Our voice is powerful : toward an aesthetics of healing in the Performing Justice Project

Over the past decade, youth workers across disciplines have adopted “trauma-informed care” approaches to working, learning, and creating with young people. Though trauma-informed care practices seek to attend to the needs of young people who have and continue to experience trauma, such practices also tend to embrace a limited definition of trauma that focuses on preventing symptoms rather than addressing root causes and promoting well-being. This MFA thesis examines a semester-long performance-building process that explored racial and gender justice with youth at a residency for young people living within the foster care system in central Texas. Using a reflective practitioner research method, the author identifies and considers moments of youth and adult healing centered engagement within a shared youth-centered devising process. Through qualitative research methods of thematic coding and analysis, the author discusses the relationship between healing and aesthetics and advocates for an “aesthetics of healing” in applied drama and theatre with youth that centers commitment, openness, and disruption.Theatre and Danc

A Computational Model of Reactive Oxygen Species and Redox Balance in Cardiac Mitochondria

AbstractElevated levels of reactive oxygen species (ROS) play a critical role in cardiac myocyte signaling in both healthy and diseased cells. Mitochondria represent the predominant cellular source of ROS, specifically the activity of complexes I and III. The model presented here explores the modulation of electron transport chain ROS production for state 3 and state 4 respiration and the role of substrates and respiratory inhibitors. Model simulations show that ROS production from complex III increases exponentially with membrane potential (ΔΨm) when in state 4. Complex I ROS release in the model can occur in the presence of NADH and succinate (reverse electron flow), leading to a highly reduced ubiquinone pool, displaying the highest ROS production flux in state 4. In the presence of ample ROS scavenging, total ROS production is moderate in state 3 and increases substantially under state 4 conditions. The ROS production model was extended by combining it with a minimal model of ROS scavenging. When the mitochondrial redox status was oxidized by increasing the proton permeability of the inner mitochondrial membrane, simulations with the combined model show that ROS levels initially decline as production drops off with decreasing ΔΨm and then increase as scavenging capacity is exhausted. Hence, this mechanistic model of ROS production demonstrates how ROS levels are controlled by mitochondrial redox balance

Half the World: Refugees Transform the City of Trees

Nearly 1 out of every 100 people worldwide is a person displaced and seeking asylum, imperiled by persecution and war. Half the World takes measure of that staggering crisis in stories from a city transformed.https://scholarworks.boisestate.edu/fac_books/1481/thumbnail.jp

In our own backyard: urban health inequities and Aboriginal experiences of neighbourhood life, social capital and racism.

This report is about Aboriginal and Torres Strait Islander people who live in urban areas. Thus it contributes to filling the gap in literature and knowledge about the health and everyday life experience of urban Indigenous peoples.This study, the Adelaide Aboriginal and Torres Strait Islander Health (AATSIH) project, was funded by the National Health and Medical Research Council (NHMRC) and focused on neighbourhood life, social capital, experiences of racism and health. This was a ‘companion’ project to another NHMRC project (the General Location and Health project (the General L&H project) – see Baum, Ziersch, Zhang et al, 2007) that explored neighbourhood life and social capital for the general population in four contrasting socio-economic areas in Adelaide

Redefining flux ropes in heliophysics

Magnetic flux ropes manifest as twisted bundles of magnetic field lines. They carry significant amounts of solar mass in the heliosphere. This paper underlines the need to advance our understanding of the fundamental physics of heliospheric flux ropes and provides the motivation to significantly improve the status quo of flux rope research through novel and requisite approaches. It briefly discusses the current understanding of flux rope formation and evolution, and summarizes the strategies that have been undertaken to understand the dynamics of heliospheric structures. The challenges and recommendations put forward to address them are expected to broaden the in-depth knowledge of our nearest star, its dynamics, and its role in its region of influence, the heliosphere.Fil: Nieves Chinchilla, Teresa. National Aeronautics and Space Administration; Estados UnidosFil: Pal, Sanchita. George Mason University. School Of Physics. Astronomy And Computational Sciences; Estados Unidos. National Aeronautics and Space Administration; Estados UnidosFil: Salman, Tarik M.. George Mason University. School Of Physics. Astronomy And Computational Sciences; Estados Unidos. National Aeronautics and Space Administration; Estados UnidosFil: Carcaboso, Fernando. Catholic University Of America; Estados Unidos. National Aeronautics and Space Administration; Estados UnidosFil: Guidoni, Silvina E.. American University. College Of Arts & Sciences. Physics Departament.; Estados Unidos. National Aeronautics and Space Administration; Estados UnidosFil: Cremades Fernandez, Maria Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Mendoza. Facultad de Ingenieria; ArgentinaFil: Narock, Ayris. National Aeronautics and Space Administration; Estados UnidosFil: Balmaceda, Laura Antonia. George Mason University. School Of Physics. Astronomy And Computational Sciences; Estados Unidos. National Aeronautics and Space Administration; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lynch, Benjamin J.. University of California at Berkeley; Estados UnidosFil: Al Haddad, Nada. University Of New Hampshire; Estados UnidosFil: Rodríguez García, Laura. Universidad de Alcalá; EspañaFil: Narock, Thomas W.. Goucher College; Estados UnidosFil: Dos Santos, Luiz F. G.. Shell Global Solutions; Estados UnidosFil: Regnault, Florian. University Of New Hampshire; Estados UnidosFil: Kay, Christina. Catholic University Of America; Estados Unidos. National Aeronautics and Space Administration; Estados UnidosFil: Winslow, Réka M.. University Of New Hampshire; Estados UnidosFil: Palmerio, Erika. Predictive Science Inc.; Estados UnidosFil: Davies, Emma E.. University Of New Hampshire; Estados UnidosFil: Scolini, Camilla. University Of New Hampshire; Estados UnidosFil: Weiss, Andreas J.. National Aeronautics and Space Administration; Estados UnidosFil: Alzate, Nathalia. National Aeronautics and Space Administration; Estados UnidosFil: Jeunon, Mariana. Catholic University Of America; Estados Unidos. National Aeronautics and Space Administration; Estados UnidosFil: Pujadas, Roger. Universidad Politécnica de Catalunya; España. National Aeronautics and Space Administration; Estados Unido

A stalled revolution? What can we learn from women’s drop-out to part-time jobs: A comparative analysis of Germany and the UK

This study examines how within-couple inequalities, that is power differences between men and women in a partnership, act as predictors of transitions from full-time to part-time employment applying Heckman corrected probit models in three different institutional and cultural contexts; Eastern Germany, Western Germany and the United Kingdom. The analyses show that when women are in a weaker position within their relationships they are more likely to drop-out of full-time work, but that this propensity varies by context. The authors also find an increased tendency over time for women to leave full-time for part-time employment in both Eastern and Western Germany, but observe no such trend in the UK. This is suggestive of ongoing incompatibilities in the institutional support for equality in dual-earning in Germany. The study uses longitudinal data covering the period 1992 until 2012 from the German Socio-Economic Panel (SOEP) for Germany and from the British Household Panel (BHPS) and the ‘Understanding Society’ data for the UK

The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure

Phase I Study of Ficlatuzumab and Cetuximab in Cetuximab-Resistant, Recurrent/Metastatic Head and Neck Cancer

etuximab, an anti-EGFR monoclonal antibody (mAb), is approved for advanced head and neck squamous cell carcinoma (HNSCC) but benefits a minority. An established tumor-intrinsic resistance mechanism is cross-talk between the EGFR and hepatocyte growth factor (HGF)/cMet pathways. Dual pathway inhibition may overcome cetuximab resistance. This Phase I study evaluated the combination of cetuximab and ficlatuzumab, an anti-HGF mAb, in patients with recurrent/metastatic HNSCC. The primary objective was to establish the recommended Phase II dose (RP2D). Secondary objectives included overall response rate (ORR), progression-free survival (PFS), and overall survival (OS). Mechanistic tumor-intrinsic and immune biomarkers were explored. Thirteen patients enrolled with no dose-limiting toxicities observed at any dose tier. Three evaluable patients were treated at Tier 1 and nine at Tier 2, which was determined to be the RP2D (cetuximab 500 mg/m2 and ficlatuzumab 20 mg/kg every 2 weeks). Median PFS and OS were 5.4 (90% CI = 1.9–11.4) and 8.9 (90% CI = 2.7–15.2) months, respectively, with a confirmed ORR of 2 of 12 (17%; 90% CI = 6–40%). High circulating soluble cMet levels correlated with poor survival. An increase in peripheral T cells, particularly the CD8+ subset, was associated with treatment response whereas progression was associated with expansion of a distinct myeloid population. This well-tolerated combination demonstrated promising activity in cetuximab-resistant, advanced HNSCC

Trading people versus trading time: What is the difference?

BACKGROUND: Person trade-off (PTO) elicitations yield different values than standard utility measures, such as time trade-off (TTO) elicitations. Some people believe this difference arises because the PTO captures the importance of distributive principles other than maximizing treatment benefits. We conducted a qualitative study to determine whether people mention considerations related to distributive principles other than QALY-maximization more often in PTO elicitations than in TTO elicitations and whether this could account for the empirical differences. METHODS: 64 members of the general public were randomized to one of three different face-to-face interviews, thinking aloud as they responded to TTO and PTO elicitations. Participants responded to a TTO followed by a PTO elicitation within contexts that compared either: 1) two life-saving treatments; 2) two cure treatments; or 3) a life-saving treatment versus a cure treatment. RESULTS: When people were asked to choose between life-saving treatments, non-maximizing principles were more common with the PTO than the TTO task. Only 5% of participants considered non-maximizing principles as they responded to the TTO elicitation compared to 68% of participants who did so when responding to the PTO elicitation. Non-maximizing principles that emerged included importance of equality of life and a desire to avoid discrimination. However, these principles were less common in the other two contexts. Regardless of context, though, participants were significantly more likely to respond from a societal perspective with the PTO compared to the TTO elicitation. CONCLUSION: When lives are at stake, within the context of a PTO elicitation, people are more likely to consider non-maximizing principles, including the importance of equal access to a life-saving treatment, avoiding prejudice or discrimination, and in rare cases giving treatment priority based purely on the position of being worse-off