Designing Sugaropolis:digital games as a medium for conveying transnational narratives

In this paper, the authors present a case study of ‘Sugaropolis’: a two-year practice-based project that involved interdisciplinary co-design and stakeholder evaluation of two digital game prototypes. Drawing on the diverse expertise of the research team (game design and development, human geography, and transnational narratives), the paper aims to contribute to debates about the use of digital games as a medium for representing the past. With an emphasis on design-as-research, we consider how digital games can be (co-)designed to communicate complex histories and geographies in which people, objects, and resources are connected through space and time

Accelerometer and GPS Data to Analyze Built Environments and Physical Activity

Purpose: Most built environment studies have quantified characteristics of the areas around participants' homes. However, the environmental exposures for physical activity (PA) are spatially dynamic rather than static. Thus, merged accelerometer and global positioning system (GPS) data were utilized to estimate associations between the built environment and PA among adults. Methods: Participants (N = 142) were recruited on trails in Massachusetts and wore an accelerometer and GPS unit for 1-4 days. Two binary outcomes were created: moderate-to-vigorous PA (MVPA vs. light PA-to-sedentary); and light-to-vigorous PA (LVPA vs. sedentary). Five built environment variables were created within 50-meter buffers around GPS points: population density, street density, land use mix (LUM), greenness, and walkability index. Generalized linear mixed models were fit to examine associations between environmental variables and both outcomes, adjusting for demographic covariates. Results: Overall, in the fully adjusted models, greenness was positively associated with MVPA and LVPA (odds ratios [ORs] = 1.15, 95% confidence interval [CI] = 1.03, 1.30 and 1.25, 95% CI = 1.12, 1.41, respectively). In contrast, street density and LUM were negatively associated with MVPA (ORs = 0.69, 95% CI = 0.67, 0.71 and 0.87, 95% CI = 0.78, 0.97, respectively) and LVPA (ORs = 0.79, 95% CI = 0.77, 0.81 and 0.81, 95% CI = 0.74, 0.90, respectively). Negative associations of population density and walkability with both outcomes reached statistical significance, yet the effect sizes were small. Conclusions: Concurrent monitoring of activity with accelerometers and GPS units allowed us to investigate relationships between objectively measured built environment around GPS points and minute-by-minute PA. Negative relationships between street density and LUM and PA contrast evidence from most built environment studies in adults. However, direct comparisons should be made with caution since most previous studies have focused on spatially fixed buffers around home locations, rather than the precise locations where PA occurs

Alcohol dependence in a community sample of Aboriginal and Torres Strait Islander Australians : Harms, getting help and awareness of local treatments

Background Few studies have examined links between current alcohol dependence and specific harms among Indigenous Australians. We investigated these associations as well as help seeking for drinking, awareness of local treatments and recommendations to help family or friends cut down or stop drinking in two Indigenous communities. Methods A representative sample of Indigenous Australians was surveyed in one urban and one remote community in South Australia. Data were collected via the Grog Survey App. Participants were dependent if they reported two or more symptoms of alcohol dependence (ICD-11). Pearson chi-square tests were used to describe relationships between employment by gender, and dependence by awareness of medicines and local treatment options. Multivariate logistic regressions were used to predict the odds of dependent drinkers experiencing harms and getting help for drinking, controlling for age, gender, schooling and income. Results A total of 775 Indigenous Australians took part in the study. After controlling for confounders, dependent drinkers were nearly eight times more likely to report a harm and nearly three times more likely to get help for their drinking—compared with non-dependent drinkers. Participants recommended accessing local support from an Aboriginal alcohol and other drugs worker, or a detoxification/ rehabilitation service. Discussion and conclusions More support and funding is needed for Indigenous Australians to ensure local treatment options for dependent drinkers are readily available, appropriate and accessible. Involvement of local Aboriginal or Torres Strait Islander health professionals in delivery of care can help ensure that it is appropriate to an individual’s culture and context

Recurrence patterns of locally advanced head and neck squamous cell carcinoma after 3D conformal (chemo)-radiotherapy

<p>Abstract</p> <p>Background</p> <p>To establish recurrence patterns among locally advanced head and neck non-nasopharyngeal squamous cell carcinoma (HNSCC) patients treated with radical (chemo-) radiotherapy and to correlate the sites of loco-regional recurrence with radiotherapy doses and target volumes</p> <p>Method</p> <p>151 locally advanced HNSCC patients were treated between 2004-2005 using radical three-dimensional conformal radiotherapy. Patients with prior surgery to the primary tumour site were excluded. The sites of locoregional relapses were correlated with radiotherapy plans by the radiologist and a planning dosimetrist.</p> <p>Results</p> <p>Median age was 59 years (range:34-89). 35 patients had stage III disease, 116 patients had stage IV A/B. 36 patients were treated with radiotherapy alone, 42 with induction chemotherapy, 63 with induction and concomitant chemoradiotherapy and 10 concomitant chemoradiotherapy. Median follow-up was 38 months (range 3-62). 3-year cause specific survival was 66.8%. 125 of 151 (82.8%) achieved a complete response to treatment. Amongst these 125 there were 20 local-regional recurrence, comprising 8 local, 5 regional and 7 simultaneous local and regional; synchronous distant metastases occurred in 7 of the 20. 9 patients developed distant metastases in the absence of locoregional failure. For the 14 local recurrences with planning data available, 12 were in-field, 1 was marginal, and 1 was out-of-field. Of the 11 regional failures with planning data available, 7 were in-field, 1 was marginal and 3 were out-of-field recurrences.</p> <p>Conclusion</p> <p>The majority of failures following non-surgical treatment for locally advanced HNSCC were loco-regional, within the radiotherapy target volume. Improving locoregional control remains a high priority.</p

The Ursinus Weekly, March 12, 1962

Nobel Prize-winner here tonight: Dr. Linus Pauling to address special forum on Science and international relations • Book No more war! Dr. Pauling\u27s credo • Local high school pupils invited to PSEA panel • UC students attend I.C.G. convention • Student-faculty talent show to finish Campus Chest charity drive Friday • College\u27s concert band to perform next Thursday • Lauderdale braces for Spring influx • Civil liberty\u27s Cox visits U.C. campus • Campus Chest activities continue this week • Ursinus invites public to use College Library • St. Pat\u27s twist theme of frosh dance Saturday • Pre-med club to see films depicting Caesarian birth • Editorial: Just this once • Penna. folk festival planned for Harrisburg • Ursinus in the past • Curtain Club offers two plays; One-act shows given last Thursday • Women\u27s hairbreadth victories mark basketball play; Sansenbach stars • High scoring continues; Intramural finish nears • Mermaids win two in week\u27s action • Sports publicist evaluates season • Intramural corner • Cindermen seem strong as five lettermen return • Chief McClure hustles vagrant to county jail • Collegeville tops Phoenix YMCA basketball league • Collegeville firemen take part in Phila. exhibit • Faculty hoopsters triumph in benefit against girls • Graduate grantshttps://digitalcommons.ursinus.edu/weekly/1314/thumbnail.jp

Local stellar kinematics from RAVE data: III. Radial and Vertical Metallicity Gradients based on Red Clump Stars

We investigate radial and vertical metallicity gradients for a sample of red clump stars from the RAdial Velocity Experiment (RAVE) Data Release 3. We select a total of 6781 stars, using a selection of colour, surface gravity and uncertainty in the derived space motion, and calculate for each star a probabilistic (kinematic) population assignment to a thin or thick disc using space motion and additionally another (dynamical) assignment using stellar vertical orbital eccentricity. We derive almost equal metallicity gradients as a function of Galactocentric distance for the high probability thin disc stars and for stars with vertical orbital eccentricities consistent with being dynamically young, e_v<=0.07, i.e. d[M/H]/dR_m = -0.041(0.003) and d[M/H]/dR_m = -0.041(0.007) dex/kpc. Metallicity gradients as a function of distance from the Galactic plane for the same populations are steeper, i.e. d[M/H]/dz_{max} = -0.109(0.008) and d[M/H]/dz_{max} = -0.260(0.031) dex/kpc, respectively. R_m and z_{max} are the arithmetic mean of the perigalactic and apogalactic distances, and the maximum distance to the Galactic plane, respectively. Samples including more thick disc red clump giant stars show systematically shallower abundance gradients. These findings can be used to distinguish between different formation scenarios of the thick and thin discs.Comment: 27 pages, including 15 figures and 4 tables, accepted for publication in MNRA

The distance of M33 and the stellar population in its outskirts

We present deep V,I photometry of two $9.4' x 9.4' field in the outer regions of the M33 galaxy. We obtain a robust detection of the luminosity of the Red Giant Branch Tip (I{TRGB}=20.72 +- 0.08) from which we derived a new estimate of the distance modulus of M33, (m-M)_0=24.64 +- 0.15, corresponding to a distance D=847 +- 60 Kpc. By comparison of the color and magnitude of the observed Red Giant Branch stars with ridge lines of template globular clusters we obtained the photometric metallicity distribution of the considered fields in three different metallicity scales. The derived metallicity distributions are very similar over a range of distances from the galactic center 10' <= R <= 33', and are characterized by a well defined peak at [M/H] ~ -0.7 ([Fe/H] ~ -1.0, in the Zinn & West scale) and a weak metal-poor tail reaching [M/H] ~ -2.0. Our observations demonstrate that Red Giant Branch and Asymptotic Giant Branch stars have a radial distribution that is much more extended than the young MS stars associated with the star-forming disc.Comment: 10 pages,10 figures,accepted for publication in Astronomy & Astrophysic

In Vitro Intracellular Trafficking of Virulence Antigen during Infection by Yersinia pestis

Yersinia pestis, the causative agent of plague, encodes several essential virulence factors on a 70 kb plasmid, including the Yersinia outer proteins (Yops) and a multifunctional virulence antigen (V). V is uniquely able to inhibit the host immune response; aid in the expression, secretion, and injection of the cytotoxic Yops via a type III secretion system (T3SS)-dependent mechanism; be secreted extracellularly; and enter the host cell by a T3SS-independent mechanism, where its activity is unknown. To elucidate the intracellular trafficking and target(s) of V, time-course experiments were performed with macrophages (MΦs) infected with Y. pestis or Y. pseudotuberculosis at intervals from 5 min to 6 h. The trafficking pattern was discerned from results of parallel microscopy, immunoblotting, and flow cytometry experiments. The MΦs were incubated with fluorescent or gold conjugated primary or secondary anti-V (antibodies [Abs]) in conjunction with organelle-associated Abs or dyes. The samples were observed for co-localization by immuno-fluorescence and electron microscopy. For fractionation studies, uninfected and infected MΦs were lysed and subjected to density gradient centrifugation coupled with immunoblotting with Abs to V or to organelles. Samples were also analyzed by flow cytometry after lysis and dual-staining with anti-V and anti-organelle Abs. Our findings indicate a co-localization of V with (1) endosomal proteins between 10–45 min of infection, (2) lysosomal protein(s) between 1–2 h of infection, (3) mitochondrial proteins between 2.5–3 h infection, and (4) Golgi protein(s) between 4–6 h of infection. Further studies are being performed to determine the specific intracellular interactions and role in pathogenesis of intracellularly localized V