Fundamental noise limitations to supercontinuum generation in microstructure fiber

Broadband noise on supercontinuum spectra generated in microstructure fiber is shown to lead to amplitude fluctuations as large as 50 % for certain input laser pulse parameters. We study this noise using both experimental measurements and numerical simulations with a generalized stochastic nonlinear Schroedinger equation, finding good quantitative agreement over a range of input pulse energies and chirp values. This noise is shown to arise from nonlinear amplification of two quantum noise inputs: the input pulse shot noise and the spontaneous Raman scattering down the fiber.Comment: 16 pages with 6 figure

Optical microbubble resonator

We develop a method for fabricating very small silica microbubbles having a micrometer-order wall thickness and demonstrate the first optical microbubble resonator. Our method is based on blowing a microbubble using stable radiative CO2 laser heating rather than unstable convective heating in a flame or furnace. Microbubbles are created along a microcapillary and are naturally opened to the input and output microfluidic or gas channels. The demonstrated microbubble resonator has 370 µm diameter, 2 µm wall thickness, and a Q factor exceeding 10

Super FSR tunable optical microbubble resonator

An optical resonator is often called fully tunable if its tunable range exceeds the spectral interval that contains the resonances at all the characteristic modes of this resonator. For the high Q-factor spheroidal and toroidal microresonators, this interval coincides with the azimuthal free spectral range. In this Letter, we demonstrate the first mechanically fully tunable spheroidal microresonator created of a silica microbubble having a 100 micron order radius and a micron order wall thickness. The tunable bandwidth of this resonator is more than two times greater than its azimuthal free spectral range

Prognostic markers in cancer: the evolution of evidence from single studies to meta-analysis, and beyond

In oncology, prognostic markers are clinical measures used to help elicit an individual patient's risk of a future outcome, such as recurrence of disease after primary treatment. They thus facilitate individual treatment choice and aid in patient counselling. Evidence-based results regarding prognostic markers are therefore very important to both clinicians and their patients. However, there is increasing awareness that prognostic marker studies have been neglected in the drive to improve medical research. Large protocol-driven, prospective studies are the ideal, with appropriate statistical analysis and clear, unbiased reporting of the methods used and the results obtained. Unfortunately, published prognostic studies rarely meet such standards, and systematic reviews and meta-analyses are often only able to draw attention to the paucity of good-quality evidence. We discuss how better-quality prognostic marker evidence can evolve over time from initial exploratory studies, to large protocol-driven primary studies, and then to meta-analysis or even beyond, to large prospectively planned pooled analyses and to the initiation of tumour banks. We highlight articles that facilitate each stage of this process, and that promote current guidelines aimed at improving the design, analysis, and reporting of prognostic marker research. We also outline why collaborative, multi-centre, and multi-disciplinary teams should be an essential part of future studies

Is there a gain from "chance-corrected" measures of diagnostic validity?

Several authors have proposed alternatives to sensitivity and specificity which they recommend as so-called "chance-corrected" versions of these parameters of diagnostic validity. We argue that these new measures have some undesirable properties in comparison with the established measures and no substantial advantages. In particular, the extension of this concept to chance-corrected ROC curves is shown to be less useful than classical ROC analysis

Effects of structural irregularities on modulational instability phase matching in photonic crystal fibers

International audienceThe effect of structural irregularities in photonic crystal fibers on scalar and vector modulational instability (MI) processes is studied by numerical simulations and experiments. For an anomalous-dispersion regime pump, variations in core ellipticity as small as 0.5% over length scales of the order of several meters are shown to have a negligible effect on scalar MI, yet they completely suppress vector MI. In contrast, for a normal-dispersion regime pump, vector MI is shown to be robust against such fluctuations