetology. The next part discusses cosmetic products currently available, which contain plant ingredients described earlier. Cosmetics are divided into categories and their effects on skin and hair are discussed. The last part presents cosmetic procedures in which South Asian plant materials are used

Effect of the Addition of Whole and Milled Flaxseed on the Quality Characteristics of Yogurt

The present study aimed to analyze the effect of the addition of whole and milled flaxseed on the quality characteristics of yogurt. In the first stage of the research, the optimal dose of flaxseed was determined. In the second stage of the research, it was assessed whether the selected qualities of yogurt were affected by the form of flaxseed (whole or milled) and the time of addition (before or after fermentation). The yogurts obtained were stored at 5 °C for 21 days, and the changes in active acidity, apparent viscosity, syneresis, and the number of yogurt bacteria were determined. The results of the second stage of the study were subjected to two-way analysis of variance (ANOVA) (p < 0.05). The study showed that the addition of milled flaxseed to yogurts in the amount of 1% was optimal. Time and form of flaxseed supplementation significantly influenced the changes in active acidity, apparent viscosity, and syneresis in the tested yogurts. The addition of flaxseed did not significantly change the content of yogurt bacteria. The results indicate that to achieve increased apparent viscosity and reduced syneresis, it is more advantageous to use milled flaxseed rather than whole flaxseed

Health status after invasive or conservative care in coronary and advanced kidney disease

BACKGROUND In the ISCHEMIA-CKD trial, the primary analysis showed no significant difference in the risk of death or myocardial infarction with initial angiography and revascularization plus guideline-based medical therapy (invasive strategy) as compared with guideline-based medical therapy alone (conservative strategy) in participants with stable ischemic heart disease, moderate or severe ischemia, and advanced chronic kidney disease (an estimated glomerular filtration rate of <30 ml per minute per 1.73 m2 or receipt of dialysis). A secondary objective of the trial was to assess angina-related health status. METHODS We assessed health status with the Seattle Angina Questionnaire (SAQ) before randomization and at 1.5, 3, and 6 months and every 6 months thereafter. The primary outcome of this analysis was the SAQ Summary score (ranging from 0 to 100, with higher scores indicating less frequent angina and better function and quality of life). Mixed-effects cumulative probability models within a Bayesian framework were used to estimate the treatment effect with the invasive strategy. RESULTS Health status was assessed in 705 of 777 participants. Nearly half the participants (49%) had had no angina during the month before randomization. At 3 months, the estimated mean difference between the invasive-strategy group and the conservative-strategy group in the SAQ Summary score was 2.1 points (95% credible interval, 120.4 to 4.6), a result that favored the invasive strategy. The mean difference in score at 3 months was largest among participants with daily or weekly angina at baseline (10.1 points; 95% credible interval, 0.0 to 19.9), smaller among those with monthly angina at baseline (2.2 points; 95% credible interval, 122.0 to 6.2), and nearly absent among those without angina at baseline (0.6 points; 95% credible interval, 121.9 to 3.3). By 6 months, the between-group difference in the overall trial population was attenuated (0.5 points; 95% credible interval, 122.2 to 3.4). CONCLUSIONS Participants with stable ischemic heart disease, moderate or severe ischemia, and advanced chronic kidney disease did not have substantial or sustained benefits with regard to angina-related health status with an initially invasive strategy as compared with a conservative strategy

Management of coronary disease in patients with advanced kidney disease

BACKGROUND Clinical trials that have assessed the effect of revascularization in patients with stable coronary disease have routinely excluded those with advanced chronic kidney disease. METHODS We randomly assigned 777 patients with advanced kidney disease and moderate or severe ischemia on stress testing to be treated with an initial invasive strategy consisting of coronary angiography and revascularization (if appropriate) added to medical therapy or an initial conservative strategy consisting of medical therapy alone and angiography reserved for those in whom medical therapy had failed. The primary outcome was a composite of death or nonfatal myocardial infarction. A key secondary outcome was a composite of death, nonfatal myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. RESULTS At a median follow-up of 2.2 years, a primary outcome event had occurred in 123 patients in the invasive-strategy group and in 129 patients in the conservative-strategy group (estimated 3-year event rate, 36.4% vs. 36.7%; adjusted hazard ratio, 1.01; 95% confidence interval [CI], 0.79 to 1.29; P=0.95). Results for the key secondary outcome were similar (38.5% vs. 39.7%; hazard ratio, 1.01; 95% CI, 0.79 to 1.29). The invasive strategy was associated with a higher incidence of stroke than the conservative strategy (hazard ratio, 3.76; 95% CI, 1.52 to 9.32; P=0.004) and with a higher incidence of death or initiation of dialysis (hazard ratio, 1.48; 95% CI, 1.04 to 2.11; P=0.03). CONCLUSIONS Among patients with stable coronary disease, advanced chronic kidney disease, and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of death or nonfatal myocardial infarction