443 research outputs found
The properties of extragalactic radio sources selected at 20 GHz
We present some first results on the variability, polarization and general
properties of radio sources selected in a blind survey at 20 GHz, the highest
frequency at which a sensitive radio survey has been carried out over a large
area of sky. Sources with flux densities above 100 mJy in the AT20G Pilot
Survey at declination -60 to -70 were observed at up to three epochs during
2002-4, including near-simultaneous measurements at 5, 8 and 18 GHz in 2003. Of
the 173 sources detected, 65% are candidate QSOs, BL Lac objects or blazars,
20% galaxies and 15% faint (b > 22 mag) optical objects or blank fields.
On a 1-2 year timescale, the general level of variability at 20 GHz appears
to be low. For the 108 sources with good-quality measurements in both 2003 and
2004, the median variability index at 20 GHz was 6.9% and only five sources
varied by more than 30% in flux density.
Most sources in our sample show low levels of linear polarization (typically
1-5%), with a median fractional polarization of 2.3% at 20 GHz. There is a
trend for fainter sources to show higher fractional polarization.
At least 40% of sources selected at 20GHz have strong spectral curvature over
the frequency range 1-20 GHz. We use a radio `two-colour diagram' to
characterize the radio spectra of our sample, and confirm that the radio-source
population at 20 GHz (which is also the foreground point-source population for
CMB anisotropy experiments like WMAP and Planck) cannot be reliably predicted
by extrapolating the results of surveys at lower frequencies. As a result,
direct selection at 20 GHz appears to be a more efficient way of identifying 90
GHz phase calibrators for ALMA than the currently-proposed technique of
extrapolation from all-sky surveys at 1-5 GHz.Comment: 14-page paper plus 5-page data table. Replaced with published versio
The Iowa Homemaker vol.3, no.4-5
Table of Contents
We “Do Over” Our Rooms by Irma Camp and Alice Dodge, page 1
The Mysteries of Amateur Make Up by Frederica Shattuck, page 2
Fall Time Is Pickling Time by Katherine Howells, page 4
Episodes Concerning Evolution of Home Economics by Ruth Elaine Wilson, page 5
Tea – Suggestive of the Rainbow by Esther Ellen Rayburn, page 6
Vary the Vegetable by Blanche Ingersoll, page 7
Constipation and Its Dangers by Anne Mundt, page 8
Graduate Credit Conference for Vocational Home Economics at Iowa State by Eleanor Murray, page 9
Fish That Is Appetizing by Maxine Smith, page 9
Economy, Or a Wrong Idea by Harriett Wallace, page 1
The Australia Telescope 20GHz (AT20G) Survey: analysis of the extragalactic source sample
The Australia Telescope 20 GHz (AT20G) survey is a blind survey of the whole
Southern sky at 20 GHz with follow-up observations at 4.8, 8.6, and 20 GHz
carried out with the Australia Telescope Compact Array (ATCA). In this paper we
present an analysis of radio spectral properties in total intensity and
polarisation, sizes, optical identifications, and redshifts of the sample of
the 5808 extragalactic sources in the survey catalogue of confirmed sources
over the whole Southern sky excluding the strip at Galactic latitude
|b|<1.5deg. The sample has a flux density limit of 40 mJy. Completeness has
been measured as a function of scan region and flux density. Averaging over the
whole survey area the follow-up survey is 78% complete above 50mJy and 93%
complete above 100mJy. 3332 sources with declination <-15deg have good quality
almost simultaneous observations at 4.8, 8.6, and 20GHz. The spectral analysis
shows that the sample is dominated by flat-spectrum sources. The fraction of
flat-spectrum sources decreases from 81% for 20GHz flux densities S>500mJy, to
60% for S<100mJy. There is also a clear spectral steepening at higher
frequencies with the median spectral index decreasing from -0.16 between 4.8
and 8.6GHz to -0.28 between 8.6 and 20GHz. Simultaneous observations in
polarisation are available for all the sources at all the frequencies. 768
sources have a good quality detection of polarised flux density at 20GHz; 467
of them were also detected in polarisation at 4.8 and/or at 8.6GHz so that it
has been possible to compare the spectral behaviour in total intensity and
polarisation. We have found that the polarised fraction increases slightly with
frequency and decreases with flux density. Cross matches and comparisons have
been made with other catalogues at lower radio frequencies, and in the optical,
X-ray and gamma-ray bands. Redshift estimates are available for 825 sources.Comment: 15 pages, 16 figures, accepted for publication in MNRA
Identification of Pharmacodynamic Transcript Biomarkers in Response to FGFR Inhibition by AZD4547
The challenge of developing effective pharmacodynamic biomarkers for preclinical and clinical testing of FGFR signaling inhibition is significant. Assays that rely on the measurement of phospho-protein epitopes can be limited by the availability of effective antibody detection reagents. Transcript profiling enables accurate quantification of many biomarkers and provides a broader representation of pathway modulation. To identify dynamic transcript biomarkers of FGFR signaling inhibition by AZD4547, a potent inhibitor of FGF receptors 1, 2, and 3, a gene expression profiling study was performed in FGFR2-amplified, drug-sensitive tumor cell lines. Consistent with known signaling pathways activated by FGFR, we identified transcript biomarkers downstream of the RAS-MAPK and PI3K/AKT pathways. Using different tumor cell lines in vitro and xenografts in vivo, we confirmed that some of these transcript biomarkers (DUSP6, ETV5, YPEL2) were modulated downstream of oncogenic FGFR1, 2, 3, whereas others showed selective modulation only by FGFR2 signaling (EGR1). These transcripts showed consistent time-dependent modulation, corresponding to the plasma exposure of AZD4547 and inhibition of phosphorylation of the downstream signaling molecules FRS2 or ERK. Combination of FGFR and AKT inhibition in an FGFR2-mutated endometrial cancer xenograft model enhanced modulation of transcript biomarkers from the PI3K/AKT pathway and tumor growth inhibition. These biomarkers were detected on the clinically validated nanoString platform. Taken together, these data identified novel dynamic transcript biomarkers of FGFR inhibition that were validated in a number of in vivo models, and which are more robustly modulated by FGFR inhibition than some conventional downstream signaling protein biomarkers
The Australia Telescope 20 GHz Survey: The Source Catalogue
We present the full source catalogue from the Australia Telescope 20 GHz
(AT20G) Survey. The AT20G is a blind radio survey carried out at 20 GHz with
the Australia Telescope Compact Array (ATCA) from 2004 to 2008, and covers the
whole sky south of declination 0 deg. The AT20G source catalogue presented here
is an order of magnitude larger than any previous catalogue of high-frequency
radio sources, and includes 5890 sources above a 20 GHz flux-density limit of
40 mJy. All AT20G sources have total intensity and polarisation measured at 20
GHz, and most sources south of declination -15 deg also have near-simultaneous
flux-density measurements at 5 and 8 GHz. A total of 1559 sources were detected
in polarised total intensity at one or more of the three frequencies. We detect
a small but significant population of non-thermal sources that are either
undetected or have only weak detections in low-frequency catalogues. We
introduce the term Ultra-Inverted Spectrum (UIS) to describe these radio
sources, which have a spectral index alpha(5, 20) > +0.7 and which constitute
roughly 1.2 per cent of the AT20G sample. The 20 GHz flux densities measured
for the strongest AT20G sources are in excellent agreement with the WMAP 5-year
source catalogue of Wright et al. (2009), and we find that the WMAP source
catalogue is close to complete for sources stronger than 1.5 Jy at 23 GHz.Comment: 21 pages, accepted for publication in MNRA
The Australia Telescope 20 GHz (AT20G) Survey: The Bright Source Sample
The Australia Telescope 20 GHz (AT20G) Survey is a blind survey of the whole
Southern sky at 20 GHz (with follow-up observations at 4.8 and 8.6 GHz) carried
out with the Australia Telescope Compact Array (ATCA) from 2004 to 2007. The
Bright Source Sample (BSS) is a complete flux-limited subsample of the AT20G
Survey catalogue comprising 320 extragalactic (|b|>1.5 deg) radio sources south
of dec = -15 deg with S(20 GHz) > 0.50 Jy. Of these, 218 have near simultaneous
observations at 8 and 5 GHz. In this paper we present an analysis of radio
spectral properties in total intensity and polarisation, size, optical
identifications and redshift distribution of the BSS sources. The analysis of
the spectral behaviour shows spectral curvature in most sources with spectral
steepening that increases at higher frequencies (the median spectral index
\alpha, assuming S\propto \nu^\alpha, decreases from \alpha_{4.8}^{8.6}=0.11
between 4.8 and 8.6 GHz to \alpha_{8.6}^{20}=-0.16 between 8.6 and 20 GHz),
even if the sample is dominated by flat spectra sources (85 per cent of the
sample has \alpha_{8.6}^{20}>-0.5). The almost simultaneous spectra in total
intensity and polarisation allowed us a comparison of the polarised and total
intensity spectra: polarised fraction slightly increases with frequency, but
the shapes of the spectra have little correlation. Optical identifications
provided an estimation of redshift for 186 sources with a median value of 1.20
and 0.13 respectively for QSO and galaxies.Comment: 34 pages, 19 figures, tables of data included, replaced with version
published in MNRA
Manual / Issue 13 / Storage
Manual, a journal about art and its making. Storage. Manual 13 opens with an introduction by Fred Wilson, who confides, “You can look at all the opulence on display in a museum and begin to understand that something nefarious might be behind it. Storage, for me, is where the action is.” Museums usually make choices for viewers, their curators presenting what they think most important within a category. They can be so good at doing this that visitors sometimes don’t realize there’s anything else to see: they don’t realize the nature of the decisions behind an exhibition, and they accept that the elites have made a judgment about which shoe is the shoe to see. Visitors can learn about what’s great, but they don’t necessarily consider the process of discernment. –– Fred Wilson
The RISD Museum’s thirteenth issue of Manual unpacks the idea and reality of storage—objects museums don’t put on view, works made as containers of various sorts, and more metaphorical considerations about how meanings and narratives are stored. This issue serves as a companion to the Raid the Icebox Now series of exhibitions on view at the RISD Museum through November 2020, in which nine contemporary artists and design collectives use the museum and its collections as a site for critical creative production and presentation. Raid the Icebox Now marks the 50th anniversary of Raid the Icebox 1 with Andy Warhol, held in 1970 at the RISD Museum. Softcover, 120 pages. Published Fall/Winter 2019 by the RISD Museum. Manual 13 (Storage) contributors include: Christina Alderman, Issac M. Alderman, A.H. Jerriod Avant, Hannah Carlson, Wai Yee Chiong, John Dunnigan, Maria Morris Hambourg, David Hartt, Elaine Tyler May, Claire McCardell, Denise Murrell, Ingrid Schaffner, Holly Shaffer, Tanya Sheehan, John W. Smith, Mimi Smith, Sassan Tabatabai, Allen Wexler, and Fred Wilson.https://digitalcommons.risd.edu/risdmuseum_journals/1039/thumbnail.jp
Ingredients for Success? A Nation-Wide Survey of Teachers and Stakeholders on Food Education Across the UK
Undergraduate research. Genomics Education Partnership
The Genomics Education Partnership offers an inclusive model for undergraduate research experiences incorporated into the academic year science curriculum, with students pooling their work to contribute to international data bases
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