Stacked Micro Heat Exchange System for Optimized Thermal Coupling of MicroTEGs

This study presents modeling and experimental results of micro thermoelectric generators (μTEGs) integrated into a multilayer micro heat exchange system. The multilayer configuration benefits from low heat transfer resistances at small fluid flow rates and at the same time from low required pumping powers. The compact stacked power device allows for high net output power per volume, and therefore a reduction in size, weight, and cost compared with conventional large-scale heat exchangers. The influence of the boundary conditions and the system design parameters on the net output power of the micro heat exchange system was investigated by simulation. The theoretical results showed a major impact of the microchannel dimensions and the μTEG thickness on the overall output performance of the system. By adapting the applied fluid flow rate, the system's net power output can be maximized for varying operating temperatures. Experimental measurements of the cross-flow micro heat exchange system were in good agreement with the performed simulations. A net μTEG output power of 62.9mW/cm2 was measured for a double-layer system at an applied water inlet temperature difference of 60K with a Bi2Te3 μTEG (ZT of 0.12), resulting in a net volumetric efficiency factor of 37.2W/m3/K

Novel Method for Analyzing Crack Growth in Polymeric Microtensile Specimens by In Situ Atomic Force Microscopy

In this paper a micro tensile test which allows the determination and observation of the crack growth behaviour in thin polymer layers is presented. The setup consists of micromanipulators and piezo actuators for straining the sample while an atomic force microscope (AFM) is used for scanning the crack tip area with high lateral resolution. The stress in the specimen is determined by an optical microscope for observation of the deflection of a force sensing beam. The material under investigation is an amorphous and strongly entangled thermoplastic polyimide which can be patterned photolithographically and is spin cast to form layers of 3μm thickness. The results show the potential of the setup to measure crack length, crack tip opening and nominal stress. The stress-crack length-diagram then allows to determine different stages during crack growt

Switching discharge phenomena when use composite materials Сu—Сr under low voltage DC inductive load a small power

Paper presents and discusses investigated results of composite materials Cu—Cr used in electric contacts operating under DC low voltage loads of a small power. Formulates conclusions of possibility of the use of just such material to control the arc to glow transformation for practical use in electric auxiliary switching devices.Предложены результаты исследований композиционных материалов Cu—Cr, используемых в качестве электрических контактов при коммутации в цепях постоянного тока низкого напряжения малой мощности. Сделан вывод о возможности использования именно этого материала для контроля изменения свечения дуги при практическом использовании в электрических вспомогательных коммутационных устройствах.Представлено результати досліджень композиційних матеріалів Cu—Cr, що використовують в якості електричних контактів при комутації в ланцюгах постійного струму низької напруги малої потужності. Зроблено висновок про можливість використання саме цього матеріалу для контролю зміни світіння дуги при практичному використанні в електричних допоміжних комутаційних пристроях

Performance of laminated contact material Cu—Mo in open air AC low voltage contactors

In the paper performance of laminated contact material Cu—Mo when use in open air ac low voltage contactors is presented and discussed. On the basis of the investigated results conclusions on effective application of such material to replace silver based compositions are formulated.Представлены и обсуждаются эксплуатационные качества слоистого контактного материала Cu—Mo, используемого в низковольтных контакторах на открытом воздухе. По результатам исследований сформулированы рекомендации по эффективному применению такого материала взамен серебросодержащего.Представлено і обговорюються експлуатаційні властивості шаруватого контактного матеріалу Cu—Mo, який використовується в низьковольтних контакторах на відкритому повітрі. За результатами досліджень сформульо-вано рекомендації щодо ефективного застосування такого матеріалу замість срібловміщуючого

One-Year Water-Stable and Porous Bi(III) Halide Semiconductor with Broad-Spectrum Antibacterial Performance

Hybrid metal halide semiconductors are a unique family of materials with immense potential for numerous applications. For this to materialize, environmental stability and toxicity deficiencies must be simultaneously addressed. We report here a porous, visible light semiconductor, namely, (DHS)Bi2I8 (DHS = [2.2.2] cryptand), which consists of nontoxic, earth-abundant elements, and is water-stable for more than a year. Gas- and vapor-sorption studies revealed that it can selectively and reversibly adsorb H2O and D2O at room temperature (RT) while remaining impervious to N2 and CO2. Solid-state NMR measurements and density functional theory (DFT) calculations verified the incorporation of H2O and D2O in the molecular cages, validating the porous nature. In addition to porosity, the material exhibits broad band-edge light emission centered at 600 nm with a full width at half-maximum (fwhm) of 99 nm, which is maintained after 6 months of immersion in H2O. Moreover, (DHS)Bi2I8 exhibits bacteriocidal action against three Gram-positive and three Gram-negative bacteria, including antibiotic-resistant strains. This performance, coupled with the recorded water stability and porous nature, renders it suitable for a plethora of applications, from solid-state batteries to water purification and disinfection

Prion-like domain mutations in hnRNPs cause multisystem proteinopathy and ALS

Summary Algorithms designed to identify canonical yeast prions predict that ~250 human proteins, including several RNA-binding proteins associated with neurodegenerative disease, harbor a distinctive prion-like domain (PrLD) enriched in uncharged polar amino acids and glycine. PrLDs in RNA-binding proteins are essential for the assembly of ribonucleoprotein granules. However, the interplay between human PrLD function and disease is not understood. Here, we define pathogenic mutations in PrLDs of hnRNPA2/B1 and hnRNPA1 in families with inherited degeneration affecting muscle, brain, motor neuron and bone, and a case of familial ALS. Wild-type hnRNPA2 and hnRNPA1 display an intrinsic tendency to assemble into self-seeding fibrils, which is exacerbated by the disease mutations. Indeed, the pathogenic mutations strengthen a ‘steric zipper’ motif in the PrLD, which accelerates formation of self-seeding fibrils that cross-seed polymerization of wild-type hnRNP. Importantly, the disease mutations promote excess incorporation of hnRNPA2 and hnRNPA1 into stress granules and drive the formation of cytoplasmic inclusions in animal models that recapitulate the human pathology. Thus, dysregulated polymerization caused by a potent mutant ‘steric zipper’ motif in a PrLD can initiate degenerative disease. Related proteins with PrLDs must be considered candidates for initiating and perhaps propagating proteinopathies of muscle, brain, motor neuron and bone

Laser spectroscopy for breath analysis : towards clinical implementation

Detection and analysis of volatile compounds in exhaled breath represents an attractive tool for monitoring the metabolic status of a patient and disease diagnosis, since it is non-invasive and fast. Numerous studies have already demonstrated the benefit of breath analysis in clinical settings/applications and encouraged multidisciplinary research to reveal new insights regarding the origins, pathways, and pathophysiological roles of breath components. Many breath analysis methods are currently available to help explore these directions, ranging from mass spectrometry to laser-based spectroscopy and sensor arrays. This review presents an update of the current status of optical methods, using near and mid-infrared sources, for clinical breath gas analysis over the last decade and describes recent technological developments and their applications. The review includes: tunable diode laser absorption spectroscopy, cavity ring-down spectroscopy, integrated cavity output spectroscopy, cavity-enhanced absorption spectroscopy, photoacoustic spectroscopy, quartz-enhanced photoacoustic spectroscopy, and optical frequency comb spectroscopy. A SWOT analysis (strengths, weaknesses, opportunities, and threats) is presented that describes the laser-based techniques within the clinical framework of breath research and their appealing features for clinical use.Peer reviewe

Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming

Endothelial barrier (EB) breaching is a frequent event during inflammation, and it is followed by the rapid recovery of microvascular integrity. The molecular mechanisms of EB recovery are poorly understood. Triggering of MHC molecules by migrating T-cells is a minimal signal capable of inducing endothelial contraction and transient microvascular leakage. Using this model, we show that EB recovery requires a CD31 receptor-induced, robust glycolytic response sustaining junction re-annealing. Mechanistically, this response involves src-homology phosphatase activation leading to Akt-mediated nuclear exclusion of FoxO1 and concomitant \u3b2-catenin translocation to the nucleus, collectively leading to cMyc transcription. CD31 signals also sustain mitochondrial respiration, however this pathway does not contribute to junction remodeling. We further show that pathologic microvascular leakage in CD31-deficient mice can be corrected by enhancing the glycolytic flux via pharmacological Akt or AMPK activation, thus providing a molecular platform for the therapeutic control of EB response

The widening spectrum of C9ORF72-related disease; genotype/phenotype correlations and potential modifiers of clinical phenotype

The GGGGCC (G4C2) repeat expansion in C9ORF72 is the most common cause of familial amyotrophic lateral sclerosis (ALS), frontotemporal lobar dementia (FTLD) and ALS–FTLD, as well as contributing to sporadic forms of these diseases. Screening of large cohorts of ALS and FTLD cohorts has identified that C9ORF72-ALS is represented throughout the clinical spectrum of ALS phenotypes, though in comparison with other genetic subtypes, C9ORF72 carriers have a higher incidence of bulbar onset disease. In contrast, C9ORF72-FTLD is predominantly associated with behavioural variant FTD, which often presents with psychosis, most commonly in the form of hallucinations and delusions. However, C9ORF72 expansions are not restricted to these clinical phenotypes. There is a higher than expected incidence of parkinsonism in ALS patients with C9ORF72 expansions, and the G4C2 repeat has also been reported in other motor phenotypes, such as primary lateral sclerosis, progressive muscular atrophy, corticobasal syndrome and Huntington-like disorders. In addition, the expansion has been identified in non-motor phenotypes including Alzheimer’s disease and Lewy body dementia. It is not currently understood what is the basis of the clinical variation seen with the G4C2 repeat expansion. One potential explanation is repeat length. Sizing of the expansion by Southern blotting has established that there is somatic heterogeneity, with different expansion lengths in different tissues, even within the brain. To date, no correlation with expansion size and clinical phenotype has been established in ALS, whilst in FTLD only repeat size in the cerebellum was found to correlate with disease duration. Somatic heterogeneity suggests there is a degree of instability within the repeat and evidence of anticipation has been reported with reducing age of onset in subsequent generations. This variability/instability in expansion length, along with its interactions with environmental and genetic modifiers, such as TMEM106B, may be the basis of the differing clinical phenotypes arising from the mutation