Marital Adjustment and Spouses’ Ratings of their own and their Partners’ Specific Affects During a Conversation

Estudios previos han mostrado una asociación entre el ajuste marital y la evaluación de una persona de su propio afecto o el de su cónyuge durante una conversación marital. Sin embargo, tales mediciones de la conversación han quedado restringidas a las categorías globales de afecto positivo y negativo. En este estudio, 60 personas evaluaron durante cada minuto de su conversación marital la intensidad de su experiencia y la de su pareja en torno a 7 emociones específicas: enojo, tristeza, temor, interés, alegría, cariño y tranquilidad. Un subconjunto de estas variables explicó un 64% de la varianza en el ajuste marital femenino y otro un 70% de la varianza en el ajuste marital masculino.Previous studies have shown an association between marital adjustment and selfrating or partner’s rating of affect during a marital conversation. However, suchassessments of the conversation have been restricted to the global categories of positive and negative affect. In this study, 60 persons rated every minute of their marital conversation in terms of their own and their partners’ experience on 7 specific emotions: anger, sadness, fear, interest, joy, love and calmness. A subset of these variables accounted for 64% of wife marital adjustment and another accounted for 70% of husband marital adjustment

Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling.

BACKGROUND:Human cerebral malaria (HCM) is a severe form of malaria characterized by sequestration of infected erythrocytes (IRBCs) in brain microvessels, increased levels of circulating free heme and pro-inflammatory cytokines and chemokines, brain swelling, vascular dysfunction, coma, and increased mortality. Neuregulin-1β (NRG-1) encoded by the gene NRG1, is a member of a family of polypeptide growth factors required for normal development of the nervous system and the heart. Utilizing an experimental cerebral malaria (ECM) model (Plasmodium berghei ANKA in C57BL/6), we reported that NRG-1 played a cytoprotective role in ECM and that circulating levels were inversely correlated with ECM severity. Intravenous infusion of NRG-1 reduced ECM mortality in mice by promoting a robust anti-inflammatory response coupled with reduction in accumulation of IRBCs in microvessels and reduced tissue damage. METHODS:In the current study, we examined how NRG-1 treatment attenuates pathogenesis and mortality associated with ECM. We examined whether NRG-1 protects against CXCL10- and heme-induced apoptosis using human brain microvascular endothelial (hCMEC/D3) cells and M059K neuroglial cells. hCMEC/D3 cells grown in a monolayer and a co-culture system with 30 μM heme and NRG-1 (100 ng/ml) were used to examine the role of NRG-1 on blood brain barrier (BBB) integrity. Using the in vivo ECM model, we examined whether the reduction of mortality was associated with the activation of ErbB4 and AKT and inactivation of STAT3 signaling pathways. For data analysis, unpaired t test or one-way ANOVA with Dunnett's or Bonferroni's post test was applied. RESULTS:We determined that NRG-1 protects against cell death/apoptosis of human brain microvascular endothelial cells and neroglial cells, the two major components of BBB. NRG-1 treatment improved heme-induced disruption of the in vitro BBB model consisting of hCMEC/D3 and human M059K cells. In the ECM murine model, NRG-1 treatment stimulated ErbB4 phosphorylation (pErbB4) followed by activation of AKT and inactivation of STAT3, which attenuated ECM mortality. CONCLUSIONS:Our results indicate a potential pathway by which NRG-1 treatment maintains BBB integrity in vitro, attenuates ECM-induced tissue injury, and reduces mortality. Furthermore, we postulate that augmenting NRG-1 during ECM therapy may be an effective adjunctive therapy to reduce CNS tissue injury and potentially increase the effectiveness of current anti-malaria therapy against human cerebral malaria (HCM)

Refractive index of a transparent liquid measured with a concave mirror

This paper describes the spherical concave mirror method for measuring the index of refraction of transparent liquids. We derived the refractive index equation using Snell's law and the small-angle approximation. We also verified the validity of this method using the traditional spherical mirror and thin-lens Gaussian equations.Comment: IOPart, 8 pages, 4 figure

Productive, Distributive, Dynamic, and Allocative Efficiency Improvement Model in Colombian Public Universities: Modelo de mejoramiento de la eficiencia Productiva, distributiva, de asignación y dinámica en las universidades públicas de Colombia

The measurement of efficiency in public universities has been a topic of interest for researchers and state officials in Colombia; this article presents a model that transcends the view of productive efficiency, and expands it by including aspects of equity with distributive efficiency, of acceptance by society in the allocative efficiency, and finally with the dynamic efficiency includes the time variable, with which the state can measure the stability of the indicators of interest. For the design of the model, multivariate statistical techniques and non-parametric techniques were used, such as Structural Equation Models, Principal Component Analysis, Data Envelopment Analysis, and the Balanced Scorecard. Different ranks are obtained with which university improvement plans were identified, emphasizing public institutions with high quality accreditation. A Balanced Scorecard is proposed with the indicators extracted from the sector databases that met the conditions of the techniques used. This technique suggests a causal relationship between the indicators of distributive, productive, and allocative efficiencies, where the perspective of inclusion forms the basis of the scorecard, affecting the perspective of education and research and the latter influencing the perspective of impact. Finally, it is concluded that the public university sector has great challenges in terms of inclusion and measurement of the satisfaction of society, as well as showing improvement trends in the measured aspects as reflected in the DEA Malmquist index. As a result, a model is obtained for university administrators to identify the aspects in which they must invest the public budget that guarantees the greater multidimensional efficiency of Colombian public universities

Productive, Distributive, Dynamic, and Allocative Efficiency Improvement Model in Colombian Public Universities: Modelo de mejoramiento de la eficiencia Productiva, distributiva, de asignación y dinámica en las universidades públicas de Colombia

The measurement of efficiency in public universities has been a topic of interest for researchers and state officials in Colombia; this article presents a model that transcends the view of productive efficiency, and expands it by including aspects of equity with distributive efficiency, of acceptance by society in the allocative efficiency, and finally with the dynamic efficiency includes the time variable, with which the state can measure the stability of the indicators of interest. For the design of the model, multivariate statistical techniques and non-parametric techniques were used, such as Structural Equation Models, Principal Component Analysis, Data Envelopment Analysis, and the Balanced Scorecard. Different ranks are obtained with which university improvement plans were identified, emphasizing public institutions with high quality accreditation. A Balanced Scorecard is proposed with the indicators extracted from the sector databases that met the conditions of the techniques used. This technique suggests a causal relationship between the indicators of distributive, productive, and allocative efficiencies, where the perspective of inclusion forms the basis of the scorecard, affecting the perspective of education and research and the latter influencing the perspective of impact. Finally, it is concluded that the public university sector has great challenges in terms of inclusion and measurement of the satisfaction of society, as well as showing improvement trends in the measured aspects as reflected in the DEA Malmquist index. As a result, a model is obtained for university administrators to identify the aspects in which they must invest the public budget that guarantees the greater multidimensional efficiency of Colombian public universities

Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids

This is the pre-peer reviewed version of the following article: Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids, which has been published in final form at https://doi.org/10.1002/slct.201903835. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived VersionsThe synthesis, in silico studies, antiprotozoal and cytotoxic activities of eleven quinoline‐biphenyl hybrids are described herein. The structure of the synthesized products was elucidated by a combination of spectrometric analyses. The synthesized compounds were evaluated against Plasmodium falciparum, and amastigotes forms both Leishmania (V) panamensis and Trypanosoma cruzi. Cytotoxicity was evaluated against human U‐937 macrophages. 8‐phenylquinoline (4 a) showed similar activity than meglumine antimoniate and 4‐(quinolin‐8‐yl)phenol (4 b) exhibited an activity similar to that of benznidazole. 8‐(3,4‐dimethoxyphenyl) quinoline (4 k) showed the best activity against P. falciparum. Although these compounds were toxic for mammalian U‐937 cells, however they may still have potential to be considered as candidates for drug development because of their antiparasite activity. Molecular docking was used to determine the in silico inhibition of some of the designed compounds against PfLDH and cruzipain, two important pharmacological targets involved in antiparasitic diseases. All hybrids were docked to the three‐dimensional structures of PfLDH and T. cruzi cruzipain as enzymes using AutoDock Vina. Notably, the docking results showed that the most active compounds 4‐(quinolin‐8‐yl)phenol (4 b, CE50: 11.33 μg/mL for T. cruzi) and 8‐(3,4‐dimethoxyphenyl) quinoline (4 k, CE50: 8.84 μg/mL for P. falciparum) exhibited the highest scoring pose (−7.5 and −7.7 kcal/mol, respectively). This result shows a good correlation between the predicted scores with the experimental data profile, suggesting that these ligands could act as competitive inhibitors of PfLDH or T. cruzi cruzipain enzymes, respectively. Finally, in silico ADME studies of the quinoline hybrids showed that these novel compounds have suitable drug‐like properties, making them potentially promising agents for antiprotozoal therapy

La mecatrónica: sistemas de automatización en serie

Todo proceso industrial se maneja bajo diversos sistemas, sean estos informáticos, eléctricos, neumáticos, electrónicos, mecánicos, etc., por tanto, es necesario que en la empresa moderna, se domine todos los bloques involucrados en la producción, a fin de solventar las necesidades que se presenten. Por tanto, el talento humano no debe trabajar por separado, debe ser un solo grupo cooperativo de trabajo, con el fin de solventar, mantener y aprovechar al máximo dichos sistemas